MULTIPLE SCLEROSIS

This early-stage clinical trial is testing an experimental cell therapy called TRX319 in adults with progressive forms of multiple sclerosis (MS). The main goals are to check if the treatment is safe, find the best dose, and see if it can slow or stop the worsening of MS symptoms…

This study is testing the safety and effects of a twice-yearly infusion drug called Ublituximab (Briumvi) in people recently diagnosed with multiple sclerosis (MS). It will follow 40 adults for about two years to see how well they tolerate the treatment and if a specific blood pr…

This study is testing whether taking a probiotic supplement can help people with multiple sclerosis (MS) better manage their condition. It will involve 80 patients who are already on standard MS medications or have chosen not to take them. Participants will take either the probio…

This is a small, early-stage study to test the safety of a new cell therapy for a severe form of multiple sclerosis (MS). Researchers will give participants three injections of donor-derived stem cells into the spinal fluid over several months. The main goal is to see if the trea…

This study is testing the safety of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see how well they tolerate the treatment and to find the right…

This study is testing whether a short, high-dose course of steroids can help heal a specific type of brain lesion seen in multiple sclerosis (MS). Researchers are enrolling 30 adults with MS who have these 'ring-enhancing' lesions but no new symptoms. Participants are randomly as…

This study provides continued access to the MS medication ocrelizumab for 500 patients who were already receiving it in previous Roche-sponsored trials but don't have local access. Researchers will track how patients perceive the physical impact of their MS over time while monito…

This study is testing if giving the multiple sclerosis drug frexalimab as a shot under the skin works as well as giving it through an IV. It will involve about 160 adults with relapsing or progressive forms of MS. The main goal is to see if the shot version keeps enough medicine …

This study is testing if metformin, a medication commonly used for diabetes, can help protect the brain from damage in older adults with multiple sclerosis (MS). Researchers will compare metformin to a placebo (inactive pill) in 30 participants aged 55-75 to see if it's safe and …

This study aims to monitor the safety of fingolimod (Gilenya) in Taiwanese adults newly starting this medication for relapsing-remitting multiple sclerosis. Thirty-four participants will take the daily medication for one year while researchers track side effects and health change…

This study follows 842 people with multiple sclerosis who are receiving subcutaneous (under-the-skin) injections of ocrelizumab. The main goal is to measure how satisfied patients are with this treatment method over 12 months using questionnaires. Researchers will also track bloo…

This early-stage study is testing a new experimental drug called VT7208 for multiple sclerosis (MS). First, researchers will check the drug's safety and how the body processes it in healthy volunteers. Then, a small group of adults with MS will receive the drug to see if it's saf…

This early-stage study aims to check the safety and side effects of a new drug called RO7121932 in people with multiple sclerosis (MS). Researchers will give the drug to 129 participants, first through an IV and then as an injection under the skin, while carefully monitoring for …

This study is testing whether people with early-stage relapsing multiple sclerosis can safely stop taking the drug ocrelizumab after two years and remain in remission. All 123 participants will receive the drug for two years, then some will switch to placebo infusions while other…

This early study is testing two new long-acting injection versions of a medication called naltrexone, which is used to help manage opioid and alcohol dependence. The study will involve 40 healthy male volunteers to see how the body processes these new injections compared to the e…

This study is testing the safety and early effectiveness of an experimental mRNA injection called mRNA-1195 in adults with early-stage multiple sclerosis (MS). Researchers will give different doses or a placebo to 180 participants and monitor them for side effects and changes in …

This study tests if starting a powerful MS medication called Tyruko (natalizumab) within just 14 days of a person's first MS-like symptoms leads to better nerve repair. It will involve 40 UK adults who have recently shown signs of MS. Researchers will use special brain scans to s…

This study is testing whether a 12-week exercise program can help control multiple sclerosis (MS) and improve daily function. Researchers will enroll 40 people with MS to compare those doing the exercises (a mix of in-person and video sessions) to a group that does not. They will…

