CHRONIC PAIN
Clinical trials for CHRONIC PAIN explained in plain language.
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New program aims to break the opioid cycle after surgery
Disease control Recruiting nowThis study is testing a program to help people who have been taking opioid pain medication long-term to safely reduce their use after spine surgery. It combines counseling sessions with either a muscle relaxant or a placebo pill, comparing them to standard care. The goal is to fi…
Matched conditions: CHRONIC PAIN
Phase: PHASE3 • Sponsor: Stanford University • Aim: Disease control
Last updated Apr 03, 2026 14:42 UTC
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Magic mushroom therapy trial aims to break opioid dependence in pain patients
Disease control Recruiting nowThis small pilot study is testing whether therapy sessions using the psychedelic compound psilocybin can help people with chronic pain safely reduce or stop their opioid pain medications. The study will involve 10 adults who have previously struggled to taper off opioids. Partici…
Matched conditions: CHRONIC PAIN
Phase: PHASE2 • Sponsor: University of British Columbia • Aim: Disease control
Last updated Apr 03, 2026 14:42 UTC
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Cannabis combo tested to fight pain and curb opioid cravings
Disease control Recruiting nowThis study is testing if pills containing THC and CBD, the main compounds in cannabis, can help people who have both opioid addiction and chronic pain. The goal is to see if these pills can reduce pain and lessen cravings for opioids. Participants are adults already receiving sta…
Matched conditions: CHRONIC PAIN
Phase: PHASE2 • Sponsor: Yale University • Aim: Disease control
Last updated Apr 03, 2026 14:41 UTC
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Could Low-Nicotine cigarettes break the Smoking-Pain cycle?
Disease control Recruiting nowThis study is testing whether switching to very low nicotine cigarettes helps people with chronic pain and opioid use disorder reduce their smoking. Researchers will compare these special cigarettes to regular cigarettes to see which better reduces cravings, withdrawal symptoms, …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Duke University • Aim: Disease control
Last updated Apr 01, 2026 14:54 UTC
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New holistic program aims to tackle opioid addiction and pain together
Disease control Recruiting nowThis study is testing a comprehensive 24-week program for people who have both opioid addiction and long-term pain. The program combines standard addiction medication with therapy, exercise groups, and stress-reduction techniques like tai chi and relaxation training. Researchers …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Yale University • Aim: Disease control
Last updated Apr 01, 2026 14:43 UTC
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Can a simple text message help fight opioid addiction?
Disease control Recruiting nowThis study is testing if daily text messages can help people stay on their medication for opioid addiction. For six months, 60 participants will get medication reminders, and for one month, they'll also get mindfulness messages. Researchers want to see if these texts help people …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of New Mexico • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Blood-Based treatment challenges steroids for aching shoulders
Disease control Recruiting nowThis study compares two treatments for chronic shoulder pain from rotator cuff tendinopathy. One group gets injections of platelet-rich plasma (PRP), made from their own blood, while the other gets standard steroid shots. Both groups also follow a personalized exercise program to…
Matched conditions: CHRONIC PAIN
Phase: PHASE3 • Sponsor: Biobizkaia Health Research Institute • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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VA launches major study to break cancer Survivors' opioid dependence
Disease control Recruiting nowThis study aims to help cancer survivors who have chronic pain reduce their long-term opioid use safely. It will test four different treatment approaches, including specialized pain care and medication changes, to see which works best. The goal is to lower opioid doses by at leas…
Matched conditions: CHRONIC PAIN
Phase: PHASE4 • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Zapping brain circuits to ease depression and pain
Disease control Recruiting nowThis study is testing whether a non-invasive brain stimulation technique can help people who have both major depression and chronic pain. It will involve 54 adults who haven't gotten enough relief from standard medications. Participants will receive 30 sessions of magnetic stimul…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of California, Los Angeles • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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New approach aims to improve pain and opioid care for indigenous communities
Disease control Recruiting nowThis study aims to implement and test culturally tailored screening and brief support for chronic pain and opioid misuse in three clinics serving American Indian and Alaska Native communities. Researchers will work with community partners to develop training for healthcare provid…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of New Mexico • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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New Mind-Body approach aims to tame chronic pain and opioid dangers
Disease control Recruiting nowThis study is testing if a mindfulness training program and regular pain management visits with a doctor can help people who have long-term pain and take opioid painkillers. The goal is to see if these approaches can reduce pain, improve daily life, and lower the risks associated…
Matched conditions: CHRONIC PAIN
Phase: PHASE3 • Sponsor: University of Utah • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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Brain scans could end guesswork for chronic pain treatment
Disease control Recruiting nowThis study is testing a new approach to make a non-invasive brain stimulation treatment more effective for people with chronic pain. Researchers will use a brain scan before treatment to try to predict which patients are most likely to benefit, moving away from a one-size-fits-al…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Aalborg University • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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New Phone-Based program aims to tackle chronic pain and opioid use together
Disease control Recruiting nowThis study is testing whether a 10-session phone or online coaching program can help people who have both chronic pain and problems with opioid use. Researchers want to see if this program helps participants manage their pain better and stay engaged in treatment for opioid use di…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Pittsburgh • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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New training aims to cut opioid use for chronic pain sufferers
Disease control Recruiting nowThis study is testing whether a special training program for doctors and other healthcare providers can help people with long-term chronic pain. The training teaches providers new ways to manage pain without relying as heavily on opioid medications. Researchers will measure if pa…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Virginia Commonwealth University • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Zapping the brain to fight opioid addiction
Disease control Recruiting nowThis study is testing whether a non-invasive brain stimulation device can help people with opioid addiction and chronic pain. The device uses a combination of mild electrical and ultrasound stimulation. Researchers will measure if it helps participants reduce their drug use and m…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Case Western Reserve University • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Three-Pronged attack on opioid risks for chronic pain patients
Disease control Recruiting nowThis study is testing three different treatments to help people who have been taking prescription opioids for chronic pain for a long time. The goal is to see if adding a buprenorphine patch, a type of counseling called cognitive behavioral therapy, or a non-invasive brain stimul…
Matched conditions: CHRONIC PAIN
Phase: PHASE1, PHASE2 • Sponsor: Medical University of South Carolina • Aim: Disease control
Last updated Mar 17, 2026 13:09 UTC
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New test could predict who gets pain relief from pancreatitis surgery
Diagnosis Recruiting nowThis study is testing a new pain assessment tool to see if it can predict which patients with chronic pancreatitis will get relief from standard endoscopic or surgical treatments. Researchers will enroll 150 adults with chronic pancreatitis who are already scheduled for one of th…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Pittsburgh • Aim: Diagnosis
Last updated Mar 30, 2026 14:30 UTC
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AI steps in to tackle pain doctor shortage
Diagnosis Recruiting nowThis study is testing a new computer algorithm designed to help diagnose chronic pain. It compares the algorithm's recommendations to those made by expert pain doctors. About 200 people with chronic pain will answer an online questionnaire, and researchers will check how well the…
Matched conditions: CHRONIC PAIN
Sponsor: PG Medical Systems Ltd. • Aim: Diagnosis
Last updated Mar 24, 2026 12:02 UTC
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Nerve block or therapy to halt chronic pain before it starts
Prevention Recruiting nowThis study aims to prevent acute pain from developing into long-term chronic pain by treating PTSD symptoms early. Researchers will enroll 345 adults with PTSD who arrive at the emergency room or clinic with new, non-injury pain. Participants will be randomly assigned to receive …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Rush University Medical Center • Aim: Prevention
Last updated Mar 30, 2026 14:29 UTC
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Can walking and mindfulness break the chronic pain cycle?
