University Of Washington

This study tests whether a simple blood test that measures tumor DNA can help doctors safely reduce the amount of chemotherapy for people with advanced Hodgkin lymphoma. About 125 participants will receive either fewer or standard chemotherapy cycles based on their blood test res…

This study tests whether combining two drugs, pirtobrutinib and mosunetuzumab, can better treat follicular lymphoma that has come back or not responded to prior therapy. About 22 adults with grade 1-3a lymphoma will receive the combination. The goal is to increase the chance of c…

This study tests a health-system approach to help people with opioid use disorder stay in treatment after leaving jail. Researchers will work with clinics and jails to improve care coordination and follow-up. About 4,165 adults in King County, Washington, who receive medication f…

This study tests a lower dose of the drug mosunetuzumab in 20 adults with slow-growing B-cell lymphoma that has not been treated before. The goal is to see if it can shrink tumors and control the disease while being safe. Participants will receive the drug and be monitored for si…

This study tests whether adding venetoclax to a standard chemotherapy regimen (CLAG-M) can better control acute myeloid leukemia (AML) and related high-grade blood cancers. About 62 adults with newly diagnosed or relapsed/refractory disease will receive the combination. The goal …

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, prevention, and treatment services. Researchers will compare clinics using SAIA to those using usual procedures. The goal is to increase HIV counseling, testing, and linkage t…

This study tests a drug called odronextamab given before CAR-T cell therapy for people with large B-cell lymphomas that returned or didn't respond to treatment. The goal is to keep the cancer from growing so patients can successfully receive CAR-T therapy. About 27 adults will ta…

This study tests whether adding the WOKVAC vaccine to standard chemotherapy and HER2-targeted therapy before surgery can help the immune system better attack breast cancer cells. About 25 adults with early-stage HER2-positive breast cancer will receive the combination treatment. …

This study is for pregnant women with von Willebrand disease (VWD), a bleeding disorder. It tests a medicine called Wilate to raise clotting factor levels during delivery and after birth, aiming to prevent severe blood loss. About 110 women will take part, and researchers will tr…

This early-stage trial is testing whether adding two targeted drugs (polatuzumab vedotin and glofitamab) to standard chemotherapy can safely treat aggressive B-cell non-Hodgkin lymphoma that hasn't been treated before. About 56 adults with fast-growing lymphoma will receive the c…

This study tests a vaccine called STEMVAC, given with chemotherapy, for people with a tough-to-treat breast cancer that has spread. The vaccine is designed to train the immune system to attack cancer stem cells. About 20 adults with PD-L1 negative, triple-negative breast cancer w…

This study tests whether giving copper supplements to people with cirrhosis (scarred liver) who have low copper levels can improve liver function and reduce infections. About 30 adults with cirrhosis and low or borderline copper will take copper or a placebo for a few months. The…

This study tests a short program designed to help young adults ages 18-29 who struggle with heavy drinking, marijuana use, and poor sleep. Researchers want to see if the program can reduce alcohol and cannabis use and improve sleep quality. The study will involve 800 participants…

This study looks at whether a personalized home exercise program, delivered through a smartphone app, can improve physical function and recovery in people with bladder or upper tract cancer who are scheduled for surgery. About 128 participants will either receive the exercise pro…

This study is redesigning a proven trauma therapy (TF-CBT) so school counselors can use it more easily. Researchers will work with 102 students and providers to make the therapy simpler and more fitting for school settings. The goal is to help more kids get effective trauma care …

This study tests a virtual program called Integrative Medicine at Home (IM@Home) that includes cardio and yoga classes to help breast cancer patients undergoing radiation feel less tired and improve their quality of life. About 40 participants will try the program, and researcher…

This study looks at how to help LGBTQ+ people stay engaged with free online mental health resources. Researchers will test different strategies to see what encourages people to use these tools more. About 300 participants who have already used the Mental Health America website wi…

This study looks at how PET/CT scans change during chemoimmunotherapy and radiation therapy in people with stage IV non-small cell lung cancer. Researchers want to see if these scan changes can help predict how well the cancer responds to treatment. About 80 participants who have…

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems in the cancer affect how well the drug radium-223 works. About 48 men will take part, and the goal is to help doctors choose better treatment…

This study is for people with ovarian or other solid cancers who have had certain treatments like chemotherapy or PARP inhibitors. Researchers want to understand why some patients later develop blood cancers. They will look at genetic changes in the blood and track how these chan…

This study tests a web-based app called PST-Aid that helps therapists deliver problem-solving treatment (PST) for depression in community health centers. About 410 therapists and their patients will take part. The goal is to see if the app makes it easier for therapists to use PS…