This study is testing whether people with multiple sclerosis who have been stable on treatment for 2 years can safely switch from getting infusions every 6 months to once a year. Researchers want to see if the less frequent schedule still prevents new brain lesions while potentia…

This is a very early study to see if a new type of cell therapy called GC012F is safe and tolerable for people with multiple sclerosis (MS). The therapy involves collecting a patient's own immune cells, modifying them in a lab to potentially target MS, and then infusing them back…

This early-stage study is testing a new personalized cell therapy called AZD0120 for adults with multiple sclerosis (MS) that has not responded well to other high-efficacy treatments. The main goal is to check the safety and side effects of the treatment and to find the best dose…

This study aims to find better ways to control multiple sclerosis (MS) progression by testing if personalized drug combinations work better than single drugs. Researchers will measure inflammation markers in spinal fluid to match 250 adults with progressive MS to one of four drug…

This study is testing if a procedure that freezes specific nerves in the shoulder works as well as standard Botox injections for reducing pain and improving movement. It involves 50 adults with shoulder pain and stiffness (spasticity) caused by conditions like stroke, multiple sc…

This early-stage study is testing a new type of immune cell therapy called P-CD19CD20-ALLO1 in people with multiple sclerosis. The main goal is to check if the treatment is safe and how the modified cells behave in the body. Researchers will enroll 60 adults with either progressi…

This is an early safety study testing a new, personalized cell therapy called KYV-101 for adults with progressive forms of multiple sclerosis (MS) that are worsening and have no approved treatments. Doctors will collect a patient's own immune cells, modify them in a lab to target…

This study is observing how well the approved MS medication ofatumumab works and how safe it is for Chinese patients in real-world settings. It will follow 80 adults with relapsing MS to see if the drug reduces a blood marker linked to nerve damage. The goal is to gather more evi…

This early-stage study is testing whether a modified immune cell therapy called CC-97540 is safe for people with multiple sclerosis or myasthenia gravis. The treatment uses specially engineered T-cells that target CD19, a protein on certain immune cells thought to drive these aut…

This study is testing whether an investigational drug called frexalimab can slow the worsening of disability in adults with a progressive form of multiple sclerosis (MS) who no longer have relapses. About 900 participants will receive either frexalimab or a placebo for up to 3 ye…

This study aims to understand the real-world safety and effectiveness of the multiple sclerosis drug BRIUMVI. It will follow 500 people with MS who are starting this treatment in their regular care settings. The main goal is to see how well the drug controls relapses and to monit…

This study is testing whether following a specific brain-healthy diet, called the MIND diet, can help protect the brain and manage symptoms in people with multiple sclerosis (MS). 100 adults with MS will be randomly assigned to either follow the MIND diet for a year or continue t…

This study is testing if a new version of the MS medication ocrelizumab, given as an injection under the skin, works the same way in the body as the currently available version. About 182 adults with relapsing or primary progressive multiple sclerosis will receive one of the two …

This study is looking at whether adding GLP-1 agonist medications (often used for diabetes and weight loss) to the standard MS drug ocrelizumab can better slow down disability progression in people with multiple sclerosis. It will follow 100 adults with MS for about 18 months, tr…

This study aims to find out if an older, less expensive drug called rituximab works just as well as a newer, much more expensive drug called ocrelizumab for controlling relapsing multiple sclerosis (MS). About 386 adults with active relapsing MS will be randomly assigned to recei…

This large Phase 3 trial is testing whether a new drug called frexalimab is better at controlling relapsing multiple sclerosis than the standard daily pill, teriflunomide. It will enroll 1,600 adults with relapsing MS to see which drug more effectively reduces flare-ups and slows…

This early-stage study is testing a new type of cell therapy for people with severe neurological autoimmune diseases that have not responded to other treatments. The therapy, called universal CAR T-cells, is designed to be given 'off-the-shelf' to target and reduce specific immun…

