University Of Washington

This early-phase trial is testing whether adding the targeted drug polatuzumab vedotin (with or without another drug called glofitamab) to standard chemotherapy is safe for people with untreated, aggressive B-cell lymphoma. About 56 participants will receive the combination to se…

This phase 2 trial is testing whether combining two drugs, pirtobrutinib and mosunetuzumab, can better treat follicular lymphoma that has relapsed or is refractory. Pirtobrutinib blocks a protein that helps cancer cells grow, while mosunetuzumab helps the body's immune T cells at…

This phase 2 trial tests whether giving high levels of testosterone alongside chemotherapy (carboplatin or etoposide) or a targeted radioactive drug (LuPSMA) can shrink tumors in men with advanced prostate cancer that has stopped responding to hormone therapy. The study will enro…

This study tests a drug called 177Lu-PSMA-617, which delivers radiation directly to prostate cancer cells to damage their DNA. It is for people with prostate cancer that has spread and is no longer responding to hormone therapy. The goal is to see if this treatment can slow cance…

This study tests whether giving a chemotherapy drug (decitabine) plus a targeted therapy (ruxolitinib, fedratinib, or pacritinib) before a stem cell transplant helps people with advanced myeloproliferative neoplasms (MPN) get to transplant and have better outcomes. About 25 adult…

This study tests whether a simple text-message system can help caregivers in Kenya spot early signs of malnutrition in children exposed to HIV. About 776 caregiver-child pairs will be split into two groups: one gets weekly texts with feeding tips and reminders to measure the chil…

This study tests a health system strategy called SAIA to improve care for people with opioid use disorder as they leave jail and connect to community clinics. Researchers will work with jail and clinic staff to identify bottlenecks and improve treatment continuity. The study invo…

This phase 2 trial tests whether combining SX-682 (a drug that blocks certain immune signals) with pembrolizumab (an immunotherapy) can shrink tumors in people with advanced non-small cell lung cancer that has spread or returned. About 30 adults whose tumors have a specific PD-L1…

This early-stage trial tests whether the drug abemaciclib, combined with radiation therapy, can safely shrink high-risk retroperitoneal sarcomas before surgery. About 18 adults with a specific type of sarcoma will receive the drug and radiation, then undergo surgery. The main goa…

This phase 2 trial is testing whether adding the drug pacritinib to standard treatments (azacitidine or decitabine) can help more people with advanced myeloproliferative neoplasms (MPN) get a stem cell transplant. The study will enroll 27 adults whose MPN has progressed to a more…

This phase 2 trial is testing a type of radiation called craniospinal irradiation that avoids the hippocampus, a brain area key for memory. It is for people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. The goal is to see if …

This study tests whether disulfiram, a drug already approved for alcohol dependence, can improve vision in people with inherited retinal degeneration. The drug aims to block a harmful signaling pathway in the retina that worsens vision loss. Thirty adults with the condition will …

This study is testing whether brief behavioral therapy for insomnia, combined with alcohol and cannabis counseling, can help young adults (ages 18-29) sleep better and reduce heavy drinking and marijuana use. The researchers are recruiting 800 participants in Washington State who…

This study tests two approaches to prevent sexually transmitted infections (STIs) in cisgender men who have sex with men in Kenya. One group gets a single dose of antibiotics every few months, while another takes doxycycline after sex. The trial will track infections and antibiot…

This study tests whether adding the drug epcoritamab to standard chemotherapy (EPOCH-R) is safe and effective for people with aggressive B-cell non-Hodgkin lymphoma. About 18 participants will receive the combination as their first treatment. The goal is to see if the new combo c…

This study tests whether adding a vaccine called WOKVAC to standard chemotherapy and targeted therapy before surgery can help the immune system better attack HER2+ breast cancer. About 25 adults with early-stage breast cancer will receive the vaccine alongside their regular treat…

This study is testing whether a guided exercise program can help people who have an implantable cardioverter defibrillator (ICD) become more active and improve their overall health. About 210 adults with an ICD will take part. The program focuses on increasing daily steps and tra…

This study tests a combination of chemotherapy drugs (DA-EPOCH) plus an enzyme called asparaginase (Rylaze) in adults newly diagnosed with a fast-growing blood cancer (Philadelphia chromosome-negative ALL). The goal is to see if this mix can kill more cancer cells and achieve dee…