Symptom relief Recruiting nowThis study is testing whether a 10-week program combining gentle walking with mind-body skills (like breathing exercises and mindfulness) can help older adults with chronic musculoskeletal pain move better and feel better. The program, called GetActive+, is being compared to usua…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Apr 03, 2026 18:10 UTC
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New virtual therapy aims to tackle PTSD and pain together
Symptom relief Recruiting nowThis is a small pilot study to test a new virtual therapy program that treats PTSD and chronic pain at the same time. The study will enroll 20 adults who have both conditions to see if the 12-session program is practical and acceptable to participants. The goal is to develop a mo…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Weill Medical College of Cornell University • Aim: Symptom relief
Last updated Apr 03, 2026 14:43 UTC
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Doctors test ozone gas to ease debilitating pain when standard treatments fail
Symptom relief Recruiting nowThis study is observing whether adding ozone therapy helps improve quality of life for people with severe, hard-to-treat symptoms. It involves 105 adults with chronic pain or side effects from cancer treatments like chemotherapy or radiation. Researchers will track how patients f…
Matched conditions: CHRONIC PAIN
Sponsor: Bernardino Clavo, MD, PhD • Aim: Symptom relief
Last updated Apr 03, 2026 14:43 UTC
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Can a culturally tailored mindfulness program ease the double burden of pain and depression?
Symptom relief Recruiting nowThis pilot study is testing a mindfulness-based therapy program specifically adapted for older Black adults who experience both chronic pain and mild depression. Researchers want to see if this culturally tailored program is practical and acceptable to participants, and if it can…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Apr 03, 2026 14:42 UTC
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New Pain-Zapping device tested for chronic sufferers
Symptom relief Recruiting nowThis study is testing a special type of spinal cord stimulator that uses changing electrical pulse patterns to see if it can better manage chronic pain in the back and legs. It will involve about 70 adults who have had persistent pain for at least six months. The main goal is to …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Boston Scientific Corporation • Aim: Symptom relief
Last updated Apr 03, 2026 14:42 UTC
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Can a phone app help break the cycle of pain and addiction?
Symptom relief Recruiting nowThis study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. It aims to see if the app is easy to use and helpful for adults who are in recovery from opioid use disorder and also have chronic pain. The app delivers short video exercises 'in the m…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Arizona State University • Aim: Symptom relief
Last updated Apr 03, 2026 14:42 UTC
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New study aims to cut opioid use after knee surgery
Symptom relief Recruiting nowThis study is testing two different methods for managing pain after total knee replacement surgery. Researchers want to see if using a small, temporary catheter that continuously delivers numbing medicine to the leg for about two days works better than a standard single injection…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Hospital for Special Surgery, New York • Aim: Symptom relief
Last updated Apr 03, 2026 14:42 UTC
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Zapping back pain: does spinal stimulation really work?
Symptom relief Recruiting nowThis study is testing whether spinal cord stimulation actually reduces chronic pain or if some of the benefit is a placebo effect. Researchers are enrolling 25 adults who already have the device implanted for pain. Participants will compare their pain levels with the stimulator t…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Aarhus • Aim: Symptom relief
Last updated Apr 03, 2026 14:42 UTC
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AI-Guided brain zaps target chronic pain relief
Symptom relief Recruiting nowThis early-stage study is testing whether a faster form of non-invasive brain stimulation can reduce chronic pain. Researchers will use a computer algorithm to personalize where to apply the stimulation based on each participant's brain scans and pain patterns. The goal is to see…
Matched conditions: CHRONIC PAIN
Phase: PHASE1 • Sponsor: University of Minnesota • Aim: Symptom relief
Last updated Apr 03, 2026 14:42 UTC
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Can a quick audio clip ease your pain in the waiting room?
Symptom relief Recruiting nowThis study is testing whether a short, audio-recorded mindfulness practice can help reduce pain for patients sitting in an orthopedic clinic waiting room. Researchers will compare the mindfulness audio to standard injury management advice to see which is more effective. The goal …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Florida State University • Aim: Symptom relief
Last updated Apr 03, 2026 14:42 UTC
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Military tests acupuncture, shockwave therapy to fight pain and cut opioid use
Symptom relief Recruiting nowThis study is testing a package of non-drug treatments like acupuncture, laser therapy, and shockwave therapy to help manage chronic back and neck pain. It involves 125 military service members, veterans, and their families who receive care at Nellis Air Force Base. The main goal…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: David Moss • Aim: Symptom relief
Last updated Apr 03, 2026 14:41 UTC
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Can your phone ease your pain? new app trial seeks answers
Symptom relief Recruiting nowThis study is testing whether a smartphone app called QoLibri can help people with long-term chronic pain. Researchers will compare the app to standard care to see if it improves daily function and quality of life. The trial will involve 410 patients who have experienced moderate…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Novesia • Aim: Symptom relief
Last updated Apr 03, 2026 14:41 UTC
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Can your phone help ease chronic pain? new study tests digital coaching for arthritis
Symptom relief Recruiting nowThis study is testing whether a 6-month phone and video coaching program can help older adults with hip or knee arthritis pain become more physically active, lose weight, and reduce how much pain interferes with daily life. Researchers will enroll 200 participants aged 65+ who ar…
Matched conditions: CHRONIC PAIN
Phase: PHASE2 • Sponsor: Wake Forest University • Aim: Symptom relief
Last updated Apr 03, 2026 14:41 UTC
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Can museum visits ease chronic pain? new study explores art as medicine
Symptom relief Recruiting nowThis study is testing whether an 8-week program combining art, mindfulness, and body awareness exercises in a university museum can help women with fibromyalgia. Fibromyalgia causes widespread chronic pain, fatigue, and sleep problems. Researchers want to see if this unique, non-…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: G. d'Annunzio University • Aim: Symptom relief
Last updated Apr 03, 2026 14:41 UTC
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Can 7 minutes of mindfulness ease your pain?