This study is testing whether a newer type of MRI scan, called MP2RAGE, can find more spinal cord lesions in people with multiple sclerosis than the standard set of MRI scans currently used. Researchers will compare images from both methods in about 196 adult patients who are alr…

This study is testing if a smartphone app can help detect and monitor brain diseases like dementia, Parkinson's, multiple sclerosis, and motor neuron disease by analyzing changes in a person's speech. Researchers will compare speech recordings from 150 people with these condition…

This study aims to see if the new 2024 diagnostic rules for multiple sclerosis (MS) help doctors diagnose the disease earlier and more accurately than the old 2017 rules. Researchers will follow 100 patients in France who have symptoms that might be MS. They will compare how many…

This study aims to find simple clinical tests that can help detect early signs of multiple sclerosis (MS) and Parkinson's disease in drivers. Researchers will compare results from standard driving-related computer tests with basic neurological and cognitive exams in 200 participa…

This study is testing whether a daily supplement called hesperidin, a natural compound found in citrus fruits, can help reduce common symptoms of Multiple Sclerosis (MS). For 12 weeks, 60 adults with MS will take either the supplement or a placebo pill to see if it improves their…

This study is testing whether a simple, non-invasive device that stimulates a nerve near the ankle can help people with multiple sclerosis (MS) empty their bladders more effectively. Participants, who currently need to use a catheter to urinate, will use the device daily for 12 w…

This study is testing a home-based exercise program designed specifically for African-Americans with multiple sclerosis (MS) who live in rural areas. The goal is to see if this tailored program can help improve walking problems, reduce symptoms like fatigue, and boost quality of …

This study aims to see if a 12-week strength training program can effectively reduce chronic pain in people with multiple sclerosis (MS). Researchers will compare a group doing supervised exercise to a group receiving their usual care to measure changes in pain levels. The goal i…

This study is testing whether a non-invasive brain stimulation technique can help reduce muscle stiffness (spasticity) and improve balance in people with multiple sclerosis (MS). Researchers will use a device called transcranial magnetic stimulation (rTMS) on 24 participants. The…

This study is testing a smartphone app designed to teach people how to use walking aids like crutches and canes more safely. The goal is to see if the app helps users feel more confident, improves their balance and mobility, and reduces their risk of falls and pain. Researchers w…

This study is testing if adding a special type of musical feedback, called 'sonification,' to standard walking therapy can help people walk better. It will involve 120 people with Parkinson's disease, multiple sclerosis, or who have had a stroke. One group will get standard thera…

This study is testing a home exercise program designed to improve balance, walking, and thinking skills in people with multiple sclerosis (MS). Participants will be randomly assigned to either a functional balance training group or a gentle stretching group, and all sessions will…

This study is testing if a new type of physical therapy using robotic arms and video game-like exercises can help improve both thinking skills and arm movement in adults with Parkinson's disease, multiple sclerosis, or who have had a stroke. Researchers want to see if this high-t…

This study is testing whether adding electrical stimulation to balance training can help people with Multiple Sclerosis (MS) walk better and feel more steady. Researchers will compare three approaches: balance training alone, training with muscle stimulation, and training with bo…

This study is testing if freezing specific nerves (cryoneurolysis) works better than standard Botox injections to reduce pain caused by severe muscle stiffness (spasticity). It will involve 50 adults with conditions like stroke, multiple sclerosis, or spinal cord injury. Particip…

This study aims to see if adding music to walking exercises helps people with multiple sclerosis (MS) more than the same exercises without music. Thirty-two people with mild to moderate MS will be randomly assigned to do four weeks of guided, remote walking training either with o…

This study is testing if adding neuropsychology (brain function) support to a standard work rehabilitation program helps people with Multiple Sclerosis (MS). It will follow 20 adults with MS to see if this combined approach improves their ability to work, reduces anxiety and depr…

