University Of Washington

This study tests whether extra ultrafiltration—a gentle fluid removal process—can safely reduce excess fluid buildup in 120 adults on hemodialysis for end-stage kidney disease. The goal is to lower high blood pressure and relieve symptoms like shortness of breath and swelling. Pa…

This study tests a new online tool that gives young adults personalized feedback about their drinking habits. Participants can choose which groups to compare themselves to, like other students or athletes, to make the feedback more meaningful. The goal is to see if this approach …

This phase 2 trial tests whether adding a gene therapy (nadofaragene firadenovec) to standard chemotherapy and immunotherapy before bladder removal surgery can improve outcomes for people with muscle-invasive bladder cancer. About 33 participants will receive the combination trea…

This study tests a combination of two drugs, SX-682 and atezolizumab, in people with advanced non-small cell lung cancer whose disease worsened after chemotherapy and immunotherapy. The goal is to see if this new pair can shrink tumors or slow cancer growth. About 32 adults will …

This study is for people with advanced bladder cancer that has shrunk after initial treatment with two drugs (enfortumab vedotin and pembrolizumab). The goal is to see if adding focused radiation or surgery to remove any remaining cancer can safely get rid of the disease and allo…

This study tests a vaccine that helps the immune system attack ovarian cancer cells. It is for people whose cancer has returned based on a blood test but is not yet visible on scans. Participants receive one dose of chemotherapy followed by the vaccine. The goal is to see if this…

This study tests whether offering HIV prevention pills, STI testing, and preventive antibiotics at retail pharmacies can help young women avoid infections. About 720 women aged 15-24 who visit a pharmacy for birth control will be randomly assigned to different service packages. T…

This study tests whether a family-based weight management program can slow the start of puberty in overweight girls aged 6.5 to 8. Half of the 240 participants will join a 5-month program focused on healthy eating and exercise, while the other half receives usual care. Researcher…

This study tests whether delivering TB preventive therapy in the community, with fewer clinic visits, helps more people start and finish treatment. It includes household contacts of TB patients and people living with HIV. The goal is to reduce TB spread and make prevention simple…

This study tests whether a lead prevention program from the US can be adapted for families in Nairobi, Kenya. About 500 caregivers of young children will receive either clinic-based information or also a home visit with tailored advice. Researchers will measure blood lead levels …

This study tests whether an internet-based program called My MS Toolkit can help reduce depression in adults with multiple sclerosis. About 110 participants will either use the toolkit or receive usual care. The goal is to see if the program is accessible and helpful for easing d…

This study tests two sleep medications, doxepin and ramelteon, to see if they improve sleep quality for people recovering from knee replacement surgery. About 129 adults will be randomly assigned to take one of the drugs or a placebo. The goal is to find safe, effective options t…

This study tests a tailored online group program (VOCALE LBD) to reduce depression in family caregivers of people with Lewy Body Dementia (LBD). About 220 caregivers who feel depressed will join either the program or receive standard educational materials. The program is an 8-wee…

This study tests a home-based exercise program called CAREFit-BMT for people with high-risk acute myeloid leukemia (AML) who are about to have a stem cell transplant. The program includes aerobic and strength exercises to improve heart function and reduce complications. Researche…

This study tests whether group psilocybin retreats can safely help healthcare clinicians who feel depressed and have lost meaning in their work. About 72 doctors, nurses, and physician assistants will take part in small group retreats with different amounts of preparation. The ma…

This study tests whether adding estrogen to standard hormone therapy can improve quality of life for men with prostate cancer that has spread. Standard treatment often causes hot flashes, fatigue, and bone problems by lowering estrogen. The trial will compare hot flash scores and…

This study looks at how feeling stressed and being around other people influence whether someone chooses an alcoholic drink over a non-alcoholic one. Researchers will have 160 adults who drink regularly make choices in different situations. The goal is to understand these factors…

This study looks at the best ways to screen young children (16-24 months old) who were exposed to HIV for possible delays in brain development. Researchers will compare two screening methods used by healthcare workers during regular clinic visits in Botswana and Kenya. They want …

This study looks at how genetics and what we eat might cause brain inflammation that leads to obesity. Researchers will study 110 identical twins who eat differently to see if their brains show signs of inflammation. The goal is to understand why some people gain weight more easi…

This study tests whether a special training and feedback program helps hospital staff in Kenya better review why mothers and newborns die, and use that information to prevent future deaths. About 260 staff from 20 health facilities will take part, with half receiving the program …

This study tests a mobile app called ALRITE that helps health workers in Uganda better diagnose and manage breathing problems in young children. The tool aims to increase detection of wheezing illnesses like asthma, which are often missed. Researchers will compare data before and…

This study aims to create and test a program that teaches family members new ways to talk to their young adult loved one who has psychosis and uses cannabis heavily. The goal is to help families communicate better, reduce stress, and possibly encourage their loved one to cut back…

This study looks at what emotional, physical, and environmental factors make it easier or harder for people with multiple sclerosis (MS) and chronic pain to practice mindfulness every day. About 80 adults with MS will use a smartphone app to track their practice during an 8-week …

This study will test a program that helps mothers provide nurturing care—like healthy feeding, play, and problem-solving—for their babies from birth to age 2 in Botswana, Kenya, and Zimbabwe. About 1,260 pregnant women, both with and without HIV, will take part. The goal is to se…

This study looks at whether adding a brief online personalized feedback program to standard screening and counseling can reduce impaired driving in young adults aged 18-30. About 600 participants in Washington State who recently received standard screening will be randomly assign…

This study tests a new, non-invasive device that attaches to the outside of a prosthetic leg socket to measure how well it fits. Poor socket fit can cause pain, skin problems, and reduced mobility. The device uses air cylinders to track leg movement and assess fit. 18 adults with…

This study aims to develop and test a brief online program for young adult couples (ages 18-29) who use both alcohol and cannabis. The program includes self-paced modules over 3-5 weeks to reduce risky substance use and improve relationship skills. Researchers will compare couple…