MULTIPLE SCLEROSIS

This early-stage study tests a new treatment called P-CD19CD20-ALLO1 in 60 adults with multiple sclerosis (MS). The treatment uses specially engineered immune cells to target and possibly calm the immune attack on the nervous system. The main goal is to check safety and side effe…

This early-stage study tests a single intravenous dose of IMS001, a stem cell therapy, in 30 adults with multiple sclerosis (MS) who have not responded well to standard treatments. The main goal is to check safety and tolerability, while also looking for signs that the treatment …

This study tests whether stem cells taken from a person's own belly fat and given through an IV can help people with relapsing-remitting multiple sclerosis. Ten adults who previously received a placebo in an earlier trial will get multiple infusions of these cells. The main goal …

This program offers early access to an experimental drug called CNM-Au8 for up to 25 adults with multiple sclerosis (MS). It is for people who have relapsing MS, non-active secondary progressive MS, or primary progressive MS. The goal is to provide treatment before the drug is fu…

This study tests an investigational drug called LY3541860 in 63 adults with relapsing multiple sclerosis (MS). The goal is to see if it can safely reduce the number of new active brain lesions compared to a placebo. Participants receive the drug or placebo for about 9 months, wit…

This study compares a new drug, RPH-035, to the approved drug Ocrevus in 180 adults with relapsing or progressive multiple sclerosis. The goal is to see if RPH-035 works similarly in the body and has a comparable safety profile. This is an early-phase trial, so it focuses on how …

This study tests whether N-acetyl cysteine (NAC), a supplement, can slow brain damage in people with progressive multiple sclerosis. About 98 adults with primary or secondary progressive MS will receive either NAC or a placebo for 15 months. Researchers will measure brain shrinka…

This phase 3 study tests an oral medication called IMU-838 against a placebo in about 1,100 adults with relapsing multiple sclerosis. The goal is to see if the drug can delay or prevent relapses and reduce new brain lesions over 72 weeks. Participants must have had recent relapse…

This study tests whether Truvada, an antiviral drug that fights Epstein-Barr virus (EBV), can reduce EBV levels in saliva and blood of 50 adults with multiple sclerosis (MS). Researchers also want to see if the drug is safe and tolerable for people with MS. The goal is to underst…

This program provides siponimod, a medication that helps control disease activity, to adults with secondary progressive multiple sclerosis who have no satisfactory alternative treatments. Patients must have active disease and a doctor's request. The goal is to manage the conditio…

This study tests whether a special cell mixture taken from a patient's own fat and given through the bloodstream can improve quality of life and slow nerve damage in people with multiple sclerosis. The treatment aims to calm the immune system and reduce inflammation. The trial in…

This study tests whether a higher dose of the drug ocrelizumab can better slow disability progression in people with relapsing multiple sclerosis (MS) compared to the standard dose. About 864 adults with MS will receive either the higher or standard dose every 24 weeks. The main …

This study tests whether a higher dose of the drug ocrelizumab can better slow disability progression in adults with primary progressive multiple sclerosis (PPMS). About 769 participants receive either the approved dose or a higher dose every 24 weeks. The main goal is to see if …

This study looks at the long-term safety and effectiveness of the drug ocrelizumab in people with multiple sclerosis (MS). About 1,300 participants who were already taking ocrelizumab in earlier studies will continue treatment and be monitored for side effects and disease progres…

This study compares two multiple sclerosis (MS) treatments in children aged 10 to 17: a daily pill (fingolimod) versus a weekly injection (interferon beta-1a). The goal is to see which better reduces relapses and brain lesions over two years. About 240 participants will be follow…

This study was designed to test a new treatment called GC012F, a type of CAR T cell therapy, in people with multiple sclerosis. The goal was to see if it is safe and if it can help control the disease. However, the study was withdrawn before any participants were enrolled, so no …

This study looks at whether switching from natalizumab to cladribine tablets is safe and effective for people with relapsing forms of multiple sclerosis. About 40 adults aged 18 to 60 will take cladribine and be monitored for changes in immune cells and relapse rates over two yea…

This phase 3 study tests whether the drug frexalimab can delay disability worsening in people with nonrelapsing secondary progressive multiple sclerosis (nrSPMS). About 943 adults aged 18–60 are receiving either frexalimab or a placebo for up to 36 months. The main goal is to see…

