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ICU kidney treatment may stun the heart, new study suggests

NCT ID NCT05209230

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether continuous kidney replacement therapy can cause temporary heart muscle weakness (myocardial stunning) in critically ill patients with severe acute kidney injury. Researchers used echocardiograms to measure changes in heart wall motion in 42 adults. The goal was to understand if this heart effect is common and independent of changes in blood volume.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

42 people

The number who actually took part.

Started

Apr 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years old * Acute Kidney Injury grade 3 (KDIGO) * Indication for renal replacement therapy for the clinician in charge Exclusion Criteria: * Emergency indication to renal replacement therapy (pH\<7.15, Kaliemia \> 6mmol/L, refractory pulmonary oedema) * Poor echogenicity with speckle tracking analysis failure * Chronic hemodialysis * Extra corporeal membrane oxygenation, left ventricular assist device.

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Conditions

The condition(s) this trial relates to.

acute kidney injury myocardial stunning

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury kdigo 3 Continuous renal replacement therapy initiated by the clinician in charge without emergency Myocardial stunning

Contacts and locations

Locations

  • Département d'anesthésie-réanimation Hôpital cardiologique Louis Pradel Groupe Hospitalier Est

    Bron, Bron, 69500, France

  • Hopital Edourd Herriot

    Lyon, 69008, France

  • Ruste Martin

    Bron, BRON, 69500, France

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