MULTIPLE SCLEROSIS

This study tests a new treatment called MB-CART2019.1 for people with active multiple sclerosis (MS) that has not responded to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to target and attack harmful immune cells driving MS. The goal is …

This early study is testing a new treatment called GC012F, which uses a patient's own immune cells (CAR T cells) to target multiple sclerosis. The main goal is to see if it is safe and tolerable for people with MS. Only 9 participants will be enrolled, and they will be monitored …

This study looks at whether adding a GLP-1 agonist (a type of diabetes drug) to the MS treatment ocrelizumab can reduce disability progression in people with multiple sclerosis. Researchers will track 100 adults with MS over 72 weeks, measuring changes in walking, hand function, …

This study offers ongoing access to the medication ocrelizumab for up to 500 people with multiple sclerosis (MS) who were already taking it in a previous study. Researchers will also ask participants about their physical abilities, like walking and daily tasks, to better understa…

This study tests if a shot under the skin (subcutaneous) of the drug frexalimab works as well as the IV version for people with multiple sclerosis. About 160 adults aged 18-60 will receive either the shot or the IV every 4 weeks for 48 weeks. The goal is to see if the shot is a s…

This study follows 2000 people with relapsing multiple sclerosis who are prescribed BRIUMVI, a medication given by infusion. Researchers want to see how well it works and what side effects occur in everyday medical practice, not just in a controlled trial. Participants must not h…

This early-stage study tests a new drug called VT7208 for multiple sclerosis (MS). First, healthy volunteers will receive single or multiple doses to check safety and how the drug moves through the body. Then, a small group of MS patients will receive the drug to further evaluate…

This study compares two versions of the drug ocrelizumab given as a shot under the skin for people with multiple sclerosis. About 182 participants with relapsing or primary progressive MS will receive either the test or the marketed version. The goal is to see if the new formulat…

This study looks at whether people with early relapsing multiple sclerosis (MS) can stop taking the drug ocrelizumab after two years and still stay relapse-free. About 123 participants will receive ocrelizumab for two years, then be randomly assigned to either continue the drug o…

This study tests whether taking a probiotic twice a day for six months can help people with relapsing-remitting multiple sclerosis (MS). The goal is to see if the probiotic increases certain immune cells (Treg cells) that may help control the disease. 80 adults with MS will be ra…

This study tests whether a drug originally used for diabetes can slow brain and eye damage in people with multiple sclerosis (MS). About 120 adults with stable MS will receive either the study drug or a placebo for 96 weeks. The main goal is to see if the drug reduces brain shrin…

This early-phase study tests a new treatment called CC-97540, which uses a patient's own immune cells modified to target and attack harmful immune cells in people with relapsing or progressive multiple sclerosis (MS) or refractory myasthenia gravis (MG). The main goals are to che…

This study tests whether giving the drug natalizumab (Tyruko®) within 14 days of first MS symptoms can help repair nerve damage better than a placebo. It involves 40 adults aged 18-55 who have had a first episode of demyelination (suggestive of MS) and show at least two brain les…

This study tests whether rituximab, an older and less expensive drug, works as well as ocrelizumab for people with relapsing-remitting multiple sclerosis. About 386 adults aged 18-55 with active MS will receive either drug and be followed for 2 years. The main goal is to see if r…

This study looks at whether people with active multiple sclerosis (MS) who have been on ocrelizumab for at least 2 years can switch to getting infusions once a year instead of every 6 months. The goal is to see if the yearly schedule still prevents new brain lesions while lowerin…

This study tests whether following the MIND diet—a mix of Mediterranean and DASH diets—for one year can protect brain health and reduce symptoms like fatigue in people with multiple sclerosis (MS). About 100 adults with MS will either follow the diet or continue their usual eatin…

This early-stage study is testing a new drug called RO7121932 in 129 people with multiple sclerosis. The main goal is to see if the drug is safe and tolerable when given as a single dose or multiple doses, either through a vein or under the skin. Participants are not taking any o…

This early-stage study is testing a new treatment called KITE-363 for people with autoimmune neurologic diseases like multiple sclerosis, myasthenia gravis, and chronic inflammatory demyelinating polyneuropathy that have not responded to standard therapies. KITE-363 uses a patien…

This early-phase study tests a new treatment using specially engineered immune cells (CAR T-cells) that target two proteins, CD19 and BCMA, in up to 12 adults with severe autoimmune diseases affecting the brain and nerves, such as multiple sclerosis and myasthenia gravis. The mai…