This study is testing whether a gentle, non-invasive brain stimulation technique can reduce the severe fatigue that many people with multiple sclerosis experience. Researchers will compare the effects of real stimulation versus a sham (fake) treatment on 84 participants over seve…

This study is testing whether a specially designed 'serious game' (a video game made for training) can help improve memory, learning, and thinking speed in people with multiple sclerosis (MS). Researchers will enroll 150 adults with MS who are experiencing cognitive difficulties.…

This study is testing whether a non-invasive brain stimulation technique can reduce overactive bladder symptoms in women with multiple sclerosis (MS). Participants will receive either real or sham stimulation sessions targeting specific brain areas. The goal is to see if this app…

This study is testing if a 12-week mindset coaching program, delivered via a smartphone app, can make a standard 6-week brain training program more effective for people with multiple sclerosis (MS). Researchers want to see if this personalized approach helps improve memory, conce…

This study is testing a smart wearable device called gaitQ, which is worn on the legs. It uses gentle vibrations to help people with long-term movement conditions like Parkinson's, stroke, and multiple sclerosis improve their walking, reduce freezing episodes, and potentially low…

This study is testing two different ways to deliver a proven talk therapy for insomnia to people with multiple sclerosis (MS). Researchers want to see if one-on-one video sessions with a therapist work better than a self-guided online program at improving sleep, reducing fatigue,…

This study is testing if a 6-month, internet-delivered walking program can help improve slowed thinking speed and memory in people with multiple sclerosis (MS). Researchers will enroll 280 physically inactive adults with MS who have mild walking disability and self-reported 'brai…

This study is testing a home-based virtual reality (VR) therapy program designed to improve hand and arm function in people with multiple sclerosis (MS). Sixty participants will use VR headsets at home for 15 sessions over three weeks, with one group watching and practicing hand …

This study is testing whether two different exercise programs—Tai Chi and square stepping exercises—can help women with multiple sclerosis improve their balance, leg strength, and reduce fatigue. Researchers will compare these approaches to traditional coordination exercises over…

This large study is testing whether two different online educational programs can help people with multiple sclerosis (MS) manage their fatigue. The trial will enroll 2,000 people across the US, with a focus on including groups often left out of research. Participants will either…

This study is testing whether an online course can help people with conditions like multiple sclerosis, fibromyalgia, and long COVID feel better. 400 participants will be randomly assigned to either take the course right away or wait. The course teaches about healthy diets, exerc…

This study is testing a new physical therapy program designed to help people with multiple sclerosis (MS) become more physically active. Researchers want to see if regular consultations with a physical therapist are a practical and helpful way to encourage exercise. The goal is t…

This study aims to figure out which specific parts of a proven talk therapy are most effective at reducing severe fatigue in people with multiple sclerosis (MS). Researchers will test three different therapy components—relaxation training, activity scheduling, and changing unhelp…

This study is observing whether wearing a special suit that delivers mild electrical stimulation can help people with conditions like multiple sclerosis, stroke, or cerebral palsy. It aims to see if the suit improves balance, reduces pain, and makes walking easier over time. Abou…

This study is exploring whether hypnosis can be a helpful add-on therapy for people with neurological conditions like stroke, traumatic brain injury, or multiple sclerosis. It will test if hypnosis sessions are practical and acceptable for patients and if they show early signs of…

This study is testing whether a daily routine of guided breathing exercises can improve brain health and mental well-being. It is enrolling patients with multiple sclerosis or certain cancers, as well as their caregivers, to see if the practice reduces symptoms like fatigue, anxi…

This study is testing whether a mental practice technique can help improve walking for people with Multiple Sclerosis (MS). Twenty participants will either watch walking videos while imagining themselves walking, or watch nature scenes as a comparison. Researchers will measure mu…

