AMYOTROPHIC LATERAL SCLEROSIS (ALS)

This early-stage study tests whether a new stem cell therapy (XS228CN) is safe for people with ALS, a disease that damages nerve cells controlling movement. Researchers will give the cells to 12 adults aged 18-75 and watch for side effects over 28 days. The goal is to see if the …

This study tests an experimental drug called ALN-SOD in people with ALS caused by a specific gene change (SOD1 mutation). The main goal is to check safety and how well the drug is tolerated. Researchers will also measure drug levels in blood and spinal fluid, and look at biomarke…

This trial tests an experimental drug called NB-4746 in 80 people with ALS. The study has two parts: first, a short safety check with low or high doses, then a longer 12-week test. Researchers will watch for side effects, measure how the drug moves in the body, and check a blood …

This study tests a brain implant that records and stimulates brain areas to help adults with paralysis control assistive devices like computers or wheelchairs and receive sensory feedback. The trial enrolls 5 people with conditions like spinal cord injury or ALS. The main goal is…

This study tests whether PHENOGENE-1A (cromolyn) can help people with mild to moderate ALS when added to their usual care. About 105 participants will receive either the drug or a placebo twice daily for 24 weeks. Researchers will measure changes in muscle function, breathing, an…

This study tests whether a daily breathing exercise using a device called the LIC Trainer can help people with ALS maintain lung function and delay the need for a breathing machine or tracheostomy. Fifteen adults with early-stage ALS will use the device twice a day at home and vi…

This study tests whether a new treatment using a person's own regulatory T cells (a type of immune cell) is safe for people with amyotrophic lateral sclerosis (ALS), a progressive nerve disease. Twelve adults aged 18 to 70 will receive the cell infusion and be closely monitored f…

This study tests whether a high-calorie diet given through a feeding tube can slow the progression of ALS, a disease that weakens muscles. Researchers will compare a diet with 20% more calories than needed to a standard-calorie diet in 76 people with ALS who already use a feeding…

This early-stage study tests whether transplanting healthy gut bacteria can help people with rapidly progressing ALS. Twenty adults with ALS will receive the transplant after a bowel cleanse. Researchers will track changes in muscle function, quality of life, and nerve damage mar…

This Phase 2 trial tests an investigational drug called COYA 302 in 120 adults with ALS. The treatment combines two agents to reduce inflammation in the nervous system. Participants receive either COYA 302 or a placebo for 24 weeks, then may continue on the active drug for anothe…

This study tests whether a single, 30-minute session of non-invasive electrical stimulation on the face can reduce jaw pain and improve chewing in people with ALS or PLS. Ten participants will receive the treatment during one clinic visit and report their pain and jaw movement be…

This study looks at how people with ALS and their caregivers talk to each other and how that changes over time. About 152 participants will read words and sentences during conversations. Researchers will measure speech clarity, sentence structure, and pauses to better understand …

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study aims to find better ways to detect and track ALS (Lou Gehrig's disease) early. Researchers will analyze nerve tissue and blood from 400 people with ALS or related nerve conditions to identify molecular changes that signal disease onset or progression. The goal is to de…

This study is an online registry for people with ALS, MND, or PLS. Participants report their symptoms, diet, supplements, and therapies each month. Researchers will look for patterns to see which approaches are linked to better outcomes. No new treatments are tested—this is about…

This study is creating a large collection of data and biological samples from people with and without neurodegenerative diseases like Alzheimer's, ALS, and Parkinson's. Researchers will use this information to better understand how these diseases progress and to develop new treat…

This study tests a new PET scan tracer to measure a protein called Hsp90 in the brain. Hsp90 helps proteins fold correctly, and problems with this process are linked to Alzheimer's, Parkinson's, and ALS. Researchers will scan 48 people—healthy volunteers and patients—to see if th…

This study aims to find early markers for ALS, a nerve disease that weakens muscles. Researchers will compare blood, tears, urine, and spinal fluid from 60 people—including those with ALS gene mutations but no symptoms, early ALS patients, and healthy controls. The goal is to dev…

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…