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Can imagining future events and brain zaps ease pain and cravings?

NCT ID NCT05901610

Knowledge-focused Sponsor: Kirstin M Gatchalian Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 2 times

Summary

This study looks at whether imagining positive future events (Episodic Future Thinking) and using low-intensity focused ultrasound on the brain can help people with both chronic pain and alcohol use disorder. Ten adults will try these interventions and report changes in pain, cravings, and decision-making. The goal is to understand how these approaches might influence behavior and pain perception.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Episodic Future Thinking (behavioral) and Low-intensity Focused Ultrasound (device)
What this could lead to
If successful, this could point toward new ways to help people with chronic pain and alcohol use disorder manage their conditions by changing how they think about the future.
What could go wrong
This is a very small, early study (10 people) that is currently suspended. It tests short-term effects only, so results may not lead to a real treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

4 people

The number who actually took part.

Started

Jun 2024

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 21 years old or older 2. Report chronic pain 3. Have sufficiently stable self-reported mental and physical health in order to complete the survey 4. Meet DSM-V clinical criteria for alcohol use disorder (i.e., four or more criteria) 5. Not have unmanaged medical or psychiatric conditions the survey Exclusion Criteria: 1. Claustrophobia (scanning environment may be uncomfortable) 2. Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants. 3. Contraindications to CT: pregnancy 4. Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's) 5. History of neurologic disorder (e.g. Parkinson's, Epilepsy, or Essential Tremor) 6. History of head injury resulting in loss of consciousness for \>10 minutes 7. Failure to provide a Social Security Number or Tax ID number. This is required for tax purposes.

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Conditions

The condition(s) this trial relates to.

alcohol abuse Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alcohol use disorder Chronic pain

Contacts and locations

Locations

  • Fralin Biomedical Research Institute at VTC

    Roanoke, Virginia, 24016, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.