This study is testing a home-based video coaching program called HOBSCOTCH-MS. It aims to help people with multiple sclerosis (MS) who are struggling with memory and thinking problems. Participants will work one-on-one with a coach to learn problem-solving and relaxation techniqu…

This study is testing a breathing treatment called Acute Intermittent Hypoxia (AIH) to see if it can improve arm and hand function in people with multiple sclerosis (MS). Participants will breathe brief periods of low oxygen, which has been shown in early research to safely incre…

This study is testing a wearable device called the Cionic Neural Sleeve to see if it can help people with MS walk better and be more active. Fourteen participants will wear the sleeve on one leg for six weeks while following a walking program. Researchers will measure changes in …

This study is testing whether a wearable robotic exoskeleton suit can help people with multiple sclerosis (MS) walk farther and improve their memory and thinking skills. Researchers will compare the results of 10 participants who use the robotic device during therapy to those who…

This study is testing whether breathing short bursts of low-oxygen air, similar to the air on a tall mountain, can improve ankle strength in people with multiple sclerosis (MS). Researchers will measure participants' strength and brain activity before and after the breathing sess…

This study is testing whether combining a proven memory training technique with an exercise program can improve learning and memory in people with multiple sclerosis (MS) who have mobility issues. Researchers want to see if this combined approach works better than memory training…

This study is testing a special strength training method for people with advanced multiple sclerosis (MS) who use canes, walkers, or wheelchairs. The method uses a cuff to partially restrict blood flow during low-intensity leg exercises, which may help build strength without caus…

This study is testing whether wearing a full-body stimulation suit at home for 6 weeks can help people with Multiple Sclerosis reduce symptoms like muscle stiffness and poor coordination. Researchers will compare 70 participants who either use the suit along with their usual care…

This study is testing a special full-body suit that uses gentle electrical stimulation. It aims to see if wearing the suit is safe and can help reduce pain, muscle stiffness, and improve balance for people with conditions like multiple sclerosis and fibromyalgia. About 15 partici…

This study is testing whether a special garment called the Mollii suit can help improve movement, balance, and quality of life for people who have had a stroke or who have multiple sclerosis (MS). Researchers will compare the suit's effects to a placebo (a non-active version) in …

This study is testing whether a non-invasive brain stimulation technique called rTMS can improve walking ability in people with Multiple Sclerosis who have leg stiffness and walking difficulties. Researchers will compare real brain stimulation to a sham (fake) treatment over 6 we…

This study is testing if combining a medication that helps with walking (dalfampridine) and a physical therapy program works better for improving mobility in people with multiple sclerosis than either treatment by itself. Researchers will enroll 48 adults with MS who have trouble…

This study aims to understand why some inflammation continues in people with multiple sclerosis (MS) even after they start strong treatments. Researchers will use specialized brain scans and analyze spinal fluid from 25 adults with MS before and after they begin treatment. The go…

This study aims to find out if a specific type of immune cell is linked to the severe fatigue that many people with Multiple Sclerosis (MS) experience. Researchers will enroll 40 people with MS to complete questionnaires, perform simple movement tasks, and give blood samples. By …

This is a small, early-stage study to see if a new radioactive tracer can help special PET scans detect certain immune cells in the brains of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). The goal is to better understand how these diseas…

This study aims to improve care for people with Multiple Sclerosis (MS) by creating a large patient registry. It will collect health records and survey data from 2,000 participants to track how MS affects their daily life and thinking. The goal is to use this information to find …

This study aims to understand if the multiple sclerosis medication BRIUMVI affects pregnancy outcomes. Researchers will compare birth defect rates between pregnant women with MS who take BRIUMVI and those who don't. The registry will follow 728 participants to collect safety info…

This study aims to identify early warning signs of multiple sclerosis (MS) before any symptoms appear. Researchers will follow 1,000 adults who have risk factors for MS but don't have the disease yet. By collecting blood samples, survey data, and optional tissue samples over time…

