University Of Washington

This study tests a vaccine called STEMVAC, designed to train the immune system to attack breast cancer stem cells. It is given alongside chemotherapy to 20 adults with metastatic triple-negative breast cancer that does not respond to PD-L1 drugs. The goal is to see if the vaccine…

This study tests whether adding an experimental drug (SX-682) to a standard immunotherapy (pembrolizumab) helps shrink or control advanced non-small cell lung cancer. About 30 adults with stage IIIC or IV lung cancer that hasn't been treated yet will receive both drugs. The goal …

This study tests two ways to prevent sexually transmitted infections (STIs) like gonorrhea, chlamydia, and syphilis in cisgender men who have sex with men in Kenya. About 2,900 participants will either take antibiotics regularly (WHO-recommended periodic treatment) or take doxycy…

This study tests a drug called 177Lu-PSMA-617 for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The drug delivers radiation directly to cancer cells to damage their DNA. The trial aims to see if it can delay cancer progression and wi…

This study tests whether copper supplements can improve liver function and safety in people with cirrhosis who have low copper levels. Researchers will give 30 participants either copper or a placebo and measure changes in blood copper levels and other health markers. The goal is…

This early-stage trial tests whether combining the drug abemaciclib with radiation therapy before surgery can shrink high-risk fatty tumors in the abdomen. About 18 adults with a specific type of sarcoma will receive the treatment to find the safest dose and check for side effect…

This study is for people with advanced Hodgkin lymphoma. It tests whether a blood test that measures tumor DNA can help doctors safely give fewer chemotherapy treatments. Participants will receive a combination of drugs, and the number of cycles will be personalized based on thei…

This study tests whether adding a cancer vaccine (WOKVAC) to standard chemotherapy and HER2-targeted therapy before surgery can help the immune system better attack breast cancer. About 25 adults with early-stage HER2-positive breast cancer will receive the vaccine alongside thei…

This study tests whether adding three targeted antibodies (tafasitamab, retifanlimab, and rituximab) to standard chemotherapy can safely treat people with untreated diffuse large B-cell lymphoma. About 35 adults will receive the antibody combination before and during chemo. The g…

This study tests two drugs, pirtobrutinib and mosunetuzumab, together in 22 adults with a type of slow-growing lymphoma (grades 1-3a) that came back or didn't respond to at least two prior treatments. Pirtobrutinib blocks a protein that helps cancer grow, while mosunetuzumab help…

This study tests a health systems strategy to help people with opioid use disorder stay in treatment after leaving jail. Researchers will work with clinics and jails to improve care coordination and follow-up. About 4,186 adults on medication for opioid use disorder while incarce…

This study tests whether a targeted drug called gemtuzumab ozogamicin can clear tiny amounts of leukemia that remain after initial treatment in adults with acute myeloid leukemia (AML). The drug works like a smart bomb, attaching to a protein on cancer cells and delivering a chem…

This study tests whether a simple text-message system can help caregivers in Kenya spot early signs of malnutrition in children exposed to HIV. About 600 caregiver-child pairs will be split into two groups: one gets weekly texts with feeding tips and reminders to measure the chil…

This study looks at whether giving a medicine called Wilate to pregnant women with von Willebrand disease can prevent severe bleeding during and after childbirth. About 110 women will receive Wilate to keep their clotting factor levels high enough during delivery. The goal is to …

This study tests a precise radiation method that treats the entire brain and spinal cord while avoiding the memory center (hippocampus). It is for adults with breast or lung cancer that has spread to the fluid and tissues around the brain and spinal cord. The goal is to see if th…

This study tests an 8-week exercise program for people with HIV who are at risk for heart failure. The program combines weekly supervised workouts at a center with two home-based sessions, plus education and coaching. Researchers want to see if it helps participants become more a…

This study tests whether valsartan, a drug already used for high blood pressure, can help people with pulmonary arterial hypertension (PAH). PAH causes high pressure in the lung arteries, making it hard to breathe and putting strain on the heart. Researchers will give 60 adults e…

This study tests a combination of chemotherapy drugs (DA-EPOCH) plus a targeted pill (ponatinib) for adults newly diagnosed with a fast-growing blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The goal is to see if this approach is safe…

