MULTIPLE SCLEROSIS

This study tests a new medicine called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases such as lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to see if the drug is safe and can help control disease activity. Participants will receive the drug and …

This early-phase study tests a new treatment for multiple sclerosis (MS) that combines an antibody (CD20 monoclonal antibody) with immune cells (NK042 cell injection). The goal is to see if the combination is safe and can reduce MS disability. About 20 adults with relapsing or pr…

This study tests a drug called ublituximab for people with relapsing multiple sclerosis. It compares injecting the drug under the skin at different body sites and using an auto-injector device versus a regular syringe. The goal is to see how the drug moves through the body and if…

This study tests a digital program that gives people with multiple sclerosis personalized strategies to avoid falls. About 80 participants who have MS and have fallen recently will take part. The program analyzes each person's fall risks and offers tailored advice, with the goal …

This early-phase trial tests a personalized treatment for people with progressive multiple sclerosis (MS). The therapy uses the patient's own immune cells, trained in the lab to become 'tolerogenic' (calming) and loaded with myelin proteins, then injected back to retrain the immu…

This early-stage study tests a new treatment called CABA-201 for people with multiple sclerosis (MS). It uses a patient's own immune cells, modified to target and destroy certain immune cells that may be attacking the nervous system. The main goals are to check safety and see if …

This study will test if hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) helps people with over 30 different conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. About 100 participants will receive the treatment and repor…

This early-stage study tests a new treatment called S103 (BCMA-CAR T cells) for people with progressive or hard-to-treat multiple sclerosis (MS). The main goal is to check if the treatment is safe and to find the right dose. Only 9 adults will take part, and the study is not yet …

This early-phase study tests a new treatment called QT-019C, which uses specially engineered immune cells (CAR T-cells) to target and attack faulty immune cells in people with severe autoimmune diseases like multiple sclerosis, neuromyelitis optica, and myasthenia gravis. Up to 1…

This study aims to see if a new remote breathing exercise program can improve breathing strength, quality of life, and physical function in people with multiple sclerosis. The program adjusts the breathing resistance based on each person's maximum ability, similar to how weightli…

This study looks at whether a 12-week exercise program can help people with relapsing-remitting multiple sclerosis (MS) by reducing nerve damage and preserving brain volume. Researchers will measure a blood marker called neurofilament light chain and use MRI scans to see changes.…

This study tests a new, portable, and low-cost MRI scanner designed to diagnose multiple sclerosis (MS) in places where standard MRI machines are not available, such as rural areas or developing regions. About 50 people with suspected MS will be scanned with both the portable dev…

This study tests a home-based exercise system that uses artificial intelligence to give instant feedback. The goal is to see if it helps people with multiple sclerosis improve their mobility and leg strength. The study will include 94 participants who have some walking ability bu…

This study tests whether a 12-week program focused on nutrition, exercise, sleep, and stress management can improve fatigue, physical function, and quality of life in 30 adults with relapsing-remitting multiple sclerosis. Participants first undergo a 12-week observation period, t…

This study tests whether using a virtual reality headset at home can improve hand dexterity in people with multiple sclerosis. Sixty adults with MS who have trouble with hand tasks will be randomly assigned to either VR training or standard care. The main goal is to see if the VR…

This study tests whether cetirizine (Zyrtec) or diphenhydramine (Benadryl) is better tolerated by multiple sclerosis patients before their infusion therapy. About 60 adults with MS will receive one of the two medicines and report sleepiness and fatigue. The goal is to find a pre-…

This study tests whether a special virtual reality headset that flashes lights and sounds can reduce fatigue in people with multiple sclerosis. Thirty adults with moderate to severe fatigue will either get the real stimulation or a fake version for 4 weeks. Researchers will check…

This study tests whether a gentle brain stimulation technique called tDCS can help people with multiple sclerosis (MS) move better, feel less tired, sleep better, and think more clearly. Forty adults with MS will receive either real or fake stimulation sessions over two weeks, th…

This study looks at whether ongoing ocrelizumab treatment helps with extreme tiredness and thinking skills (like memory and attention) in veterans with multiple sclerosis. About 30 veterans who have been on the drug for at least a year will be followed for 12 months. They will ta…

This study will test if augmented reality (AR) exercises can help people with multiple sclerosis (MS) improve their walking and thinking at the same time. Forty adults with MS will try structured AR scenarios that combine physical and mental tasks. The goal is to see if this appr…

This study tests whether a smartphone app called MSCopilot Boost can reduce the impact of fatigue in people with multiple sclerosis (MS) better than standard care. About 208 adults with MS and significant fatigue will use the app for remote monitoring and personalized exercise pr…

This study looks at whether a 12-week aerobic exercise program is practical and helpful for people with advanced multiple sclerosis who use wheelchairs. Twelve participants will exercise twice a week under supervision, and researchers will check if it improves fitness, daily func…

