CHRONIC PAIN

This study tests a new way to help people with chronic non-cancer pain who have been on opioids for a long time. Instead of usual care, a team of doctors, pharmacists, and therapists will create a personalized plan to reduce pain and opioid use. The goal is to see if this approac…

This study looks at whether daily text reminders and mindfulness messages can help people taking medication for opioid use disorder stick to their treatment and better manage cravings, pain, and withdrawal. About 60 adults who recently started or restarted methadone or buprenorph…

This study tests a program for adults who have used opioids for a long time and are having surgery. The program combines counseling and a muscle relaxant to help them safely reduce opioid use and manage pain after surgery. Researchers will compare this approach to standard care t…

This study looks at whether a combination of THC and CBD (cannabis compounds) can help people who have both opioid use disorder and chronic pain. Participants are on methadone therapy and will take the study drug by mouth. Researchers will measure pain sensitivity and opioid crav…

This study is for adults with chronic pain who have been taking daily prescription opioids for at least 3 months. It tests three approaches in sequence: a low-dose buprenorphine patch, a brief pain-focused cognitive behavioral therapy, and a type of brain stimulation called rTMS.…

This study is following 2,000 people who have been implanted with an Abbott neurostimulator to manage chronic pain. Researchers are collecting information on how safe and effective the device is over both the short and long term. The goal is to better understand real-world outcom…

This study tests whether treating PTSD symptoms can prevent acute pain (like from an injury) from becoming long-term chronic pain. Researchers will use either a nerve block procedure or talk therapy to reduce PTSD in 345 adults. The goal is to see if lowering PTSD symptoms helps …

This study is testing a mobile app called Wysa for Chronic Pain to see if personalized notifications can help people aged 45 and older who have chronic pain along with depression or anxiety. Participants use the app for several weeks and complete surveys about their mood, pain, p…

This study tests a 10-week program called GetActive+ that combines gentle walking with mind-body techniques to help older adults (55+) with long-term muscle or joint pain. Two hundred participants will either join the program or continue their usual care. Researchers will measure…

This study is testing whether a non-invasive brain stimulation technique (tDCS combined with ultrasound) can reduce drug use and improve well-being in people with opioid use disorder and chronic pain. About 126 adults on methadone treatment will receive either real or sham stimul…

This study tests if a common anti-inflammatory drug (diclofenac) can control pain after a needle procedure for chronic elbow pain as well as a narcotic (tramadol) does. About 92 adults will be randomly assigned to one of two groups and track how many pain pills they take over two…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who have been taking opioids for at least three months. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. Abou…

This study tests whether adding shiatsu therapy to usual medical care can improve quality of life for children and teens (ages 10-18) with chronic pain that is not caused by inflammation. About 40 participants will receive a 30-minute shiatsu session once a week for six weeks and…

This study tests whether a specially designed mobile app (WebMAP Onc) can help adolescent survivors of childhood cancer reduce chronic pain and improve daily activities. About 228 teens and their caregivers will participate across four U.S. hospitals. The app uses cognitive behav…

This study looks at whether getting Chuna (a type of manual therapy) every two weeks for 20 weeks can reduce chronic neck pain and disability better than doing self-exercises. About 250 adults aged 19-69 with mild but long-lasting neck pain will take part. The goal is to see if r…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of using a one-size-fits-all method, researchers will tailor the stimulation based on each participant's brain signals. The goal is to improve pain relief and quality of l…

This study compares two treatments for long-term shoulder pain caused by rotator cuff problems. One group gets injections of platelet-rich plasma (PRP) made from their own blood, plus a personalized exercise program. The other group gets standard steroid injections with the same …

This study tests whether freezing specific nerves around the knee (cryoneurolysis) at least 24 hours before total knee replacement surgery can reduce pain and improve function. About 100 adults with knee arthritis will be randomly assigned to receive either the freezing procedure…

