Talking away fatigue: new study tests CBT for MS patients
NCT ID NCT05848323
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether three types of cognitive behavioral therapy (CBT) delivered online could help reduce fatigue in people with multiple sclerosis. 21 adults with MS and chronic fatigue tried relaxation training, behavioral activation, or cognitive therapy. The goal was to see if these approaches were acceptable and helpful for managing fatigue symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
21 people
The number who actually took part.
- Started
-
Oct 2023
- Finished
-
Sep 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. MS diagnosis of any subtype per chart review 2. Score 4 or higher on the Fatigue Severity Scale 3. Presence of chronic, problematic fatigue that, in the opinion of the patient, has interfered with their daily activities for 3 or more months 4. Are able to comply with study procedures and complete measures independently assessed via self-report 5. All genders 6. 18 years of age or older 7. Able to read and speak English 8. Are willing to maintain current fatigue treatment regimen for duration of study (although individuals who want to make a change to their fatigue treatment regimen will be considered eligible 3 months after making that change) Exclusion Criteria: 1. Score greater than 7 on the Patient Determined Disease Steps Scale 2. Has significant cognitive impairment as indicated by 1 or more errors on the 6-item Cognitive Screener 3. Change in disease modifying medications in the prior three months assessed via self-report (although participants will be considered eligible after the 3-month window) 4. History of MS relapse within the last 30 days prior to screening assessed via self-report (although participants will be considered eligible after the 30-day window) 5. Current suicidal ideation with intent or plan as indicated by a score of 1 or higher on the Patient Health Questionnaire-9 suicide item and further assessment with the Columbia-Suicide Severity Rating Scale (although individuals with suicidal ideation but no intent or plan will be considered eligible) 6. Currently engaged in psychotherapy for fatigue assessed via self-report 7. Current pregnancy (although participants will be considered eligible when they are no longer pregnant) 8. Currently participating in another research study that could impact fatigue such as intervention studies targeting mood, energy management, exercise/physical activity, and diet (although participants can be screened for eligibility once they have completed the other research study).
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Fatigue are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Multiple Sclerosis Center at UW Medical Center - Northwest
Seattle, Washington, 98133, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can exercise rebuild muscle and balance in MS?
- Can diet ease the crushing fatigue of multiple sclerosis?
- One-Time CAR-T infusion tested against progressive MS
- Can PET scans reveal hidden brain inflammation in MS?
- Can a pill rebuild the Brain's insulation? MS trial puts remyelination to the test
- Migraines and tension headaches may be hidden companions to multiple sclerosis