This study tests the safety and best dose of ocrelizumab in children and teens (ages 10 to 18) with relapsing-remitting multiple sclerosis. Over 2 years, researchers will monitor how the drug works in the body and its effects on immune cells. The goal is to find the right dose fo…

This study looks at whether switching from anti-CD20 drugs (like ocrelizumab) to cladribine can improve immune function and lower infection risk in people with relapsing multiple sclerosis. About 70 participants will be followed for 2 years. The goal is to see if the switch helps…

This study tests an experimental drug called SAR441344 in 129 adults with relapsing multiple sclerosis. The drug blocks a protein (CD40L) to reduce new active brain lesions seen on MRI. Participants receive either the drug or a placebo for several weeks. The goal is to see if the…

This large Phase 3 study compares a new investigational drug, frexalimab, to an approved daily pill (teriflunomide) in about 1655 adults with relapsing forms of multiple sclerosis. The main goal is to see if frexalimab reduces the number of relapses more effectively. Participants…

This early-phase study tests whether a patient's own stem cells, injected into the spinal fluid, can repair nerve damage caused by progressive multiple sclerosis (MS). The trial involves 18 adults with secondary or primary progressive MS. Researchers will measure changes in nerve…

This study looks at whether people over 50 with a stable, inactive form of secondary progressive multiple sclerosis can stop taking their disease-modifying therapy without worsening their disability. Researchers will follow 250 participants for two years to compare disability pro…

This study tests a non-invasive device that uses low-frequency electromagnetic waves to help immune cells communicate better. The goal is to reduce flare-ups in people with lupus, rheumatoid arthritis, or multiple sclerosis. 120 adults will receive either real or placebo sessions…

This study looks at whether measuring kappa free light chains (KFLC) in spinal fluid can help diagnose multiple sclerosis (MS) and its early stage, clinically isolated syndrome (CIS). Researchers will compare KFLC to the current standard test (oligoclonal bands) in over 1100 adul…

This study aims to create detailed brain charts for the Chinese population by collecting MRI scans from over 10,000 healthy people of different ages. These charts will show what a normal brain looks like at each age, helping doctors detect diseases like multiple sclerosis, Alzhei…

This study looks at whether a specific brain scan feature, called the central vein sign, can help doctors diagnose multiple sclerosis (MS) more accurately. About 420 adults with suspected MS will get MRI scans at the start and after two years. The goal is to see if this sign can …

This study aimed to see if using an immersive virtual reality headset for balance exercises is safe and practical for people with multiple sclerosis who experience dizziness and fatigue. The researchers planned to compare this new approach to standard vestibular therapy. However,…

This study tests a 6-month online program designed to help people with multiple sclerosis (MS) increase their physical activity. The program uses coaching and goal-setting to encourage exercise, with the goal of improving walking, thinking, fatigue, mood, and quality of life. Abo…

This study is testing a smartphone app called MS Falls Insight Track (MS FIT) that helps people with multiple sclerosis log their falls and near-falls, view their health data, and share it with their care team. The goal is to see if using the app can help patients and doctors wor…

This study looks at whether education from a nurse — either in person or through video calls — can help people with multiple sclerosis (MS) manage common problems like fatigue, pain, poor sleep, and urinary tract infections. About 96 adults with relapsing-remitting MS will take p…

This study tests whether doing physical therapy sessions at home via video call can improve balance and quality of life for people with multiple sclerosis or Parkinson's disease. Thirty-six participants will either receive 20 telerehabilitation sessions with a hospital physiother…

This study tests whether a robotic leg brace called the Hybrid Assistive Limb (HAL) can improve walking and balance in people with multiple sclerosis. Eight participants will use the device for one hour a day, five days a week, for two months. Their walking speed, endurance, and …

This study tests whether using a wearable bladder device along with pelvic floor therapy at home can help people with multiple sclerosis manage overactive bladder symptoms. About 20 women with MS and mild to moderate bladder problems will try the treatment for three months. The m…

This study tests whether a tele-rehabilitation program is safe and helpful for people with multiple sclerosis who can walk (EDSS score 6.5 or lower). 75 participants will do three online rehab sessions per week and attend three in-person visits. Researchers will compare this to s…

