EPILEPSY

This early study tests a new deep brain stimulation (DBS) approach that adjusts stimulation based on whether the person is awake or asleep. Four adults with Lennox-Gastaut syndrome will receive a Medtronic Percept DBS device. Researchers will compare personalized day/night stimul…

This study tests a new device that detects brain signals linked to seizures and delivers targeted stimulation to stop them. It involves 40 people with epilepsy whose seizures are not controlled by medication. The goal is to see if the device is safe and reduces how often seizures…

This study tests whether MRI-guided high-intensity focused ultrasound (HIFU) can safely treat adults with drug-resistant focal epilepsy. The treatment uses sound waves to heat and destroy small brain areas causing seizures, without needing open surgery. The goal is to see if the …

This early-stage trial tests a new treatment called UX-GIP001 for adults with drug-resistant epilepsy that starts in one side of the brain's temporal lobe. The treatment involves injecting special brain cells that may help calm overactive nerve signals. The study will enroll 12 p…

This study looks at whether a non-invasive technique called focused ultrasound can safely treat brain lesions that cause seizures in children with drug-resistant epilepsy. About 20 children aged 4-17 will be treated and followed to see if their seizures become less frequent and l…

This study tests an experimental drug called RAP-219 to see if it safely reduces the number of focal seizures in adults with epilepsy. About 312 participants will take either the drug or a placebo for a set period. The main goal is to measure how much seizure frequency drops and …

This pilot study tests a new care pathway for 60 adults with epilepsy who are starting a new anti-seizure medication. The program combines remote monitoring with nurse support for six months to help patients stick to their medication schedule and catch side effects or seizure cha…

This study tests a liquid seizure medicine (zonisamide) in 40 children aged 1 month to 17 years who have partial-onset seizures. The goal is to find the best dose that is safe and works well. The study lasts about 13 weeks, with regular checkups and blood tests.

This study tests a new, more comfortable brain scanner (OPM MEG) that uses tiny sensors placed directly on the scalp to find where seizures start in people with epilepsy. About 70 children and adults will get this scan before their planned epilepsy surgery. Researchers will check…

This study looks at whether measuring a protein called S100B in the blood can help emergency room doctors quickly tell if a person's fainting spell is due to epilepsy or another cause. About 100 adults who come to the ER after losing consciousness will give an extra blood sample.…

This study tests the Korus smart mattress in 10 healthy adults to see if it can accurately detect body positions (like lying on the stomach) and automatically reposition the person to a safer side-lying position. The goal is to prevent sudden unexpected death in epilepsy (SUDEP) …

This study tests a non-invasive technique called temporal interference electrical stimulation to boost deep sleep in people with epilepsy. Researchers will compare real stimulation to a sham (fake) treatment over 4 nights each, measuring sleep quality, seizure frequency, alertnes…

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) to reduce seizures in people with drug-resistant temporal lobe epilepsy. Researchers will treat 30 adults for 5 days and track seizure frequency for one to two months. The goal is to s…

This study tests a non-invasive brain training technique called neurofeedback to help reduce seizures in adults with drug-resistant epilepsy. About 22 participants will either receive real neurofeedback or a sham (fake) version to see if the training lowers seizure frequency and …

This study tests whether a short program of compassion-focused therapy and loving-kindness meditation can improve mental health in children aged 12-17 with epilepsy. Participants attend three online therapy sessions and practice meditation for four weeks. The goal is to see if th…

This study tests whether adding dog-assisted therapy to standard psychomotor therapy can improve quality of life for adults with hard-to-treat epilepsy. Researchers will measure changes in quality of life, anxiety, and seizure frequency after 10 sessions. The goal is to see if in…

This study tests a drug called cenobamate to quickly stop frequent seizures or ongoing seizure emergencies (status epilepticus) in intensive care patients. Ten adults aged 18-70 who have many seizures per hour will receive the drug while being closely monitored. The main goals ar…

This study looks at how epilepsy changes certain brain areas that control breathing and waking up. Researchers will use special brain scans to compare 50 people with drug-resistant epilepsy to healthy volunteers. The goal is to understand why some epilepsy patients may stop breat…

This study looks at whether people with epilepsy digest food and liquids at a normal rate before surgery, even after following standard fasting rules. Researchers will use a quick, painless ultrasound scan to check the stomach contents of 30 adults with epilepsy scheduled for sur…

This study aims to find out how often children with epilepsy also have symptoms of ADHD, and what factors might make that more likely. Researchers will follow 185 children over 12 weeks to track changes in ADHD symptoms and quality of life. The goal is to better understand the co…

This study will test the EPIDAY mobile app, which uses daily symptom reports and machine learning to predict the risk of epileptic seizures in people with focal epilepsy. Researchers will enroll 50 adults aged 18 to 65 who have at least two seizure days per month. The goal is to …

This study tests if watching a medical TV drama (House M.D.) can improve young adults' knowledge of neurocysticercosis, a brain infection caused by a parasite. Sixty people aged 18-35 will be split into two groups: one watches the show, the other does not. Both groups take a quiz…

This study looks at whether a health literacy education program can improve knowledge, medication adherence, and reduce stigma among 60 adolescents with epilepsy aged 12-18. Participants will complete surveys about their understanding of epilepsy, how well they take their medicat…

This study will use artificial intelligence to analyze sleep recordings from 1,500 adults with chronic insomnia and/or epilepsy. The goal is to see if a computer can accurately identify sleep stages as well as sleep experts can. If successful, this could lead to faster and more c…

This study looks at how the drug Cobenfy KarXT affects memory and brain activity in 50 adults with epilepsy who are already having brain surgery for seizure monitoring. Participants will take either the drug or a placebo on two separate days and perform memory tasks while their b…

This study tests a new device that records brain activity and delivers small electrical pulses to prevent seizures in people with epilepsy that doesn't respond to medication. The device is used externally (not implanted) in a hospital setting. The goal is to see if the system can…

This study aims to find out if using virtual reality headsets raises the risk of seizures in teenagers and adults with epilepsy. Researchers will monitor brain activity with EEG while participants wear a VR headset, first with the display off, then on without hand controllers, an…

This study will follow 200 children with epilepsy to find out why some don't respond to standard seizure medicines. Researchers will look at brain scans, EEG patterns, and medical history to spot early clues. The goal is to identify resistant cases sooner and explore alternative …

This study works with epilepsy patients who are already having brain surgery to learn more about how the brain works and what goes wrong in epilepsy. Researchers will use tiny electrodes to record brain signals while patients do tasks like speaking or remembering. The goal is to …