University Of Washington

This early-stage study tests the safety of adding two targeted drugs (polatuzumab vedotin and possibly glofitamab) to standard chemotherapy for people with untreated, fast-growing B-cell lymphoma. About 56 participants will receive the combination to see if it is tolerable and ca…

This study tests whether a precise type of radiation to the brain and spinal cord can control cancer that has spread to the fluid around the brain, while protecting a memory-related area called the hippocampus. About 22 adults with breast or lung cancer that has spread to the bra…

This study tests whether an intensive support program helps stroke patients with sleep apnea use their CPAP machine more regularly. About 250 participants will be split into two groups: one gets extra coaching and mobile health tools, the other gets standard care. The goal is to …

This study tests whether a low dose of the drug mosunetuzumab is safe and works well for people with slow-growing B-cell lymphoma who have not had treatment before. About 20 adults with follicular or marginal zone lymphoma will receive the drug to see if it shrinks tumors. The go…

This study tests a new combination of drugs for people with acute myeloid leukemia (AML) and related blood cancers. The treatment adds a targeted drug called venetoclax to a standard chemotherapy regimen (CLAG-M). The goal is to find the safest dose and see if the combo can bette…

This early-stage trial tests the safety and best dose of the drug abemaciclib when given with radiation therapy before surgery for a rare, high-risk type of abdominal cancer called retroperitoneal sarcoma. About 18 adults with this cancer will receive the drug and radiation to sh…

This study tests whether a combination of decitabine (a chemotherapy drug) and a JAK inhibitor (ruxolitinib, fedratinib, or pacritinib) can help prepare patients with advanced myeloproliferative neoplasms (blood cancers) for a stem cell transplant. About 25 adults will receive th…

This study tests whether giving high levels of testosterone alongside chemotherapy or a targeted radiation drug can help men with advanced prostate cancer that has stopped responding to standard hormone therapy. About 69 participants will receive testosterone injections plus eith…

This study tests a drug called odronextamab in people with large B-cell lymphomas that have returned or not responded to treatment. The drug is given before CAR-T cell therapy to control the cancer and help patients successfully receive the full treatment. About 27 adults will ta…

This study tests a health system approach to improve care for people with opioid use disorder as they leave jail and connect to community clinics. Researchers will work with over 4,000 adults in King County, Washington, to see if using systems engineering tools can increase the n…

This study tests an 8-week exercise program designed to improve cardiovascular health in people with HIV who are at risk for heart failure. The program combines weekly supervised workouts at a center with two home-based sessions, plus education and coaching. Researchers will enro…

This study tests whether a simple text-message system can help caregivers in Kenya monitor their child's nutrition at home and prevent wasting. About 600 caregiver-child pairs (children aged 6-24 months who are HIV-exposed) will be split into two groups: one gets weekly texts wit…

This study tests whether adding a mix of three targeted antibodies (tafasitamab, retifanlimab, and rituximab) before and alongside standard chemotherapy can safely treat people with untreated diffuse large B-cell lymphoma. About 35 adults will take part. The goal is to see if thi…

This study tests whether special PET/CT scans (PSMA or fluciclovine) can find small areas of prostate cancer that have spread beyond the prostate. Doctors will then treat only those spots with targeted radiation or surgery. The goal is to lower PSA levels and delay the need for l…

This study tests a drug called gemtuzumab ozogamicin in people with acute myeloid leukemia who have tiny amounts of cancer left after initial treatment. The drug works like a guided missile, attaching to a protein on leukemia cells and delivering a chemotherapy payload to kill th…

This study tests whether a simple blood test that measures tumor DNA can help doctors safely reduce the amount of chemotherapy for people with advanced Hodgkin lymphoma. About 125 participants will receive either fewer or standard chemotherapy cycles based on their blood test res…

This study tests whether combining two drugs, pirtobrutinib and mosunetuzumab, can better treat follicular lymphoma that has come back or not responded to prior therapy. About 22 adults with grade 1-3a lymphoma will receive the combination. The goal is to increase the chance of c…

This study tests whether adding the WOKVAC vaccine to standard chemotherapy and HER2-targeted therapy before surgery can help the immune system better attack breast cancer cells. About 25 adults with early-stage HER2-positive breast cancer will receive the combination treatment. …

This study is for pregnant women with von Willebrand disease (VWD), a bleeding disorder. It tests a medicine called Wilate to raise clotting factor levels during delivery and after birth, aiming to prevent severe blood loss. About 110 women will take part, and researchers will tr…

This study tests a vaccine called STEMVAC, given with chemotherapy, for people with a tough-to-treat breast cancer that has spread. The vaccine is designed to train the immune system to attack cancer stem cells. About 20 adults with PD-L1 negative, triple-negative breast cancer w…

This study tests whether giving copper supplements to people with cirrhosis (scarred liver) who have low copper levels can improve liver function and reduce infections. About 30 adults with cirrhosis and low or borderline copper will take copper or a placebo for a few months. The…

This study tests a 12-week digital group program called IMAGINE to see if it can prevent depression in pregnant people and new mothers who are at higher risk. About 100 participants will either join the IMAGINE groups or receive standard care. Researchers will track depression an…

This study tests a new way to treat kidney stones using ultrasound waves to break them into tiny pieces and help them move out of the body. The procedure does not require anesthesia and aims to make passing stones easier and safer. About 140 adults with small kidney stones will t…

