University Of Washington

This study looks at whether a smaller, skin-deep dose of the HPV vaccine can trigger a strong immune response in adults aged 27 to 45. About 40 participants will receive either a bivalent or nonavalent HPV vaccine as a single fractional injection. Researchers will measure antibod…

This study looks at whether giving a smaller (one-fifth) dose of the HPV vaccine, either into the skin or muscle, can still trigger a strong immune response in adults aged 27 to 45. About 92 men and women in Seattle will have their antibody levels checked over a year. The goal is…

This study tests a DNA-based vaccine called STEMVAC in 33 people with early-stage triple negative breast cancer. The vaccine targets proteins found on breast cancer stem cells and aims to train the immune system to recognize and destroy these cells. The main goal is to see if the…

This early-phase trial tests a DNA vaccine called STEMVAC in 42 people with advanced HER2-negative breast cancer whose disease is stable or gone after standard treatment. The vaccine targets cancer stem cells, which are thought to resist chemotherapy and help cancer spread. The m…

This study tests whether giving the drug brentuximab vedotin weekly, alone or with nivolumab, can shrink tumors in people with CD30+ lymphoma that no longer responds to the usual every-3-week dosing. About 28 adults with relapsed or refractory Hodgkin or non-Hodgkin lymphoma will…

This study tests a combination of four drugs (isatuximab, carfilzomib, pomalidomide, and dexamethasone) in 30 adults whose multiple myeloma has returned or is not responding to prior treatments. The goal is to see how well this drug mix shrinks or controls the cancer. Participant…

This early-phase study tests a combination of two drugs, niraparib and dostarlimab, in 18 adults with BRCA-mutated breast, pancreas, or ovary cancer that has spread or cannot be surgically removed. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the…

This study tests whether combining two drugs, golimumab and apalutamide, can help men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The goal is to see if this combination can lower PSA levels by at least 50%. Eight participants are e…

This study tests a drug called abemaciclib in 20 people with advanced digestive neuroendocrine tumors that have stopped responding to standard treatments and cannot be surgically removed. The drug works by blocking certain enzymes that help cancer cells grow. The goal is to see i…

This study tests a program called MIAPP that adds a patient navigator, smartphone check-ins, and small rewards to usual care for people who start buprenorphine for opioid use in the hospital and also use methamphetamine. The goal is to help them connect to outpatient treatment wi…

This study tests whether combining an immunotherapy drug (pembrolizumab) with chemotherapy (carboplatin) can delay or prevent ovarian, fallopian tube, or primary peritoneal cancer from coming back after a rise in CA-125 levels. It includes 22 adults whose cancer has returned but …

This study tests whether a mobile health program that sends text messages and offers counseling can help women living with HIV make better decisions about contraception and pregnancy. About 3,300 women in HIV care will take part. The goal is to see if the program reduces unplanne…

This study tests whether using simple, on-the-spot urine tests and viral load checks can help people with HIV stick to their medication and keep the virus under control. About 539 people starting HIV treatment in South Africa will be followed for 72 weeks. The goal is to see if t…

This study tests whether measuring blood pressure at home, rather than only at the dialysis center, helps prevent dangerous blood pressure drops during dialysis. 200 adults with end-stage kidney disease on dialysis will be assigned to either home or clinic blood pressure targets.…

This study tests a combination of two drugs, ixazomib and rituximab, in people with slow-growing B-cell non-Hodgkin lymphoma. The goal is to see how well the drugs shrink or control the cancer. About 33 adults with different types of this lymphoma are taking part.

This study tests whether adding the drug acalabrutinib to CAR T-cell therapy (a treatment that uses a patient's own immune cells to fight cancer) is safe and effective for adults with certain types of B-cell lymphoma. About 23 participants will receive the combination. The goal i…

This study tests whether adding a targeted drug called tafasitamab to standard chemotherapy can improve treatment for adults newly diagnosed with a fast-growing blood cancer (Ph- B-ALL). About 32 adults who cannot receive standard intensive chemo will get the combination. The goa…

This study tests a combination of three immunotherapy drugs (INCMGA00012, INCAGN02385, and INCAGN02390) in 12 adults with advanced Merkel cell carcinoma that continued to grow after standard treatment. The drugs are given by IV to help the immune system fight the cancer. The main…

