MULTIPLE SCLEROSIS

This study tested whether combining two existing medications—metformin (a diabetes drug) and clemastine (an antihistamine)—could help repair the protective coating around nerves in people with relapsing-remitting multiple sclerosis (MS). All 70 participants continued their standa…

This study tested a new skin patch designed to deliver the drug ozanimod, which is used for multiple sclerosis and ulcerative colitis. Researchers compared how the body absorbs the drug from three different patch formulas versus the standard oral capsule. The goal was to see if t…

This study tested whether a series of infusions using a patient's own stem cells could improve quality of life for people with multiple sclerosis (MS). Twenty-four participants with relapsing-remitting MS received either the stem cell treatment or a placebo over a year, while con…

This study followed 1,055 people with multiple sclerosis who continued receiving ocrelizumab treatment after completing earlier clinical trials. Participants received intravenous infusions every 6 months for two years to evaluate long-term effectiveness and safety. The research m…

This study tested whether a personalized approach to walking therapy works better than standard therapy for people with spinal cord injuries or multiple sclerosis. Researchers used 3D motion capture to analyze each person's specific walking problems and then designed a six-week t…

This study looked at how well a drug called cladribine tablets worked for people with relapsing multiple sclerosis (MS) when their previous oral or infusion treatments were not controlling their disease well enough. It followed 291 patients in a real-world setting for two years t…

This study aimed to understand and compare the experiences of people with Multiple Sclerosis (MS) who were starting one of two different injectable treatments. It focused on side effects at the injection site, like pain or redness, and how satisfied patients were with the process…

This study tested whether a daily oral liquid called CNM-Au8 could improve the energy levels of brain cells in people with multiple sclerosis (MS). Thirty-three participants with different types of MS took the treatment for 12 weeks. Researchers used a special brain scan to measu…

This study tested whether personalized advice from a dietitian helps people with multiple sclerosis (MS) get enough calcium from their diet better than just receiving a standard information sheet. It involved 182 adults with MS who could walk and had never had specific calcium ad…

This study compared a monthly self-injected medication called ofatumumab against standard first-line MS therapies in people newly diagnosed with relapsing multiple sclerosis. The goal was to see which treatment was better at keeping the disease quiet—preventing relapses, stopping…

This study followed 1,710 people with multiple sclerosis (MS) who were prescribed the medication ocrelizumab as part of their regular care. The goal was to see how well the drug works in real-world settings by tracking changes in symptoms like fatigue, mobility, and cognition, as…

This study tested a new spinal fluid analysis method to improve how multiple sclerosis (MS) is diagnosed and understood. Researchers analyzed samples from 161 people with MS and other neurological conditions to see if specific biological markers could accurately identify MS, dist…

This study tested a new type of MRI contrast dye called RVP-001, which is based on manganese instead of the commonly used gadolinium. It involved 18 adults with known brain or spinal cord lesions from conditions like tumors or multiple sclerosis. The main goal was to see if RVP-0…

This study tested a small, wearable sensor to see if it could detect early walking and balance problems in people with multiple sclerosis (MS). Researchers compared the sensor's readings to those from a complex, lab-based motion analysis system. The goal was to see if this simple…

This study aimed to find out which of two advanced types of 3 Tesla MRI brain scans is better at detecting active, inflamed lesions in people with multiple sclerosis (MS). Researchers compared two specific scanning techniques in 180 adults with MS who needed a brain scan for thei…

This study tested two different types of specialized MRI brain scans to see which one is better at spotting a specific sign of multiple sclerosis (MS). Researchers compared the scans in 60 adults with recently diagnosed MS who were already getting an MRI as part of their regular …

This study tested an online group program designed to help people with multiple sclerosis (MS) prevent falls. 240 participants who had experienced at least one fall in the past year were assigned to either take the 8-session online course or receive a standard brochure. Researche…

This study tested a new online program designed to help people with multiple sclerosis (MS) prevent falls. The program taught self-management strategies during weekly group sessions. Researchers wanted to see if the program was practical and acceptable, and if it helped participa…