This study aims to understand why multiple sclerosis (MS) is mild for some people and aggressive for others. Researchers will analyze blood samples from 130 people, including those with aggressive MS, non-aggressive MS, and healthy volunteers. They will look for differences in ge…

This study aims to better understand how multiple sclerosis (MS) starts and progresses by collecting detailed health data from about 100 Swiss patients. Participants will use a smartphone app and undergo regular tests to track their symptoms and function over time. The goal is to…

This study aims to see if a substance in urine (called S1P) can tell doctors about bladder muscle overactivity in people with multiple sclerosis (MS). Researchers will check urine samples from 400 MS patients before and after they receive a standard bladder treatment. The goal is…

This study is testing a new type of PET scan that uses a special radioactive tracer to look for inflammation in the brain. Researchers want to see if this scan can detect more inflammation in people with Multiple Sclerosis compared to healthy adults. The goal is to gather informa…

This study aims to understand why women with multiple sclerosis (MS) often experience urinary incontinence. Researchers will measure pelvic floor muscle activity and see how it relates to the severity of bladder symptoms, disability, and quality of life. The goal is to gather inf…

This study aims to understand why multiple sclerosis progresses differently in each person and why treatments work better for some than others. Researchers will follow 7,500 participants (including people with MS and healthy volunteers) for 30 years, collecting health data, biolo…

This study aims to collect health information from thousands of people with conditions like Long COVID, ME/CFS, autoimmune diseases, and brain inflammation disorders over 10+ years. Participants will use a secure app to share symptoms, health history, and daily activity data. The…

This study aims to understand how accurately people with Multiple Sclerosis (MS) can perceive changes in their own movement during tasks like walking and standing up from a chair. Researchers will compare 88 participants—half with MS and half healthy—by having them perform these …

This study aims to understand what factors are related to urinary incontinence in people with multiple sclerosis (MS). Researchers will observe 47 participants with MS and incontinence, measuring their pelvic floor muscle activity and asking questions about symptoms and daily lif…

This study aims to understand how the antibiotic vancomycin affects the gut bacteria and immune system in people with multiple sclerosis (MS). Researchers will give vancomycin to 12 newly diagnosed, untreated MS patients and measure changes in their gut bacteria, blood markers, a…

This study aims to understand how stressful childhood experiences affect multiple sclerosis (MS) in adults. Researchers will work with communities to develop better ways to measure childhood adversity and examine its connection to MS severity using MRI scans and blood tests. The …

This study aims to understand how changes seen on brain scans in living people with Multiple Sclerosis (MS) relate to the actual physical damage found in the brain after death. Researchers will follow about 250 participants, including people with MS and some without, for many yea…

This study aims to understand if multiple sclerosis (MS) affects a woman's ovarian reserve, which is linked to fertility. It will compare 160 women with MS to a group of healthy women, all aged 25-35. Researchers will measure hormone levels and perform ultrasounds to see if there…

This study aims to understand multiple sclerosis (MS) better by looking at how the brain uses sugar (glucose). Researchers will use a special PET scan to measure glucose consumption in the brains of 50 people, including those with different types of MS and healthy volunteers. The…

This research study aims to understand how specific immune cells contribute to different forms of multiple sclerosis (MS). Researchers will analyze blood and spinal fluid samples from 150 adults with MS or early symptoms to identify which cell types are most involved in the disea…

This study is testing whether short videos people record at home on their smartphones can help doctors track multiple sclerosis symptoms as accurately as in-person visits. Researchers want to see if this low-cost, convenient method can monitor changes in walking, speech, and hand…

This study aims to understand how aging affects muscles in people with Multiple Sclerosis (MS) and how their bodies respond to exercise. Researchers will compare 10 older adults with MS to older adults without MS, measuring muscle health before and after a 4-month exercise progra…

This study aims to better understand what causes migraine by investigating the immune system. Researchers will compare levels of specific immune cells and inflammatory signals in women with and without migraine, some of whom also have other autoimmune conditions. The goal is to g…

