University Of Washington

This early-stage trial tests a DNA vaccine called STEMVAC in 42 people with advanced HER2-negative breast cancer whose disease is stable or gone after standard treatment. The vaccine is designed to help the immune system recognize and attack cancer stem cells, which are often res…

This study looks at whether a smaller, skin-deep dose of the HPV vaccine can trigger a strong immune response in adults aged 27 to 45. About 40 participants will receive either a bivalent or nonavalent HPV vaccine as a single fractional injection. Researchers will measure antibod…

This study looks at whether giving a smaller (one-fifth) dose of the HPV vaccine, either into the skin or muscle, can still trigger a strong immune response in adults aged 27 to 45. About 92 men and women in Seattle will have their antibody levels checked over a year. The goal is…

This study tests a DNA-based vaccine called STEMVAC in 33 people with early-stage triple negative breast cancer. The vaccine targets proteins found on breast cancer stem cells and aims to train the immune system to recognize and destroy these cells. The main goal is to see if the…

This study tests whether giving people with HIV their viral load and medication-level results on the same day helps them stay on treatment and keep the virus under control. About 539 adults starting HIV therapy in South Africa will get these quick tests. The goal is to see if thi…

This phase II trial tests a DNA vaccine called STEMVAC in 5 people with stage IV non-small cell lung cancer. The vaccine gives the body instructions to make parts of five proteins found on lung cancer cells, with the goal of activating immune cells to attack the tumor. Participan…

This phase 3 trial tests whether a combination of pentoxifylline (a muscle pain drug) and vitamin E can help heal jaw bone damage caused by osteoporosis or cancer treatments. About 100 people with medication-related jaw bone death will receive either the drug combo plus standard …

This phase II trial tests whether combining the immunotherapy drug pembrolizumab (Keytruda) with the chemotherapy carboplatin can prevent or delay cancer progression in women with recurrent ovarian, fallopian tube, or primary peritoneal cancer. The study enrolls 22 participants w…

This phase 2 trial tests the drug emicizumab (Hemlibra) as a regular injection to prevent bleeding in 51 adults with acquired hemophilia A, a rare condition where the immune system attacks clotting factors. Participants receive two loading doses then weekly shots, along with stan…

This study tests whether text messages and counseling can help women living with HIV make better decisions about contraception and pregnancy. About 3,310 women in Kenya will receive either standard care or the mobile health program. The goal is to reduce unplanned pregnancies and…

This study tests a program called ED LINC, which provides coordinated care starting in the emergency department for people with opioid use disorder. About 500 adults with moderate to severe opioid use disorder will either receive this program or usual care. The goal is to see if …

This study tests whether giving the drug brentuximab vedotin weekly, alone or with nivolumab, can shrink tumors in people with CD30+ lymphoma that no longer responds to the usual every-3-week dosing. About 28 adults with relapsed or refractory Hodgkin or non-Hodgkin lymphoma will…

This study tests a combination of four drugs (isatuximab, carfilzomib, pomalidomide, and dexamethasone) in 30 adults whose multiple myeloma has returned or is not responding to prior treatments. The goal is to see how well this drug mix shrinks or controls the cancer. Participant…

This early-phase study tests a combination of two drugs, niraparib and dostarlimab, in 18 adults with BRCA-mutated breast, pancreas, or ovary cancer that has spread or cannot be surgically removed. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the…

This study tests whether combining two drugs, golimumab and apalutamide, can help men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The goal is to see if this combination can lower PSA levels by at least 50%. Eight participants are e…

This study tests a drug called abemaciclib in 20 people with advanced digestive neuroendocrine tumors that have stopped responding to standard treatments and cannot be surgically removed. The drug works by blocking certain enzymes that help cancer cells grow. The goal is to see i…

This study tests a program called MIAPP that adds a patient navigator, smartphone check-ins, and small rewards to usual care for people who start buprenorphine for opioid use in the hospital and also use methamphetamine. The goal is to help them connect to outpatient treatment wi…

This study tests whether measuring blood pressure at home, rather than only at the dialysis center, helps prevent dangerous blood pressure drops during dialysis. 200 adults with end-stage kidney disease on dialysis will be assigned to either home or clinic blood pressure targets.…

This study tests a combination of two drugs, ixazomib and rituximab, in people with slow-growing B-cell non-Hodgkin lymphoma. The goal is to see how well the drugs shrink or control the cancer. About 33 adults with different types of this lymphoma are taking part.

