Super MRI scans aim to unlock secrets of brain resilience

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age:Female or male, aged 18 years or older. * Health Status: No uncontrolled general diseases, such as cancer, autoimmune diseases, liver failure, severe or untreated high blood pressure, or severe rhythm disorders. No chronic psychiatric illnesses, including severe dementia. * MRI Compatibility: No contraindications for MRI exams (e.g., claustrophobia, metal foreign bodies, pacemakers, severe kidney failure). * Social Security Coverage: Participants must have social security coverage. * Informed Consent: The participant must have read, understood, and signed the informed consent after being adequately informed about the study. * Specific Disease Criteria (For Disease Groups): Specific inclusion criteria apply to each pathology, such as MS (based on McDonald criteria), NMOSD (Wingerchuk 2015), Alzheimer's (meeting NINCDS-ADRDA criteria), etc. Exclusion Criteria: * Pregnancy: Pregnant women are excluded from the study. * Inability to Provide Informed Consent: * Any participant who refuses to sign the informed consent or is unable to do so due to mental or physical conditions. * Refusal of MRI: Individuals who refuse to undergo brain MRI. * Contraindications for MRI:Participants with contraindications for MRI exams, such as claustrophobia, metal foreign bodies, pacemakers, or severe kidney failure. * Medical Conditions: Known allergy to Dotarem (contrast agent) for neuroinflammatory patients. Individuals with severe renal insufficiency or other conditions that prevent MRI scanning. Cognitive or Psychiatric Issues: Chronic psychiatric conditions, including severe dementia or cognitive dysfunction that could hinder participation. Legal or Institutional Restrictions: Adults under legal protection (e.g., under guardianship or curatorship). Individuals deprived of their liberty. Other Medical Conditions: Individuals with neurological diseases such as ischemic accidents, brain trauma, or encephalitis. Patients on treatments that would interfere with the study, as outlined for each disease. Allergy to Contrast Agent: Allergy to Dotarem for neuroinflammatory patients (MS, NMOSD, etc.). Inability to Adhere to Protocol: Participants who are unable or unwilling to comply with the study protocol.