Symptom relief Recruiting nowThis study is testing whether a very short, 7-minute mindfulness session can help reduce pain and anxiety for people undergoing specific spinal procedures. Researchers will enroll 80 adults who are having either a kyphoplasty or radiofrequency ablation. The goal is to see if this…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Florida State University • Aim: Symptom relief
Last updated Apr 03, 2026 14:41 UTC
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Gentle brain ultrasound tested to quiet pain and cravings
Symptom relief Recruiting nowThis study is testing whether a gentle, non-invasive ultrasound treatment can help people who struggle with chronic back pain, opioid use disorder, and anxiety all at once. Researchers will apply low-intensity focused ultrasound to the brain and measure changes in pain levels, cr…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Virginia Polytechnic Institute and State University • Aim: Symptom relief
Last updated Apr 03, 2026 14:41 UTC
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VR headsets may offer new path to ease chronic neck pain
Symptom relief Recruiting nowThis study is testing whether adding virtual reality (VR) to standard neck exercises helps people with chronic neck pain or whiplash feel better. 72 participants will do rehab twice a week for 6 weeks, with half using a VR headset during exercises and half doing the same exercise…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: IRCCS San Raffaele • Aim: Symptom relief
Last updated Apr 02, 2026 14:58 UTC
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Virtual groups aim to ease the hidden burden of health stigma
Symptom relief Recruiting nowThis study is testing a new group counseling program designed to help people cope with the stigma they feel because of their health condition. Researchers are enrolling 195 adults with conditions like obesity, cancer, HIV, or diabetes who report feeling stigmatized. Participants …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Florida • Aim: Symptom relief
Last updated Apr 02, 2026 14:57 UTC
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VR headsets aim to zap back pain in new study
Symptom relief Recruiting nowThis study is testing whether two different types of virtual reality (VR) therapy can help people manage chronic low back pain. Researchers are recruiting 200 adults who have had back pain for at least six months. Participants will use a VR headset at home for 8 weeks to learn pa…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: CognifiSense Inc. • Aim: Symptom relief
Last updated Apr 02, 2026 14:57 UTC
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Headband zaps dialysis pain at home
Symptom relief Recruiting nowThis study is testing whether a small, battery-powered headband that delivers a gentle, barely noticeable electrical current can help reduce chronic pain in people receiving ongoing kidney dialysis. The goal is to see if this non-drug, at-home therapy can lessen pain and potentia…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Weill Medical College of Cornell University • Aim: Symptom relief
Last updated Apr 02, 2026 14:57 UTC
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Can online therapy help ease the pain of endometriosis?
Symptom relief Recruiting nowThis small pilot study is testing an online therapy program designed to help women with endometriosis manage their chronic pain. Ten participants will use a secure website to learn about pain, practice mindfulness and acceptance exercises, and work on valued activities they may h…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Skane University Hospital • Aim: Symptom relief
Last updated Apr 02, 2026 14:57 UTC
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Hands-On therapy vs. nerve block: which eases chronic tailbone pain better?
Symptom relief Recruiting nowThis study aims to find out which of two common treatments works better for people with long-lasting tailbone pain (coccydynia). 100 participants will be randomly assigned to receive either osteopathic manual therapy (a specialized hands-on treatment) or a ganglion impar block (a…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Istanbul Medeniyet University • Aim: Symptom relief
Last updated Apr 02, 2026 14:57 UTC
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Virtual program aims to help teens fight chronic pain through activity
Symptom relief Recruiting nowThis study is testing a new virtual program called PREP-Y that teaches teens with chronic musculoskeletal pain skills to become more physically active and better manage their pain. The program includes four weekly sessions focusing on building resilience, motivation, and confiden…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: William Black • Aim: Symptom relief
Last updated Apr 02, 2026 14:57 UTC
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Virtual yoga vs. talk therapy: which eases Veterans' chronic pain better?
Symptom relief Recruiting nowThis study compares two online approaches to help veterans manage chronic musculoskeletal pain. Researchers will test whether weekly online yoga classes work as well as Acceptance and Commitment Therapy (ACT) over 12 weeks. The study aims to see which approach better reduces pain…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Palo Alto Veterans Institute for Research • Aim: Symptom relief
Last updated Apr 02, 2026 14:57 UTC
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New coaching program aims to ease pain and lift mood without pills
Symptom relief Recruiting nowThis study is testing a coaching program designed to help Black patients who have both long-term pain and depression. The program uses four coaching sessions to help people learn about and stick with non-drug treatments, like physical therapy or mindfulness, and to talk more effe…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Indiana University • Aim: Symptom relief
Last updated Apr 02, 2026 14:56 UTC
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Can a 7-Week online course help you live better with chronic pain?
Symptom relief Recruiting nowThis study is testing an online self-help program designed to help people with chronic pain. The program uses Acceptance and Commitment Therapy (ACT) to teach skills for accepting pain and focusing on living a meaningful life. Researchers will compare the program to a waitlist gr…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Catholic University of the Sacred Heart • Aim: Symptom relief
Last updated Apr 01, 2026 14:43 UTC
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Can better sleep help break the Pain-Opioid cycle?
