CHRONIC PAIN

This study tested a new method for starting buprenorphine (a medication for opioid use disorder) that avoids the usual withdrawal symptoms. Instead of stopping all opioids first, patients started with very low doses of buprenorphine while still taking their regular opioids. The s…

This study looked at whether adding guanfacine (a blood pressure medication) to morphine could reduce pain sensitivity and tolerance in people with chronic neck or back pain. It involved 137 adults who had not taken opioids recently. The study was terminated early, so results are…

This study looked at whether buprenorphine can safely control chronic pain in people who are dependent on opioid painkillers, while also preventing withdrawal symptoms. Only 4 people were enrolled before the study was stopped early. The goal was to see if buprenorphine could impr…

This study compared a 6-week digital home exercise program (SimpleTherapy) to standard physical therapy for people with chronic knee osteoarthritis pain. Researchers wanted to see if the home program was just as effective. The study enrolled 32 adults with knee OA and chronic pai…

This small study looked at whether adding guanfacine to opioid painkillers could reduce the extra pain sensitivity that sometimes develops with long-term opioid use. It involved 8 adults with chronic neck or back pain who were already taking opioids. The study was stopped early, …

This study looked at whether people with chronic pain who have strong negative thoughts about their pain (called pain catastrophizing) also have stronger cravings for their opioid medications. Researchers measured cravings, stress hormones, and mood in 93 adults. The goal was to …

This study aimed to find out how many people experience short-term and long-term pain after a specific type of heart surgery called hybrid arrhythmia ablation. Researchers contacted patients who had the surgery at least three months earlier and asked them to fill out a survey abo…

This early-stage study aimed to find a safe dose of Kindolor Tosylate, a potential pain treatment, in 16 healthy adults. Participants received either the drug or a placebo and were monitored for side effects and how the body processes the drug. The study was terminated early, so …

This study aimed to understand how paresthesia-free spinal cord stimulation (PF-SCS) relieves chronic pain and affects sensation. Researchers planned to enroll 10 adults already using PF-SCS for chronic pain. The study was terminated early, so results are limited.