AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Clinical trials for AMYOTROPHIC LATERAL SCLEROSIS (ALS) explained in plain language.
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New breathing device could help ALS patients breathe easier, live longer
Disease control Recruiting nowThis study is testing whether a special breathing training device can help people with ALS maintain their lung function and potentially extend survival. Fifteen adults with ALS will use the device twice daily at home and visit the clinic every three months for breathing tests and…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: NA • Sponsor: National Center of Neurology and Psychiatry, Japan • Aim: Disease control
Last updated Apr 03, 2026 21:10 UTC
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New inhaled treatment could slow ALS progression
Disease control Recruiting nowThis study is testing whether an inhaled medication called PHENOGENE-1A (cromolyn) can help slow the progression of ALS when added to standard treatment. Researchers will enroll 105 adults with mild to moderate ALS to receive either the study drug or a placebo for 24 weeks. The m…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: PHASE2 • Sponsor: PhenoNet, Inc. • Aim: Disease control
Last updated Apr 02, 2026 14:56 UTC
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First-in-Human trial tests immune cells to fight ALS
Disease control Recruiting nowThis early-stage study is testing whether a patient's own immune cells, called regulatory T cells (Tregs), can be safely injected into the spinal fluid to potentially slow the progression of ALS. The study will enroll 12 adults with ALS to receive up to three injections over two …
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: PHASE1 • Sponsor: Novabio Therapeutics • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Could a poop pill slow this devastating nerve disease?
Disease control Recruiting nowThis study is testing whether transplanting healthy gut bacteria from a donor can help slow the progression of ALS. Twenty people with ALS will take specially prepared capsules containing the transplanted microbes for eight weeks. Researchers will track their symptoms, quality of…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: PHASE1, PHASE2 • Sponsor: Duke University • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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First patients receive new experimental drug targeting genetic cause of ALS
Disease control Recruiting nowThis is the first study to test an experimental drug called ALN-SOD in people with ALS caused by a specific change in the SOD1 gene. The main goal is to check the drug's safety and how well it's tolerated when given via spinal injection. Researchers will also measure how the drug…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: PHASE1, PHASE2 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New Two-Pronged attack on devastating ALS nerve disease
Disease control Recruiting nowThis study is testing an investigational combination therapy called COYA 302 for adults with Amyotrophic Lateral Sclerosis (ALS). It aims to see if the treatment is safe and can slow the progression of the disease by targeting inflammation in the body. About 120 participants will…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: PHASE2 • Sponsor: Coya Therapeutics • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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First human test of Lab-Grown motor neurons for ALS patients
Disease control Recruiting nowThis early-stage study is testing whether motor neuron cells grown from stem cells are safe for people with ALS. Researchers will give these lab-grown cells to 12 ALS patients and monitor them closely for side effects. The main goal is to see if this experimental treatment is wel…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: PHASE1 • Sponsor: XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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Zap to ease the pain: electrical pads tested for ALS jaw discomfort
Symptom relief Recruiting nowThis study is testing whether a single 30-minute session of gentle electrical stimulation on the face can help reduce jaw pain and improve chewing and mouth movement for people with ALS or PLS. Ten participants will have the treatment in a clinic and report their pain and ability…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: NA • Sponsor: Nova Southeastern University • Aim: Symptom relief
Last updated Mar 24, 2026 12:02 UTC
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Scientists hunt for early warning signs of ALS in Patients' blood
Knowledge-focused Recruiting nowThis study aims to discover new biological markers (biomarkers) for Amyotrophic Lateral Sclerosis (ALS) to help diagnose the disease earlier and track its progression. Researchers will analyze small nerve and skin samples, along with blood, from 400 participants, including people…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Scientists hunt for early warning signs of devastating nerve disease
Knowledge-focused Recruiting nowThis study aims to find biological markers that could help doctors diagnose ALS much earlier, before major symptoms appear. Researchers will compare blood, urine, and spinal fluid from 60 people, including those with a genetic risk but no symptoms, early ALS patients, and healthy…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: NA • Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:31 UTC
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New brain scan could unlock secrets of devastating diseases
Knowledge-focused Recruiting nowThis study is testing a new type of brain scan to measure levels of a specific protein called Hsp90. Researchers will compare scans from healthy volunteers to those from people with Alzheimer's disease, Parkinson's disease, or ALS. The goal is to see if this scan can help underst…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Phase: NA • Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:31 UTC
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Scientists launch massive brain bank to crack code of Alzheimer's, ALS, and other neurological diseases
Knowledge-focused Recruiting nowThis study aims to create a large collection of information to help researchers better understand brain diseases like Alzheimer's, ALS, and frontotemporal degeneration. It will enroll 1000 people, including those diagnosed with these conditions, people with a family history, and …
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:39 UTC
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Massive online study hunts for clues to slow or reverse ALS
Knowledge-focused Recruiting nowThis is an online registry study for people diagnosed with ALS, MND, or PLS. It aims to observe which treatments, supplements, diets, and lifestyle factors are linked to better outcomes by tracking the health data of 1,000 participants over time. The study does not provide treatm…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Sponsor: Healing Advocates Registry and Ministry • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:38 UTC
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Scientists use Super-Powered scans to unlock Brain's secrets in aging and disease
Knowledge-focused Recruiting nowThis study aims to understand how the brain changes and adapts in various neurological conditions and during normal aging. Researchers will use advanced, high-powered MRI scans to look at brain structure, function, and energy use in 700 participants, including people with disease…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:15 UTC
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Eye scans could spot Alzheimer's years before symptoms
Knowledge-focused Recruiting nowThis study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Mar 18, 2026 14:41 UTC