ALCOHOL USE DISORDER

This study tests whether tirzepatide (Mounjaro), a drug used for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. Researchers will give 108 participants either tirzepatide or a placebo for 16 weeks and track changes in heavy drink…

This Phase 2 trial tests whether the hormone pregnenolone can help people with alcohol use disorder drink less heavily. 150 adults aged 18-70 will take either 300 mg of pregnenolone or a placebo daily for 12 weeks. The main goal is to see if more people in the pregnenolone group …

This study tests whether a single dose of psilocybin or ketamine, combined with talk therapy, can help people with alcohol use disorder drink less. Eighty adults with moderate to severe alcohol problems will receive either 30 mg of psilocybin or a weight-based dose of ketamine, a…

This early-phase study tests whether spironolactone, a drug currently used for high blood pressure and heart failure, can be safely used in people with alcohol use disorder. Twenty participants will each stay at a clinic four times, taking either the drug or a placebo for five da…

This study is testing whether a computer-delivered therapy program can help people who have both an anxiety disorder and alcohol use disorder. Participants will use an online program that teaches skills like breathing control and problem solving to break the cycle of anxiety and …

This study tests a computer-based training program designed to change the automatic urge to approach alcohol in people being treated for alcohol use disorder. 112 participants will be randomly assigned to one of three versions of the training, including a sham version. The goal i…

This study tests whether a smartphone app called Connections can help people with alcohol-related liver disease stop drinking. About 298 participants from two medical centers will use the app along with their usual care, or just receive usual care alone. The goal is to see if the…

This study tests whether combining a gentle brain stimulation technique called tDCS with computer-based cognitive training can help people with alcohol use disorder stay abstinent. Forty participants who are already in a treatment program will receive 10 sessions of either active…

This study is testing whether cannabidiol (CBD) can help people who drink alcohol regularly cut down on their drinking. Researchers are giving 150 adults either full-spectrum CBD, broad-spectrum CBD, or a placebo daily for 12 weeks. They will measure how much participants drink i…

This study tests whether suvorexant, a drug used for insomnia, can help people with alcohol use disorder drink less. About 250 adults who want to cut back on alcohol will take the drug or a placebo nightly for 8 weeks. Researchers will track drinking habits, stress responses, and…

This study tests a computer-based training called Approach Avoidance Training (AAT) for veterans with alcohol use disorder. The training aims to change automatic urges to approach alcohol, helping veterans drink less and recover from alcohol-related problems in work, home, and so…

This study is testing a treatment called IR-TMS, which uses magnetic pulses to target specific brain areas, to see if it can help people with Alcohol Use Disorder drink less. About 150 adults who drink heavily will receive several sessions of this treatment, along with brain scan…

This study tests whether combining fMRI neurofeedback (brain activity training) and TMS (magnetic brain stimulation) can help people with alcohol use disorder drink less and feel fewer cravings. About 90 adults aged 19-65 who are already in treatment will attend weekly sessions f…

This study tests an adaptive web-based program called Partners Connect for military couples. It aims to reduce drinking in concerned partners and encourage service members to seek help for alcohol use. About 744 couples will participate, comparing the online program to standard w…

This study tests whether a modified ketogenic (low-carb, high-fat) diet can help people with alcohol use disorder drink less. Fifty adults who have recently had alcohol will follow the diet for a period, and researchers will measure their drinking levels and cravings. The goal is…

This phase 3 study tests whether brenipatide, an injectable drug, can help adults with moderate-to-severe alcohol use disorder drink less and feel less craving. About 1100 participants will receive either brenipatide or a placebo for 56 weeks. The study tracks changes in drinking…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with therapy can change brain activity and reduce drinking in people with alcohol use disorder. Two hundred participants will receive either psilocybin or a placebo, plus supp…

This study compares an app-based brief intervention to traditional in-person counseling for people with unhealthy alcohol use. About 1,200 adults in Mexico and South Africa who screen positive for risky drinking will receive either the app or a face-to-face session. Researchers w…

This study tests whether offering specialized alcohol use disorder treatment right in the liver clinic helps people newly diagnosed with alcohol-related liver disease stop drinking. About 221 participants will either get this offer plus standard care, or standard care alone. The …

This early-phase study tests whether suvorexant, a drug currently used for insomnia, can reduce people's motivation to drink alcohol. Researchers will give 30 adults with moderate-to-severe Alcohol Use Disorder either suvorexant or a placebo, then measure how often they choose al…

This study is testing a new drug called CMND-100 (MEAI) in healthy volunteers and people with alcohol use disorder. The goal is to find a safe dose and see if it can reduce drinking and cravings. The trial is currently recruiting 84 participants.

This study tests whether MDMA-assisted therapy can help veterans with both PTSD and alcohol use disorder. Eighty veterans will receive either a full dose of MDMA or a low-dose placebo during three therapy sessions. Researchers will measure changes in PTSD symptoms and drinking ha…

This study tests whether tirzepatide, a drug approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. 120 adults will receive weekly injections of tirzepatide or a placebo for 12 weeks. Researchers wi…

This study tests a new telehealth program called B-FIT, which adds a family member or friend to standard therapy for veterans with alcohol use disorder. The goal is to see if involving a loved one helps veterans drink less and improve family relationships. About 400 veterans and …

This study tests a device that uses magnetic pulses to stimulate the brain (Deep TMS) to help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will get either real or fake (sham) treatment over several weeks. The goal is to see if the re…

This study tests whether a drug called donepezil, combined with cognitive training (brain exercises), can help people with alcohol use disorder drink less heavily. Researchers will compare this combo to a placebo in 160 adults aged 18-80. The goal is to see if the treatment reduc…