This study looks at whether a special training program using a reaction system can improve thinking, walking, and balance in people with multiple sclerosis (MS). About 40 adults with MS, ages 18-55, who can walk without major help will take part. The training combines physical ag…

This study tests whether a 5-week home exercise program can help people with multiple sclerosis (MS) improve their balance and prevent falls. Thirty participants will be split into two groups, both doing exercises three times a week, but one group gets extra balance and mobility …

This study tests whether a digital cognitive behavioral therapy program for insomnia can help people with multiple sclerosis sleep better and feel less tired during the day. About 550 adults with MS and insomnia will either receive the online therapy or digital education about sl…

This study tests a thinking skills program called CIRCuiTS, adapted for people with multiple sclerosis (MS). Twenty-four adults with MS will either start the program right away or wait 13 weeks. The program includes up to 36 hours of therapist-led and independent sessions over 12…

This study tests whether a smartphone app called MS CATCH can improve depression care for people with multiple sclerosis (MS). Participants use the app to regularly report their mood, and their neurologist can see this information and get alerts if there are concerns. The goal is…

This study looks at whether combining a supervised exercise program with a long-term DHA (a type of omega-3 found in fish oil) supplement can improve physical function, thinking, fatigue, and quality of life in 100 adults with multiple sclerosis. Participants will be randomly ass…

This study explores whether using the ABLE Exoskeleton—a wearable robotic device—once a week for a year can help people with multiple sclerosis maintain their physical and mental health. Nineteen participants will have 60-minute gait training sessions at the clinic and be tested …

This study tests a combination of brain stimulation (rTMS), virtual reality exercises, and physical therapy in 30 people with multiple sclerosis. The goal is to see if this approach improves balance, fatigue, thinking, and quality of life. Participants receive both real and fake …

This study looks at whether backward walking training can help people with multiple sclerosis (MS) improve their balance and reduce falls. About 90 adults with MS who have trouble walking or have had recent falls will take part. They will be assigned to either backward or forward…

This study tests a home-based exercise program combined with a gentle brain stimulation technique (tDCS) to reduce fatigue in people with multiple sclerosis. Sixty participants will either get real or placebo stimulation while doing the exercises. The goal is to see if the combin…

This study is testing a set of five virtual reality games (exergames) in the metaverse designed to improve cognitive skills like memory, attention, and problem-solving in people with neurological disorders such as multiple sclerosis, Parkinson's disease, stroke, and traumatic bra…

This study looks at whether Qigong, a gentle exercise combining movement, breathing, and focus, can improve balance, overall well-being, and mood in people with multiple sclerosis (MS). About 36 adults with MS who can walk on their own will be randomly assigned to either Qigong s…

This study tests a special walking training that uses visual cues to help people with multiple sclerosis improve their balance and mobility. Forty participants with relapsing-remitting MS who can walk without aids will be followed to see if the training reduces their risk of fall…

This study looks at how two parts of cannabis, THC and CBD, affect thinking and bladder problems in people with Multiple Sclerosis (MS). Thirty adults with MS will take either THC or CBD oil for 15 weeks and complete thinking tests and bladder symptom questionnaires. The goal is …

This study tests a 16-week home-based exercise program for people diagnosed with multiple sclerosis within the last two years. The goal is to see if the program helps them become more active and improves fatigue, mood, and quality of life. Participants wear an activity tracker an…

This small pilot study is testing whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted to help people with multiple sclerosis (MS) who have memory and thinking difficulties. Eleven participants will work one-on-one with a coach in nine v…

This study looks at whether a mix of in-person group exercise and at-home telerehabilitation can help people with multiple sclerosis improve their balance and walking. About 50 adults with MS will take part in a 12-week program with weekly group sessions led by two physiotherapis…

This study looks at whether N-acetyl cysteine (NAC), an antioxidant supplement, can improve brain function in people with Multiple Sclerosis (MS). Researchers will use special brain scans (PET-MRI) to measure changes in brain activity and inflammation. The study involves 55 adult…

This study tested two teaching methods for nursing students: a 360-degree video about the brain and multiple sclerosis (MS), and a standard slideshow. About 50 students from three nursing schools took part. Researchers measured how much they learned about MS and MRI, and how they…

