Can pregnancy and neurological disease coexist safely? a new registry seeks answers
NCT ID NCT06940323
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study is a pregnancy registry that gathers information from women with chronic neurological conditions like multiple sclerosis, NMOSD, and myasthenia gravis who are planning pregnancy, currently pregnant, or within one year postpartum. Participants can contribute blood, breast milk, infant stool, and other samples, as well as complete online surveys, all from home. The goal is to better understand how pregnancy interacts with these conditions and how treatments may affect maternal and infant health.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- This registry could help researchers understand how pregnancy affects chronic neurological conditions and how these conditions and their treatments affect infants, potentially guiding safer treatment choices for mothers.
- What could go wrong
- As an observational registry, it cannot prove cause and effect. Participation is voluntary and sample collection is optional, which may limit the completeness of data.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 250 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2017
- Expected to finish
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Jun 2035
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult women diagnosed with multiple sclerosis (MS), clinically isolated syndrome (CIS), Neuromyelitis optica spectrum disorder (NMOSD), and/or myasthenia gravis who are planning pregnancy, currently pregnant, or postpartum.
- Ages
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18 to 64 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Pregnant or contemplating pregnancy * Female, aged 18 to 64 years * Diagnosis of one of the following conditions: * Clinically Isolated Syndrome (CIS) or Multiple Sclerosis (MS), based on the 2010 McDonald Criteria * Neuromyelitis Optica Spectrum Disorder (NMOSD) * Inflammatory Bowel Disease (IBD) * Rheumatoid Arthritis (RA) * Myasthenia Gravis * Lupus * Other chronic neurological conditions * Willing to provide biosamples and/or complete surveys at specified timepoints * Women without a chronic condition who are pregnant or contemplating pregnancy (as part of the control group) Exclusion Criteria: \- Unwillingness to provide informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of California-San Francisco
RECRUITINGSan Francisco, California, 94158, United States
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