This study tests a new virtual program called PREP-Y designed to help adolescents aged 12-17 with chronic musculoskeletal pain become more physically active and better manage their pain. The program includes four weekly online sessions teaching skills like motivation, confidence,…

This study tests a new training program that helps people with chronic pain and emotional distress learn to accept their pain rather than fight it. Researchers will enroll 100 adults aged 18-70 who have significant pain and emotional symptoms. The training is based on dialectical…

This study is testing whether a focused muscle contraction exercise program can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Participants will complete 90 exercise sessions and 4 testin…

This early study tests a mind-body program for people with chronic migraines. The goal is to see if the approach is practical and to pick the best ways to measure its effects on pain and daily life. Ten adults with frequent migraines will take part in remote sessions to help desi…

This study tests if a safe, non-invasive brain stimulation technique called tDCS can reduce chronic pain in military veterans. About 100 veterans receiving care at Emory Healthcare will use a headset at home to deliver mild electrical currents to the brain. The goal is to see if …

This study looks at four different programs to help cancer survivors who have been on strong painkillers (opioids) for a long time reduce or stop using them. The goal is to find safe alternatives that control pain without the risk of addiction or overdose. About 294 veterans who …

This study tests two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV. Participants must be 25-65, have HIV, chronic pain, and in…

This study explores whether an 8-week program combining art, mindfulness, and body awareness in a university museum can reduce pain and improve quality of life for women with fibromyalgia. About 44 women will be randomly assigned to either the museum program or a control group. T…

This study tests whether Pain Reprocessing Therapy (PRT) helps veterans with chronic back or neck pain more than cognitive behavioral therapy (CBT) or their usual care. About 360 veterans will be randomly assigned to one of the three groups. Those in PRT or CBT will have nine wee…

This study tests two behavioral treatments for chronic insomnia in 165 adults who have both chronic pain and take prescribed opioids. The goal is to see if improving sleep can also help reduce or stop opioid use. Participants will be randomly assigned to one of the treatments and…

This study tests whether customizing magnetic brain stimulation can better relieve chronic pain. Researchers will measure brain signals before treatment to personalize the stimulation for each of the 90 adult participants. The goal is to improve pain intensity and quality of life…

This study tests a coaching program for Black patients with long-term muscle or joint pain and depression. The program helps patients learn about non-drug pain treatments and talk to their doctors about them. Researchers want to see if this approach reduces pain interference and …

This study compares a single-session pain management program called Empowered Relief (ER) to standard care for reducing pain after elective orthopedic surgery. Researchers will enroll 134 adults who have had pain for more than 3 months related to their surgical condition. The goa…

This study tests whether virtual reality (VR) therapy can reduce pain and improve daily function in people with chronic low back pain. About 200 adults aged 18 to 85 with back pain lasting at least 6 months will use VR exercises for 8 weeks. Researchers will compare two types of …

This study tests a wearable device called the Sana Pain Reliever (Sana PR) to see if it can reduce chronic pain in people with Post-treatment Lyme Disease Syndrome. About 20 participants will use the device at home for 15 minutes at a time over 14 weeks. The device uses flashing …

This study tests a new type of spinal cord stimulation (called TVP-SCS) to see if it can reduce chronic low back and leg pain by at least 50% in 70 adults. Participants must have had pain for 6 months or more and be able to complete English questionnaires. The main goal is to mea…

This study is testing whether a group-based training program for parents can help children aged 10-17 who have chronic pain (lasting 3 months or more). The program aims to teach parents skills to support their child and reduce pain-related disability. About 48 parent-child pairs …

This study is testing a device called Inceptiv, which uses mild electrical pulses to the spinal cord to help people with long-term, hard-to-treat pain. About 970 adults who have not tried this therapy before will get the implant and be followed for 6 months. The main goal is to s…

This early-stage study tests if stem cells taken from a patient's own bone marrow can reduce long-term pain caused by chronic pancreatitis. Researchers will also check if the treatment improves pancreas function and quality of life. The study involves 40 adults with confirmed chr…