This study tests an experimental mRNA medicine called mRNA-1195 in 180 adults aged 18 to 55 who have multiple sclerosis (MS). The goal is to see if it is safe and how the body reacts to it. Participants will receive either the study drug or a placebo injection, and researchers wi…

This study tests whether metformin, a common diabetes drug, is safe and can protect the brain in people aged 55 to 75 with multiple sclerosis (MS). Participants will receive metformin alone, with their current MS treatment, or a placebo for 9 months. The goal is to see if metform…

This early-stage trial tests a new treatment called AZD0120 for adults with hard-to-treat multiple sclerosis (MS). The therapy uses a patient's own immune cells, modified to target and potentially calm the immune attack on the brain and spinal cord. The main goal is to check if t…

This study looks at whether the drug ofatumumab can reduce nerve damage in people with relapsing multiple sclerosis (RMS). Researchers will measure a blood marker called sNfL, which indicates nerve injury. About 80 adults with RMS will receive ofatumumab and be followed in a real…

This early-stage study tests two new long-acting injections, IVL3004 and IVL4002, in 40 healthy men aged 18-55. The goal is to see how the body processes these drugs compared to the approved medication Vivitrol, and to check for safety. If successful, these injections could offer…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This early-phase study tests a new treatment called KYV-101 for people with progressive forms of multiple sclerosis (MS) that are not responding to standard therapies. The treatment uses a patient's own immune cells, modified to target and remove faulty immune cells that may driv…

This study tests the safety and effectiveness of Ublituximab (Briumvi) given twice a year for early relapsing multiple sclerosis. About 40 adults with mild disability will receive the drug and be monitored for about a year. Researchers will measure nerve damage markers in the blo…

This early-stage study tests whether repeated injections of stem cells from donated fat tissue are safe for people with primary progressive multiple sclerosis (MS), a form that steadily worsens. Ten adults aged 18–55 with moderate disability will receive the cells directly into t…

This early-stage trial tests TRX319, a cell therapy, in 39 adults with primary or secondary progressive MS. The goal is to see if it is safe, find the best dose, and check if pre-treatment with another drug helps it work. Participants receive up to 3 doses over a year and undergo…

This study is testing whether a smartphone app can help diagnose and monitor brain diseases like dementia, Parkinson's, multiple sclerosis, and motor neuron disease by recording and analyzing speech. Researchers will compare speech patterns from 150 people with these conditions t…

This study compares a new MRI sequence called MP2RAGE with standard scans to see if it finds more spinal cord lesions in people with multiple sclerosis (MS). About 196 adults with MS will get both types of scans, and two radiologists will count the lesions without knowing which s…

This study follows 40 people with multiple sclerosis (MS) for 48 months to see if two MRI brain scan markers—the central vein sign and paramagnetic rim lesions—can help doctors diagnose MS more accurately and track how the disease changes over time. Participants will have brain M…

This study compares the latest 2024 McDonald criteria with the 2017 version for diagnosing multiple sclerosis (MS) in everyday medical practice. Researchers will enroll 100 people with symptoms suggestive of MS and track them for two years. The goal is to see if the new criteria …

This study tests whether a smartphone app called iROLL-O+ can help people who use wheelchairs or scooters prevent and manage falls better than standard advice from the CDC. The study includes 120 adults with spinal cord injury or multiple sclerosis who have had at least one fall …

This study tests whether a gentle, non-invasive brain stimulation technique called rTMS can reduce urgent, frequent urination in women with multiple sclerosis. About 29 women will receive either real or sham stimulation over 10 sessions. The goal is to see if targeting specific b…

This study tests whether a 3-month exercise program combining aerobic, strength, and balance training can improve disease activity, walking, thinking, and fatigue in people with multiple sclerosis. About 40 adults with mild-to-moderate disability will participate either in person…

This study tests whether listening to Quran recitation can reduce fatigue and boost mental well-being in people with multiple sclerosis. Researchers will compare a group that listens to the Quran to a control group that continues usual care. The trial involves 52 adults with MS a…

This study tests whether a specially designed, at-home exercise program can improve walking, reduce fatigue, and enhance quality of life for African-Americans with multiple sclerosis who live in rural areas. About 100 participants will be randomly assigned to either the exercise …