This study tests whether adding the drug acalabrutinib to CAR T-cell therapy (a treatment that uses a patient's own immune cells to fight cancer) is safe and effective for adults with certain types of B-cell lymphoma. About 23 participants will receive the combination. The goal i…

This study tests whether adding a targeted drug called tafasitamab to standard chemotherapy can improve treatment for adults newly diagnosed with a fast-growing blood cancer (Ph- B-ALL). About 32 adults who cannot receive standard intensive chemo will get the combination. The goa…

This study tests a combination of three immunotherapy drugs (INCMGA00012, INCAGN02385, and INCAGN02390) in 12 adults with advanced Merkel cell carcinoma that continued to grow after standard treatment. The drugs are given by IV to help the immune system fight the cancer. The main…

This phase 3 trial tests whether the immunotherapy drug avelumab can keep Merkel cell carcinoma from returning in patients whose cancer has spread to lymph nodes and who have already had surgery or radiation. About 100 adults will receive either avelumab or a placebo every two we…

This study tests whether new software for ultrasound machines can improve how doctors find and measure kidney stones. Researchers will compare the new ultrasound images to standard clinical methods in 370 adults with calcium-based kidney stones. The goal is to make diagnosis more…

This study is testing a short (under 5 minutes) MRI technique called DWI that does not require an injection of contrast dye. The goal is to see if it can find breast cancers that mammograms miss in women with dense breasts. About 269 women with dense breasts will participate. If …

This study tests a special PET scan (68Ga-PSMA-11) to see if it can find and monitor prostate cancer more accurately than standard scans. About 141 men with prostate cancer that has come back or spread will get the scan. The goal is to help doctors choose the best treatment.

This study tests a program called Journey of Transformation for Native American tenth graders at an off-reservation boarding school. The program uses traditional storytelling, cultural arts, and outdoor activities to teach leadership and healthy decision-making around substance u…

This study aims to help Kenyan clinics offer PrEP (HIV prevention pills) to pregnant and postpartum women more effectively. Researchers will provide clinics with a training toolkit, quality improvement support, and a community of practice for staff. The goal is to see if this pac…

This study tests whether nurse-navigators can help adolescent girls and young women in Kenya start and continue taking PrEP, a daily medication that prevents HIV. About 1,900 participants will get PrEP at local pharmacies after buying birth control, and half will also receive ext…

This study tests a 12-week digital group program called IMAGINE to see if it can prevent depression in pregnant people and new mothers who are at higher risk. About 100 participants will either join the online group or receive standard care. Researchers will check depression and …

This study tests a device that uses focused ultrasound to gently push kidney stones, helping them pass or relieving pain. Researchers are enrolling 172 people with kidney stones, including those waiting for treatment or recently treated. The goal is to see if the ultrasound can m…

This pilot study tests whether a virtual mind-body program called IM@Home can help breast cancer patients manage fatigue and other symptoms during radiation therapy. The program includes online cardio and yoga classes, plus a FitBit to track activity. Researchers will enroll 40 p…

This study tests a treatment called Hypnosis Enhanced Cognitive Therapy (HYPCT) for people with new spinal cord injuries who are in rehab. It compares HYPCT to standard pain education to see if it can lower pain intensity and prevent chronic pain. Participants will attend four se…

This study tests whether a special app can help children and teens (ages 8-17) with autism improve their toothbrushing. Participants use either the autism-friendly app or a basic control app for 3 months. Researchers will check if the app leads to better brushing coverage, longer…

This study tests whether a nurse care management program can help rural adults with chronic pain feel better and function more in daily life. The program includes care coordination, cognitive behavioral therapy, and referrals to an exercise program. About 450 rural patients will …

This study tests whether training early intervention providers in Reciprocal Imitation Training can help children with autism improve imitation and communication skills. The program involves 440 children and their caregivers, with providers learning simple strategies during play.…

This early-phase study tests whether MDMA-assisted therapy can help people with pathological narcissism. Twelve adults will receive three monthly MDMA sessions plus therapy, with follow-up over six months. The goal is to see if symptoms improve and if the treatment is safe.

