University Of Washington

This phase 2 trial tests whether adding a gene therapy called nadofaragene firadenovec to standard chemotherapy and immunotherapy can improve outcomes for people with muscle invasive bladder cancer before they have their bladder removed. The gene therapy is placed directly into t…

This study tests whether adding extra ultrafiltration (a gentle fluid-removal procedure) for 4 or 8 weeks can safely reduce excess fluid in people on hemodialysis. The goal is to lower high blood pressure and relieve symptoms like congestion. About 120 adults with end-stage kidne…

This early-stage trial tests a drug called samuraciclib in 15 people with localized pancreatic cancer that can be surgically removed. Participants will take the drug for about two weeks before their planned surgery. Researchers will check safety and look for changes in tumor cell…

This study tests a new approach to help young adults reduce harmful drinking. Participants can customize which peer groups they compare their drinking to, making the feedback more personal. The trial will enroll 250 University of Washington students who drink regularly and will m…

This study tests a new two-drug combination for people with advanced non-small cell lung cancer that has worsened after standard treatments like chemotherapy and immunotherapy. The drugs, SX-682 and atezolizumab, work together to help the immune system attack cancer cells. About …

This study is for people with advanced bladder cancer that has shrunk after initial treatment with two drugs (enfortumab vedotin and pembrolizumab). The goal is to see if adding focused radiation or surgery to remove any remaining cancer can safely get rid of the disease and allo…

This study tests a vaccine that helps the immune system attack ovarian cancer cells. It is for people whose cancer has returned based on a blood test but is not yet visible on scans. Participants receive one dose of chemotherapy followed by the vaccine. The goal is to see if this…

This study tests a simpler way to give TB preventive therapy to household contacts of TB patients and people living with HIV. Instead of monthly clinic visits, some participants get the full course of pills at once in their community. Researchers want to see if this approach help…

This study tests if a family-based weight management program can delay the start of puberty in overweight girls aged 6.5 to 8. About 240 girls from low-income households will either join the program or receive usual care. Researchers will track puberty signs over 3 years to see i…

This study will test whether offering HIV prevention medication, routine STI testing, and a preventive antibiotic at retail pharmacies helps young women avoid infections. About 720 women aged 15 to 24 who visit pharmacies for birth control will take part. Researchers will check h…

This study is developing and testing a brief online program for young adult couples (ages 18-29) who use both alcohol and cannabis. The program aims to reduce risky substance use and improve relationship skills. Sixty couples in Washington State will be randomly assigned to eithe…

This study tests whether a tailored online support group (VOCALE LBD) can reduce depression in family caregivers of people with Lewy body dementia (LBD). LBD caregivers often face high stress and depression rates. The 8-week program brings small groups together online to discuss …

This study tests whether adding estrogen to standard prostate cancer treatment can improve quality of life for 60 men with metastatic hormone-sensitive prostate cancer. Standard therapy often causes hot flashes and other side effects by lowering estrogen. The study compares estro…

This study tests two sleep medications, doxepin and ramelteon, to see if they can improve sleep quality in people recovering from knee replacement surgery. Poor sleep is common after this surgery and can slow healing. The trial will enroll 129 adults aged 18-80 and compare the dr…

This study tests whether an internet-based program called My MS Toolkit can help reduce depression in adults with multiple sclerosis. About 110 participants will either use the toolkit or receive usual care. The goal is to see if the program is easy to use and truly helps improve…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely help healthcare clinicians who feel depressed and have lost meaning in their work. Seventy-two doctors, nurses, and physician assistants will take part in small groups,…

This study tests a home-based exercise program called CAREFit-BMT for people with high-risk acute myeloid leukemia (AML) who are about to have a stem cell transplant. The program includes aerobic and strength exercises to improve heart function and reduce complications. Researche…

This study tests whether a lead exposure prevention program originally designed for the US can work in Nairobi, Kenya. About 500 caregivers of children aged 1-6 will either get lead risk information only at a clinic or also receive a home visit with tailored advice. Researchers w…

This study tests a new, non-invasive device that attaches to the outside of a prosthetic leg socket to measure how well it fits. Poor socket fit can cause pain, skin problems, and limit mobility. The device uses air cylinders and a computer game-like test to track movement. Resea…

This study will enroll 80 adults with multiple sclerosis and chronic pain to take part in an 8-week online Mindfulness-Based Cognitive Therapy (MBCT) program. Researchers want to understand what emotional, physical, and environmental factors make it easier or harder to practice m…

This study looks at how feeling stressed and being with a friend influence people's decisions to drink alcohol. Researchers will have 160 regular drinkers choose between alcoholic and non-alcoholic drinks in different situations. The goal is to understand what drives drinking cho…

This study tests whether a package of coaching, feedback, and mentorship can help hospital teams in Kenya better review and respond to maternal and newborn deaths. Twenty facilities will take part, with half receiving the extra support. Researchers will measure if the approach im…

This study is developing and testing a program called Cannabis Conversation Skills for Families (CCSF) that teaches family members how to talk to their young adult loved one who has psychosis and uses cannabis. The goal is to improve communication, reduce caregiver stress, and ev…

This study tests a mobile app called ALRITE that helps health workers in Uganda diagnose and manage breathing illnesses like pneumonia and asthma in young children. About 48 healthcare workers at 4 health centers will use the app for 6 months, and researchers will compare how oft…

This study looks at the best ways to screen young children (16-24 months old) who were exposed to HIV for possible delays in brain development. Researchers will compare two screening methods used by healthcare workers during regular clinic visits in Botswana and Kenya. They want …

This study looks at how genetics and what we eat might cause brain inflammation that leads to obesity. Researchers will study 110 identical twins who eat differently to see if their brains show signs of inflammation. The goal is to understand why some people gain weight more easi…

This study will test a program that helps mothers provide nurturing care—like healthy feeding, play, and problem-solving—for their babies from birth to age 2 in Botswana, Kenya, and Zimbabwe. About 1,260 pregnant women, both with and without HIV, will take part. The goal is to se…

This study looks at whether adding a brief online personalized feedback program to standard screening and counseling can reduce impaired driving in young adults aged 18-30. About 600 participants in Washington State who recently received standard screening will be randomly assign…