This study tests whether adding two types of electrical stimulation to balance training can improve mobility and reduce fall risk in people with Multiple Sclerosis (MS). Up to 24 participants will be randomly assigned to balance training alone, with muscle stimulation (FES), or w…

This study tests whether a 3-week home program using virtual reality and action observation can improve hand dexterity in people with multiple sclerosis. 60 participants will either watch and imitate hand tasks in VR or watch landscapes before doing the same tasks. The goal is to…

This study looks at whether a short course of high-dose steroids can help heal a specific type of brain lesion in people with multiple sclerosis (MS). These ring-enhancing lesions may not heal as well on their own. About 30 adults with MS and such a lesion will either receive ste…

This study tests whether adding music to technology-based walking exercises helps people with multiple sclerosis walk better. Thirty-two participants with mild to moderate disability will do rhythmic gait training at home via telerehabilitation, either with or without music, for …

This study tests two online programs designed to help people with multiple sclerosis (MS) manage their fatigue. About 2,000 adults with MS in the U.S. will be randomly assigned to one of the programs plus their usual care, or to usual care alone. The programs provide information …

This study tests whether taking a daily 500mg hesperidin supplement (a natural compound found in citrus fruits) for 12 weeks can reduce fatigue, improve mood, and sharpen thinking in people with multiple sclerosis. About 60 adults with MS will be randomly assigned to receive eith…

This study tests whether a free online course can help people with multiple sclerosis, fibromyalgia, long COVID, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health over time. The go…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. Researchers will use EEG to monitor brain activity during hypnosis sessions. The goal is to see if this approach is practica…

This study tests whether a combined thinking and movement training program done at home can improve memory and walking in people with multiple sclerosis (MS). About 90 adults with MS will be randomly assigned to different training groups. The goal is to see if combining cognitive…

This study tests whether one-on-one sleep therapy via video calls works better than a self-guided website for improving sleep and reducing fatigue in people with multiple sclerosis (MS). About 90 adults with MS and insomnia will receive either live therapy, web-based lessons, or …

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's disease, stroke, multiple sclerosis, and arthritis walk better. Researchers will measure walking speed, step length, and safety in 150 participa…

This study tests whether relaxation, behavioral activation, and cognitive therapy can reduce fatigue and improve daily life in adults with multiple sclerosis. About 112 participants will be randomly assigned to different combinations of these therapies. The goal is to find which …

This study tests a gentle strength training program using blood flow restriction (BFR) for people with advanced multiple sclerosis (MS) who have trouble walking or use a wheelchair. BFR partially blocks blood flow to the exercising limb, allowing low-intensity exercise to build s…

This study looks at whether a 12-week coaching app that trains goal-directed thinking can make a 6-week cognitive rehab program more effective for people with Multiple Sclerosis (MS). About 126 adults with MS will use the coaching app or a sham version, then all complete memory a…

This study tests whether using virtual reality (VR) with wearable sensors can help people with multiple sclerosis (MS) improve their walking while using a leg brace. Twelve adults with MS will try VR-based walking tasks in a safe, controlled environment. The goal is to see if thi…

This study tests a non-invasive device that stimulates a nerve in the leg to improve bladder emptying in people with multiple sclerosis. 68 participants who currently use a catheter to empty their bladder will be randomly assigned to receive either real stimulation or a placebo f…

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet virtually with a coach for 8 weekly sessions to learn problem-solving and relaxation techniques. The goal is to see if the program …

This study tests whether a low-intensity exercise program combined with blood flow restriction (a technique that partially limits blood flow to the muscles) can improve arm and hand strength, coordination, and quality of life in people with multiple sclerosis. Twenty participants…

This study looks at whether a physical therapy program can help people with multiple sclerosis (MS) get more exercise. Exercise can ease symptoms like fatigue, but many with MS aren't active enough. The study will involve 40 adults with MS who are not very active, and they will w…

This study looks at whether a 12-week progressive resistance exercise program can help reduce chronic pain in people with multiple sclerosis. Researchers will compare a group that exercises to a waitlist group that continues usual care. The goal is to find a drug-free way to mana…

This study tests a robotic leg brace (exoskeleton) combined with mild electrical pulses to help people with brain injury, spinal cord injury, or multiple sclerosis walk better. Researchers will check if the device is safe and easy to use in 15 adults aged 18-80. The goal is to se…