This study looks at whether giving very preterm infants extra sodium (based on blood and urine tests) helps them gain muscle and fat better than standard milk fortification. About 150 babies born between 24 and 31 weeks will be enrolled from three hospitals. Researchers will trac…

This study tests whether giving high levels of testosterone (much higher than normal) can make chemotherapy or a targeted radiation drug work better in men with advanced prostate cancer that has stopped responding to standard hormone therapy. About 69 men will receive testosteron…

This study tests whether adding milk proteins (lactoferrin and lysozyme) to the diet of malnourished children aged 6-24 months can prevent repeat severe diarrhea and help them regain healthy weight. The children, who were recently hospitalized for diarrhea, will receive daily sup…

This study tests a text-message program called Motivation Matters! to help HIV-positive women in Africa who have recently started antiretroviral therapy (ART) take their medication regularly. About 350 women will either get standard care or standard care plus personalized texts a…

This study tests whether a low dose of the drug mosunetuzumab is safe and works well for people with slow-growing B-cell lymphoma (a type of blood cancer) that has not been treated before. About 20 adults with stage II to IV follicular or marginal zone lymphoma will receive the d…

This study tests whether adding the drug epcoritamab to standard chemotherapy (EPOCH-R) is safe and effective for people with aggressive B-cell non-Hodgkin lymphoma. About 18 participants will receive the combination as their first treatment. The goal is to see if the new mix can…

This study tests whether adding pacritinib to standard chemotherapy drugs (azacitidine or decitabine) can help more people with advanced myeloproliferative neoplasms (MPN) become eligible for a stem cell transplant. The trial enrolls 27 adults whose cancer has progressed to an ac…

This study looks at whether a special short-stay center (less than 24 hours) can help people who have had an opioid overdose. Participants are adults in Seattle who are stable after emergency medical services arrive. The center offers monitoring, medications for opioid use disord…

This study tests a vaccine called STEMVAC combined with standard hormone therapy or chemotherapy for people with hormone receptor-positive, HER2-negative breast cancer that has spread. The vaccine is designed to train the immune system to attack cancer cells. The trial will check…

This study tests whether giving premature babies (born before 32 weeks) a combination of darbepoetin and slow-release intravenous iron can reduce the need for blood transfusions, maintain healthy iron levels, and improve brain development. About 120 infants will receive either th…

This study tests a drug called loncastuximab tesirine in adults with B-cell lymphomas that have returned or not responded to prior treatment. The drug works like a smart bomb, attaching to a marker on cancer cells and delivering chemotherapy directly to them. The main goal is to …

This study tests whether a guided exercise program helps people who have an implantable cardioverter defibrillator (ICD) become more active and improve their overall health. About 210 adults with an ICD will take part. The program focuses on increasing daily steps and tracking qu…

This study tests whether disulfiram, a drug already approved for alcohol abuse, can improve vision in people with inherited retinal degeneration. The drug aims to block a harmful chemical signal in the eye that may worsen vision loss. About 30 adults with mild to moderate vision …

This study tests whether giving the drug odronextamab before CAR-T cell therapy can help control aggressive large B-cell lymphomas that have returned or not responded to prior treatment. About 27 adults will receive odronextamab to slow disease progression and increase the chance…

This study tests whether giving a chemotherapy drug (decitabine) with a targeted therapy (ruxolitinib, fedratinib, or pacritinib) before a stem cell transplant helps people with advanced myeloproliferative neoplasms (MPNs). The goal is to reduce cancer cells enough to make the tr…

This study is for men with prostate cancer that has returned after surgery and radiation, but only shows up in a few places on a special PET scan. The goal is to treat those specific spots with targeted therapy, which may help control the cancer and delay the need for long-term h…

This study tests whether tinidazole, a drug already approved for other infections, can cure Mycoplasma genitalium in men with urethritis. About 40 men will take the medication and be checked 21 days later to see if the bacteria are gone. The goal is to find a new treatment option…

This study tests a chemotherapy cocktail (DA-EPOCH) plus a drug called Rylaze in adults newly diagnosed with Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL). The goal is to see if this combination can kill more cancer cells and achieve deep remission. About 30…