This study tested whether specific parts of online cognitive behavioral therapy (CBT) could help people with multiple sclerosis (MS) manage their severe fatigue. Researchers worked with 21 adults with MS to see if three therapy components—relaxation training, activity planning, a…

This study tested whether a specific pelvic floor muscle exercise program could help women with multiple sclerosis (MS) who experience urinary incontinence. Researchers worked with 46 female MS patients to see if doing these exercises three times a day for three months could redu…

This study tested whether a 16-week online exercise coaching program is practical and helpful for people with multiple sclerosis who use wheelchairs. Researchers enrolled 24 participants to compare the exercise program against a general wellness program. The main goals were to se…

This study tested whether adding a mild electrical stimulation therapy to standard swallowing exercises helps people with multiple sclerosis who have trouble swallowing. 136 participants were randomly assigned to receive either the real electrical stimulation or a fake version al…

This study tested whether adding cognitive behavioral therapy (a type of talk therapy) to supervised Pilates exercises could improve balance, walking, fatigue, and daily function in people with multiple sclerosis (MS). 90 participants with MS were split into two groups: one recei…

This small pilot study tested whether a personalized program combining different types of therapy and lifestyle advice is practical and helpful for people with conditions affecting thinking and memory, like brain injuries or multiple sclerosis. Fifteen participants were randomly …

This study tested whether adding two mental training techniques—imagining movements and watching videos of movements—to standard physical therapy could help people with multiple sclerosis. Researchers worked with 48 adults with MS to see if these methods improved how far they cou…

This small pilot study tested whether a proven voice therapy program could be delivered effectively through video calls (telerehabilitation) to people with Multiple Sclerosis (MS). The therapy, called LSVT-Loud, aims to help people speak louder and more clearly to improve daily c…

This small pilot study tested whether two different computer brain training programs, combined with light physical activity, could help improve thinking skills like memory and attention in people with multiple sclerosis (MS). Participants used either a large-screen motion-sensing…

This study explored whether a single session of moderate cycling, especially when combined with virtual reality (VR), could temporarily improve the speed of thinking in people with multiple sclerosis (MS) who have mobility issues. Twenty-three participants with MS tried three dif…

This small pilot study tested whether daily bright light therapy could safely help people with multiple sclerosis (MS) sleep better. Researchers wanted to see if this non-drug approach could reduce insomnia and fatigue by potentially resetting the body's internal clock. The study…

This study compared two different exercise programs to see which helps people with multiple sclerosis feel better. Twenty MS patients either did gentle yoga or standard physical therapy for eight weeks. Researchers measured their fatigue, balance, walking ability, and overall qua…

This study tested whether a special training method using 3D virtual reality (VR) could help people with multiple sclerosis (MS) improve their arm and hand function. Thirty-two participants with recent MS attacks watched videos of arm movements through VR headsets and then practi…

This study tested whether a combination of gentle, non-invasive brain stimulation (tDCS) and cognitive training exercises could improve memory, attention, and other thinking skills in people with multiple sclerosis (MS). Researchers worked with 45 adults with MS to see if this ap…

This small study tested whether a two-month water exercise program could help people with multiple sclerosis improve their balance and feel less fatigued. Twenty-six participants with a specific type of MS were split into two groups: one did exercises in the sea, and the other di…

This study tested two non-drug approaches to help people with multiple sclerosis manage persistent symptoms like fatigue, pain, and mood issues. 132 participants tried either a comprehensive lifestyle education program, a brain retraining program focused on calming overactive str…

This study tested two different online exercise programs designed to help people with multiple sclerosis manage leg stiffness and muscle tightness (spasticity). The programs were delivered through group video classes to 232 participants. Researchers measured whether these exercis…

This study tested whether a 4-month exercise program delivered remotely by coaches could help Hispanic/Latino adults with multiple sclerosis (MS). Researchers wanted to see if the program improved physical function, reduced symptoms like fatigue, and boosted quality of life. They…

