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Could a diabetes drug ease stubborn tendon pain?

NCT ID NCT06100822

Symptom relief Sponsor: James Wang Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 2 times

Summary

This early study is testing whether metformin, a common diabetes medicine, can reduce pain and help heal chronic Achilles tendon problems. Forty people with long-term tendon pain will take either metformin or a placebo pill for 16 weeks, along with a home exercise program. Researchers will measure changes in pain, function, and tendon thickness using ultrasound.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Metformin (extended-release capsules)
What this could lead to
If it works, this could point toward a new, low-cost treatment for chronic tendon pain using a common diabetes drug.
What could go wrong
This is a very early phase 1 trial with only 40 people. It may show no benefit over placebo, and metformin can cause stomach upset or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

21 people

The number who actually took part.

Started

May 2024

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Willing and able to provide informed consent for participation * Clinical diagnosis of Achilles tendinopathy * Pain disability index score of between 20 - 70 points (0-100 scale VISA-A) * Sonopalpation tenderness with tendon thickening and/or loss of fibrillary architecture. * Ability to read, speak, and understand English Exclusion Criteria: * Any intervention (corticosteroids or other orthobiologic intervention as injection) to targeted tissue within the last 6 months. * Previous Achilles tendon surgery. * Known platelet abnormality or hematological disorder. * Presence of other conditions that might affect the functional scale of the indexed limb. * Unwillingness to be randomized. * Body Mass Index (BMI) greater than 30. * Occult tear in the indexed tendon. * Systemic inflammatory disease. * Use of fluoroquinolone in the past 6 months. * Subjects must not be pregnant or breastfeeding, or planning to become pregnant or breastfeed during the course of the trial * Chronic kidney disease (eGFR \<60) * Diagnosis of diabetes mellitus or elevated HbA1c at screening (\> 6.5) * Unable to take an oral medication in a non crushable pill form * Taking metformin presently or within the last 6 months * History of allergy to metformin * History of lactic acidosis or elevated lactate at screening (\> 2.2) * Severe Hepatic dysfunction * Currently taking a diabetic medication such as sitagliptin, saxagliptin, linagliptin, alogliptin, sitagliptin with metformin * Currently taking a Carbonic anhydrase inhibitor such as topiramate, zonisamide, acetazolamide, dichlorphenamide, methazolamide * Currently taking cimetidine

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome disease of the tendon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Achilles tendinopathy Chronic pain Tendinopathy

Contacts and locations

Locations

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15213, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.