This study looks at whether a 6-week music class (including drumming and rhythm exercises) can improve mental and physical health in older adults living in residential care. About 60 participants will attend weekly one-hour sessions and complete surveys before and after. The goal…

This early-phase study tests a new way to treat chronic pain using a type of brain stimulation called accelerated TMS. The method uses a smart algorithm to choose the best spot to stimulate for each person. The goal is to see if this personalized approach is safe and can reduce p…

This study tests whether group-based pain management can help low-income adults with chronic pain feel better and more supported. About 360 participants will join group sessions that address pain, stigma, and social isolation. The goal is to reduce pain's impact on daily life and…

This early study tests whether a special nerve-stimulating device can restore touch sensation to the breast area and reduce chronic pain in people who have had both breasts removed. Eight adults scheduled for mastectomy with reconstruction will take part. The goal is to see if th…

This study tests if a single infusion of donor stem cells can reduce long-term pain in people with chronic pancreatitis. Researchers will track pain scores, opioid use, and quality of life in 48 adults over six months. The goal is to find a new way to manage pain that doesn't rel…

This study tests a high-CBD (cannabidiol) product taken under the tongue for 9 weeks in 25 adults with chronic pain conditions like arthritis or injury. Researchers will compare it to a placebo to see if it reduces pain, improves quality of life, and affects medication use. The g…

This study looks at whether a smartphone-based mindfulness program is practical and helpful for teens and young adults (ages 15-39) with sickle cell disease who have chronic pain and sleep problems. Participants use a guided mindfulness app for about 8 weeks. The goal is to see i…

This study is testing whether herbal medicines and vitamin IV therapy can reduce symptoms of anxiety, fibromyalgia, arthritis, chronic pain, and high blood pressure. About 25 adults will receive natural treatments aimed at improving health and quality of life. The goal is to see …

This study tests an online therapy program for people who have both PTSD and long-term pain. The goal is to see if it helps reduce PTSD symptoms and pain-related struggles. About 40 adults who speak Swedish and have stable medication will take part, with some starting the program…

This study tests a walking program that uses a short course of anti-inflammatory pain medication to help people with painful hip or knee osteoarthritis walk more. The goal is to see if taking the medication only around planned walks can improve walking ability without causing sid…

This study explores whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two guided therapy sessions over 8 weeks, wit…

This study looks at whether a 12-week progressive resistance exercise program can help reduce chronic pain in people with multiple sclerosis. Researchers will compare a group that exercises to a waitlist group that continues usual care. The goal is to find a drug-free way to mana…

This study looks at whether taking methadone once a day or twice a day works better for people who have both chronic pain and opioid use disorder. About 150 adults currently on methadone treatment will take part. Researchers will track pain levels and pain tolerance over 12 weeks…

This study tests a physiotherapy program that combines gentle exercise with pain education for women with endometriosis. 62 women will be split into two groups: one gets the full program, the other gets only pain education. Researchers will check pain, movement, quality of life, …

This study is testing a new therapy that treats PTSD and chronic pain together in one program. It is for adults who have both conditions. The therapy includes 12 virtual sessions over six weeks, combining proven techniques for each condition. The goal is to see if this combined a…

This study explores whether a virtual reality (VR) mindfulness program can help veterans with spinal cord injury (SCI) and chronic pain. Researchers will first adapt an existing mindfulness course for SCI needs, then test 1-2 modules using VR in 10 veterans. The goal is to see if…

This study looks at whether using a midline catheter (a type of IV line) is a safe and practical way to give repeated lidocaine infusions for chronic pain in an outpatient setting. About 500 adults who need these infusions will receive ten sessions through the catheter. The goal …

This study tests a new way to deliver spinal cord stimulation for people with long-term pain in the trunk or limbs. The device uses special software to adjust signals in real time. About 200 adults who already have or plan to get the Evoke System will take part. The goal is to se…

This study tests four coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Researchers want to see if this approach improves pain and related symptoms. The trial involves 468 veterans and is conducted entirely online.