This study tests a DNA vaccine called STEMVAC in people with stage IV non-small cell lung cancer. The vaccine gives the body instructions to make parts of five proteins found on lung cancer cells, helping the immune system recognize and attack them. About 5 participants who have …

This phase 3 trial tests whether the immunotherapy drug avelumab can keep Merkel cell carcinoma from returning in patients whose cancer has spread to lymph nodes and who have already had surgery or radiation. About 100 adults will receive either avelumab or a placebo every two we…

This study tests a drug called emicizumab given regularly to prevent bleeding episodes in people with acquired hemophilia A, a rare condition where the immune system attacks a clotting factor. About 51 adults with active bleeding joined this phase 2 trial. Researchers will count …

This study tests whether a combination of two drugs (pentoxifylline and tocopherol, a form of vitamin E) can help heal jaw bone damage caused by medications used for osteoporosis or cancer. About 100 adults with stage 1-3 medication-related osteonecrosis of the jaw (MRONJ) will r…

This study tests a program called ED LINC, which starts in the emergency room and provides ongoing support for people with opioid use disorder. The program helps connect patients to medication and care to reduce illicit opioid use and prevent return trips to the ER. About 500 adu…

This study is testing a short (under 5 minutes) MRI technique called DWI that does not require an injection of contrast dye. The goal is to see if it can find breast cancers that mammograms miss in women with dense breasts. About 269 women with dense breasts will participate. If …

This study tests a special PET scan (68Ga-PSMA-11) to see if it can find and monitor prostate cancer more accurately than standard scans. About 141 men with prostate cancer that has come back or spread will get the scan. The goal is to help doctors choose the best treatment.

This study tests whether new software can improve ultrasound images to more accurately find and measure kidney stones. About 370 adults with calcium-based kidney stones will have a research ultrasound, and the results will be compared to standard clinical imaging and surgery find…

This study aims to make HIV prevention pills (PrEP) more available to pregnant women and new mothers in Kenya. Researchers will work with 17,000 women and healthcare workers across many clinics, using training and quality improvement tools to boost screening and PrEP use. The goa…

This study tests a program called Journey of Transformation for Native youth. It aims to delay or reduce tobacco, alcohol, and other drug use, and improve sexual health. About 182 tenth graders at an off-reservation boarding school will take part. The program focuses on cultural …

This study tests whether nurse-navigators can help adolescent girls and young women in Kenya start and continue taking PrEP, a daily medication that prevents HIV. About 1,900 participants will get PrEP at local pharmacies after buying birth control, and half will also receive ext…

This study tests a 12-week digital group program called IMAGINE to see if it can prevent depression in pregnant people and new mothers who are at higher risk. About 100 participants will either join the online group or receive standard care. Researchers will check depression and …

This study tests a new way to treat kidney stones using focused ultrasound, or sound waves, to gently push stones into a better position for passing or to relieve pain. Researchers are studying this in 172 people with kidney stones, including those waiting for treatment or recent…

This study tests a program designed to reduce loneliness and improve well-being in cancer survivors. Researchers will work with 36 adults who have had cancer and feel lonely. The program uses social prescribing to connect participants with community resources and support.

This study tests whether a special mobile app can help children and teens with autism (ages 8-17) brush their teeth more thoroughly and regularly. Participants will use either the autism-friendly app or a basic control app for 3 months. Researchers will measure brushing coverage,…

This study tests a virtual program called Integrative Medicine at Home (IM@Home) that includes cardio and yoga classes to help breast cancer patients manage fatigue and other symptoms during radiation. About 40 patients will try the program to see if it is easy to use and helps t…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This study tests a new mobile health program for young adults ages 18-29 who use cannabis frequently or use high-potency products. Participants receive personalized feedback and weekly text messages to reflect on their cannabis use and personal goals. The program aims to reduce t…

This study tests whether a nurse care management program can help rural adults with chronic pain feel better and do more in daily life. The program includes care coordination, talk therapy, and a remote exercise plan. About 450 people from rural areas will take part. The goal is …

This early-stage study tests whether MDMA (the drug in ecstasy) combined with talk therapy can help people with pathological narcissism. Twelve adults will receive three monthly MDMA therapy sessions and be followed for six months. The goal is to see if symptoms improve and if th…

This study tests a non-drug treatment called Hypnotic Cognitive Therapy for people with new spinal cord injuries who have pain. Participants will receive either four sessions of this therapy or four sessions of pain education during their hospital rehab stay. The goal is to see i…