Symptom relief Recruiting nowThis study is testing whether a behavioral therapy that improves sleep can also help reduce pain and lower the use of opioid pain medication. It will involve 165 adults who have chronic pain, trouble sleeping, and are currently prescribed opioids. Researchers believe that by impr…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of South Florida • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Study tests if common painkillers can replace opioids after elbow procedure
Symptom relief Recruiting nowThis study compares different pain relief approaches after a minimally invasive elbow tendon procedure. Researchers want to see if common anti-inflammatory drugs (NSAIDs) work as well as opioid painkillers for managing post-procedure pain. The goal is to find effective pain contr…
Matched conditions: CHRONIC PAIN
Phase: PHASE4 • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Two-Hour class aims to cut Post-Surgery pain
Symptom relief Recruiting nowThis study is testing if a single 2-hour class teaching pain management skills works better than standard care alone for reducing pain after joint or bone surgery. It will enroll 134 adults who have had chronic pain before their elective surgery. Researchers will compare pain lev…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Université de Sherbrooke • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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New hope for veterans: can talk therapy ease chronic pain without more pills?
Symptom relief Recruiting nowThis study is testing whether a specific type of talk therapy, called Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), can help veterans who have both serious mental illness and chronic back pain. Researchers will compare the therapy to a general health education program i…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Can community classes ease your chronic back pain? new study seeks answers
Symptom relief Recruiting nowThis study is testing two different community-based group programs to see which one better helps people manage chronic back or neck pain. Participants will be randomly assigned to attend one of two 9-week programs: one focuses on mind-body skills like mindfulness, while the other…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Minnesota • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Mindfulness vs. talk therapy: new study tests pain relief without drugs
Symptom relief Recruiting nowThis study is testing two different brief talk therapy programs to help adults manage chronic pain. Researchers are comparing a mindfulness-based approach with a cognitive-behavioral therapy approach, with both available in English and Spanish. The goal is to see which approach w…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Florida State University • Aim: Symptom relief
Last updated Apr 01, 2026 14:40 UTC
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Nerve block showdown: which method best shields breast cancer patients from chronic pain?
Symptom relief Recruiting nowThis study aims to see which of two different nerve-block injection techniques is better at preventing long-term (chronic) pain after breast removal surgery (mastectomy). Researchers will compare a pectoral nerve block to a paravertebral block in 90 female patients. The goal is t…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Assiut University • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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Brain stimulation meets therapy in new At-Home treatment for pain and trauma
Symptom relief Recruiting nowThis study is testing a two-week, completely remote treatment program for people suffering from both chronic pain and PTSD. Researchers want to see if combining a mild, non-invasive brain stimulation technique with a specialized talk therapy is more effective than the therapy alo…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: The University of Texas Health Science Center, Houston • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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CBD tested as potential aid for opioid addiction and pain
Symptom relief Recruiting nowThis study is testing if the compound CBD (cannabidiol) can safely help people who have both opioid addiction and long-term pain. Researchers will give different doses of CBD to 34 people who are already receiving standard medication treatment for their addiction. They will measu…
Matched conditions: CHRONIC PAIN
Phase: EARLY_PHASE1 • Sponsor: Yale University • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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Can learning about pain make exercise more effective for seniors?
Symptom relief Recruiting nowThis study is testing whether combining physical exercise with short educational sessions about how pain works is better at helping older adults manage long-term pain than exercise alone. It involves 100 people aged 65+ who have had pain for over 3 months. Participants are random…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Salamanca • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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Strength training trial aims to ease MS pain without pills
Symptom relief Recruiting nowThis study is testing whether a 12-week supervised strength training program can reduce chronic pain in people with multiple sclerosis (MS). Researchers will compare pain levels in 116 participants who either start the exercise program right away or continue with their usual care…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Aarhus • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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New approach helps arthritis sufferers walk again with timed pain relief
Symptom relief Recruiting nowThis study tests a walking program designed to help people with painful hip or knee osteoarthritis become more active. Participants take common anti-inflammatory pain medication only before planned walks, combined with proper footwear and education, to reduce pain during movement…
Matched conditions: CHRONIC PAIN
Phase: PHASE4 • Sponsor: University Hospital, Clermont-Ferrand • Aim: Symptom relief
Last updated Mar 31, 2026 12:11 UTC
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Four-Session therapy aims to ease debilitating pelvic pain
Symptom relief Recruiting nowThis study is testing a very brief, 4-session cognitive behavioral therapy (CBT) program designed to help people manage the symptoms of urologic chronic pelvic pain syndrome (UCPPS). Researchers are comparing this short therapy to a basic education program in 240 adults diagnosed…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: State University of New York at Buffalo • Aim: Symptom relief
Last updated Mar 30, 2026 14:34 UTC
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Sticky patch zaps away lingering shingles pain
Symptom relief Recruiting nowThis study is testing a non-invasive skin patch that delivers gentle electrical pulses to try to reduce chronic nerve pain caused by shingles, known as postherpetic neuralgia. It will involve 35 adults who still have pain despite standard treatments. Researchers will check if the…
Matched conditions: CHRONIC PAIN
Sponsor: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization • Aim: Symptom relief
Last updated Mar 30, 2026 14:34 UTC
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Can your mind heal your pain? scientists test mindfulness with 'Honest' placebos
Symptom relief Recruiting nowThis study is testing whether combining mindfulness training with open-label placebo pills (sugar pills patients know are placebos) is a practical and acceptable way to help people with chronic pain. Researchers will recruit 45 adults with ongoing pain to try either mindfulness c…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Arizona State University • Aim: Symptom relief
Last updated Mar 30, 2026 14:33 UTC
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Could a Cannabis-Derived pill ease your back pain?
Symptom relief Recruiting nowThis study is testing whether a pill containing synthetic THC (the main active compound in cannabis) can help reduce chronic low back pain. About 75 adults with long-term back pain will take either the THC pill or a placebo (sugar pill) daily for 8 weeks. The main goal is to see …
Matched conditions: CHRONIC PAIN
Phase: PHASE2 • Sponsor: Christopher D. Verrico • Aim: Symptom relief
Last updated Mar 30, 2026 14:33 UTC
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New zoom therapy aims to ease chronic pain and opioid cravings
Symptom relief Recruiting nowThis study is testing a new group therapy delivered over Zoom to help adults who have both chronic pain and opioid use disorder. The therapy focuses on understanding and expressing emotions to reduce pain, disability, and opioid-related problems. Researchers want to see if this a…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Michigan • Aim: Symptom relief
Last updated Mar 30, 2026 14:33 UTC
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New Mind-Body approach targets lingering pain after trauma
Symptom relief Recruiting nowThis study is testing whether a new type of talk therapy can help people who still have pain months after a serious bone or muscle injury. About 30 participants will attend 8 weekly therapy sessions focused on emotional awareness and expression. The main goal is to see if this ap…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 30, 2026 14:31 UTC
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New program tackles the 'Double Whammy' of pain and loneliness for rural seniors
Symptom relief Recruiting nowThis study is testing a new program called SCOOP, which uses weekly coaching sessions and videos to teach older adults in rural areas how to better manage chronic pain and increase social connections. Researchers want to see if the program helps reduce how much pain interferes wi…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Michigan • Aim: Symptom relief
Last updated Mar 30, 2026 14:31 UTC
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New approach tested for dual struggle of pain and trauma
Symptom relief Recruiting nowThis pilot study is testing whether a flexible, stepped care program is a practical and acceptable way to help people who have both chronic pain and PTSD. Researchers will compare this new approach to usual care in two primary care clinics. The main goal is to see if the program …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Washington • Aim: Symptom relief
Last updated Mar 30, 2026 14:31 UTC
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Zapping the spine to ease diabetic leg pain?
