University Of Washington

This phase 3 trial tests whether the immunotherapy drug avelumab can keep Merkel cell carcinoma from returning in patients whose cancer had spread to lymph nodes and was removed by surgery or radiation. About 100 adults with stage III Merkel cell cancer will receive either avelum…

This study tests a DNA vaccine called STEMVAC in people with stage IV non-small cell lung cancer. The vaccine gives the body instructions to make parts of five proteins found on lung cancer cells, helping the immune system recognize and attack them. The trial includes 5 participa…

This study tests a drug called emicizumab in 51 adults with acquired hemophilia A, a rare condition where the immune system attacks a clotting protein, causing severe bleeding. The goal is to see if regular emicizumab injections can prevent bleeding episodes over 12 weeks. Resear…

This early-phase trial tests a combination of two drugs—niraparib and dostarlimab—in people with breast, pancreas, or ovarian cancers that have a BRCA gene mutation and have spread or can't be removed by surgery. Niraparib blocks a DNA repair process that cancer cells rely on, wh…

This study tests a drug called abemaciclib in 20 people with advanced digestive neuroendocrine tumors that have stopped responding to standard treatments. The drug works by blocking certain enzymes that help cancer cells grow. The goal is to see if it can shrink or slow the tumor…

This study tests a program called ED LINC, which provides ongoing support and care coordination for people with opioid use disorder starting in the emergency department. About 500 adults with moderate to severe opioid use disorder will be randomly assigned to either the ED LINC p…

This study tests whether combining two drugs—golimumab (which reduces inflammation) and apalutamide (which blocks male hormones)—can shrink or slow advanced prostate cancer that no longer responds to standard hormone therapy. Eight men with metastatic castration-resistant prostat…

This study tests whether text messages and counseling can help women living with HIV make informed choices about pregnancy and contraception. About 3,300 women in Kenya will receive either standard care or the mobile health program. The goal is to reduce unplanned pregnancies and…

This study tests a program that combines a patient navigator, a smartphone app, and small rewards to help people who use both opioids and methamphetamine stay connected to addiction treatment after leaving the hospital. Forty adults who started buprenorphine while hospitalized wi…

This early-phase study tests whether adding the drug acalabrutinib to CAR T-cell therapy (axicabtagene ciloleucel) is safe and works better for people with certain B-cell lymphomas. About 23 adults whose lymphoma has returned or not responded to prior treatment will receive the c…

This study tests whether combining an immunotherapy drug (pembrolizumab) with chemotherapy (carboplatin) can prevent ovarian, fallopian tube, or peritoneal cancer from progressing after a blood test shows it may be coming back. About 22 adults whose cancer had previously responde…

This study tests whether using simple, fast tests at the clinic can help people with HIV stick to their medication and keep the virus at undetectable levels. About 539 people starting HIV treatment in South Africa will get either standard care or these quick tests. The goal is to…

This study looks at whether using home blood pressure readings to guide treatment can reduce sudden drops in blood pressure during dialysis. About 200 adults with end-stage kidney disease on dialysis will take part. Researchers will compare targeting a home blood pressure below 1…

This study tests whether new software can improve ultrasound images to more accurately find and measure kidney stones. About 370 adults with calcium-based kidney stones will have a research ultrasound, and the results will be compared to standard clinical imaging and surgery find…

This study aims to make HIV prevention medication (PrEP) more available to pregnant women and new mothers in Kenyan health clinics. Researchers will train healthcare workers and improve clinic processes to help more women get screened and start PrEP. The goal is to protect both m…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury. The goal is to reduce PTSD symptoms and the number of emergency room visits. Participants are 424 injured patients who speak English or Spanish and show early signs of PTSD. The progra…

This study tests a program to reduce loneliness and improve well-being in cancer survivors. About 36 adults who had cancer in the past 7 years and feel lonely will take part. The program uses social prescribing to help build connections and support.

This study looks at whether group or one-on-one peer support helps Black patients with endometrial cancer complete their treatment. About 252 participants will be randomly assigned to group support, one-on-one support, or standard care. The main goal is to see if social support i…

This study looks at whether a chatbot called Cecebot can help breast cancer survivors with insomnia sleep better. About 60 women with stage I-III breast cancer who have trouble sleeping will use the chatbot, which sends text messages with tips from cognitive behavioral therapy an…

This early-phase study tests whether MDMA (the drug in ecstasy) combined with talk therapy can help people with pathological narcissism. Twelve adults will receive the treatment during three monthly sessions and be followed for six months. The goal is to see if symptoms improve a…

This study was designed to test a new therapy model called 'Connections' for teens and young adults (ages 13-30) who have had suicidal thoughts or attempts in the past year but do not need immediate crisis care. The approach combines a special counseling style (Aeschi Model) with…

This study compares surgery (colectomy) to the best medical treatments for people whose diverticulitis limits their quality of life. About 255 adults with at least one confirmed episode of diverticulitis are taking part. The goal is to see which approach better improves daily liv…

This study looks at 331 adults with chronic pain to see if certain traits (like brain activity or how easily someone is hypnotized) can predict which treatment works best for them. Participants receive one of three therapies: cognitive behavioral therapy, mindfulness, or hypnotic…

This study explores whether a 20-minute writing exercise, called the Future Possible Self Task, can help high school seniors and recent graduates think differently about drinking and reduce alcohol misuse. About 468 participants will complete the writing task and answer surveys o…

This study looks at whether sending caring messages (Caring Contacts) along with helpful resources can reduce distress and prevent suicidal thoughts in stressed veterans and service members. About 521 participants will be split into two groups: one gets caring messages plus resou…

This study looks at whether a website with educational resources can help people with cystic fibrosis (CF) feel more prepared to discuss lung transplant with their doctors. Many people with CF who die never considered a lung transplant, especially those from marginalized communit…

This study looks at 40 people with HIV to see if different types of HIV medications affect the hidden virus (the HIV reservoir) and immune system differently. Researchers want to know if a drug called tenofovir might cause more immune activation and keep the virus hiding longer. …

This study looks at how women recover from posttraumatic stress disorder (PTSD) and alcohol use after a sexual assault. Researchers are testing ways to understand and improve early treatments. About 82 women who experienced a sexual assault in the past year and have heavy drinkin…

This study tests a program called Journey of Transformation for Native youth. About 182 tenth graders at an off-reservation boarding school will take part. The program aims to delay or reduce tobacco, alcohol, and other drug use, and improve sexual health. Researchers will compar…

This study tests a new way to choose treatments for people with multiple myeloma or plasma cell leukemia that has returned or stopped responding to therapy. Researchers use a lab test that checks many drugs at once, along with genetic information, to find which drugs might work b…

This study compares two treatments for people with a type of bladder cancer that keeps coming back: medication placed directly into the bladder or surgery to remove the bladder. Researchers want to see which option gives patients a better quality of life. About 570 adults with hi…

This study tests a method called SAIA-MH to help clinics in Mozambique better support people with mental health conditions. The goal is to see if this approach helps patients stay in treatment and improve their daily functioning. About 155 patients are involved, and researchers a…

This study looks at whether web resources and personalized outreach can help people who have a high inherited risk for cancer follow their doctor's recommended screenings and surgeries. About 900 adults with a genetic variant linked to cancer will take part. The goal is to improv…

This study looks at whether advanced MRI scans can help doctors understand the biology of very early breast changes called ductal carcinoma in situ (DCIS), which often show up as calcium spots on mammograms. About 122 women with these suspicious calcifications or recent DCIS diag…