Zapping away shingles pain: new trial tests pulsed radiofrequency
NCT ID NCT07390279
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a noninvasive procedure called transcutaneous pulsed radiofrequency can reduce chronic pain from postherpetic neuralgia, a complication of shingles. The procedure delivers electrical pulses through electrodes placed on the skin over the painful area. Researchers will enroll 35 adults with this condition to measure changes in pain intensity and nerve pain symptoms.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Transcutaneous pulsed radiofrequency (a noninvasive procedure using electrical pulses over the painful area)
- What this could lead to
- If it works, this could offer a new, noninvasive option to reduce chronic pain from shingles without drugs or injections.
- What could go wrong
- This is a small, early-stage trial with only 35 people, so results may not apply to everyone. The procedure may not provide lasting pain relief.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 35 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study will be conducted at the Algology Department of Istanbul Cemil Taşcıoğlu City Hospital, following approval by the institutional ethics committee, and will include patients aged 18 years and older diagnosed with postherpetic neuralgia (PHN) who are scheduled to receive transcutaneous pulsed radiofrequency (TCPRF) treatment in three sessions. Within the scope of the study, the following data will be recorded: age, sex, body mass index (BMI), side of the procedure, history of herpes zoster vaccination (live or recombinant), family history of herpes zoster, immunosuppression status (e.g., HIV infection, malignancy, steroid use), duration of symptoms, dermatome treated with TCPRF, TCPRF-related complications and adverse effects, Visual Analog Scale (VAS) scores, neuropathic pain assessment using the Douleur Neuropathique 4 (DN4) questionnaire, and health-related quality of life assessed using the Short Form-12 (SF-12).
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Diagnosis of postherpetic neuralgia (PHN) * No invasive or noninvasive treatment related to PHN (e.g., capsaicin, lidocaine patches) within the past 3 months * Provision of written informed consent Exclusion Criteria: * Patients with a cardiac pacemaker * Known allergy to transcutaneous electrode pads * Active skin infection at the pad application site * Presence of a metallic implant in the treatment area * Circulatory disorders or skin lesions at the treatment site * Inability to maintain appropriate positioning * Inability to communicate effectively * Presence of psychosis or progressive neurological deficits * Pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Istanbul Prof. Dr. Cemil Taşcioğlu City Hospital
RECRUITINGIstanbul, Istanbul, 34000, Turkey (Türkiye)
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