This study tests whether giving preterm babies (born before 32 weeks) a drug called darbepoetin plus a slow-release intravenous iron can reduce the need for blood transfusions, keep their iron levels healthy, and improve their brain development. About 120 infants will be enrolled…

This study tests a vaccine called STEMVAC in people with hormone receptor-positive, HER2-negative breast cancer that has spread. The vaccine is designed to help the immune system attack cancer cells. Participants will receive STEMVAC along with their usual hormone therapy, a targ…

This study tests whether adding milk proteins (lactoferrin and lysozyme) to the daily food of malnourished children aged 6-24 months can prevent severe diarrhea and help them recover nutritionally. Six hundred children in Kenya who were hospitalized for diarrhea will receive the …

This study tests adding venetoclax to a standard chemotherapy regimen (CLAG-M) for people with acute myeloid leukemia (AML) or related high-grade blood cancers. The goal is to find the safest dose and see if the combination improves cancer control. About 62 participants will take…

This study tests a vaccine called STEMVAC, given with chemotherapy, for people with a type of advanced breast cancer (triple-negative) that has spread. The vaccine is designed to teach the body's immune system to find and destroy cancer stem cells. About 20 adults with PD-L1 nega…

This study tests whether copper supplements can improve liver function and safety in people with cirrhosis who have low copper levels. Researchers will give 30 participants either copper or a placebo and measure changes in blood copper levels and other health markers. The goal is…

This study is for people with advanced Hodgkin lymphoma. It tests whether a blood test that measures tumor DNA can help doctors safely give fewer chemotherapy treatments. Participants will receive a combination of drugs, and the number of cycles will be personalized based on thei…

This study tests whether adding three targeted antibodies (tafasitamab, retifanlimab, and rituximab) to standard chemotherapy can safely treat people with untreated diffuse large B-cell lymphoma. About 35 adults will receive the antibody combination before and during chemo. The g…

This study tests whether a targeted drug called gemtuzumab ozogamicin can clear tiny amounts of leukemia that remain after initial treatment in adults with acute myeloid leukemia (AML). The drug works like a smart bomb, attaching to a protein on cancer cells and delivering a chem…

This study looks at whether giving a medicine called Wilate to pregnant women with von Willebrand disease can prevent severe bleeding during and after childbirth. About 110 women will receive Wilate to keep their clotting factor levels high enough during delivery. The goal is to …

This study tests whether valsartan, a drug already used for high blood pressure, can help people with pulmonary arterial hypertension (PAH). PAH causes high pressure in the lung arteries, making it hard to breathe and putting strain on the heart. Researchers will give 60 adults e…

This study tests a combination of chemotherapy drugs (DA-EPOCH) plus a targeted pill (ponatinib) for adults newly diagnosed with a fast-growing blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The goal is to see if this approach is safe…

This study looks at whether giving very preterm infants extra sodium (based on blood and urine tests) helps them gain muscle and fat better than standard milk fortification. About 150 babies born between 24 and 31 weeks will be enrolled from three hospitals. Researchers will trac…

This study tests a text-message program called Motivation Matters! to help HIV-positive women in Africa who have recently started antiretroviral therapy (ART) take their medication regularly. About 350 women will either get standard care or standard care plus personalized texts a…

This study tests whether a low dose of the drug mosunetuzumab is safe and works well for people with slow-growing B-cell lymphoma (a type of blood cancer) that has not been treated before. About 20 adults with stage II to IV follicular or marginal zone lymphoma will receive the d…

This study looks at whether a special short-stay center (less than 24 hours) can help people who have had an opioid overdose. Participants are adults in Seattle who are stable after emergency medical services arrive. The center offers monitoring, medications for opioid use disord…

This study tests a drug called loncastuximab tesirine in adults with B-cell lymphomas that have returned or not responded to prior treatment. The drug works like a smart bomb, attaching to a marker on cancer cells and delivering chemotherapy directly to them. The main goal is to …

This study tests whether giving the drug odronextamab before CAR-T cell therapy can help control aggressive large B-cell lymphomas that have returned or not responded to prior treatment. About 27 adults will receive odronextamab to slow disease progression and increase the chance…