This study looks at whether virtual telehealth visits can be as effective as regular in-person clinic visits for people with multiple sclerosis (MS). The goal is to see if virtual care can improve access, reduce costs, and maintain health outcomes. About 120 adults with a recent …

This study looks at whether pairing brief, low-oxygen breathing (AIH) with electrical muscle stimulation (NMES) can boost brain-to-muscle signals in people with relapsing forms of multiple sclerosis. Forty participants will have their ankle strength and brain responses measured a…

This study is a large registry that will follow 1,000 adults with multiple sclerosis (MS) across North America. Researchers will collect data on how well approved MS treatments work and what side effects they cause in everyday medical practice. The goal is to better understand th…

This study aimed to collect walking data from people with Parkinson's disease, dementia, multiple sclerosis, and other conditions using wearable sensors. The goal was to develop computer programs that could automatically detect walking problems and fall risks. However, the study …

This study looks at balance and movement problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use special devices to measure how patients stand and walk. The goal is to learn more about these issues so that future rehabilitation can be bett…

This study planned to see if a smartphone app could help monitor multiple sclerosis (MS) by tracking symptoms and health changes remotely. It was designed for adults with MS who owned a compatible smartphone. However, the study was withdrawn before enrolling any participants, so …

This study tests whether an AI tool (icobrain mr) that analyzes brain MRI scans can help doctors find signs of active MS more accurately than standard care. About 750 adults with multiple sclerosis or related conditions will be followed for 24 months. The goal is to see if AI-ass…

This study tests whether a smartphone app can reliably measure multiple sclerosis (MS) symptoms and predict disease worsening. About 300 adults with MS will use the app for two years to complete challenges and surveys. The goal is to develop digital biomarkers that complement tra…

This study tests whether a special MRI scan can detect brain changes linked to thinking and memory problems in people with multiple sclerosis (MS). Researchers will scan 75 adults with MS and compare the results to cognitive tests. The goal is to improve understanding of how MS a…

This study follows 367 adults with relapsing multiple sclerosis (RMS) who are taking cladribine tablets. Researchers want to find out which patient traits predict how well the drug works and how safe it is over time. The main goal is to see how long people stay on treatment, and …

This study looks at whether the Timed Up and Go (TUG) test, a common walking test, can reliably measure how people with multiple sclerosis (MS) perform when they have to walk and think at the same time. About 50 volunteers with MS will do the TUG test alone and while doing simple…

This study looks at how many people with multiple sclerosis (MS) develop antibodies against the drug natalizumab when it is given as a shot under the skin. Researchers will use data from European MS registries to track about 400 patients, including those new to the drug and those…

This study looks at how much of the multiple sclerosis (MS) drug ofatumumab gets into breast milk. About 24 breastfeeding women with relapsing MS will provide milk samples after starting or restarting the drug. The goal is to help mothers and doctors understand the safety of brea…

This study tests a wearable smart insole and phone app to track walking changes in people with Multiple Sclerosis (MS) from home. About 90 adults with MS will use the device three times a week for six months. The goal is to see if the technology can reliably detect changes in gai…

This study looks at the long-term safety of two MS drugs, Vumerity and Tecfidera, by analyzing data from over 10,500 patients in large registries. Researchers will track serious side effects like infections and cancer, comparing these drugs to other MS treatments. The goal is to …

This study looks at how natural hormone changes during the menstrual cycle impact brain-to-muscle communication, learning new motor skills, and muscle fatigue in women with multiple sclerosis (MS). Researchers will measure hormone levels and use a non-invasive brain stimulation t…

This study looks at how being overweight or obese might make multiple sclerosis (MS) worse in children. Researchers will compare brain scans and blood tests from 58 kids with MS—half of normal weight and half overweight—to see if obesity leads to more brain shrinkage or inflammat…

This study uses a special radioactive tracer and PET/MRI scans to track white blood cells entering the brain in people with fibromyalgia, chronic fatigue syndrome, or multiple sclerosis, as well as healthy volunteers. The goal is to better understand brain inflammation in these c…

