First human trial launches for targeted ALS therapy
NCT ID NCT06351592
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 28 times
Summary
This study tests an experimental drug called ALN-SOD in people with ALS caused by a specific gene change (SOD1 mutation). The main goal is to check safety and how well the drug is tolerated. Researchers will also measure drug levels in blood and spinal fluid, and look at biomarkers and symptoms. About 42 participants will receive multiple doses of the drug injected into the spine.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Concord Repatriation General Hospital
RECRUITINGConcord, New South Wales, 2139, Australia
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Hanyang University Seoul Hospital
RECRUITINGSeoul, 04763, South Korea
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Hokkaido University Hospital
RECRUITINGSapporo, Hokkaido, 060-8648, Japan
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KU Leuven
RECRUITINGLeuven, Vlaams-Brabant, 3000, Belgium
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Kaohsiung Chang Gung Memorial Hospital
RECRUITINGKaohsiung City, 83301, Taiwan
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Kyoto University Hospital
RECRUITINGKyoto, 606-8507, Japan
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Macquarie University
RECRUITINGSydney, New South Wales, 2109, Australia
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Montreal Neurological Institute and Hospital
RECRUITINGMontreal, Quebec, H3A 2B4, Canada
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Seoul National University Hospital
RECRUITINGSeoul, 3080, South Korea
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Sunnybrook Research Institute
RECRUITINGToronto, Ontario, M4N 3M5, Canada
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Sunshine Coast University Hospital
RECRUITINGBirtinya, Queensland, 4575, Australia
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Taipei Veterans General Hospital
RECRUITINGTaipei, 11211, Taiwan
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Toho University Omori Medical Center
RECRUITINGŌta-ku, Tokyo, 143-8541, Japan
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Tokushima University Hospital
RECRUITINGTokushima, Tokushima, 770-0042, Japan
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University Hospital - London Health Sciences Centre
RECRUITINGLondon, Ontario, N6A 5A5, Canada
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University of Alberta Hospital, Edmonton, Division of Neurology
RECRUITINGEdmonton, Alberta, T6G 2G3, Canada
Conditions
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