This study is for men with prostate cancer that has returned after surgery and radiation, but only shows up in a few places on a special PET scan. The goal is to treat those specific spots with targeted therapy, which may help control the cancer and delay the need for long-term h…

This study tests whether tinidazole, a drug already approved for other infections, can cure Mycoplasma genitalium in men with urethritis. About 40 men will take the medication and be checked 21 days later to see if the bacteria are gone. The goal is to find a new treatment option…

This study tests a youth-led approach to help young people with HIV in Kenya move smoothly from teen to adult clinics. About 1,920 youth and their healthcare providers will take part. The goal is to see if this strategy improves clinic attendance, viral suppression, and overall h…

This study tests whether a non-invasive spinal cord stimulation combined with arm cycling can improve blood pressure and heart rate control in people with chronic spinal cord injury at or above T6. Sixteen adults will receive either real or sham stimulation during exercise over 8…

This study tests a new technique called Burst Wave Lithotripsy (BWL) that uses bursts of low-amplitude ultrasound to break kidney stones into tiny pieces during a standard surgical procedure. About 40 adults scheduled for stone removal will receive BWL to see if it is safe and ef…

This study looks at whether grafts modified by doctors can safely treat complex aortic aneurysms near the kidneys. It includes 500 patients who have few or no other treatment options. The approach uses custom-made devices and 3D-printed models to plan the surgery.

This study tests whether offering HIV self-testing and PrEP (medication to prevent HIV) at home during routine TB contact checks increases prevention uptake compared to standard clinic referrals. About 2,480 people in Uganda who live with someone being treated for TB will take pa…

This study tests a program called Our Value, which uses community health workers in small grocery stores to encourage fruit and vegetable intake among rural Latino adults. About 400 participants who shop at these stores will be compared to those at other stores to see if they eat…

This study tests whether chewing xylitol-containing gum during pregnancy can reduce the risk of preterm birth and low birthweight. Researchers will enroll 6,000 pregnant women in Malawi, giving them either a high-dose xylitol gum, a low-dose xylitol gum, or a placebo gum. The goa…

This study tests a new way to offer HIV prevention pills (PrEP) to people visiting family planning clinics in Kenya. Instead of requiring a separate appointment, HIV counselors will provide PrEP screening and prescriptions right at the family planning visit. The goal is to see if…

This study tests whether safety planning and a type of talk therapy can reduce suicidal thoughts and actions in 2,100 secondary school students in Mozambique. Participants will be randomly assigned to receive one or both approaches, and researchers will track their progress over …

This study aims to redesign Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) so it works better in schools. Researchers will work with school counselors and students aged 7-19 to make the therapy easier to use and more engaging. The goal is to help more young people get effec…

This study tests whether an intensive support program helps stroke patients with obstructive sleep apnea use their CPAP machine more regularly during inpatient rehabilitation. About 250 participants will be randomly assigned to either the intensive support group or standard care.…

This study tests whether a structured cognitive rehabilitation program (On-TRACC) helps adults with lasting memory, attention, and thinking problems after a mild traumatic brain injury or concussion. Participants will receive six telehealth sessions of either On-TRACC or a genera…

This study tests a new type of nerve block called LAM for people having skin graft surgery. The block numbs the thigh where skin is taken, but unlike standard blocks, it does not weaken the leg. Ten adults will join to see how well and how consistently the block works.

This study tests an 8-week exercise program for people with HIV who are at risk for heart failure. The program combines one weekly supervised session at a center with two home workouts, plus education and coaching. Researchers want to see if this hybrid approach helps participant…

This study compares a home-based physical activity program delivered through the ExerciseRx app to health education alone in 100 adults with non-muscle invasive bladder cancer. Participants will use a Fitbit to track steps, and the app will set personalized goals and provide enco…

This study tests a stepped care approach that uses complementary health treatments (like acupuncture or yoga) for people with both chronic pain and PTSD. About 60 adults from two primary care clinics will either receive this stepped care or their usual treatment. Researchers want…

This study tests a new way to treat kidney stones using only ultrasound waves to break them into tiny pieces and help them pass naturally. About 140 adults with small to medium stones will get this painless, anesthesia-free treatment. The goal is to see if it is safe and effectiv…