This study tests a 3-part rehab program for people with multiple sclerosis (MS) that includes physical therapy, counseling, and nutrition advice. The goal is to improve movement, thinking, and overall well-being. About 26 adults with MS will take part in this non-drug approach to…

This study looks at whether acetaminophen (Tylenol) can reduce walking fatigue in people with multiple sclerosis. Twenty participants will take either the drug or a placebo, then walk on a treadmill until they get tired. One week later, they repeat the test with the opposite pill…

This early-phase study tests whether a diabetes drug called glibenclamide (glyburide) can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and moderate-to-severe nerve pain will take the oral extended-release drug. Researchers will measure safety, dr…

This early-stage study tests whether a non-invasive brain stimulation technique called rTMS is safe and can help ease depression and fatigue in adults with multiple sclerosis (MS). About 20 participants with MS and moderate-to-severe depression will receive daily rTMS sessions fo…

This study looks at whether a 12-week exercise program can help people with multiple sclerosis (MS). Researchers will measure changes in brain structure, a blood marker called GFAP, and physical function. The trial involves 30 adults with relapsing-remitting MS who have mild to m…

This study tests whether a home-based video game program (exergames) can improve arm and hand function in 40 people with multiple sclerosis better than standard home exercises. Participants will play specially designed games that challenge both movement and thinking, with remote …

This study tests whether a six-week, nurse-led virtual group program can help adult women with Multiple Sclerosis (MS) find more meaning and purpose in life and improve their quality of life. Participants will attend weekly online group sessions focused on reflection and values e…

This study tests a new exercise called eccentric cycling for people with multiple sclerosis. Researchers want to see if it improves muscle strength, walking, fatigue, and quality of life better than standard training. The study plans to enroll 60 adults with MS who can walk indep…

This study tests whether sensory integration therapy can improve walking stability and quality of life in people with multiple sclerosis (MS). Researchers will enroll 44 adults with relapsing-remitting MS who have mild to moderate disability. Participants will be randomly assigne…

This study tests a wearable brain-computer interface (BCI) that uses mental imagery to help people with multiple sclerosis improve arm and hand movement. Forty participants will either receive BCI-based neurofeedback plus standard therapy or standard therapy alone over 12 weeks. …

This study will test whether short bursts of high-intensity exercise (HIIT) are better than moderate, steady exercise (MICT) for improving walking, balance, and thinking in 40 adults with multiple sclerosis. Participants will be randomly assigned to one of the two exercise progra…

This study tests whether a non-invasive device called SCONE™, which sends mild electrical pulses to the spinal cord, can help people with multiple sclerosis move their arms and hands better. Sixty adults with MS will receive either real or sham stimulation while doing hand and ar…

This study will test whether a 16-week Pilates program done at home via video calls can improve walking, balance, fatigue, and pain in people with multiple sclerosis (MS). About 50 adults with mild to moderate MS will be assigned to either the Pilates group or a waitlist. Researc…

This study translates and tests a short questionnaire about bladder symptoms for Turkish-speaking adults with spinal cord injury or multiple sclerosis. Researchers will check if the Turkish version is accurate and reliable by comparing it to other surveys. The goal is to give doc…

This study looks at how trunk (core) stability is linked to balance, walking, arm function, and tiredness in people with mild to moderate multiple sclerosis. Researchers will measure these abilities in 64 participants during a single session. No treatment or intervention is given…

This study looks at how changes in tiny blood vessels at the back of the eye relate to vision loss in people with multiple sclerosis (MS). Researchers will use a special eye scan (OCT-A) and standard vision field tests in 32 participants. The goal is to better understand how MS a…

This study looks at whether people with relapsing-remitting multiple sclerosis (MS) can have a relapse without any new spots showing up on an MRI scan. Researchers will follow 136 adults who are having a suspected relapse, giving them an MRI within 6 days and checking on them 6 m…

This study looks at whether the time you eat each day can affect brain health in people with multiple sclerosis. Researchers will ask 22 adults with MS to eat only during certain hours and track their meals using a smartphone. They will measure markers of nerve health and inflamm…

This study looks at what helps people with multiple sclerosis (MS) stay employed and feel well. Researchers will survey about 75 adults with MS who have had cognitive tests, asking about their job, workplace adjustments, and well-being. The goal is to find better ways to support …

This study looks at how sleep quality influences thinking, physical activity, body awareness, and reaction time in people with multiple sclerosis. Researchers will compare those with good and poor sleep using questionnaires, computer tests, and a wearable activity tracker worn fo…

This study involves 40 adults with relapsing-remitting multiple sclerosis (MS) who have not taken disease-modifying treatments in the last two years. Researchers will use a special MRI scan to measure metabolic changes in the brain before and after starting anti-CD20 therapy. The…

This study looks at whether people with multiple sclerosis (MS) have different gum health compared to those without MS. Researchers will measure gum disease signs, bacteria, and immune markers in saliva from 100 adults. The goal is to better understand how these two chronic infla…