This study tests whether exercise that also requires thinking (like counting backwards while walking) can improve walking, balance, and memory in people with multiple sclerosis. Forty adults with MS will do supervised sessions twice a week for 8 weeks. The goal is to find better …

This study tests whether mentally practicing walking while watching videos of people walking can improve walking in people with multiple sclerosis (MS). Twenty participants will either watch walking videos and imagine themselves walking, or watch nature scenes. The study measures…

This study tests whether using mixed reality (a blend of real and virtual environments) during physical therapy can improve hand strength, coordination, and daily function in people with multiple sclerosis. Thirty adults with MS will be randomly assigned to either standard therap…

This study is testing a suit called Mollii that uses mild electrical pulses to see if it helps people with stroke or multiple sclerosis move more easily and improve their daily life. About 40 participants will wear either the active suit or a placebo version to compare results. T…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve walking in people with multiple sclerosis (MS) who have leg stiffness and moderate walking problems. Researchers will compare the walking speed and quality of life of 60 participants who r…

This study tests whether an internet-based physical activity program can improve cognitive processing speed (how quickly you think) in people with multiple sclerosis who have mild walking problems. Researchers will compare the exercise program to an active control group in 280 pa…

This study tests a procedure called cryoneurolysis, which uses cold to freeze specific nerves in the shoulder, to see if it relieves pain and improves movement in people with spasticity (muscle tightness) after stroke, brain injury, or multiple sclerosis. It compares the freezing…

This study looks at whether switching from ocrelizumab to ublituximab can reduce or delay the return of MS symptoms in 50 adults aged 18-65. Participants must have relapsing MS and have been on ocrelizumab for at least one year. The goal is to improve quality of life by easing fa…

This study is testing whether a wearable robotic exoskeleton can improve walking, memory, and thinking in people with multiple sclerosis who have trouble walking. Ten participants will use the device during therapy and be compared to those receiving traditional therapy. The goal …

This study is testing whether a special video game (a "serious game") can help people with multiple sclerosis improve their memory and thinking speed. The study will involve 150 adults with MS who have some cognitive difficulties. Participants will play the game as a form of cogn…

This study tests whether adding musical sounds that match a person's movements (sonification) to standard physical therapy can improve walking in people with Parkinson's disease, stroke, or multiple sclerosis. About 120 adults will be randomly assigned to standard rehab or rehab …

This study is testing a special full-body suit that uses mild electrical pulses to help people with conditions like multiple sclerosis or fibromyalgia who suffer from muscle tightness, overactive reflexes, or pain. About 15 adults will try the suit to see if it improves balance a…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests whether a home-based balance exercise program can improve both physical and cognitive symptoms in people with multiple sclerosis (MS). 75 adults with MS will be randomly assigned to either the balance program or a stretching routine for 4 months. All sessions are…

This study tests a treatment called cryoneurolysis, which uses controlled freezing to calm overactive nerves that cause pain and stiffness in people with brain or spinal cord conditions like stroke, multiple sclerosis, or injury. About 50 adults will be randomly assigned to get e…

This study tests whether laughter yoga, a practice combining breathing exercises and laughter, can reduce pain, stress, and fatigue in people with multiple sclerosis. Researchers will measure changes in pain levels, stress, and a natural feel-good chemical called beta-endorphin. …

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce muscle spasticity and improve balance in people with multiple sclerosis. About 24 adults aged 18–60 with MS and mild-to-moderate spasticity wi…

This study tests whether combining cognitive rehabilitation with exercise can improve learning and memory in people with multiple sclerosis who have trouble walking. About 78 participants will be assigned to different treatment groups to compare the effects. The goal is to find a…

This study compares two gentle exercise programs—tai chi and square stepping—in women with multiple sclerosis. Researchers want to see if these activities improve knee joint awareness, leg strength, and fatigue. About 39 women with relapsing-remitting MS will participate, and res…

This study tests a wearable device called the Cionic Neural Sleeve in 14 people with multiple sclerosis (MS). The sleeve uses electrical signals to help improve walking speed, reduce disability, and lower fall risk. Participants wear the sleeve for up to 8 hours a day while resea…

This study looks at whether taking a walking-improvement drug (dalfampridine) along with physical therapy helps people with multiple sclerosis walk better than either treatment alone. About 48 adults with MS who have trouble walking will first try the drug for 6 weeks, then stop …

This study tests whether a full-body stimulation suit used at home can reduce spasticity (muscle stiffness) and ataxia (poor coordination) in people with Multiple Sclerosis. About 70 participants will either use the suit for 6 weeks or continue their usual care. The goal is to se…

