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New imaging methods aim to spot dangerous carotid plaque before stroke strikes

NCT ID NCT02748941

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing several advanced imaging techniques to see if they can better predict which people with narrowed carotid arteries are at risk of a stroke. Researchers will compare 45 people who have already had a stroke with 105 who have not, using ultrasound and MRI to examine the plaque in their arteries. The goal is to find the best combination of imaging methods to identify unstable plaque that could cause a future stroke.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better ways to identify which patients with carotid narrowing are at highest risk of stroke, improving treatment decisions.
What could go wrong
This is a small, early-stage case-control study, not a treatment trial. The imaging methods may not prove reliable enough to change clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 77 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2017

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Carotid stenosis ≥ 50% NASCET * Case: ipsilateral carotid stenosis stroke, certified by MRI or CT in the preceding month, with no others causes of stroke * Control: no clinical sign or MRI hint for a recent stroke * Signed informed consent form * Patient affiliated to a social security system or equivalent Exclusion Criteria: * Modified Rankin scale \> 3 * Homolateral stroke or TIA \> 1 month * Medical history of homolateral carotid surgery, cervical radiation, carotid occlusive, homolateral intracranial stenosis, risk of developing arterial thromboembolic events * Renal failure (creatinine clearance \< 50 ml/min) * Contraindication to ultrasound (sonovue) * Contraindication to MRI and its contrast media (Gadolinium) * Inability to sign informed consent * Inability to undergo any of the technics (claustrophobia…) * Serious co-morbid disease, dementia * Neurological disease with no carotid disease * Risk of pregnancy or pregnancy or breastfeeding * Adult under reinforced guardianship or legal guardian * Patient not understanding French

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Conditions

The condition(s) this trial relates to.

carotid stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid stenosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospices Civils de Lyon - Service de radiologie

    RECRUITING

    Bron, 69500, France

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