This study aims to better understand multiple sclerosis (MS) by using a special type of brain scan called a PET scan. Researchers will compare brain images from 8 people with MS to images from 4 healthy volunteers. The goal is to see if specific changes in the brain are linked to…

This study aims to understand how common sexual dysfunction is in women living with multiple sclerosis (MS). Researchers will enroll 140 women with MS to complete surveys about their sexual health, fatigue, mood, and other symptoms. The goal is to identify connections between sex…

This study aims to discover new targets for future autoimmune disease treatments by analyzing tissue and blood samples. Researchers will collect samples from 300 adults with conditions like Crohn's disease, multiple sclerosis, or ulcerative colitis during periods of active inflam…

This study aims to understand if a specific blood test, which measures a protein called neurofilament light, can help doctors predict disease activity in people with relapsing multiple sclerosis (MS). Researchers will observe 700 patients in Germany for up to two years as they ei…

This study aims to understand how multiple sclerosis (MS) naturally progresses over time by regularly scanning patients' brains with MRI. It will follow 3,750 adults with MS or similar conditions, as well as healthy volunteers, to see how brain lesions change and relate to immune…

This study aims to better understand the different patterns of muscle stiffness (spasticity) in the arms and legs of people with Multiple Sclerosis (MS). Researchers will observe 75 adults with MS and spasticity, measuring their stiffness, movement, and quality of life. The goal …

This study aims to understand if newer, high-efficacy MS treatments are better at slowing brain shrinkage (atrophy) than older, medium-efficacy treatments. Researchers will follow 400 people with relapsing-remitting MS for three years, using brain scans and other tests to track t…

This study is testing two dietary supplements to see if people with chronic diseases find them easy to take and stick with. It will also check if taking the supplements helps the body absorb more iron and zinc, which could improve quality of life. The study is enrolling 100 adult…

This study aims to understand how the bacteria in our gut might be connected to changes in the brain during normal aging and in diseases like Alzheimer's, Parkinson's, and Multiple Sclerosis. Researchers will compare 200 participants, including healthy people of different ages an…

This study aims to use artificial intelligence (AI) to better understand and predict the course of Multiple Sclerosis (MS) and related diseases. Researchers will gather and analyze existing medical data from up to 7,000 patients to build computer models. These models are intended…

This study aims to understand how sleep quality affects people with multiple sclerosis (MS). Researchers will compare 102 adults with MS who have good versus poor sleep to see how it relates to their fatigue levels, body awareness, and ability to use their arms and legs. The goal…

This study aims to understand the connection between pelvic floor problems and the strength of other muscles in people with multiple sclerosis (MS). Researchers will measure the core, hip, and lower leg muscle strength and activity in 73 participants with MS. The goal is to gathe…

This study aims to understand how sleep problems contribute to severe fatigue and thinking difficulties in people with multiple sclerosis (MS). Researchers will use detailed overnight sleep studies and thinking tests on about 382 people with MS and a comparison group. The goal is…

This study aims to understand brain inflammation in people with Multiple Sclerosis (MS) and Alzheimer's Disease by using special PET scans. Researchers will compare brain images from 250 people, including those with active MS, progressive MS, mild Alzheimer's, and healthy volunte…

This study aims to find specific measurements in walking and balance that can identify people with Multiple Sclerosis (MS) who are at high risk of falling. Researchers will test 60 adults with MS using special mats and balance platforms to analyze their movement. The goal is to c…

This study aims to understand how multiple sclerosis (MS) affects a person's walking patterns. Researchers will measure the movements of 30 participants, including people with MS and healthy adults, using motion-capture technology and wearable sensors. The goal is to gather detai…

This study aims to measure how much of the multiple sclerosis (MS) medication ofatumumab passes into breast milk. It will enroll 20 breastfeeding mothers with relapsing MS who are starting or restarting this treatment after giving birth. Researchers will collect milk and blood sa…