Symptom relief Recruiting nowThis study is testing if a device that sends electrical pulses to the spinal cord can help reduce leg pain in people who have both painful diabetic nerve damage and poor blood circulation. Up to 15 participants who already have the device implanted will try two weeks of real stim…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Nebraska • Aim: Symptom relief
Last updated Mar 30, 2026 14:28 UTC
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Can your mind heal your back? new study tests Mind-Body therapy for chronic pain
Symptom relief Recruiting nowThis study is testing whether mind-body therapy can help people with chronic back pain. Researchers will compare two different mind-body approaches against standard medical care to see which works best at reducing pain and improving daily function. The study aims to enroll 150 ad…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Beth Israel Deaconess Medical Center • Aim: Symptom relief
Last updated Mar 27, 2026 12:40 UTC
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Teens Co-Design app to fight chronic pain, aim to cut ER trips
Symptom relief Recruiting nowThis study is testing a smartphone app designed with input from teens to help them manage long-term chronic pain. The app teaches coping skills like relaxation and managing negative thoughts, based on proven psychological therapies. Researchers will measure if using the app reduc…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Malaga • Aim: Symptom relief
Last updated Mar 27, 2026 12:40 UTC
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Can coaching help veterans use cannabis better for pain?
Symptom relief Recruiting nowThis study is testing whether four virtual coaching sessions can help veterans with chronic pain use their own cannabis products more effectively. The research aims to see if this coaching improves pain management, sleep, anxiety, and overall quality of life. The study will enrol…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Michigan • Aim: Symptom relief
Last updated Mar 27, 2026 12:40 UTC
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Two-Hour virtual class aims to ease chronic pain for spanish speakers
Symptom relief Recruiting nowThis study is testing a single, two-hour online class taught in Spanish that provides skills to help manage chronic pain. Researchers want to see if this class is helpful and easy to use for Spanish-speaking adults who have had pain for at least three months. Participants will be…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Stanford University • Aim: Symptom relief
Last updated Mar 27, 2026 12:40 UTC
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VA launches major trial to help veterans manage pain and reduce opioid risks
Symptom relief Recruiting nowThis VA study is testing whether adding Whole Health Coaching to standard pain management helps veterans with chronic pain. The coaching focuses on personal health goals across eight areas of wellness to improve daily function and reduce opioid-related safety concerns. Researcher…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Mar 27, 2026 12:39 UTC
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VA tests new team approach to ease Veterans' chronic pain
Symptom relief Recruiting nowThis study is testing whether a special pain clinic, where a team of five different specialists works together, can help Veterans with long-term pain. Researchers want to see if patients report less pain and if pain interferes less with their daily lives after six months in the p…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Salem Veterans Affairs Medical Center • Aim: Symptom relief
Last updated Mar 27, 2026 12:39 UTC
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Can a phone call ease pain and improve sleep for people with HIV?
Symptom relief Recruiting nowThis study is testing two different phone-based programs to see which one better helps people with HIV who also have chronic pain and insomnia. One program focuses on building better sleep habits, while the other teaches mindfulness techniques. Researchers want to see if these pr…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Mar 27, 2026 12:38 UTC
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Epilepsy drug trial offers hope for debilitating pancreatitis pain
Symptom relief Recruiting nowThis early-stage study is testing whether adding an existing epilepsy drug, lacosamide, to standard opioid painkillers is safe and tolerable for adults with chronic pancreatitis. The main goal is to see if the combination helps reduce severe abdominal pain and might allow patient…
Matched conditions: CHRONIC PAIN
Phase: PHASE1 • Sponsor: Indiana University • Aim: Symptom relief
Last updated Mar 27, 2026 12:37 UTC
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Brain-Retraining device offers hope for untreatable pancreatic pain
Symptom relief Recruiting nowThis study is testing whether Scrambler Therapy, a non-invasive device that delivers gentle electrical signals through the skin, can help reduce severe abdominal pain in adults with chronic pancreatitis. About 40 participants who still have pain despite standard treatments will r…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 25, 2026 14:08 UTC
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Can a simple song soothe the pain of a needle in your back?
Symptom relief Recruiting nowThis small pilot study is testing whether playing music for patients during common back pain injections can help them feel less anxious and experience less pain. Researchers will compare anxiety and pain scores between a group that listens to music and a group that does not. The …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Milton S. Hershey Medical Center • Aim: Symptom relief
Last updated Mar 25, 2026 14:08 UTC
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Glasses that fight pain? new device trial for lyme sufferers
Symptom relief Recruiting nowThis study is testing a new, non-drug device called the Sana Pain Reliever to see if it can reduce chronic pain in people with Post-treatment Lyme Disease. The device is a special mask with earbuds that pulses light and plays tones for 15-minute sessions at home. Researchers will…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Symptom relief
Last updated Mar 25, 2026 14:07 UTC
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Can a web program ease the double burden of trauma and pain?