This study tests if a continuous nerve catheter placed in the thigh provides better pain relief and reduces opioid use compared to a single nerve block after total knee replacement. About 64 adults will be randomly assigned to receive either the catheter or a sham catheter plus a…

This study tests a 6-month mobile program that combines physical activity, healthy eating, and group support to help older adults with knee or hip arthritis reduce pain and improve daily function. Two hundred participants aged 65+ will be randomly assigned to the program or usual…

This study tests whether group music therapy can help adults with chronic pain. 24 people will attend 16 sessions, some in person and some online. The main goal is to see if the program is practical and if people stick with it. If successful, it could offer a new way to ease pain…

This study is looking at whether ozone therapy can improve quality of life for people with long-lasting pain, including pain caused by cancer treatments like radiation and chemotherapy. About 105 adults will receive ozone therapy as an extra treatment alongside their usual care. …

This early-stage study tests whether adding lacosamide, a seizure medication, to standard opioid therapy is safe and tolerable for people with chronic pancreatitis and ongoing abdominal pain. About 24 adults who have been on opioids for at least 4 weeks will take lacosamide for 7…

This study tests whether a spinal cord stimulator can reduce leg pain and improve quality of life in people with type 2 diabetes, painful nerve damage, and peripheral artery disease. Fifteen adults who already have a spinal cord stimulator will receive two weeks of active stimula…

This study tests whether probenecid, a safe drug already used for gout, can reduce the unpleasant symptoms of opioid withdrawal. About 40 adults with chronic pain who are voluntarily lowering their opioid dose will receive probenecid or a placebo. The goal is to see if probenecid…

This study is testing whether a mind-body therapy program can reduce disability and pain in people with chronic back pain. About 150 adults aged 18 to 67 with persistent back pain will be randomly assigned to the mind-body program, a different mind-body approach, or usual care. R…

This study tests if adding Acceptance and Commitment Therapy (ACT) and a care management smartphone app can help people with opioid use disorder and chronic pain who are already taking buprenorphine. About 127 adults will be enrolled to see if these tools reduce pain interference…

This study tests a brief, 4-session cognitive behavioral treatment (CBT) for people with urological chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. Researchers want to see if this short therapy can reduce pain and improve quality of …

This study tests whether adding a sugar solution (dextrose) to numbing injections around knee nerves provides better pain relief than numbing medicine alone for people with chronic knee osteoarthritis. Sixty adults with knee arthritis will receive a series of three injections tar…

This study is testing whether a smartphone app can help Black and LGBTQ+ adults with long-term chronic pain feel better and do more in their daily lives. The app teaches skills to manage pain and improve well-being. Researchers will enroll 300 people across the U.S. to see if the…

This study tests whether group counseling and peer support can help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain feel less stigma about their health. About 195 adults will join counseling sessions and report how stigma affects their li…

This study tests a mindfulness-based program designed for older Black adults (age 50+) who have both chronic pain and mild depression. Participants will be randomly assigned to either the mindfulness program or a general health education program. The goal is to see if the mindful…

This study looks at whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. About 190 veterans will receive CBT and be monitored for changes in pain interference, qualit…

This early-stage study tests whether metformin, a common diabetes pill, can reduce pain and help heal the Achilles tendon in people with chronic tendinopathy. Forty non-diabetic adults will take either metformin or a placebo for 16 weeks, along with a home exercise program. The g…

This study looks at whether a 6-week pain education program can help people with chronic pain become more active and feel less pain and depression. About 50 adults with pain lasting over 3 months will attend group sessions on sleep, stress, exercise, and mindfulness. The goal is …

This study looks at whether combining mindfulness training with a placebo pill (which patients know is inactive) can help people with chronic pain. About 45 adults with ongoing pain will be split into three groups: mindfulness only, placebo only, or both together. The goal is to …

