AMYOTROPHIC LATERAL SCLEROSIS (ALS)

This is the first study to test an experimental drug called ALN-SOD in people with a specific genetic form of ALS (SOD1-ALS). The main goal is to check if the drug is safe and tolerable when given via spinal injection. Researchers will also measure how the drug affects certain pr…

This study is testing whether a special breathing training device can help people with ALS maintain their lung function and potentially extend survival. Fifteen adults with ALS will use the device twice daily at home and visit the clinic every three months for breathing tests and…

This study is testing whether an inhaled medication called PHENOGENE-1A (cromolyn) can help slow the progression of ALS when added to standard treatment. Researchers will enroll 105 adults with mild to moderate ALS to receive either the study drug or a placebo for 24 weeks. The m…

This early-stage study is testing whether a patient's own immune cells, called regulatory T cells (Tregs), can be safely injected into the spinal fluid to potentially slow the progression of ALS. The study will enroll 12 adults with ALS to receive up to three injections over two …

This study is testing whether transplanting healthy gut bacteria from a donor can help slow the progression of ALS. Twenty people with ALS will take specially prepared capsules containing the transplanted microbes for eight weeks. Researchers will track their symptoms, quality of…

This study is testing an investigational combination therapy called COYA 302 for adults with Amyotrophic Lateral Sclerosis (ALS). It aims to see if the treatment is safe and can slow the progression of the disease by targeting inflammation in the body. About 120 participants will…

This early-stage study is testing whether motor neuron cells grown from stem cells are safe for people with ALS. Researchers will give these lab-grown cells to 12 ALS patients and monitor them closely for side effects. The main goal is to see if this experimental treatment is wel…

This study aims to find early biological signs of ALS (amyotrophic lateral sclerosis) to help doctors diagnose the disease sooner. Researchers will compare samples from 60 people, including those with a genetic risk but no symptoms, early ALS patients, and healthy volunteers. The…

This study is testing whether a single 30-minute session of gentle electrical stimulation on the face can help reduce jaw pain and improve chewing and mouth movement for people with ALS or PLS. Ten participants will have the treatment in a clinic and report their pain and ability…

This study aims to understand how the brain changes in various neurological diseases and during healthy aging. Researchers will use advanced MRI scans on 700 participants, including people with conditions like Multiple Sclerosis and Alzheimer's, as well as healthy volunteers. The…

This study aims to discover new biological markers (biomarkers) for Amyotrophic Lateral Sclerosis (ALS) to help diagnose the disease earlier and track its progression. Researchers will analyze small nerve and skin samples, along with blood, from 400 participants, including people…

This study is testing a new type of brain scan to measure levels of a specific protein called Hsp90. Researchers will compare scans from healthy volunteers to those from people with Alzheimer's disease, Parkinson's disease, or ALS. The goal is to see if this scan can help underst…

This study aims to create a large collection of information to help researchers better understand brain diseases like Alzheimer's, ALS, and frontotemporal degeneration. It will enroll 1000 people, including those diagnosed with these conditions, people with a family history, and …

This is an online registry study for people diagnosed with ALS, MND, or PLS. It aims to observe which treatments, supplements, diets, and lifestyle factors are linked to better outcomes by tracking the health data of 1,000 participants over time. The study does not provide treatm…

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…