Symptom relief Recruiting nowThis study is testing an online therapy program designed to help people who have both PTSD and long-term pain. It will involve 40 participants who will either start the program right away or after a 12-week wait. The goal is to see if this internet-delivered therapy can reduce sy…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Skane University Hospital • Aim: Symptom relief
Last updated Mar 25, 2026 14:07 UTC
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Community clinics test group therapy to fight pain and loneliness
Symptom relief Recruiting nowThis study is testing whether group-based treatments can help low-income patients better manage chronic pain. Researchers will compare group medical visits and group acupuncture to usual care in community health clinics. The goal is to see if these approaches reduce pain's impact…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Mar 24, 2026 12:02 UTC
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Seniors try group therapy and chiropractic for back pain relief
Symptom relief Recruiting nowThis study is testing whether combining chiropractic care with virtual group support sessions can help adults 65 and older manage chronic spine pain. Researchers want to see if this combined approach is practical and acceptable to participants. The small pilot study will enroll 1…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Symptom relief
Last updated Mar 24, 2026 12:01 UTC
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Diabetes drug trial offers new hope for stubborn heel pain
Symptom relief Recruiting nowThis study is testing if metformin, a common diabetes medication, can help reduce pain and improve healing in people with chronic Achilles tendon problems. Forty participants with this condition will take either metformin or a placebo pill for 16 weeks while also doing a home exe…
Matched conditions: CHRONIC PAIN
Phase: PHASE1 • Sponsor: James Wang • Aim: Symptom relief
Last updated Mar 23, 2026 15:29 UTC
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Can your mind help heal your pain? new study tests mental approach to chronic arm aches
Symptom relief Recruiting nowThis small pilot study is testing whether a mind-body therapy program can help people with long-term pain in their wrists, elbows, or shoulders from repetitive stress. Researchers will see if the program improves arm function, reduces pain intensity, and lowers pain-related anxie…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Beth Israel Deaconess Medical Center • Aim: Symptom relief
Last updated Mar 23, 2026 15:19 UTC
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Can yoga help teens manage chronic pain? new study investigates
Symptom relief Recruiting nowThis study is testing whether a yoga-based occupational therapy program can help teenagers with chronic pain. Researchers want to see if the therapy improves the teens' awareness of their body's signals and their ability to do daily activities. About 49 adolescents, aged 11 to 21…
Matched conditions: CHRONIC PAIN
Sponsor: Connecticut Children's Medical Center • Aim: Symptom relief
Last updated Mar 23, 2026 15:17 UTC
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Veterans try VR mindfulness to ease debilitating pain
Symptom relief Recruiting nowThis study is exploring whether a mindfulness program can be adapted and delivered using virtual reality (VR) to help veterans with spinal cord injuries manage chronic pain. Researchers will first work with a small group of veterans to identify needed changes to the program, then…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Mar 23, 2026 15:16 UTC
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Sweet relief? sugar injections tested for aching knees
Symptom relief Recruiting nowThis study is testing if adding a simple sugar solution (dextrose) to a standard numbing injection can better relieve chronic pain from knee osteoarthritis. Researchers will compare the sugar-water mix against the numbing medicine alone in 60 adults with persistent knee pain. The…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: National and Kapodistrian University of Athens • Aim: Symptom relief
Last updated Mar 23, 2026 15:14 UTC
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Zapping brain waves to ease hand pain: new treatment tested
Symptom relief Recruiting nowThis study is testing whether two types of noninvasive brain stimulation can reduce chronic pain in people with carpal tunnel syndrome. Researchers will compare real stimulation to fake stimulation in 95 adults who have had persistent hand pain for at least six months. The goal i…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Spaulding Rehabilitation Hospital • Aim: Symptom relief
Last updated Mar 23, 2026 15:14 UTC
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Can Hands-On therapy finally ease your nagging neck pain?
Symptom relief Recruiting nowThis study is testing whether regular manual therapy sessions are better than self-exercise education for reducing chronic neck pain. Researchers will compare two groups of 125 adults with long-term mild neck pain over 20 weeks. The goal is to see which approach provides better p…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Jaseng Medical Foundation • Aim: Symptom relief
Last updated Mar 20, 2026 14:48 UTC
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Can ancient touch ease Kids' chronic pain?
Symptom relief Recruiting nowThis study is testing if adding Shiatsu therapy to regular treatment helps children and teenagers with long-lasting pain feel better and improve their quality of life. About 40 participants, aged 10 to 18, will receive weekly Shiatsu sessions for six weeks while continuing their …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Tel Aviv University • Aim: Symptom relief
Last updated Mar 19, 2026 14:56 UTC
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Can a phone app ease the pain of sickle cell disease?
Symptom relief Recruiting nowThis study is testing whether a smartphone-based mindfulness program is practical and helpful for teens and young adults with sickle cell disease. Participants will use the app for about 8 weeks to try to manage their chronic pain and sleep problems. The main goal is to see if pe…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Illinois at Chicago • Aim: Symptom relief
Last updated Mar 19, 2026 14:56 UTC
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Can your mind ease your migraines? new study explores Non-Drug treatment
Symptom relief Recruiting nowThis small, early-stage study is testing whether a mind-body intervention can help people with frequent migraines. Researchers are recruiting 10 adults to try the remote program and provide feedback. The main goal is to see if the approach is practical and to gather information f…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Beth Israel Deaconess Medical Center • Aim: Symptom relief
Last updated Mar 18, 2026 14:40 UTC
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Hot pepper patch tested to cool teen nerve pain
Symptom relief Recruiting nowThis study is testing whether a skin patch containing capsaicin, the compound that makes chili peppers hot, can reduce chronic nerve pain in teenagers. It will compare the capsaicin patch to a placebo patch in 46 teens aged 12 to 17 who have had pain for over 3 months following s…
Matched conditions: CHRONIC PAIN
Phase: PHASE3 • Sponsor: University Hospital, Brest • Aim: Symptom relief
Last updated Mar 18, 2026 14:40 UTC
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New approach tests split methadone doses to ease chronic pain in addiction treatment
Symptom relief Recruiting nowThis study is testing whether taking methadone twice a day instead of once a day helps people better manage chronic pain while being treated for opioid addiction. It will involve 150 adults already receiving stable methadone treatment. Researchers will compare pain levels and tre…
Matched conditions: CHRONIC PAIN
Phase: PHASE2, PHASE3 • Sponsor: University of Maryland, Baltimore • Aim: Symptom relief
Last updated Mar 18, 2026 14:40 UTC
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Can vitamin drips and herbs ease your pain and anxiety?
Symptom relief Recruiting nowThis study is testing whether a combination of herbal supplements and vitamin IV (intravenous) therapy can help reduce symptoms for people with conditions like anxiety, chronic pain, fibromyalgia, arthritis, and high blood pressure. It will enroll 25 participants to see if these …
Matched conditions: CHRONIC PAIN
Sponsor: Faith A. Richardson • Aim: Symptom relief
Last updated Mar 17, 2026 13:09 UTC
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Can a new workout plan ease Veterans' pain and boost mood?