This study tested whether a non-invasive electrical brain stimulation treatment could help people with multiple sclerosis (MS) feel better mentally and think more clearly. Fifty-three adults with MS received either the real stimulation or a sham (fake) treatment to see if it impr…

This study tested whether an AI-powered smartphone app could help people with multiple sclerosis (MS) build strength better than traditional paper-based exercise plans. For 20 weeks, 58 participants did strength training three times a week, with one group using the AI app for gui…

This study compared two types of online exercise programs for people with relapsing-remitting multiple sclerosis (MS). Sixteen participants were randomly assigned to either live video sessions with a therapist or pre-recorded exercise videos to follow on their own. Researchers me…

This study tested whether a specific type of exercise, called dual-task training, could help people with multiple sclerosis (MS). The training involves doing physical and mental tasks at the same time, like walking while counting backwards. Researchers compared this special train…

This study tested whether laughter yoga could help people with multiple sclerosis (MS) feel better. Forty participants were split into two groups: one did online laughter yoga sessions twice a week for six weeks, while the other did not. Researchers measured changes in fatigue, s…

This study tested whether pelvic floor exercises done at home via video calls could help women with Multiple Sclerosis manage common bladder problems. Researchers compared three types of exercises—strengthening, relaxation, and a combination of both—over 8 weeks. The goal was to …

This study tested whether a 12-week exercise program called 'movement-to-music' (M2M) could improve fitness and well-being in adults with physical disabilities like spinal cord injury, stroke, or multiple sclerosis. 108 participants were randomly assigned to either start the prog…

This study tested whether an 8-week aerobic exercise program could improve movement and function in people with multiple sclerosis (MS). Thirty adults with MS were randomly assigned to either follow the exercise program or be in a comparison group that did not. The results showed…

This study tested two non-invasive electrical stimulation methods to see if they could ease overactive bladder symptoms in women with Multiple Sclerosis (MS). Forty-two participants were split into groups to receive stimulation on the ankle or lower back, or a sham treatment, twi…

This study tested how easy a new mobile app was to use for people with MS. The app guides users through self-administered acupressure techniques aimed at managing pain and fatigue. Ten adults with MS tried the app for six weeks, and researchers interviewed them about their experi…

This study tested whether following the MIND diet, a plan focused on brain-healthy foods, could help people with multiple sclerosis (MS). For three months, 62 participants either followed the MIND diet or a standard healthy eating plan. Researchers measured if the diet improved t…

This study tested whether adding a special core stabilization exercise program to standard pelvic floor muscle training could better improve bladder symptoms and pelvic function in women with multiple sclerosis (MS). Researchers compared the two exercise approaches in 24 women ov…

This study tested whether simple writing exercises focused on gratitude and past successes could help people recently diagnosed with multiple sclerosis (MS) feel more hopeful and improve their emotional well-being. Thirty participants were randomly assigned to either start the ex…

This study aimed to see if tracking eye movements could help doctors measure the severity of multiple sclerosis (MS) and its effects on thinking. Researchers tested 200 people with MS using special eye-tracking technology during a single session. The goal was to train computer so…

This study aimed to understand how well the Pfizer COVID-19 vaccine works in adults with weakened immune systems compared to healthy adults. Researchers measured antibody levels and their ability to fight the virus in 196 participants, including people with conditions like kidney…

This study was a survey to check if doctors, nurses, and patients using the multiple sclerosis (MS) drug Mayzent (siponimod) understood its safety information. Over 300 healthcare professionals and patients/caregivers in Europe and Canada answered questions about managing side ef…

This study aimed to understand how multiple sclerosis affects people's ability to recognize emotions. Researchers compared 101 people with MS to healthy volunteers, measuring how well each group identified positive and negative emotions from faces and audio clips. The study also …

This study aimed to develop better tools for detecting and measuring nerve damage in people with early signs of multiple sclerosis (MS). Researchers followed 134 participants who had experienced a single, recent neurological episode (a clinically isolated syndrome) to see if spec…