This study tests a brief program to help young adults (ages 18-29) who have trouble sleeping and also drink heavily or use cannabis. The program aims to reduce alcohol and marijuana use and improve sleep quality. Researchers will compare the program to a control group to see if i…

This study compares two telehealth programs for adults who have ongoing thinking problems (like memory or focus issues) after a mild traumatic brain injury or concussion. Participants will complete six sessions of either a cognitive rehabilitation program called On-TRACC or a gen…

This study tests a virtual program called Integrative Medicine at Home (IM@Home) that includes online fitness and yoga classes. The goal is to see if it helps reduce fatigue and other symptoms in breast cancer patients undergoing radiation. About 40 adults with breast cancer who …

This study compares a home-based physical activity program delivered through the ExerciseRx app to health education alone in 100 adults with non-muscle invasive bladder cancer. Participants will use a Fitbit to track steps, and the app will set personalized goals and provide moti…

This study tests whether a simple, non-invasive technique called auricular acupressure (using small pellets on the ear) can improve appetite and prevent weight loss in people with advanced stomach, esophageal, or pancreatic cancer. Researchers will enroll 66 patients to see if th…

This study tests a new mobile health program for young adults aged 18-29 who use cannabis frequently or in high amounts. Participants will either receive personalized text messages and online feedback for five weeks or get standard online information about cannabis. The goal is t…

This study tests if a procedure called radiofrequency ablation (using heat to block pain signals from nerves) can reduce disability from chronic low back pain. About 300 adults with pain lasting at least 3 months will be randomly assigned to receive one of two types of this heat …

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in 18 adults with incurable cancer. Participants receive a single dose of pharmaceutical-grade psilocybin along with guided discussions an…

This study tests three parts of cognitive behavioral therapy—relaxation training, behavioral activation, and cognitive therapy—to see which best reduces fatigue and improves daily functioning in adults with multiple sclerosis. About 112 participants with MS-related fatigue will b…

This study tests a new type of nerve block called LAM for people having skin graft surgery. The block numbs the thigh where skin is taken, but unlike standard blocks, it does not weaken the leg. Ten adults will receive the block, and researchers will map how much of the thigh bec…

This study looks at whether a personalized home exercise program, delivered through a smartphone app, can improve physical function and recovery in people with bladder or upper tract cancer who are scheduled for surgery. About 128 participants will either receive the exercise pro…

This study is redesigning a proven trauma therapy (TF-CBT) so school counselors can use it more easily. Researchers will work with 102 students and providers to make the therapy simpler and more fitting for school settings. The goal is to help more kids get effective trauma care …

This study aims to understand why some people with social anxiety or body dysmorphic disorder do not fully benefit from cognitive behavioral therapy (CBT). Researchers will use brain scans, thinking tests, and questionnaires to look for early signs that someone might not respond …

This study looks at whether a parenting program delivered over Zoom works as well as in-person home visits for families involved with child welfare. About 357 parents of babies 6-12 months old will be randomly placed into one of three groups: in-home coaching, video coaching, or …

This study is testing a special radioactive tracer called [18F]FTT that attaches to a protein (PARP1) found in some cancer cells. By using a PET scan, doctors hope to see if the tracer can show how well standard treatments (PARP inhibitors with or without immunotherapy) are worki…

This study collects blood and tumor samples from 1,500 people with prostate or bladder cancer that has come back or spread. Researchers will analyze the samples to find genetic changes and other markers that explain why some cancers stop responding to therapy. The goal is to disc…

This study tests a method called SAIA to help family planning clinics in Kenya better provide HIV counseling, testing, and prevention services. About 40 clinics will either use SAIA or continue usual care. The goal is to see if SAIA improves HIV care for women and girls, especial…

This study aims to find the best ways to keep LGBTQ+ people engaged with online mental health resources. Researchers will test different strategies with 300 participants who use the Mental Health America website. The goal is to understand what helps people stay connected to these…

This study tests a web-based app called PST-Aid that helps clinicians use problem-solving therapy for depression in community health centers. About 410 clinicians and their patients will take part. The goal is to see if the app makes it easier for clinicians to adopt and stick wi…

This study is testing a smartphone app designed to help young adults aged 16 to 30 who are having suicidal thoughts. The app tracks their feelings and risk levels in real time. Researchers want to see if the app is easy to use and helpful for both patients and their doctors. The …

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems make the drug radium-223 work better. About 48 men will take part, and the goal is to help doctors choose the best treatment in the future.

This study looks at whether giving red blood cell transfusions only when hemoglobin drops below 7 gm/dL (instead of 9 gm/dL) is safe and maintains quality of life in adults with acute leukemia or related blood cancers who have had chemotherapy or a stem cell transplant. About 50 …

This study tests whether a special PET scan can predict if a drug combination (abemaciclib plus hormone therapy) will work for people with advanced hormone receptor-positive, HER2-negative breast cancer. About 60 participants will get the treatment and have scans to see if the im…

This study is for postmenopausal women with early-stage, hormone-sensitive breast cancer. It tests whether a specific gene change (HSD3B1) affects how well the drug letrozole works before surgery. The goal is to learn why some tumors respond better than others, which could help p…

This study looks at how PET/CT scans change during chemoimmunotherapy and radiation therapy in people with stage IV non-small cell lung cancer. Researchers want to see if these scan changes can help predict how well the cancer responds to treatment. About 80 participants who have…

This study is for people with ovarian or other solid cancers who have had certain treatments like chemotherapy or PARP inhibitors. Researchers want to understand why some patients later develop blood cancers. They will look at genetic changes in the blood and track how these chan…