This study tests a wearable suit called EXOPULSE that uses 50 electrodes to stimulate muscles and reduce stiffness in people with multiple sclerosis. About 77 participants with moderate disability will use the suit at home for one hour every other day. The goal is to see if it im…

This study is testing if a new type of physical therapy using robotic arms and video game-like exercises can help improve both thinking skills and arm movement in adults with Parkinson's disease, multiple sclerosis, or who have had a stroke. Researchers want to see if this high-t…

This study looks at how multiple sclerosis (MS) may affect hearing. Researchers will test the hearing of 30 adults with MS using simple ear exams and also collect a small sample of spinal fluid to check for signs of inflammation. The goal is to see if hearing problems are linked …

This study observes pregnant women with multiple sclerosis to compare the rate of major birth defects between those who took BRIUMVI and those who did not. About 728 participants will provide data during and after pregnancy. The goal is to gather safety information, not to test a…

This study looks at how multiple sclerosis (MS) damages the autonomic nervous system, which controls things like blood pressure, skin blood flow, and bladder health. Researchers at Mayo Clinic will test 13 people (with and without MS) using simple lab exercises to measure these a…

This study looks at whether a substance in urine, called S1P, can help doctors check for bladder overactivity in people with multiple sclerosis (MS). Currently, patients need an invasive test with a catheter. Researchers will measure S1P levels in 400 MS patients and compare them…

This observational study looks at how gut bacteria relate to brain changes in healthy aging and in people with early Alzheimer's, Parkinson's, or multiple sclerosis. Researchers will collect stool and blood samples, perform brain scans, and run memory tests on 200 participants. T…

This study looks at specific immune cells (B cells and CD4 T cells) in the blood and spinal fluid of 150 people with multiple sclerosis or early symptoms. The goal is to find which cell types cause damage in different forms of MS, especially the progressive type. This research do…

This study compares brain aging in 200 people—some with multiple sclerosis (MS) and some healthy—using new MRI techniques. The goal is to see if MS causes the brain to appear older than it should. Researchers hope this will help predict brain aging and disease progression.

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study is building a large registry of 2000 people with multiple sclerosis (MS) to collect health information from electronic records and patient surveys. The goal is to better understand MS disability and cognitive problems, and to find ways to improve care and quality of li…

This study explores whether specific breathing exercises can boost brain and mental health in people with multiple sclerosis or certain cancers, as well as their caregivers. Researchers will use brain scans to measure oxygen delivery and fluid flow in the brain. The goal is to un…

This study looks at why people with multiple sclerosis (MS) feel so tired. Researchers will use a gentle brain stimulation method called tDCS to see if it changes brain activity and inflammation linked to fatigue. About 84 adults with relapsing-remitting MS will take part, with s…

This study uses a special PET scan to measure brain inflammation in people with multiple sclerosis or Alzheimer's disease, compared to healthy volunteers. Researchers aim to see if the pattern of inflammation differs between these diseases and relates to symptom severity. Up to 2…

This study tests whether a smartphone app called ICanWALK can teach people to use walking aids like crutches, canes, and walkers more safely. Researchers will enroll 52 adults who use a walking aid most of the time due to a leg injury, stroke, or multiple sclerosis. The goal is t…

This study follows about 1,178 pregnant women with multiple sclerosis to see if taking the drug diroximel fumarate (VUMERITY®) during pregnancy affects their babies. Researchers will compare birth outcomes among three groups: those who took the drug, those who took other MS drugs…

This study is testing whether the EXOPULSE Mollii Suit can improve balance and reduce fall risk in people with cerebral palsy, multiple sclerosis, stroke, or fibromyalgia. Researchers will track changes in balance scores and walking speed over time. The goal is to identify which …

This study tests whether a breathing method called acute intermittent hypoxia (AIH) can improve arm and hand function in people with multiple sclerosis. AIH involves breathing short bursts of low oxygen, which may help the brain and spinal cord form new connections. Researchers w…

This study looks at why some people with multiple sclerosis (MS) have trouble controlling their bladder. Researchers will measure pelvic floor muscle activity and other factors in 47 participants. The goal is to better understand the link between MS and urinary incontinence, not …

This study is testing whether a special type of PET scan, which measures how the brain uses sugar, can help doctors better understand multiple sclerosis (MS). Researchers will compare brain scans from people with different types of MS and healthy volunteers. The goal is to see if…