Symptom relief Recruiting nowThis study is testing whether a specific, long-term exercise program can help U.S. veterans feel better. It will see if the workouts improve body composition, physical strength, and reduce symptoms of pain, fatigue, depression, and PTSD. Over 18 months, 25 participants will atten…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Illinois at Chicago • Aim: Symptom relief
Last updated Mar 16, 2026 15:25 UTC
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Freezing nerves before knee surgery could end chronic pain
Symptom relief Recruiting nowThis study tests whether freezing specific nerves around the knee at least 24 hours before total knee replacement surgery can reduce long-term pain and improve recovery. About 100 adults with knee osteoarthritis will be randomly assigned to receive either the nerve-freezing proce…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Attikon Hospital • Aim: Symptom relief
Last updated Mar 16, 2026 15:25 UTC
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Can a phone app ease the lingering pain of childhood cancer survivors?
Symptom relief Recruiting nowThis study is testing whether a specially adapted phone app that teaches pain management skills is more helpful than standard pain education for reducing chronic pain in teen survivors of childhood cancer. It will involve 204 participants (teens and their caregivers) across four …
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: St. Jude Children's Research Hospital • Aim: Symptom relief
Last updated Mar 12, 2026 13:50 UTC
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Zapping pain away? brain stimulation trial seeks relief for chronic sufferers
Symptom relief Recruiting nowThis study is testing a personalized, non-invasive brain stimulation technique to see if it can help reduce chronic pain. Researchers will recruit 144 adults with long-term pain that hasn't responded well to other treatments. Participants will receive either real or placebo stimu…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Istituti Clinici Scientifici Maugeri SpA • Aim: Symptom relief
Last updated Mar 11, 2026 14:54 UTC
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Can yoga or physical therapy break the cycle of pain and opioid use?
Symptom relief Recruiting nowThis study is testing whether offering yoga or physical therapy classes directly at opioid treatment centers can help people who are dealing with both chronic back pain and opioid use disorder. Researchers will compare these two programs to usual care to see which one better redu…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Albert Einstein College of Medicine • Aim: Symptom relief
Last updated Mar 02, 2026 15:26 UTC
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Digital hope for chronic pain: app aims to ease suffering in Under-Resourced communities
Symptom relief Recruiting nowThis study is testing whether a smartphone app can help Black and LGBTQ+ adults better manage their chronic pain. Researchers want to see if using the app is practical and helpful for 300 people who have had pain for at least 3 months that interferes with daily life. The app teac…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Feb 27, 2026 15:18 UTC
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Remote pain control: study tests Smartphone-Guided spinal stimulation
Symptom relief Recruiting nowThis study is testing whether spinal cord stimulators can be adjusted remotely to better control chronic back and leg pain. Fifteen adults already scheduled to get a spinal cord stimulator will try different stimulation patterns through a smartphone app over four months, reportin…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University of Minnesota • Aim: Symptom relief
Last updated Feb 20, 2026 14:37 UTC
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Massive 50,000-Person study tracks pain device results
Knowledge-focused Recruiting nowThis study aims to collect real-world information from patients who use or plan to use approved medical devices for chronic pain. It will track how their pain levels change after treatment using a simple 0-10 scale. The goal is to better understand how these devices work in every…
Matched conditions: CHRONIC PAIN
Sponsor: Boston Scientific Corporation • Aim: Knowledge-focused
Last updated Apr 03, 2026 18:10 UTC
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Researchers seek to map the pain experience to build better treatment centers
Knowledge-focused Recruiting nowThis study aims to gather information to help design and run a new type of chronic pain research clinic. Researchers will enroll 120 people who experience ongoing pain to complete surveys about their pain levels, medication use, and overall well-being. The goal is to learn what f…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Edward Via Virginia College of Osteopathic Medicine • Aim: Knowledge-focused
Last updated Apr 03, 2026 14:42 UTC
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Scientists listen to spinal Cord's 'Electrical Whispers' to fight chronic pain
Knowledge-focused Recruiting nowThis study aims to learn if a new measurement technique can help doctors better personalize spinal cord stimulation for chronic pain. Researchers will test 15 people who already have a temporary spinal cord stimulator implanted. The goal is to see if measuring the spinal cord's e…
Matched conditions: CHRONIC PAIN
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Apr 03, 2026 14:41 UTC
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Scientists scan brains to unlock secrets of opioid pain treatment
Knowledge-focused Recruiting nowThis study aims to understand how long-term opioid use for chronic pain affects the brain and spinal cord. Researchers will compare brain scans, behavioral tests, and questionnaires from 140 women with chronic pain (some using opioids, some not) to scans from healthy women. The g…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Apr 02, 2026 14:57 UTC
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Your phone could help predict chronic pain Flare-Ups
Knowledge-focused Recruiting nowThis study aims to understand how daily pain, mood, and activities are connected, especially as acute pain transitions to chronic pain. Researchers will enroll 800 people with acute pain, chronic pain, or no pain to use a smartphone app (SOMA) for four months to track their daily…
Matched conditions: CHRONIC PAIN
Sponsor: Brown University • Aim: Knowledge-focused
Last updated Apr 02, 2026 14:57 UTC
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Scientists search for Body's pain signals in spinal fluid
Knowledge-focused Recruiting nowThis study aims to understand how spinal cord stimulation (SCS) works to relieve chronic nerve pain. Researchers will measure specific chemicals in the blood and spinal fluid of 30 patients before and after they receive SCS treatment. The goal is to learn which body signals are l…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Pawel Sokal • Aim: Knowledge-focused
Last updated Apr 02, 2026 14:57 UTC
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Ancient herb put to the test in modern pain study
Knowledge-focused Recruiting nowThis study aims to understand how a Boswellia serrata supplement might work to reduce pain. Researchers will give the supplement or a placebo to 12 healthy volunteers and then use a capsaicin (hot pepper) patch to create temporary pain and sensitivity on the skin. They will measu…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Medical University of Graz • Aim: Knowledge-focused
Last updated Apr 02, 2026 14:56 UTC
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Scientists hunt for clues to predict sickle Cell's most debilitating pain
Knowledge-focused Recruiting nowThis study aims to find out what factors predict whether someone with sickle cell disease will develop severe, long-lasting pain. Researchers will follow 70 participants, aged 15-40, for up to four years, using surveys and pain sensitivity tests. The goal is to gather information…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Scientists track eye twitches to decode Brain's pain signals
