Nerve block or talk therapy may prevent chronic pain in PTSD patients
NCT ID NCT05700279
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether reducing PTSD symptoms can prevent acute pain from turning into chronic pain. Researchers will give 345 adults either a nerve block injection (stellate ganglion block) or trauma-focused talk therapy (cognitive processing therapy). The goal is to see if these treatments lower pain intensity and PTSD symptoms over time.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Stellate Ganglion Block (nerve block injection) and Cognitive Processing Therapy (talk therapy)
- What this could lead to
- If it works, this could point toward a way to prevent chronic pain by treating PTSD early, reducing long-term suffering.
- What could go wrong
- This is an early-stage study with 345 participants, so results may not apply to everyone. The nerve block carries risks like injection site pain or rare complications, and talk therapy may not work for all.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 345 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2023
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 18 to 70 years 2. Ability to read and write English sufficiently to understand and complete study questionnaires and participate in interviews 3. Presenting to the Rush ED with acute pain without debilitating trauma 4. A primary acute pain site 5. Self-reported symptoms consistent with a diagnosis of PTSD 6. People with well-controlled diabetes or HIV/AIDS with chronic neuropathic pain will be included if their acute pain complaint at ED presentation is not due to neuropathic pain 7. Individuals with a history of psychotic or bipolar disorder that is currently well managed, have been treated for the condition for at least 3 months, are able to coherently answer interview questions, and are judged by study staff to be capable of participating in study 8. Current chronic illness that involves constant or frequent pain if their acute pain complaint at ED presentation is not due to the chronic illness. (case-by-case basis) 9. Current chronic pain from various sources if their acute pain complaint at ED presentation is not related to their current chronic pain. (case-by-case basis) Exclusion Criteria: 1. Pain intensity great enough to impair concentration or capacity to understand instructions or the nature of being invited into a study as assessed by a member of the medical staff 2. Any injury or illness that precludes their ability to understand or follow instructions as assessed by a member of the medical staff 3. Self-reported history of chronic pain on presentation to the ED or documented in the electronic medical record (case-by-case basis) 4. Pain from traumatic event that is the source of their PTSD 5. Neurological disorder 6. Blood pressure greater than 160/100 mmHg 7. Taking anticoagulants or antiplatelet drugs other than aspirin 8. Pregnancy 9. Current alcohol or substance dependence 10. Anything that precludes interventions from being successful. 11. We will exclude people who are being treated for chronic or significant diseases such as rheumatoid disease, current influenza that may manifest temporary flu- related pain, and heart disease.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Rush University Medical Center
RECRUITINGChicago, Illinois, 60612, United States
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