Massive biobank launches to unlock secrets of MS and related disorders
NCT ID NCT00445367
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is creating a large, long-term collection of blood samples and health information from over 3,200 people with multiple sclerosis and related demyelinating diseases, as well as healthy volunteers. The goal is to provide scientists with a shared resource to better understand what causes these diseases, identify different subtypes, and discover biomarkers. Participants provide blood samples and medical data, but this study does not test any new treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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3,226 people
The number who actually took part.
- Start date
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May 2006
- Expected to finish
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Oct 2036
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Subjects with MS, selected other demyelinating diseases (Transverse Myelitis (TM), Neuromyelitis Optica (NMO) or Devic's, Acute Disseminated Encephalomyelitis (ADEM), and Optic Neuritis (ON)), and related and unrelated unaffected controls.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * age 18+ able to give informed consent or individuals younger than 18 with parental permission and able to give assent * willing to provide up to 110 ml (50 ml for \< 18 years old) of blood via venipuncture * experienced at least one CNS demyelinating event characteristic of MS, TM, NMO, ADEM, or ON Exclusion Criteria: * history of blood borne pathogens * allogeneic bone marrow transplant * clinical or radiological evidence of stroke, meningitis, or other well characterized diseases of the nervous system (with the exception of MS, TM, NMO, ADEM, or ON). * weight less than 37 pounds
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Barrow Neurological Institute
Phoenix, Arizona, 85013, United States
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Beth Israel Deaconess
Boston, Massachusetts, 02215, United States
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Johns Hopkins
Baltimore, Maryland, 21287, United States
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Multiple Sclerosis Research Center of New York
New York, New York, 10019, United States
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Shepherd Center
Atlanta, Georgia, 30309, United States
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Stanford University
Stanford, California, 94305, United States
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The Ohio State University
Columbus, Ohio, 43210, United States
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The Rocky Mountain MS Center at Anschutz Medical Campus at UC Denver
Aurora, Colorado, 80045, United States
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University of Massachusetts Medical School
Worcester, Massachusetts, 01605, United States
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University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 76051, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can diet ease the crushing fatigue of multiple sclerosis?
- One-Time CAR-T infusion tested against progressive MS
- Can PET scans reveal hidden brain inflammation in MS?
- Can a pill rebuild the Brain's insulation? MS trial puts remyelination to the test
- Migraines and tension headaches may be hidden companions to multiple sclerosis