This study aims to understand if brain inflammation is linked to chronic pain and fatigue in conditions like fibromyalgia, chronic fatigue syndrome, and multiple sclerosis. Researchers will use a special brain scan to measure inflammation levels in 120 participants, comparing peo…

This study aims to better understand ongoing brain inflammation in people with multiple sclerosis (MS). Researchers will use a special type of PET-MRI scan on 18 MS patients and 23 healthy volunteers to create detailed maps of inflammation. The goal is to see if this hidden infla…

This study is exploring whether combining aerobic exercise, like cycling, with scheduled daytime naps can help the brain learn and remember new motor skills in people with multiple sclerosis (MS). Researchers will measure brain and muscle activity in 20 participants to see if thi…

This study aims to understand how the brain changes and adapts in various neurological conditions and during normal aging. Researchers will use advanced, high-powered MRI scans to look at brain structure, function, and energy use in 700 participants, including people with disease…

This study aims to gather safety information for pregnant women with multiple sclerosis who take the medication ozanimod. Researchers will follow about 1,200 women in the US, Canada, and Germany to track health outcomes for both the mothers and their babies. The goal is to help f…

This study is testing whether a weight loss medication called liraglutide (Saxenda) affects brain health markers in people with multiple sclerosis, long COVID, or leukemia in remission who also have obesity and cognitive problems. Researchers will measure changes in a protein cal…

This study aims to understand the safety of the MS medication diroximel fumarate during pregnancy. Researchers will compare pregnancy outcomes and baby health across three groups: women who took this drug, those who took other MS medications, and those who took no MS medications …

This study is tracking the long-term safety and effects of an experimental cell therapy called KYV-101 in people who have already received it. Researchers will follow 70 participants for up to 15 years to check for any delayed side effects and see how long the treatment's effects…

This study aims to find a better way to predict how multiple sclerosis (MS) will progress in individual patients. Researchers will test a specific protein in spinal fluid to see if its levels can forecast future relapses, disability changes, and recovery from vision problems like…

This study aims to see if two specific signs seen on brain scans can help doctors more accurately diagnose and track multiple sclerosis (MS) over time. Researchers will follow 40 people for four years, using detailed MRI scans to monitor these signs. The goal is to gather informa…

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…

This study aims to learn how the body's immune system interacts with the brain and spinal cord in diseases like multiple sclerosis. Researchers will compare detailed tests, including brain scans and blood samples, from healthy volunteers and people with symptoms of immune-related…

This study aims to understand if dark rings of iron seen around brain lesions in people with Multiple Sclerosis (MS) are a sign of a more severe disease course. Researchers will recruit 100 people with MS who had a special brain scan years ago to provide a blood sample for geneti…

This study aims to better understand multiple sclerosis by tracking disease patterns and treatments in a large group of people over many years. It's a registry study, meaning participants report their health information regularly but don't receive any treatment. The information h…

This study aims to understand how multiple sclerosis affects brain aging by comparing advanced MRI scans of 200 people—half with MS and half healthy. Researchers will measure brain age using special imaging techniques and see how it relates to symptoms like walking difficulty, fa…

This Mayo Clinic study aims to understand how multiple sclerosis affects the body's automatic control systems that regulate blood pressure, heart rate, and other vital functions. Researchers will compare 13 people with MS to healthy volunteers using lab tests that measure how wel…

This study aims to understand how progressive multiple sclerosis affects connections between brain cells. Researchers will use a new type of brain scan (PET) to measure these connections in 30 people with different types of MS and healthy volunteers. The goal is to see if changes…

This study aims to understand the connections between body awareness, core (trunk) strength, and hand/arm function in people with multiple sclerosis (MS). Researchers will measure these factors in 50 people with MS and compare them to healthy individuals. The goal is to gather kn…