Could a simple drug combo reverse jaw bone damage from common meds?

NCT ID NCT03040778

Ongoing Disease control Sponsor: University of Washington Source: ClinicalTrials.gov ↗

First seen May 07, 2026 · Last updated Jun 05, 2026 · Updated 7 times

Summary

This study tests whether a combination of two drugs (pentoxifylline and tocopherol, a form of vitamin E) can help heal jaw bone damage caused by medications used for osteoporosis or cancer. About 100 adults with stage 1-3 medication-related osteonecrosis of the jaw (MRONJ) will receive either standard care alone or standard care plus the drug combo. The main goal is to see if the drug combo reduces the size of exposed bone after one year.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

New York Center for Orthognathic and Maxillofacial Surgery

Lake Success, New York, 11042, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35242, United States
University of Michigan

Ann Arbor, Michigan, 48109-0018, United States
University of Washington

Seattle, Washington, 98195, United States

Conditions

Explore the condition pages connected to this study.

AVASCULAR NECROSIS BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAW MEDICATION-RELATED OSTEONECROSIS OF THE JAW