This study compares surgery (removing part of the colon) to the best medical treatments for people whose diverticulitis symptoms seriously affect their daily life. About 255 adults with at least one confirmed episode of diverticulitis and ongoing quality-of-life issues are taking…

This study tests a program designed to reduce loneliness and improve well-being in cancer survivors. Researchers will work with 36 adults who have had cancer and feel lonely. The program uses social prescribing to help participants build connections and improve their quality of l…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This study tests a new mobile health program for young adults ages 18-29 who use cannabis frequently or use high-potency products. Participants receive personalized feedback and weekly text messages to reflect on their cannabis use and personal goals. The program aims to reduce t…

This study tests two simple, scalable methods to help people with inherited cancer risk follow through on recommended screenings. Researchers will provide online educational resources and personalized phone outreach to 900 participants. The goal is to see if these approaches impr…

This study looks at whether matching people with chronic pain to a specific type of talk therapy—like cognitive behavioral therapy, mindfulness, or hypnosis—can lead to better pain relief. About 331 adults with chronic pain will be randomly assigned to one of these treatments. Th…

This study compares two treatments for a type of bladder cancer that keeps coming back: medication placed directly into the bladder or surgery to remove the bladder. Researchers want to see which option gives patients a better quality of life and fewer side effects. About 570 adu…

This study looks at how the Shingrix vaccine, which prevents shingles, changes immune cells in the skin and blood. Researchers will compare two groups: adults aged 30-40 and those 70 or older. The goal is to understand how the vaccine creates long-lasting protection, especially i…

This study looks at whether doing computer-based brain exercises in the morning or late afternoon works better for older adults who have been in the intensive care unit (ICU). Many ICU survivors have trouble thinking clearly and sleeping well. The goal is to see which time of day…

This study looks at whether sending caring text messages to stressed or distressed veterans and service members can lower their emotional pain and reduce thoughts of suicide. Over 500 participants will receive either the caring messages plus helpful resources, or just the resourc…

This study tests whether a research website helps people with cystic fibrosis (CF) feel more prepared to discuss lung transplant with their doctors. About 132 adults with CF and low lung function will use the website and attend Zoom sessions over 6 months. The goal is to increase…

This study tests a new online decision-support tool that helps local health departments identify heat risks in their communities and choose effective ways to respond. Researchers will compare health departments that use the tool with those that only receive general heat-health in…

This study tests a new way to choose treatments for people with multiple myeloma or plasma cell leukemia that has returned or stopped responding to standard therapy. Researchers use a lab test that checks many drugs at once, along with genetic information, to find which drug or d…

This study looks at whether a 20-minute writing task, called the Future Possible Self Task (FPST), can help high school seniors and recent graduates think differently about drinking and reduce alcohol misuse. About 468 participants will complete the writing exercise and answer qu…

This study tests a special PET scan (FES) that tracks estrogen receptors in breast cancer tumors. Researchers want to see if changes in scan results before, during, and after hormone therapy can show how well the treatment is working. The study involves adults with estrogen recep…

This study looks at whether group support or one-on-one peer support helps Black patients with endometrial cancer complete their treatment. About 252 participants will be randomly assigned to one of three groups: group support, one-on-one peer support, or enhanced usual care. The…

This study looks at whether a simple urine pregnancy test taken 2 weeks after a medication abortion can reliably show the abortion is complete, instead of waiting the usual 4 weeks. About 400 people with very early pregnancies (up to 42 days) will take weekly tests and answer sym…

This study looks at whether a 20-minute writing task can change how college seniors view themselves as drinkers and help them drink less after graduation. About 468 students from two universities will complete the writing exercise and answer surveys over a year. Researchers hope …

This study looks at whether special MRI scans can tell us more about early breast changes called DCIS, which show up as tiny calcium spots on mammograms. About 122 women with these spots or a recent DCIS diagnosis will get an MRI before surgery. The goal is to see if MRI can meas…

This study looks at 40 people with HIV to see if a common drug, tenofovir, causes more immune system activation and helps the virus hide better in the body. Participants are already on stable HIV treatment and will provide blood and gut samples. The goal is to find ways to reduce…

This study was designed to develop and test a new therapy model for young people aged 13-30 who have suicidal thoughts but don't need emergency care. The goal was to improve the bond between patient and therapist and reduce suicide risk. However, the study was withdrawn before en…

This study tests a new approach to help people with mental health conditions stay in treatment and get better. Researchers are working with 155 patients in Mozambique to see if a step-by-step improvement plan helps clinics diagnose, treat, and follow up more effectively. The goal…