This study tests whether a procedure called radiofrequency ablation (using heat to quiet pain nerves) can reduce chronic low back pain better than a fake procedure. About 300 adults with long-term back pain will be randomly assigned to one of two real ablation methods or a simula…

This study tests a new prosthetic socket that automatically adjusts to daily changes in limb size for people with below-knee amputations. The goal is to improve comfort, prevent skin problems, and reduce the need for manual adjustments. About 100 adults who have used a prosthesis…

This study tests a smartphone app designed to help teenagers and young adults who have suicidal thoughts. The app lets teens and their doctors create a personalized safety plan and includes videos to teach coping skills and improve communication with parents. Researchers want to …

This study tests whether a mobile app called ExerciseRx can help people with axial spondyloarthritis (a type of arthritis affecting the spine) exercise more easily. Forty adults who are not very active will either use the app for guided exercises and step goals or receive standar…

This study looks at whether doing simple exercises at home before bladder or upper tract cancer surgery can help patients feel stronger and recover faster. About 128 adults scheduled for surgery will either receive a personalized home exercise plan via a smartphone app or standar…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with incurable cancer. Participants will receive a pharmaceutical-grade psilocybin along with guided discussions to help them ga…

This study tests whether a smartphone app can help people with schizophrenia in Ghana feel better. Researchers will compare usual care to two app-based programs. The goal is to see if the apps reduce symptoms like depression, anxiety, and paranoia.

This study tests three parts of cognitive behavioral therapy—relaxation training, behavioral activation, and cognitive therapy—to see which best reduces fatigue and improves daily functioning in adults with multiple sclerosis. About 112 participants with MS-related fatigue will b…

This early study tests a brain stimulation device in 4 people who had an ischemic stroke at least 6 months ago and still have arm weakness. The goal is to see if the treatment is safe and can help rewire the brain to improve arm movement. Participants will have weekly therapy ses…

This study tests a 1-month online self-management program for people who recently received a shock from their implantable defibrillator (ICD). The program teaches heart rate monitoring and coping skills to reduce anxiety and prevent PTSD. 60 participants will be randomly assigned…

This study tests whether adding a short course of the steroid dexamethasone to standard supportive care helps more people recover from an adhesive small bowel obstruction without needing surgery. About 550 adults with this condition will be randomly assigned to receive either dex…

This study follows 500 mother-child pairs where the mother has a severe hemophilia A gene. Researchers want to learn why some mothers have heavy bleeding after childbirth and why some children develop antibodies to factor VIII treatment. By observing families over time, the study…

This study tests an online program called eBASIS designed to help school mental health providers feel more confident and motivated to use evidence-based practices. Researchers will compare providers who use eBASIS to those who don't, measuring changes in their attitudes and skill…

This study looks at how early-life stress affects a baby's cells and whether a parenting program can help. Researchers will give 250 low-income mothers either a 10-week home visiting program (PFR-PC) or usual care. They will measure stress, parenting sensitivity, and markers of c…

This study follows 2,000 people with ovarian or other solid cancers to understand why some later develop blood cancers. Researchers will look for genetic changes and other risk factors. The goal is to better predict and prevent these secondary cancers.

This study looks at whether stopping vaginal washing can lower inflammation in the cervix, which might help explain why this practice is linked to a higher risk of HIV. Researchers will measure immune cells and protective bacteria in 122 women who currently wash inside the vagina…

This study aims to find better ways to help teachers use proven behavioral skills interventions for autistic children in elementary schools. Researchers will work with 160 participants, including teachers and autistic students, to redesign and test a support strategy. The goal is…

This study looks at how mindfulness meditation and self-hypnosis work in the brains of adults aged 60 and older who have had chronic pain for at least 3 months. Participants will be randomly assigned to mindfulness, hypnosis, or story listening, and will undergo brain scans and E…

This study aims to understand why some people with social anxiety or body dysmorphic disorder respond fully to cognitive behavioral therapy while others do not. Researchers will use brain scans, thinking tests, and questionnaires to look for early signs of non-response. The study…