This study aims to understand why multiple sclerosis (MS) is mild for some people but quickly becomes severe for others. Researchers will analyze blood cells from 130 people, including those with aggressive MS, non-aggressive MS, and healthy volunteers. By comparing their genes a…

This study looks at whether adding a brain specialist (neuropsychologist) to a rehab team can help people with multiple sclerosis (MS) stay at work and feel better. Twenty adults with MS will get cognitive testing and support, then be followed for two years. The goal is to see if…

This study looks at how body awareness and trunk (core) stability are linked to arm and hand function in people with multiple sclerosis (MS). Researchers will measure these abilities in 50 adults with MS and compare them to healthy volunteers. The goal is to better understand the…

This study looks at how genes, environment, and the immune system work together to increase the risk of developing multiple sclerosis (MS). Researchers will enroll 5,000 people in the U.S., including relatives of MS patients and others at higher risk. The goal is to create a risk…

This study gathers health data from 7,000 people with multiple sclerosis and related conditions. The goal is to use this information to train artificial intelligence that can help doctors better diagnose, predict disease progression, and tailor treatments. No new treatments are t…

This study follows 400 people with relapsing-remitting multiple sclerosis (MS) for 3 years. Researchers will use MRI scans to measure brain shrinkage and compare those on high-efficacy treatments versus medium-efficacy treatments. The goal is to understand which treatment better …

This study looks for easy ways to find early signs of multiple sclerosis and Parkinson's disease in drivers. Researchers will test 200 people with these conditions using computer tasks that measure attention, reaction time, and impulse control. The goal is to make routine driver …

This study is watching for side effects in 30 adults in Taiwan who are starting fingolimod for relapsing-remitting multiple sclerosis. Participants will be followed for one year to record any safety issues like slow heart rate, eye swelling, liver problems, or low white blood cel…

This study looks at whether certain proteins in spinal fluid can help predict how multiple sclerosis (MS) will progress over time. Researchers will follow 100 adults with MS or optic neuritis, measuring disability, vision, and brain scans. The goal is to find better ways to forec…

This study looks at how well people with multiple sclerosis (MS) can sense changes in their own walking and standing up from a chair. Researchers will compare 44 people with MS to 44 healthy volunteers of similar age and gender. The goal is to find out if people with MS have trou…

This study explores whether sleep apnea makes multiple sclerosis (MS) worse. Researchers will collect sleep tests, MRI scans, and lab results from 800 adults with MS to see if there is a link. The goal is to understand how sleep apnea might affect MS symptoms and brain changes. N…

This study tests a breathing technique called Acute Intermittent Hypoxia (AIH) in people with multiple sclerosis. Participants breathe short bursts of low oxygen (like at high altitude) to see if it can improve ankle strength and change brain activity. The goal is to understand h…

This study looks at why some women with multiple sclerosis (MS) have trouble controlling their bladder. Researchers will measure pelvic floor muscle activity and ask about quality of life, fatigue, and physical activity. The goal is to better understand the connection between MS …

This study looks at whether short selfie videos taken on a smartphone can accurately measure walking and speech changes in people with multiple sclerosis (MS). About 300 adults with MS will record 5 videos every 3 months for a year and also visit the clinic for standard tests. Th…

This study looks at whether aerobic exercise (stationary biking) and daytime naps can help people with relapsing-remitting multiple sclerosis learn and remember motor skills. Twenty adults aged 18-70 will take part. The goal is to see if these simple activities can boost brain fu…

This study looks at how common sexual problems are in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. Researchers will survey 140 women with relapsing-remitting MS who have a regular partner and are s…

This study is creating a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, and severe asthma. Researchers will track disease activity, quality of life, and treatment responses over time. The goal is to find new markers …

This study uses powerful MRI scans to find early signs of disability progression in people with multiple sclerosis (MS). Researchers will track 50 participants over two years, using special imaging techniques to measure brain changes that may predict worsening. The goal is to ide…

This study looks at how muscle stiffness (spasticity) appears in the arms and legs of people with multiple sclerosis and how it affects their daily life. Researchers will examine 75 adults with MS to classify different spasticity patterns and link them to quality of life. The goa…

This study uses a special PET scan to look at a brain chemical system (norepinephrine) in people with multiple sclerosis (MS) and healthy volunteers. The goal is to see if damage to this system is linked to MS symptoms like fatigue and thinking problems. About 19 adults aged 18 t…