This study tested a Turkish version of a questionnaire designed to better understand and measure bladder symptoms in people with multiple sclerosis (MS). Researchers enrolled 71 adults with MS to see if the survey questions were clear, consistent, and accurately captured their ex…

This study followed 168 women with Multiple Sclerosis (MS) who were pregnant or planning pregnancy. Researchers conducted regular phone interviews to collect information about the women's MS, their pregnancies, and their babies' development for up to three years after birth. The …

This study aims to develop a better way to predict who might develop multiple sclerosis (MS). Researchers are testing a new risk score that combines information about a person's genes, medical history, and environmental factors. They are studying people with MS and their close fa…

This study aimed to better understand and measure the severe fatigue experienced by most people with Multiple Sclerosis (MS). Researchers enrolled 60 adults with a specific type of MS to compare different ways of assessing fatigue. They used patient questionnaires alongside physi…

This study looked back at how the first wave of the COVID-19 pandemic affected the care of people with multiple sclerosis (MS) when they had a relapse. Researchers compared 51 patients who had a relapse in spring 2020 to a similar group from spring 2019. The goal was to see if th…

This study aimed to understand if there is a connection between muscle loss (sarcopenia) and breathing strength in people with Multiple Sclerosis (MS). Researchers measured the breathing muscle strength and lung function of 40 participants with MS and sarcopenia in a single sessi…

This study aimed to understand how thinking and emotional problems affect walking in people with multiple sclerosis (MS). Researchers measured the walking patterns, eye movements, and muscle activity of 32 MS patients while they performed walking tasks. The goal was to gather kno…

This study looked at how conflict affects healthcare for people with multiple sclerosis in Libya. Researchers examined 369 patients' medical records to understand how long it takes to get diagnosed, who receives effective treatments, and how these delays relate to disability leve…

This early-stage study checked how two common medications (gemfibrozil and rifampicin) affect the way the body processes an experimental drug for multiple sclerosis (SAR442168). It involved 30 healthy male volunteers to measure drug levels and safety. The goal was to understand p…

This study aimed to find a new biological marker (biomarker) in the blood to help monitor multiple sclerosis (MS). Researchers compared blood samples from 100 healthy people and people with stable MS who were on different treatments. They measured the levels of a specific seroton…

This study aimed to understand how the menstrual cycle affects the experience and physical response to exercise in women with multiple sclerosis (MS). Researchers compared 15 women with MS to women without the condition, having them perform high-intensity and strength training se…

This small study aimed to understand how different types of exercise immediately affect the brain and body in people with multiple sclerosis (MS). Researchers compared standard exercises, traditional aerobic exercise, and aerobic exercise using virtual reality (VR) headsets in 12…

This early study aimed to understand how the body processes an experimental drug for multiple sclerosis (SAR442168). Six healthy male volunteers took a single, traceable dose so researchers could measure how much drug was absorbed, how it was broken down, and how it left the body…

This study aimed to understand exactly how the drug cladribine works in people with multiple sclerosis (MS). Researchers tested blood cells from 77 MS patients and healthy donors in the lab to see how the drug affects the immune system and whether it might protect nerve cells. Th…

This study aimed to create personalized mathematical models of how much muscle force people with arm weakness from stroke, multiple sclerosis, or spinal cord injury can still produce. Researchers measured 32 patients' shoulder and elbow strength to understand their remaining abil…

This was a small, completed lab study that tested whether specially engineered versions of a natural immune protein (called IL-2 muteins) could selectively boost a type of calming immune cell (regulatory T cells) taken from patients with various autoimmune and inflammatory diseas…

This study aimed to understand if a specific gene mutation (ABCG2) affects how much of the multiple sclerosis drug teriflunomide stays in a patient's body and its safety. It involved 82 Chinese patients with relapsing multiple sclerosis who took the standard 14 mg dose daily for …

This study aimed to see if a shorter, 6-meter version of a standard walking test works as well as the usual 30-meter version for people with multiple sclerosis (MS). Researchers tested 21 adults with MS to compare the two versions. The goal was to create a test that is easier to …