This study compares surgery to the best medical care for people whose diverticulitis limits their quality of life. 255 adults will be randomly assigned to either surgery or medication to see which approach helps them feel better day-to-day. The goal is to find out if surgery offe…

This study looks at two common treatments for a type of bladder cancer that keeps coming back: medication placed directly into the bladder or surgery to remove the bladder. Researchers want to see which option gives patients a better quality of life and overall experience. About …

This study tests whether a research website helps people with cystic fibrosis (CF) feel more prepared to discuss lung transplant with their doctors. About 132 adults with CF and low lung function will use the website and attend Zoom sessions over 6 months. The goal is to increase…

This study looks at how the Shingrix vaccine, which protects against shingles, affects immune cells in the skin and blood. Researchers will measure specific antibodies and T-cells in healthy adults aged 30-40 and 70 or older. The goal is to understand how the vaccine creates long…

This study looks at whether matching adults with chronic pain to specific treatments—like cognitive behavioral therapy, mindfulness, or hypnosis—can lead to better pain relief. Researchers are testing 331 participants to find out which personal traits predict the best response to…

This study tests a new online decision-support tool that helps local health departments identify heat risks in their communities and choose effective ways to respond. Researchers will compare health departments that use the tool with those that only receive general heat-health in…

This study tests a new way to choose treatments for people with multiple myeloma or plasma cell leukemia that has returned or stopped responding to standard therapy. Researchers use a lab test that checks many drugs at once, along with genetic information, to find which drug or d…

This study looks at whether a 20-minute writing task, called the Future Possible Self Task (FPST), can help high school seniors and recent graduates think differently about drinking and reduce alcohol misuse. About 468 participants will complete the writing exercise and answer qu…

This study looks at ways to help people who have a high inherited risk for cancer stick to their recommended screenings and preventive surgeries. Researchers will test two approaches: online resources and personalized outreach. About 900 participants with a genetic variant linked…

This study tests a special PET scan (FES) that tracks estrogen receptors in breast cancer tumors. Researchers want to see if changes in scan results before, during, and after hormone therapy can show how well the treatment is working. The study involves adults with estrogen recep…

This study looks at whether group support or one-on-one peer support helps Black patients with endometrial cancer complete their treatment. About 252 participants will be randomly assigned to one of three groups: group support, one-on-one peer support, or enhanced usual care. The…

This study tests a program that trains early intervention providers to use a parent-led therapy for children with autism. The goal is to improve access to specialized care for kids under three. Researchers will work with 440 families to see if this approach helps children's socia…

This study looks at whether a simple urine pregnancy test taken 2 weeks after a medication abortion can reliably show the abortion is complete, instead of waiting the usual 4 weeks. About 400 people with very early pregnancies (up to 42 days) will take weekly tests and answer sym…

This study looks at whether doing computer-based brain exercises in the morning or late afternoon helps older adults (60+) recover thinking skills after a stay in the intensive care unit (ICU). Many ICU survivors have trouble with memory, attention, and sleep. The goal is to find…

This study looks at whether a 20-minute writing task can change how college seniors view themselves as drinkers and help them drink less after graduation. About 468 students from two universities will complete the writing exercise and answer surveys over a year. Researchers hope …

This study looks at whether special MRI scans can tell us more about early breast changes called DCIS, which show up as tiny calcium spots on mammograms. About 122 women with these spots or a recent DCIS diagnosis will get an MRI before surgery. The goal is to see if MRI can meas…

This study looks at whether sending caring text messages and providing helpful resources can reduce distress and lower suicide risk in veterans and service members who are feeling stressed or overwhelmed. About 521 participants will be split into two groups: one gets the caring m…

This study looks at 40 people with HIV to see if a common drug, tenofovir, causes more immune system activation and helps the virus hide better in the body. Participants are already on stable HIV treatment and will provide blood and gut samples. The goal is to find ways to reduce…

This study was designed to develop and test a new therapy model for young people aged 13-30 who have suicidal thoughts but don't need emergency care. The goal was to improve the bond between patient and therapist and reduce suicide risk. However, the study was withdrawn before en…

This study tests a new approach to help people with mental health conditions stay in treatment and get better. Researchers are working with 155 patients in Mozambique to see if a step-by-step improvement plan helps clinics diagnose, treat, and follow up more effectively. The goal…