This study looks at how sleep issues contribute to tiredness and thinking problems in people with multiple sclerosis (MS). About 382 MS patients and a control group without MS will have overnight sleep tests, thinking assessments, and questionnaires. The goal is to better underst…

This study is collecting health data from 100 people with multiple sclerosis (MS) to find new ways to track the disease using artificial intelligence. Researchers will look at medical images, blood tests, and smartphone data to better understand how MS changes over time. The goal…

This study is testing whether a new digital test battery called Mindmore Distance can accurately assess thinking and memory skills in people with neurological conditions like traumatic brain injury, stroke, multiple sclerosis, Parkinson's disease, epilepsy, or brain tumors. Resea…

This study looks at how people with mild multiple sclerosis adjust their walking when faced with obstacles or sudden changes, compared to healthy adults. Researchers will use motion sensors and brain activity monitors to understand these walking adaptations. The goal is to find b…

This study looks at how multiple sclerosis (MS) affects the autonomic nervous system—the part that controls things like heart rate, blood pressure, and sweating. Researchers will test 60 people with relapsing-remitting or primary progressive MS using simple physical challenges an…

This study uses a new type of PET scan to measure the density of synapses (connections between brain cells) in people with progressive multiple sclerosis (MS). Researchers will compare these measurements with those from people with relapsing-remitting MS and healthy volunteers. T…

This study looks at whether signs of inflammation in spinal fluid can help predict which multiple sclerosis (MS) drugs a person will respond to. About 250 adults with progressive MS will take one or two study drugs for up to 18 months. Researchers will track changes in biomarkers…

This study looks at whether low levels of immunoglobulins (antibodies) are a treatable cause of fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue levels and infection rates in 106 MS patients with and without low antibody levels. The goal is to unde…

This study looks at whether a blood test for a protein called neurofilament light (sNfL) can help doctors predict and manage disease activity in people with relapsing multiple sclerosis (MS). About 700 adults with MS in Germany will be observed for 24 months. The goal is to see h…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study follows about 1,200 pregnant women with multiple sclerosis who have taken the drug ozanimod (ZEPOSIA). Researchers will track the health of mothers, fetuses, and babies to better understand any risks. The goal is to help patients and doctors make informed decisions abo…

This study follows a large group of people with multiple sclerosis over many years to understand how the disease changes and how treatments affect it. Participants fill out surveys twice a year about their health and lifestyle. The information is used for research only and is kep…

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…

This study is creating a smartphone app that tracks eye movements to monitor multiple sclerosis (MS) and related thinking changes. About 168 adults with MS and healthy volunteers will take short cognitive tests while the app records their eye responses. The goal is to build a too…

This study explores whether a brain-computer interface (BCI) can help people with motor disorders, like spinal cord injury or stroke, control assistive devices just by thinking about moving. Researchers will use electrical stimulation to train the brain and improve BCI accuracy. …

This study looks at how immune cells and inflammation might play a role in migraine. Researchers will compare 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The goal is to measure levels of certain …

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode intended movements or speech, aiming to restore communica…

This study uses MRI scans to follow how multiple sclerosis (MS) changes over time in up to 3750 people, including those with MS and healthy volunteers. Researchers will compare brain images with immune system markers to better understand the disease. The goal is to learn more abo…

This study looks at how walking patterns and balance scores can help identify people with multiple sclerosis (MS) who are at risk of falling. Researchers will measure gait variability and balance in 60 adults with MS who can walk independently. The goal is to find cut-off values …

This study examines whether iron-rimmed brain lesions in people with multiple sclerosis (MS) are linked to more severe disability. Researchers will analyze old MRI scans and new blood samples from 100 participants to explore genetic factors that may cause these lesions. The goal …

This study aims to find early warning signs and risk factors for multiple sclerosis (MS) in people who do not yet have any symptoms. Researchers will collect medical data and samples from 1,000 adults with certain MS risk factors, such as family history or past Epstein-Barr virus…

This study looks at how aging affects muscle and heart health in people over 60 with multiple sclerosis (MS) compared to those without MS. Participants will do an exercise program for about 4 months to see how their bodies respond. The goal is to understand differences between mo…

This study uses a special PET scan tracer to see inflammation in the brains of 41 people with active multiple sclerosis (MS). The goal is to better understand how inflammation relates to MS and to create a standard method for using this scan across multiple hospitals. Participant…

