Personalized pain therapy: One-Size-Fits-All may be over
NCT ID NCT05699252
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether matching adults with chronic pain to specific psychological treatments—like cognitive behavioral therapy, mindfulness, or hypnosis—based on their personal traits (such as brain activity or thinking patterns) leads to better pain relief. Researchers will study 331 participants to find out which factors predict who benefits most from each therapy. The goal is to move away from a one-size-fits-all approach and toward personalized pain care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cognitive Behavioral Therapy, Mindfulness-Based Cognitive Therapy, Hypnotic Cognitive Therapy
- What this could lead to
- If successful, this could help doctors choose the best psychological treatment for each person with chronic pain, improving pain relief for many.
- What could go wrong
- This is an early-stage study focused on finding patterns, not testing a new treatment. Results may not lead to a simple matching tool, and individual responses vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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331 people
The number who actually took part.
- Started
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Apr 2023
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ≥ 18 years old. * Having chronic pain, operationalized as average pain intensity in the last week rated as ≥ 3 on a 0-10 Numerical Rating Scale (NRS) and having pain on most days for 3 months or more. * Able to read, speak, and understand English. * Willingness to be randomized to condition and use videoconferencing with audio and video enabled. * Access to a private place with adequate internet reception to support participation in videoconferencing treatment sessions. * Not currently participating in another clinical trial or interventional study for chronic pain and willing to refrain from participation in any other clinical trial or interventional study for chronic pain during active participation in this study. * Willing, able, and committed to participate in an in-person EEG assessment. * Able to use a smart phone, tablet, or computer independently to access email and webpages or have someone available in their home who can help them with initial session set-up and then leave for the treatment sessions. Exclusion Criteria: The exclusion criteria for Veteran participants will be assessed via self-report and verified by VA medical records chart review. Eligibility for non-Veteran participants will be assessed by self-report (no medical records chart review). An individual who meets any of the following criteria at the time of screening will be excluded from participation in this study and will not be enrolled: * Active suicidal ideation/intent indicating significant risk. * Unstable medical or psychiatric condition (e.g., mania, psychotic symptoms) that would interfere with study participation. * Behavioral issues noted in the record or observed during the screening process that would interfere with appropriate or safe videoconferencing treatment session participation or study procedures. * Alcohol abuse (operationalized as scoring 15 or more if male or 13 or more if female on the Alcohol Use Disorders Identification Test), or any illicit drugs, all of which may impact EEG measures. * Severe cognitive impairment defined as two or more errors on the Six-Item Screener. * Having an EEG confounder (e.g., congenital or acquired skull defects, missing sections or holes in the skull, or plates, screws, or other implants within the skull or brain) that would interfere with reliable EEG data collection. * Active cancer treatment or primary pain is due to cancer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Washington, Ninth and Jefferson Building
Seattle, Washington, 98104, United States
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VA Puget Sound Health Care System, American Lake
Tacoma, Washington, 98493, United States
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VA Puget Sound Health Care System, Seattle Division
Seattle, Washington, 98108, United States
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Other studies related to the condition(s) this trial covers.
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