This study tests a youth-led approach to help young people with HIV in Kenya move smoothly from teen to adult clinics. About 1,920 youth and their healthcare providers will take part. The goal is to see if this strategy improves clinic attendance, viral suppression, and overall h…

This early-phase study tests whether adding the targeted drug polatuzumab vedotin (with or without glofitamab) to standard chemotherapy is safe for people with untreated, aggressive B-cell lymphoma. About 56 participants will receive the combination to see how well they tolerate …

This study tests whether a non-invasive spinal cord stimulation combined with arm cycling can improve blood pressure and heart rate control in people with chronic spinal cord injury at or above T6. Sixteen adults will receive either real or sham stimulation during exercise over 8…

This study tests a new technique called Burst Wave Lithotripsy (BWL) that uses bursts of low-amplitude ultrasound to break kidney stones into tiny pieces during a standard surgical procedure. About 40 adults scheduled for stone removal will receive BWL to see if it is safe and ef…

This study tests adding venetoclax to a standard chemotherapy regimen (CLAG-M) for people with acute myeloid leukemia (AML) or related high-grade blood cancers. The goal is to find the safest dose and see if the combination improves how long patients stay cancer-free. About 62 ad…

This study looks at whether grafts modified by doctors can safely treat complex aortic aneurysms near the kidneys. It includes 500 patients who have few or no other treatment options. The approach uses custom-made devices and 3D-printed models to plan the surgery.

This study tests whether chewing xylitol-containing gum during pregnancy can reduce the risk of preterm birth and low birthweight. Researchers will enroll 6,000 pregnant women in Malawi, giving them either a high-dose xylitol gum, a low-dose xylitol gum, or a placebo gum. The goa…

This study tests a new way to offer HIV prevention pills (PrEP) to people visiting family planning clinics in Kenya. Instead of requiring a separate appointment, HIV counselors will provide PrEP screening and prescriptions right at the family planning visit. The goal is to see if…

This study tests whether offering HIV self-testing and PrEP (HIV prevention pills) at home during routine TB household visits can increase prevention uptake compared to standard clinic referrals. About 2,480 people in Uganda who live with someone being treated for TB will take pa…

This study tests a program called Our Value that helps people in rural areas eat more fruits and vegetables. It works with small grocery stores and community health workers. About 400 Latino adults who shop at these stores will take part. The goal is to see if the program increas…

This study tests whether safety planning and a type of talk therapy can reduce suicidal thoughts and actions in 2,100 secondary school students in Mozambique. Participants will be randomly assigned to receive one or both approaches, and researchers will track their progress over …

This study tests whether a procedure called radiofrequency ablation (using heat to quiet pain nerves) can reduce chronic low back pain better than a fake procedure. About 300 adults with long-term back pain will be randomly assigned to one of two real ablation methods or a simula…

This study tests a new prosthetic socket that automatically adjusts to daily changes in limb size for people with below-knee amputations. The goal is to improve comfort, prevent skin problems, and reduce the need for manual adjustments. About 100 adults who have used a prosthesis…

This study tests a smartphone app designed to help teenagers and young adults who have suicidal thoughts. The app lets teens and their doctors create a personalized safety plan and includes videos to teach coping skills and improve communication with parents. Researchers want to …

This study tests whether a mobile app called ExerciseRx can help people with axial spondyloarthritis (a type of arthritis affecting the spine) exercise more easily. Forty adults who are not very active will either use the app for guided exercises and step goals or receive standar…

This study compares a home-based physical activity program delivered through the ExerciseRx app against standard health education in 100 adults with early-stage bladder cancer. Participants will use a Fitbit to track steps, and the app will set personalized goals and provide moti…

This study compares two programs for adults who have ongoing cognitive issues (like memory or attention problems) for at least 3 months after a mild traumatic brain injury or concussion. Participants will complete 6 telehealth sessions of either a cognitive rehab program called O…

This study tests a new type of nerve block called LAM for people having skin grafts taken from their thigh. The goal is to reduce pain at the donor site without weakening the leg, which can happen with standard blocks. Ten adults will receive the block, and researchers will map h…

This study looks at whether doing simple exercises at home before bladder or upper tract cancer surgery can help patients feel stronger and recover faster. About 128 adults scheduled for surgery will either receive a personalized home exercise plan via a smartphone app or standar…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with incurable cancer. Participants will receive a pharmaceutical-grade psilocybin along with guided discussions to help them ga…

This study tests whether a smartphone app can help people with schizophrenia in Ghana feel better. Researchers will compare usual care to two app-based programs. The goal is to see if the apps reduce symptoms like depression, anxiety, and paranoia.