This study aims to design and test rehabilitation strategies that combine physical and mental tasks (like walking while solving a puzzle) for people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will work with 48 participants to see if these dua…

This study tests two new digital tools to monitor how Multiple Sclerosis (MS) affects movement and vision. Ten people with stable MS will use apps that analyze their balance and motion, and have their eyes scanned with a special camera. The goal is to see if these tools are as re…

This study looks at how happy doctors and people with multiple sclerosis (MS) are with current treatments in everyday medical practice. Researchers will survey doctors and patients in several countries to understand satisfaction levels and what factors influence them. The goal is…

This study uses MRI scans to better understand white matter hyperintensities (bright spots on brain images) in women with migraines. Researchers will compare these spots to those seen in small vessel ischemic disease and multiple sclerosis. The goal is to classify the underlying …

This study looks at how changing the timing of deep brain stimulation (DBS) pulses affects movement symptoms and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test different stimulation patterns in 180 parti…

This study looks at how the stiffness of leg and breathing muscles affects lung function, tiredness, and anxiety or depression in people with multiple sclerosis (MS). About 29 adults with MS will have their muscle properties measured with a device, along with breathing tests and …

This study looks at whether increased activity of certain brain immune cells (microglia) is linked to faster growth of MS lesions over 10 years. Researchers will use PET and MRI scans to measure this in 100 people with MS. The goal is to better understand how MS progresses, not t…

This study involves 150 people with relapsing-remitting multiple sclerosis (MS) and their doctors. The goal is to create a questionnaire that can confirm MS relapses without requiring an in-person visit, saving patients time and travel. Researchers will also test if better commun…

This study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-health marker called BDNF in people with multiple sclerosis, long-COVID, or leukemia (in remission) who also have obesity and memory or thinking problems. About 30 participants w…

This study aims to find a set of markers—from genes, immune system tests, and brain scans—that can tell how severe multiple sclerosis (MS) will become. Researchers will follow 120 people with MS and their siblings who also have the condition. The goal is to better understand why …

This observational study looks at why about 43% of people with multiple sclerosis (MS) feel their walking gets worse the longer they walk. Researchers will measure changes in walking patterns and brain activity in 70 MS patients and 30 healthy volunteers during short and long wal…

This study looks at how multiple sclerosis (MS) symptoms, especially fatigue, change during different phases of the menstrual cycle. About 300 women with MS will use a phone app to track their symptoms and cycle for six months. The goal is to find patterns that could help manage …

This study looks at how the MSCopilot mobile app fits into the daily routines of people with multiple sclerosis (MS) and their doctors. About 60 adults with MS will use the app at home to track their condition, while doctors use a dashboard to review the data. The goal is to see …

This study looks at people with multiple sclerosis who have trouble swallowing. Researchers want to understand how swallowing problems relate to nutrition and muscle strength. About 34 adults with MS will be assessed using questionnaires and simple physical tests. The goal is to …

This study was designed to see if the drug alemtuzumab calms overactive immune cells in the brains of people with relapsing-remitting multiple sclerosis (RRMS). Researchers planned to use a special PET scan to track these cells over 18 months. The study was withdrawn before enrol…

This study follows 440 people in Scotland who were recently diagnosed with relapsing-remitting multiple sclerosis (MS). Researchers will track their health for 5 to 10 years using brain scans and other tests to see how the disease progresses. The goal is to better predict what ea…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study follows 200 people with Parkinson's disease or multiple sclerosis for one year. Participants use a smartphone app to track their daily steps and exercise. The goal is to learn how physical activity and confidence in exercising change over time, without providing any tr…

This study looks at whether special brain scans can help predict if multiple sclerosis (MS) will get worse over time. Researchers will scan the brains of 35 people with MS, aged 40 to 50, to measure certain proteins linked to brain inflammation. The goal is to find a way to ident…

This study collects lymph fluid from the chest of 24 people (some with MS, some healthy) to compare immune cells in the blood versus deep in the lymphatic system. In MS participants, researchers will also look at how these cells change after treatment with the approved drug ofatu…

This study creates a large collection of blood samples and health data from over 3,200 people with multiple sclerosis and similar conditions like transverse myelitis and optic neuritis. The goal is to provide researchers with a shared resource to study causes, subtypes, and bioma…