This study tests whether dronabinol (a synthetic THC pill) can safely reduce chronic low back pain. About 75 adults with pain lasting at least 3 months will take either the drug or a placebo for 8 weeks. The main goal is to see if the drug is safe enough for larger future studies…

This study tests a new, personalized brain stimulation technique called HD-tDCS to help people with long-term (chronic) pain. Researchers will enroll 144 adults who have had pain for at least six months. Participants will be randomly assigned to receive either real stimulation or…

This small pilot study tests an internet-based therapy (Acceptance and Commitment Therapy) for 10 people with endometriosis and chronic pain. Participants learn skills like mindfulness and acceptance to reduce pain's impact on daily life. The goal is to see if this approach helps…

This study tests a trilingual mobile app and telehealth coaching program to help people with chronic pain manage their symptoms without medication. Researchers will enroll 586 adults from Black, Chinese, and Latinx communities in the San Francisco Bay Area. Participants will be r…

This study compares two online programs—yoga and Acceptance and Commitment Therapy (ACT)—to see which better reduces chronic musculoskeletal pain in veterans. About 274 veterans with pain lasting over 6 months will participate. The goal is to find effective, accessible ways to ea…

This study looks at whether doing yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their usu…

This study tests whether a very short (7-minute) mindfulness exercise can reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard care. The goal is to …

This study looks at whether a new method called ECAPS can improve spinal cord stimulation for people with chronic pain. Researchers will enroll 15 adults who already have spinal cord implants to see if the approach is practical and acceptable. The goal is to make pain management …

This study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain how the brain perceives pain. Adults with chronic pancreatitis and persistent abdominal pain not helped by standard treatments will receive 5-10 sessions and be fol…

This study tests a smartphone app called QoLibri designed to help people with chronic pain. The goal is to see if using the app improves quality of life and reduces how much pain interferes with daily activities. About 410 adults with moderate or worse pain for over 3 months will…

This study tests a smartphone app called Digital SPA, co-designed with teens, to help 12-17 year olds manage chronic pain and prevent long-term disability. Participants will use the app, fill out online questionnaires, and join interviews. The goal is to see if the app reduces pa…

This study tests a program for adults who take opioids for chronic pain before surgery. The program includes pain education, therapy, and a mobile app to help patients reduce opioid use and manage pain better after surgery. Researchers will compare how many patients successfully …

This study tests a telehealth program that teaches rural veterans with chronic pain how to use mind-body skills to better manage their pain. The program focuses on the link between mental and physical health. About 500 veterans will participate, learning tools to reduce pain's im…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve both depression and chronic pain symptoms. Fifty-four adults with moderate depression and pain will receive 30 sessions of active treatment, along with surveys, blood draws, MRIs, and EEGs…

This study tests whether virtual reality-based exercises can reduce neck pain and improve daily activities in people with chronic neck pain or whiplash. Seventy-two adults will be randomly assigned to either VR-enhanced rehabilitation or the same exercises without VR. The goal is…

This pilot study tests a mind-body intervention for adults with chronic upper extremity pain from repetitive stress injury. Researchers want to see if the program improves arm, shoulder, and hand function, and reduces pain and anxiety. The study enrolls 40 participants who have h…

This study tests whether personalized lifestyle coaching can reduce chronic muscle and joint pain in people aged 60 and older. 268 participants will either receive four face-to-face coaching sessions or continue their usual care. The goal is to see if coaching improves pain, slee…

This study compares two treatments for chronic tailbone pain (coccydynia): hands-on osteopathic manual therapy and a nerve block injection. About 100 adults with persistent pain will be randomly assigned to one treatment. Researchers will measure pain and daily function at 3 week…

This study is testing whether using a weighted blanket at night can reduce chronic pain and improve sleep in veterans. Researchers will give 160 veterans either a light (3-pound) or heavy (15-pound) blanket to use at home for 6 weeks. They will track changes in pain, sleep qualit…