This study tests three parts of cognitive behavioral therapy—relaxation training, behavioral activation, and cognitive therapy—to see which best reduces fatigue and improves daily functioning in adults with multiple sclerosis. About 112 participants with MS-related fatigue will b…

This study is redesigning a proven therapy for youth trauma so it works better in schools. Researchers will work with school counselors and students aged 7-19 to make the therapy simpler and more fitting for the school setting. The goal is to help more kids get effective trauma c…

This early study tests a brain stimulation device in 4 people who had an ischemic stroke at least 6 months ago and still have arm weakness. The goal is to see if the treatment is safe and can help rewire the brain to improve arm movement. Participants will have weekly therapy ses…

This study tests a short program to help young adults ages 18-29 who have trouble sleeping and also drink heavily or use marijuana. The program gives tips to cut back on alcohol and cannabis and improve sleep. Researchers will track changes in sleep quality and substance use over…

This study tests whether an intensive support program helps stroke patients with sleep apnea use their CPAP machine more consistently. About 250 participants will be randomly assigned to either the intensive support or usual care. The goal is to see if better CPAP use improves sl…

This study tests a 1-month online self-management program for people who recently received a shock from their implantable defibrillator (ICD). The program teaches heart rate monitoring and coping skills to reduce anxiety and prevent PTSD. 60 participants will be randomly assigned…

This study tests whether a stepped care approach using complementary and integrative health (CIH) methods can help people with both chronic pain and PTSD. About 60 adults from two primary care clinics will either receive the stepped care or usual treatment. Researchers will check…

This study tests a new way to treat kidney stones using ultrasound waves to break them into tiny pieces and reposition them, all without anesthesia. About 140 adults with small kidney stones (2-7 mm) will take part. The goal is to help stones pass naturally and safely, reducing t…

This study tests whether adding a short course of the steroid dexamethasone to standard supportive care helps more people recover from an adhesive small bowel obstruction without needing surgery. About 550 adults with this condition will be randomly assigned to receive either dex…

This study aims to improve how schools support autistic children by redesigning the way teachers are trained and supported to use behavioral skills interventions. Researchers will work with 160 participants, including elementary school staff and autistic students, to test a new i…

This study looks at whether parenting support given over video calls works as well as in-home visits for families involved with child welfare. About 357 parents of babies 6-12 months old will be placed into one of three groups: in-home coaching, video coaching, or a control group…

This study looks at how children with cerebral palsy (CP) adapt their walking when given feedback from a treadmill, sensors, and a wearable exoskeleton. Researchers want to understand how kids learn new movement patterns and whether training or surgery can improve their walking. …

This study aims to understand why some people with social anxiety or body dysmorphic disorder don't fully benefit from cognitive behavioral therapy (CBT). Researchers will use brain scans, thinking tests, and questionnaires to look for early signs that someone might not respond w…

This study follows 3,000 men with early-stage prostate cancer who have chosen active surveillance (close monitoring instead of immediate treatment). The goal is to discover biological markers that can tell apart aggressive cancers from slow-growing ones. Researchers hope this wil…

This study tests whether a special type of PET scan (FFNP-PET/CT) can predict how well a drug combination (abemaciclib plus hormone therapy) works in people with advanced hormone receptor-positive, HER2-negative breast cancer. About 60 participants with metastatic or locally adva…

This study is testing a new radioactive tracer called [18F]FTT to see if it can help doctors see how well standard treatments are working in people with metastatic breast cancer. The tracer attaches to a protein in cancer cells and shows up on a PET scan. About 22 participants wi…

This study looks at how early-life stress may affect a baby's cells and long-term health. Researchers will test a 10-week parenting program to see if it reduces stress in mothers and improves their sensitivity to their baby. About 250 mothers and their infants will take part, wit…