Knowledge-focused Recruiting nowThis study aims to understand if a hormone called oxytocin affects a specific type of pupil movement (hippus) as a way to measure brain activity. Researchers will compare healthy volunteers to people with chronic knee pain from arthritis. Participants receive either oxytocin or a…
Matched conditions: CHRONIC PAIN
Phase: PHASE2 • Sponsor: Wake Forest University Health Sciences • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Brain scans reveal why quitting smoking hurts more for chronic pain sufferers
Knowledge-focused Recruiting nowThis study aims to understand why people with chronic pain find it harder to quit smoking. Researchers will use brain scans and smartphone surveys to see how temporary smoking withdrawal changes pain signals in the brain and affects quit attempts. The goal is to gather informatio…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Scientists search for the Brain's 'Pain Signature' in jaw disorder
Knowledge-focused Recruiting nowThis study aims to understand chronic jaw pain by looking at how different areas of the brain communicate. Researchers will use MRI brain scans on about 95 women with and without chronic jaw pain to see if specific brain connection patterns are linked to how disabling the pain is…
Matched conditions: CHRONIC PAIN
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Brain scans and walking tests aim to unlock mystery of knee pain
Knowledge-focused Recruiting nowThis study aims to understand why people with similar knee arthritis damage experience very different levels of pain, especially when walking. Researchers will recruit 300 adults with chronic knee pain to complete surveys, walking tests, knee scans, and non-invasive brain imaging…
Matched conditions: CHRONIC PAIN
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:30 UTC
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Brain scans aim to unlock secrets of pain relief
Knowledge-focused Recruiting nowThis study aims to understand how different types of spinal cord stimulation (some with a tingling sensation, some without) relieve chronic nerve pain. Researchers will use brain scans and pain tracking in 90 patients to learn how these treatments work in the body and to identify…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University Health Network, Toronto • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC
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The hidden pain of survival: major study probes ICU aftermath
Knowledge-focused Recruiting nowThis study aims to understand why some people develop long-term pain after surviving a serious illness in the Intensive Care Unit (ICU). Researchers will follow 800 Danish ICU survivors for up to a year, asking about their pain, sleep, mood, and quality of life. The goal is to id…
Matched conditions: CHRONIC PAIN
Sponsor: Zealand University Hospital • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:40 UTC
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Scientists scan brains to unlock why chronic pain steals motivation
Knowledge-focused Recruiting nowThis study aims to understand how chronic nerve pain affects the brain's reward system and motivation. Researchers will compare brain scans and learning tasks in 50 people with chronic pain against healthy volunteers. The goal is to learn why pain can reduce motivation, not to te…
Matched conditions: CHRONIC PAIN
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:40 UTC
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Massive study aims to unlock why kids suffer pain long after surgery
Knowledge-focused Recruiting nowThis study aims to understand why some children develop long-lasting pain after common surgeries. Researchers will follow 5,000 children, aged 0-16, for a year after their operations using questionnaires. The goal is to identify risk factors so doctors can better prevent and mana…
Matched conditions: CHRONIC PAIN
Sponsor: Telethon Kids Institute • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:39 UTC
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Scientists test if fake feedback in VR can train your brain
Knowledge-focused Recruiting nowThis study aims to understand if a system giving fake feedback in a virtual reality (VR) environment can change specific brain waves linked to attention control. Researchers will measure brain activity in 35 adults with conditions like rumination or chronic pain while they experi…
Matched conditions: CHRONIC PAIN
Sponsor: National Council of Scientific and Technical Research, Argentina • Aim: Knowledge-focused
Last updated Mar 25, 2026 14:08 UTC
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Mapping the hidden aftermath: nerve damage in cancer survivors
Knowledge-focused Recruiting nowThis study aims to map and understand nerve-related issues like numbness, tingling, and pain in patients who were treated for mouth or throat cancer 1 to 5 years ago. Researchers will examine 120 patients during their regular follow-up visits to document these sensations and thei…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: University Hospital, Clermont-Ferrand • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:03 UTC
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Can a chatbot understand your pain? study tests new digital tools
Knowledge-focused Recruiting nowThis study is testing new digital chat software designed to collect detailed health information from people with chronic pain. Researchers want to see if these tools are easy to use, practical, and acceptable for patients to share information about their physical symptoms, emotio…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: AugMend Health Inc. • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:01 UTC
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Scientists map pain to predict treatment success
Knowledge-focused Recruiting nowThis study aims to better understand the chronic pain experienced by people with pancreatitis. Researchers will use a special pain mapping test on 500 participants, including healthy volunteers and patients, to see if certain pain patterns can predict who will benefit from treatm…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Anna Evans Phillips • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:19 UTC
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Massive 13-Year study tracks 2,000 patients with Brain-Zapping pain implants
Knowledge-focused Recruiting nowThis study aims to collect real-world safety and effectiveness data on Abbott's implanted neurostimulation devices for chronic pain. It will follow 2,000 patients for up to five years after they receive the device to track any side effects and how well it works over time. The goa…
Matched conditions: CHRONIC PAIN
Sponsor: Abbott Medical Devices • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:18 UTC
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Massive review of 15,000 pain patients seeks best treatments
Knowledge-focused Recruiting nowThis study aims to learn which treatments work best for chronic pain by looking back at the anonymous medical records of 15,000 people. Researchers will not give any new treatments; they will only review past outcomes from different approaches. The goal is to gather knowledge to …
Matched conditions: CHRONIC PAIN
Sponsor: Boston Scientific Corporation • Aim: Knowledge-focused
Last updated Mar 16, 2026 15:26 UTC
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Can a sleep apnea mask ease your chronic pain?
Knowledge-focused Recruiting nowThis study aims to understand if using a CPAP machine to treat obstructive sleep apnea can also help reduce chronic pain. Researchers will follow 80 people newly diagnosed with sleep apnea as they start CPAP therapy, tracking their pain levels and CPAP use over 6 months. The goal…
Matched conditions: CHRONIC PAIN
Sponsor: Vrije Universiteit Brussel • Aim: Knowledge-focused
Last updated Mar 11, 2026 14:53 UTC