This study tests a training program for healthcare practitioners to help them better treat chronic pain without relying on opioids. About 1,188 patients and their doctors will take part. The program teaches team-based, behavioral approaches to pain management, with the goal of im…

This study tests a non-invasive treatment called transcutaneous pulsed radiofrequency for people with postherpetic neuralgia, a chronic nerve pain that can last for years after a shingles rash heals. The treatment uses mild electrical pulses through the skin to reduce pain. The t…

This study looks at whether cannabidiol (CBD) is safe and can help with pain and opioid cravings in people who are already on medication (methadone or buprenorphine) for opioid use disorder. About 34 adults with chronic pain will take CBD or a placebo in a random order over four …

This study tests whether low-intensity focused ultrasound (LIFU) can safely reduce pain, cravings, and anxiety in adults with chronic back pain, opioid use disorder, and anxiety. About 25 participants will receive the ultrasound and be monitored for side effects and changes in mo…

This pilot study tests whether a group-based behavioral therapy delivered over Zoom can help 30 adults with both chronic pain and opioid use disorder. The therapy focuses on emotional awareness and expression to reduce pain, disability, depression, and anxiety. Researchers will m…

This pilot study tests a smartphone app called Mindful Journey that teaches mindfulness skills to adults recovering from opioid use disorder who also have chronic pain. The study aims to see if the app is easy to use and helpful for this group. Ten participants will use the app a…

This study tests a program called SCOOP for adults aged 60 and older living in rural areas who have chronic pain and feel lonely. Participants watch short videos and have up to 7 weekly coaching sessions with a community health worker. The goal is to see if the program reduces pa…

This study tests whether adding online pain education to standard physical therapy helps people with chronic low back pain. 60 adults aged 20-60 will be split into two groups: one gets physical therapy plus six weekly online sessions about how pain works, and the other gets physi…

This study looks at two types of nerve blocks—pectoral nerve block and paravertebral block—to see which one better prevents chronic pain after mastectomy. About 90 women having breast removal surgery will be randomly assigned to receive one of the blocks. The goal is to reduce lo…

This study tests whether a gentle brain stimulation technique (tDCS combined with ultrasound) can reduce chronic pain in people with carpal tunnel syndrome. Researchers will compare active stimulation to a sham (fake) treatment in 95 adults aged 18–80 who have had pain for at lea…

This study looks at a new method called 'telefitting' to fine-tune spinal cord stimulators for people with chronic back or leg pain. Participants will try different stimulation settings without knowing which one they are using, and a smart algorithm will pick the best option. The…

This study tests a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) for people who have persistent pain after a serious bone or muscle injury. Researchers want to see if it's practical to run a larger study later. About 30 adults will attend weekly th…

This study tests whether a capsaicin 8% skin patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 who have had pain for more than 3 months after surgery or an injury. Half of the 46 participants will get the real patch, and the other hal…

This study tests whether a team of five pain specialists (pain doctor, psychologist, pharmacist, dietitian, and physical therapist) can help veterans with chronic pain feel better and do more in daily life. About 150 veterans will either join the program right away or wait six mo…

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study tests if a 2-week, fully remote treatment can help people with both chronic pain and PTSD. Participants receive either real or fake brain stimulation (tDCS) along with talk therapy, all from home. The goal is to see if this combination reduces pain and PTSD symptoms be…

This study tests two short behavioral treatments—mindfulness and cognitive-behavioral therapy—for adults with chronic pain. Both are offered in English and Spanish. The goal is to see which approach is more feasible and acceptable, and how well they reduce pain, depression, and a…

This study looks at whether adding short lessons about how pain works to a supervised exercise program can help adults over 65 with chronic pain feel better and move easier. About 100 participants will be split into three groups: exercise only, exercise plus 8 weeks of pain educa…