This study aims to see if artificial intelligence can predict how multiple sclerosis (MS) will progress over time. Researchers will collect basic health information from 53 people with MS and use that data to train a computer model. The goal is to better understand and forecast d…

This study looks at 200 people who had internuclear ophthalmoplegia (a specific eye movement problem) to see how many later develop multiple sclerosis (MS). Researchers want to find clues that help diagnose MS earlier. Participants' medical records will be reviewed to track who c…

This study aims to see if mixed reality (a blend of real and virtual worlds) can be used to measure walking, standing, and balance in people with multiple sclerosis (MS). Researchers will compare standard physical tests with digital versions done on a Meta Quest 3 headset. The go…

This pilot study tests whether a musical tool called Ipsilon can screen and improve cognitive function in people with multiple sclerosis (MS). Thirty-two participants will either play the Ipsilon for 15 minutes daily for a week or start with no intervention, then switch. The goal…

This study looks at how getting tired while walking changes the way people with multiple sclerosis (MS) walk and whether it makes them more likely to fall. Researchers will compare two groups of people with MS—those who experience walking fatigue and those who don't—by measuring …

This study looks at two common multiple sclerosis (MS) medications, teriflunomide and dimethyl fumarate, to see how they affect physical and mental fatigue during everyday activities. Researchers will follow 100 adults with MS for one year, measuring walking endurance, hand funct…

This study looks at how a device that sends small electrical signals to the leg muscles affects walking in people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults who have trouble lifting the…

This study looks at whether lead in the blood plays a role in multiple sclerosis (MS). Researchers will measure lead levels, oxidative stress markers, and DNA changes in 140 people with MS and healthy controls. The goal is to understand how lead might affect the disease, not to t…

This study looks at 40 adults with multiple sclerosis to find specific breathing muscle strength and endurance values that can tell apart different disability levels. Researchers will measure how well participants can breathe in and out, and how long they can keep it up. The goal…

This study looks at how chewing ability is connected to thinking skills, disease severity, and nutrition in people with multiple sclerosis. Researchers will assess 86 adults with MS using tests for disability, memory, swallowing, and chewing. The goal is to better understand thes…

This pilot study tests whether a mild electrical stimulation called TENS can change brain activity in people with Multiple Sclerosis (MS) who have fatigue and walking problems. Researchers will use brain scans (fMRI) to see how the brain responds during stimulation. The goal is t…

This study looks at what emotional, physical, and environmental factors affect daily mindfulness practice in 80 adults with multiple sclerosis and chronic pain. Participants will use a smartphone app to report their practice and access guided meditations. The goal is to understan…

This study will follow 1550 adults diagnosed with various neurological autoimmune diseases (like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis) to see how these conditions progress and respond to treatments in everyday medical practice. Unlike controlled drug…

This study looks at how doing other things at the same time—like listening, watching, or moving—affects chewing in people with multiple sclerosis. About 48 adults with MS and healthy volunteers will take part. The goal is to understand if multitasking makes chewing harder for peo…

This study looks at how a short session of virtual reality affects balance and motion sickness in people with multiple sclerosis (MS). Researchers will compare MS patients with and without central vestibular problems to healthy volunteers. The goal is to learn more about how the …

This study aims to create and test advanced MRI scanning methods to measure brain changes in people with multiple sclerosis (MS). Researchers will scan healthy volunteers and people with MS using powerful 3-tesla and 7-tesla MRI machines. The goal is to develop standard, reliable…

This study looks at whether three substances in the blood (GFAP, NfL, and VEGF) can show how multiple sclerosis (MS) is getting worse over time. Researchers will measure these markers in 22 adults with progressive MS and compare them to standard tests of disability and thinking. …

This observational study follows 111 children born to women with multiple sclerosis who received rituximab or similar drugs before or during pregnancy. Researchers want to see if the drug affects the baby's immune cells, increases infections, or weakens vaccine responses in the f…

This study looks at how people with multiple sclerosis (MS) take their medicines at home. Researchers will visit participants once to review all their medications and supplements, ask about their routines and any problems, and check for safety issues. No changes will be made to t…

This study looks at how multiple sclerosis (MS) affects a person's sense of smell and the related nerve sensations in the nose. Researchers will test 200 women with MS to measure how they perceive smells and cooling or tingling feelings. The goal is to better understand these sen…

This study looks at whether adding computerized cognitive training to walking and resistance exercises can improve gait and reduce falls in older veterans with multiple sclerosis. Thirty participants will be assigned to exercise with or without cognitive training for 10 weeks, th…

This study looks at how treatment failure impacts the quality of life, anxiety, depression, and daily activities of 150 adults with relapsing-remitting multiple sclerosis. Researchers will use questionnaires to measure patients' well-being and their experience with healthcare. Th…