This study used advanced brain scans to see if the approved MS drug ocrelizumab reduces inflammation in the brain. Researchers scanned 22 patients with multiple sclerosis before and after about a year of standard ocrelizumab treatment. The goal was to understand how the drug work…

This study looked back at medical records to see if people's gender, race, or economic background affected their access to a multiple sclerosis drug called Ocrelizumab and how well the treatment worked for them. Researchers analyzed data from 800 patients at two major hospitals t…

This study aimed to understand why people swing their arms while walking and how this movement is connected to balance and energy use. Researchers observed 25 people, including healthy individuals and those with conditions like stroke, Parkinson's, or multiple sclerosis, while th…

This study tested whether it was practical and acceptable for people with Multiple Sclerosis (MS) to take a daily probiotic drink for 12 weeks. Researchers enrolled 29 UK adults with MS to see if they could stick to the regimen and to explore any early effects on their quality of…

This study aimed to understand if people with unusual forms of multiple sclerosis (MS) have a different or more severe disease process. Researchers compared blood levels of specific proteins (neurofilament light chain and GFAP) in 15 patients with atypical MS to 30 patients with …

This study looked at how multiple sclerosis (MS) and the medications used to treat it might affect women's fertility. Researchers analyzed blood samples from over 800 women with MS or similar conditions, aged 18-35, to measure a hormone that indicates ovarian reserve. The goal wa…

This study aimed to understand and describe breathing problems in people with severe multiple sclerosis. Researchers observed 70 patients with advanced MS to measure their breathing function during sleep and while awake. The goal was to gather information about how MS affects bre…

This study tested a new blood test to measure antibodies that some patients develop against the multiple sclerosis drug alemtuzumab. Researchers followed 15 patients for two years to see if these antibodies were linked to side effects, changes in immune cells, or the drug's effec…

This study aimed to understand if a multiple sclerosis (MS) medication called ocrelizumab passes into breastmilk and affects breastfeeding infants. Researchers measured the drug levels in breastmilk and checked the babies' immune cells and responses to standard childhood vaccines…

This study aimed to understand the connection between depression and the ability to recognize facial emotions in people with multiple sclerosis (MS). Researchers compared 38 participants, including MS patients and healthy controls, using emotion recognition tests, brain scans (MR…

This study aimed to understand how the approved MS drug, oral cladribine, changes specific immune cells in the body and spinal fluid over two years. It involved 10 people with relapsing-remitting MS who were already taking the drug. Researchers measured detailed changes in B-cell…

This study looked at how COVID-19 lockdowns in France impacted people with long-term health conditions like heart disease, multiple sclerosis, and cancer. Researchers followed over 1,300 patients to see if lockdowns changed their medication use, lifestyle habits, and access to me…

This study aimed to understand if a multiple sclerosis medication called ocrelizumab passes from a pregnant mother to her baby. Researchers followed 70 infants whose mothers took the drug around the time of pregnancy to check the babies' immune cell levels and see if they respond…

This study tested whether an FDA-approved iron supplement called ferumoxytol could be used as a special dye to make inflammation in the brain show up more clearly on powerful MRI scans. Researchers enrolled 14 adults, some with multiple sclerosis and some healthy, to see if the i…

This study aimed to find better ways to predict if people with early brain scan abnormalities will develop multiple sclerosis (MS). Researchers tested new markers in blood and spinal fluid from 100 people who had these early scan findings. The goal was to see if these markers cou…

This study tested a new walking assessment called the 'L test' in 50 people with Multiple Sclerosis (MS). The goal was to see if this test is a reliable and valid way to measure the common challenge of walking while also thinking or talking, which can increase fall risk. Research…

This study aimed to understand why some people with Multiple Sclerosis (MS) develop liver problems when taking a common drug called beta-interferon. Researchers compared the genes of 300 MS patients who had liver injury with those who did not, using saliva samples. The goal was t…