This study looks at whether combining chiropractic care with group medical visits can help adults 65 and older who have chronic spine pain. Ten participants will receive chiropractic adjustments and attend virtual group sessions. The goal is to see if this approach is practical a…

This study looks at how well spinal cord stimulation works for people with long-term pain. About 25 adults who already have a spinal cord stimulator will rate their pain with the device on and off. The goal is to see if the stimulation truly reduces pain compared to a placebo eff…

This study tests whether a stepped care approach using complementary health treatments (like mind-body therapies) can help people with both chronic pain and PTSD. About 60 adults from two primary care clinics will either receive this stepped care or their usual treatment. Researc…

This study tests an internet-based guided self-help program for adults with chronic pain. The program uses Acceptance and Commitment Therapy (ACT) to help people accept their pain and focus on living a meaningful life. Researchers will enroll 140 participants to see if the progra…

This study tests whether customizing magnetic brain stimulation to each person's brain signals can better relieve chronic pain. About 90 adults with long-term pain will receive personalized treatment based on their brain activity. The goal is to improve pain intensity and overall…

This study tests a single online class called Empowered Relief, delivered in Spanish, to help adults with chronic pain. Participants learn pain relief skills in a group video session. The goal is to see if the class reduces pain and distress and is well-liked. Researchers will fo…

This study looks at whether adding Whole Health Coaching (a program that focuses on overall well-being) to standard pain management helps veterans with chronic pain. About 432 veterans who take long-term opioids and have safety concerns will take part. The goal is to see if coach…

This study tests a small, battery-powered headband that delivers a gentle electrical stimulation to the scalp to reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is…

This study is for active-duty military members and their families who have chronic back or neck pain. It will test treatments like acupuncture, laser therapy, and shockwave therapy to see if they help reduce pain and improve quality of life. The goal is to find safer, non-drug op…

This study looks at how teenagers with chronic pain notice and understand signals from their own bodies, like heartbeat or tension. Researchers want to see if occupational therapy changes this body awareness and improves daily function. About 49 teens aged 11 to 21 will fill out …

This study looks at how Boswellia serrata, a herbal supplement used in Ayurvedic medicine, affects the way healthy people process pain. Researchers will use a capsaicin (chili pepper) cream to create temporary skin sensitivity and then measure pain responses. The goal is to under…

This study will look at anonymous medical records from up to 15,000 adults with chronic pain who have used Boston Scientific devices. The goal is to see how well different treatments relieve pain over time. No new treatments or procedures are given—researchers are just reviewing …

This study looks at how quitting smoking temporarily increases pain, especially in people with chronic pain. Researchers will use brain scans to see how withdrawal changes pain processing and whether this makes it harder to stay smoke-free. The goal is to find better ways to help…

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By applying mild stimuli, researchers hope to group patients by pain type and eventually predict who will benefit from specific treatme…

This study aims to find out why some people with sickle cell disease develop severe, disabling pain while others do not. Researchers will track 70 participants aged 15 to 40 over up to 48 months using surveys and pain tests. The goal is to improve pain management and guide future…

This study tests whether digital software that talks with patients like a conversation can effectively collect health information from people with chronic pain. Researchers want to see if patients find these tools easy and acceptable to use. The study involves 100 adults with chr…

This study looks at 200 adults with failed back surgery syndrome who have had low back pain for at least 3 months. Researchers will group their pain into three types—nerve-related, muscle-related, or other—and see how each type affects pain severity and quality of life. The goal …

This study looks at nerve-related issues like numbness, tingling, and pain in people who finished treatment for mouth or throat cancer 1 to 5 years ago. Researchers will examine 120 participants using simple touch tests and pain questionnaires to map these problems. The goal is t…

This study aims to better understand chronic pain by following 5,000 patients through a smartphone app called e-DOL. Participants will regularly report their pain, treatments, and daily experiences. The goal is to learn how pain changes over time and what factors influence it, wi…

This study checks if a computer algorithm can correctly diagnose chronic pain by comparing its results to those of pain specialists. About 200 adults with pain lasting at least one month will take part. The goal is to see how well the digital tool works, not to provide treatment.