This study is testing a smartphone app designed to help young adults aged 16 to 30 who are having suicidal thoughts. The app asks users to answer quick questions about their feelings and risks throughout the day. The goal is to see if the app is easy to use and helpful for both p…

This study aims to find the best ways to encourage LGBTQ+ people to use and stay engaged with free online mental health resources. Researchers will follow 2,300 participants who use the Mental Health America website and test different engagement strategies. The goal is to underst…

This study looks at the genes of people with retinoblastoma, a rare eye cancer, to learn how changes in the RB1 gene cause the disease. Researchers will collect saliva or blood samples from 100 participants to map their DNA and understand why some cancers spread. The goal is to g…

This study looks at whether giving blood transfusions only when hemoglobin drops below 7 gm/dL (instead of 9 gm/dL) is safe and keeps quality of life similar in leukemia patients. About 50 adults with acute leukemia or related cancers who had chemotherapy or a stem cell transplan…

This study looks at how sleep helps clean the brain. Researchers will use special MRI scans to see the brain's waste-clearing system in 16 healthy young adults. They will also test a headband that tracks brain waves and uses mild electrical pulses to improve sleep and brain funct…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, treatment, and prevention services. About 40 clinics will either use SAIA or continue their usual routines. The goal is to see if this approach increases the number of women a…

This study tests a digital program called eBASIS designed to help school mental health providers better use evidence-based therapies. Researchers will compare providers using eBASIS to those using a standard digital control, measuring how well they stick to the therapy and how th…

This study looks at how PET/CT scans change during chemoimmunotherapy and radiation for stage IV non-small cell lung cancer. Researchers want to see if these scans can help predict how well the cancer responds to treatment. About 80 adults with advanced lung cancer who haven't ha…

This study looks at how to find aggressive prostate cancer earlier in people who have a higher genetic risk. Researchers will collect blood, urine, and tissue samples from 450 participants to learn more about the genetics of this cancer. The goal is to improve future screening an…

This study looks at why people's gums respond differently to the buildup of dental plaque. Researchers will monitor 80 healthy adults aged 18-35 as they stop brushing for a period to allow plaque to grow naturally. The goal is to identify the biological reasons behind varying lev…

This study follows pregnant women with a severe hemophilia A gene and their babies after birth. The goal is to learn why some mothers have heavy bleeding after delivery and why some children develop antibodies that block treatment. No new treatments are tested—just careful observ…

This study looks at how two mind-based treatments—mindfulness meditation and self-hypnosis—work in the brains of adults aged 60 and older who have had chronic pain for at least 3 months. Participants will be randomly assigned to one of three groups: mindfulness, hypnosis, or stor…

This study tests whether a two-way text messaging system can help reduce newborn deaths in rural Kenya. About 3,000 pregnant women will use SMS to communicate with community health volunteers. The goal is to see if this digital connection improves newborn survival and care practi…

This study is for people who have had ovarian or other solid cancers. It aims to understand why some survivors later develop blood cancers. Researchers will look at genetic changes and treatment history to find risk factors. The goal is to improve monitoring and prevention for fu…

This study looks at whether stopping vaginal washing can lower inflammation in the cervix, which may reduce the risk of getting HIV. Researchers will compare women who stop washing to those who continue, measuring immune cells and protective bacteria. The goal is to understand if…

This study looks at two common treatments for a type of bladder cancer that keeps coming back: treatments that keep the bladder (like medicine placed directly into the bladder) versus surgery to remove the bladder. The goal is to see which option is better for patients' wallets, …

This study collects tissue and blood samples from 1,500 people with prostate or bladder cancer that has returned or spread. Researchers will analyze the samples to find genetic changes and other markers that explain why some cancers stop responding to therapy. The goal is to disc…

This study looks at whether a web-based app can help therapists in community health centers better use a proven therapy for depression called Problem-Solving Treatment. About 410 clinicians and their patients will take part. The goal is to see if the app makes it easier for thera…

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems in the cancer cells make the drug radium-223 work better or worse. The goal is to help doctors choose the best treatment for each patient in …

This study tests a short suicide prevention program for teens (ages 10-18) who have low to moderate suicide risk. The program is delivered in pediatric primary care clinics to make it easier for teens to get help. Researchers will check if doctors and families find the program us…