This study looks at how PET/CT scans change during chemoimmunotherapy and radiation for stage IV non-small cell lung cancer. Researchers want to see if these scans can help predict how well the cancer responds to treatment. About 80 adults with advanced lung cancer who haven't ha…

This study looks for better ways to find aggressive prostate cancer early in people who have a genetic risk. Researchers will collect blood, urine, and tissue samples from 450 participants to learn more about the genetics of this disease. The goal is to improve future screening a…

This study collects tissue and blood samples from 1,500 people with prostate or bladder cancer that has come back or spread. Researchers will analyze the samples to find genetic changes and other markers that may explain why some cancers stop responding to treatment. The goal is …

This study tests whether a web-based app called PST-Aid helps clinicians better deliver problem-solving therapy to people with depression in community health centers. About 410 clinicians and their patients will take part. The goal is to see if the app improves how often therapy …

This study looks at the genes of 100 people with retinoblastoma, a rare eye cancer, to learn how changes in the RB1 gene cause the disease and related cancers. Participants give a blood or saliva sample for genetic testing. The goal is to better understand the link between a pers…

This study looks at whether parenting support given over video calls works as well as in-home visits for families involved with child welfare. About 357 parents of babies 6-12 months old will be placed into one of three groups: in-home coaching, video coaching, or a control group…

This study looks at how children with cerebral palsy (CP) adapt their walking when given feedback from a treadmill, sensors, and a wearable exoskeleton. Researchers want to understand how kids learn new movement patterns and whether training or surgery can improve their walking. …

This study follows 3,000 men with early-stage prostate cancer who have chosen active surveillance (close monitoring instead of immediate treatment). The goal is to discover biological markers that can tell apart aggressive cancers from slow-growing ones. Researchers hope this wil…

This study tests whether a special type of PET scan (FFNP-PET/CT) can predict how well a drug combination (abemaciclib plus hormone therapy) works in people with advanced hormone receptor-positive, HER2-negative breast cancer. About 60 participants with metastatic or locally adva…

This study is testing a new radioactive tracer called [18F]FTT to see if it can help doctors see how well standard treatments are working in people with metastatic breast cancer. The tracer attaches to a protein in cancer cells and shows up on a PET scan. About 22 participants wi…

This study is testing a smartphone app designed to help young adults aged 16 to 30 who are having suicidal thoughts. The app asks users to answer quick questions about their feelings and risks throughout the day. The goal is to see if the app is easy to use and helpful for both p…

This study aims to find the best ways to encourage LGBTQ+ people to use and stay engaged with free online mental health resources. Researchers will follow 2,300 participants who use the Mental Health America website and test different engagement strategies. The goal is to underst…

This study looks at whether giving blood transfusions only when hemoglobin drops below 7 gm/dL (instead of 9 gm/dL) is safe and keeps quality of life similar in leukemia patients. About 50 adults with acute leukemia or related cancers who had chemotherapy or a stem cell transplan…

This study looks at how sleep helps clean the brain. Researchers will use special MRI scans to see the brain's waste-clearing system in 16 healthy young adults. They will also test a headband that tracks brain waves and uses mild electrical pulses to improve sleep and brain funct…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, treatment, and prevention services. About 40 clinics will either use SAIA or continue their usual routines. The goal is to see if this approach increases the number of women a…

This study looks at why people's gums respond differently to the buildup of dental plaque. Researchers will monitor 80 healthy adults aged 18-35 as they stop brushing for a period to allow plaque to grow naturally. The goal is to identify the biological reasons behind varying lev…

This study tests whether a two-way text messaging system can help reduce newborn deaths in rural Kenya. About 3,000 pregnant women will use SMS to communicate with community health volunteers. The goal is to see if this digital connection improves newborn survival and care practi…

This study looks at two common treatments for a type of bladder cancer that keeps coming back: treatments that keep the bladder (like medicine placed directly into the bladder) versus surgery to remove the bladder. The goal is to see which option is better for patients' wallets, …

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems in the cancer cells make the drug radium-223 work better or worse. The goal is to help doctors choose the best treatment for each patient in …

This study tests a short suicide prevention program for teens (ages 10-18) who have low to moderate suicide risk. The program is delivered in pediatric primary care clinics to make it easier for teens to get help. Researchers will check if doctors and families find the program us…