This study follows 800 adults who spent at least 48 hours in the ICU to track how many develop ongoing pain. Researchers will call participants at 90 and 180 days after leaving the ICU to ask about pain, sleep, mood, and quality of life. A smaller group will also have a detailed …

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain. Researchers will measure certain molecules in the blood and spinal fluid of 30 adults before and after SCS to see which ones change. The goal is to learn how SCS works and find ways to m…

This study looks at how two mind-based treatments—mindfulness meditation and self-hypnosis—work in the brains of adults aged 60 and older with chronic pain. Participants will be randomly assigned to one of three groups: mindfulness, hypnosis, or story listening. The goal is to un…

This study follows 5,000 children aged 0-16 years before and after surgery to find out how many develop chronic pain and why. Parents and children fill out questionnaires at several time points over a year. The goal is to identify risk factors like anxiety or pain history so doct…

This study is testing how well a culturally tailored screening and brief intervention works for chronic pain and opioid misuse in three clinics serving American Indian and Alaska Native people. About 225 participants who have chronic pain or opioid problems will take part. The go…

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain in the back or legs. Researchers will use brain scans to understand why some types of SCS work better than others. The goal is to find out which patients are most likely to benefit and im…

This study looks at how oxytocin, a natural hormone, affects the part of the nervous system that controls rest and digestion. Researchers will measure changes in pupil size after an injection of oxytocin or a placebo. The goal is to understand how the body responds to pain, not t…

This observational study looks at why some people with knee osteoarthritis feel more pain than others, even when their knee damage looks similar. About 300 adults aged 45-80 with chronic knee pain will complete surveys, walking tests, knee X-rays and MRIs, brain scans, and sensor…

This study compares two types of pain medications (anticonvulsants and antidepressants) in 450 adults with chronic pain. The goal is to see which works better in real-world patients, including those with other health issues often excluded from traditional trials. Researchers will…

This study looks at how CPAP therapy, a common treatment for sleep apnea, affects pain in people who also have chronic pain. Researchers will follow 80 adults for 6 months, asking them about their pain levels and checking how well they use their CPAP machine. The goal is to under…

This observational study in Seoul, Korea, follows 180 adults aged 60 and older to see how everyday emotional stress impacts memory and thinking. Participants use a smartphone app and a smartwatch for two weeks, then return for check-ups at 6 months and 1 year. The goal is to find…

This study looks at how chronic pain changes the brain's reward system, which can make it harder to feel motivated or learn from rewards. Researchers will compare 50 people with chronic pain to healthy volunteers using brain scans and a learning task. The goal is to better unders…

This study explores whether a sham (fake) neurofeedback system in a virtual reality environment can change brain wave patterns related to attention. Researchers will compare real-time brain activity in 35 adults with rumination, chronic pain, or fibromyalgia under three condition…

This study is testing a new method called Pancreatic Quantitative Sensory Testing (P-QST) to see if it can predict which patients with chronic pancreatitis will have less pain after a procedure like endoscopy or surgery. About 150 adults with chronic pancreatitis and blocked panc…

This study looks at whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in daily smokers who have chronic pain and are on buprenorphine for opioid use disorder. About 60 participants will be randomly assigned to either very low nicotine or …

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain, those with opioid use, and healthy women. The goal is to find new ways to treat chronic pain withou…

This study looks at how different parts of the brain connect in people with long-term jaw pain (TMD) compared to those without pain. Researchers will use MRI scans to find patterns that may explain why pain becomes chronic. The goal is to better understand the condition, not to t…

This study is gathering information from 120 people with chronic pain to help design a new type of pain clinic. Researchers want to understand different pain types and how they affect daily life. No new treatments are being tested; the goal is to learn what a future clinic should…