This study collects tissue and blood samples from 300 people with autoimmune diseases like ulcerative colitis, multiple sclerosis, and Crohn's disease. Researchers will identify which T-cells are active in inflamed tissues and find their targets. The goal is to discover new targe…

This study looks at how difficult childhood experiences impact the course of multiple sclerosis (MS). Researchers will work with 300 young adults with relapsing-remitting MS, most of whom are Black, Hispanic, or from low-income backgrounds. Participants will have MRI scans and bl…

This study looks at how the antibiotic vancomycin changes gut bacteria and immune cells in people newly diagnosed with multiple sclerosis (MS). Researchers want to understand the link between gut health and brain inflammation in MS. Twelve participants will take vancomycin for a …

This study looks at whether multiple sclerosis (MS) affects a woman's egg supply (ovarian reserve). Researchers will compare blood hormone levels and ultrasound results between 160 women with MS and healthy women aged 25 to 35. The goal is to better understand MS's impact on fert…

This study looks at two new tests—the Walking Adaptability Ladder Test and the Foot Tap Test—to see if they can detect subtle walking and motor problems in people with mild multiple sclerosis (MS). About 100 participants with mild MS and healthy volunteers will take part. The goa…

This study tests whether a radioactive tracer can help PET scans detect certain immune cells in the brain and spinal cord of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). About 15 adults will receive the tracer and undergo scans to see w…

This study looks at how well adults with chronic conditions like inflammatory bowel disease, high blood pressure, anemia, or multiple sclerosis accept and stick with two dietary supplements (Goodphyte IB Defense and Goodphyte Immunity). The supplements contain a natural enzyme th…

This study aims to understand how people with multiple sclerosis (MS) experience their care journey and what makes it better or worse. Researchers will interview 57 participants, including patients, carers, and healthcare professionals, to identify key moments in the care pathway…

This study looks at how mood, sleep problems, and the stress of caregiving are connected in people caring for someone with multiple sclerosis. Researchers will ask 50 caregivers and their loved ones with MS to fill out questionnaires about their feelings, sleep, and daily challen…

This study watches 842 people with multiple sclerosis who are starting a new under-the-skin injection of ocrelizumab. Researchers will ask how satisfied patients are with the injection after 12 months and check nerve health markers. The goal is to understand real-world experience…

This study aims to understand how multiple sclerosis (MS) damages the brain and spinal cord over a person's lifetime. Researchers will follow 250 adults with MS or similar conditions, using yearly MRI scans, eye tests, and other exams. Participants agree to donate their brain and…

This study is following 7,500 people with multiple sclerosis (MS) and healthy volunteers for up to 30 years. The goal is to learn why MS affects each person differently and why some treatments work better for some. By tracking participants over time, researchers hope to find ways…

This study looks at how pelvic floor problems in people with multiple sclerosis (MS) are related to core endurance, hip rotation strength, and activation of two key leg muscles. Researchers will assess 73 participants using questionnaires and muscle tests. The goal is to better u…

This study looks at how multiple sclerosis (MS) changes the way people walk. Researchers will use motion cameras, pressure mats, and wearable sensors to measure walking patterns in 30 people with MS and healthy adults. The goal is to better understand gait quality, not to test a …

This study looks at 25 people with relapsing-remitting multiple sclerosis to understand why inflammation in the brain doesn't fully go away even after treatment. Researchers will use brain scans and analyze spinal fluid to compare different types of inflammation. The goal is to l…

This study looks at how walking patterns and MRI brain scans can help explain walking difficulties in people with multiple sclerosis (MS). About 100 adults with MS will wear a small device while walking and have an MRI scan. The goal is to better understand walking problems, not …

This study tracks 70 people who have already received an infusion of KYV-101, a CAR T cell therapy, for autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to watch for delayed side effects, new cancers, or other health problems over up to 15…

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…

This study tests a new radioactive tracer called [18F]FZTA to see if it can spot inflammation in the brain using PET scans. Researchers will compare healthy adults and people with Multiple Sclerosis (MS) to see if the tracer lights up areas of inflammation. The goal is to better …

This study aims to learn more about inflammatory diseases of the brain and spinal cord, such as multiple sclerosis (MS), which may be caused by the immune system attacking the body. Researchers will compare tests from 2,400 people—both healthy volunteers and those with symptoms o…