This study tests an experimental medicine called brenipatide to see if it helps adults with alcohol use disorder drink less and reduce cravings. About 1,100 participants will receive either the drug or a placebo by injection for nearly a year. The goal is to find a safe, effectiv…

This study tests whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) for 6 months can help people with alcohol use disorder reduce heavy drinking and improve liver health. Researchers will compare the probiotic to a placebo in 60 adults who drink heavily. The goal …

This study tests whether the drug apremilast can help people with alcohol use disorder drink less. About 80 adults aged 21-65 will receive either apremilast or a placebo, and researchers will measure how much alcohol they consume during a lab drinking session. The goal is to see …

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from a Johns Hopkins HIV clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and drink le…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with alcohol use disorder drink less. About 80 adults will receive either the drug or a placebo shot weekly for 5 months. Researchers will measure changes in drinking, brain activity, …

This study is testing a medication called brexpiprazole to see if it can help people with alcohol use disorder drink less. Researchers want to know if a person's genes affect how well the drug works. The study involves 250 adults who are not currently seeking treatment for their …

This study tests whether the drug apremilast can reduce cravings for alcohol in people with moderate to severe alcohol use disorder. About 100 adults who want to cut back or quit drinking will take either a low or high dose of apremilast or a placebo daily for two weeks. Research…

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce heavy drinking and the brain's response to alcohol-related images. About 86 adults with alcohol use disorder will receive either real or fake TBS over the fron…

This study tests a new therapy called InTEGRA that combines 12-step support with motivational counseling to help teens aged 14-21 reduce alcohol and cannabis use. About 294 teens will be randomly assigned to InTEGRA or standard therapy. The goal is to see if InTEGRA leads to more…

This study tests whether guanfacine, a drug used for high blood pressure, can help 200 adults with moderate to severe alcohol use disorder drink less. Participants take the drug or a placebo for 12 weeks and report their drinking, stress, and cravings through a smartphone app and…

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes and weight loss, can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking. About 42 participants will receive either the drug or a placebo for 8 weeks. The main g…

This study tests whether deep brain stimulation (DBS) can safely help people with severe alcohol use disorder who haven't gotten better with standard treatments. DBS uses small electrical signals to change activity in brain areas linked to craving and self-control. The study will…

This early-stage study tests an experimental drug called NTX-2001 in 50 adults with Alcohol Use Disorder. Participants take the drug or a placebo daily for two weeks to see if it reduces alcohol consumption and is safe. The goal is to find a new treatment option for people who st…

This study looks at whether having regular motivational conversations after leaving the hospital for alcohol withdrawal can help people stay sober longer. About 104 adults who want to quit drinking completely will be split into two groups: one gets standard care, the other also g…

This pilot study at the University of Michigan will test whether short, regular sessions of virtual reality nature immersion can reduce depression, anxiety, and stress in adults with alcohol use disorder. Fifty participants in an intensive outpatient program will either receive s…

This study looks at whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study involves …

This study explores whether adding Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for 30 adults who have both alcohol use disorder and treatment-resistant depression. Participants will receive weekly ketamine infusions and ACT sessions for 8 weeks. The…

This study tests whether a non-invasive device that gently stimulates the vagus nerve can reduce withdrawal symptoms, anxiety, and cravings in 80 veterans with moderate-to-severe alcohol use disorder. Participants will receive the stimulation and complete questionnaires and a bra…

This study tests a small device worn on the ear that sends mild electrical pulses to nerves, aiming to ease alcohol withdrawal symptoms and reduce cravings. Twenty adults with alcohol use disorder will wear the device for 5 days during detox. Half get the real device, half get a …

This study tests whether adding cognitive processing therapy (CPT) to standard relapse prevention (RP) helps people with both PTSD and alcohol use disorder more than RP alone. About 200 adults with moderate to severe alcohol use disorder and current PTSD will receive either CPT+R…

This study tests whether a short, four-session therapy program that helps people rethink their identity and memories related to drinking can reduce alcohol use and cravings. Sixty adults with alcohol use disorder will be randomly assigned to either receive this therapy plus usual…

This study looks at how the drug acamprosate affects brain function in people with moderate to severe alcohol use disorder. Researchers will use EEG to measure brain waves in 48 adults who stay in the clinic for about 3 weeks. Half get acamprosate, half get a placebo, and brain a…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This study tests whether a supervised exercise program can improve sleep quality in people with alcohol use disorder. Researchers will enroll 40 adults who have sleep problems and drink heavily. Participants will attend exercise sessions and track their sleep using diaries and wr…

This study looks at whether a special ketone drink can change how the brain responds to alcohol cues and reduce the urge to drink in people with alcohol use disorder. Twenty adults who drink heavily but are not seeking treatment will take part. On two separate days, they will dri…

This study tests a digital program called RITch®CBT that uses an avatar to guide men through cognitive behavioral therapy for addiction. The goal is to reduce cravings and substance use while also addressing relationship conflict. Forty men entering addiction treatment will use t…

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery for people with opioid or alcohol use disorder. Sixty adults in an intensive outpatient program will receive TMS alongside standard treatment. Researchers will measure changes in c…

This study tests whether a single dose of insulin given as a nasal spray can reduce cravings and the effects of alcohol in people with alcohol use disorder. Forty non-treatment-seeking adults will receive either insulin or a placebo spray, then be exposed to alcohol-related cues …

This study tests whether a ketone supplement drink can reduce alcohol withdrawal symptoms in 30 adults with moderate to severe alcohol use disorder during a 4-day hospital detox. Participants will receive either the ketone drink or a placebo, and researchers will measure how much…

This study looks at how stress and oral health habits relate to inflammation in people with alcohol use disorder (AUD). Researchers will test a new questionnaire about oral care and collect saliva, blood, and dental X-rays from 72 participants (AUD patients and healthy volunteers…

This study looks at how impulsivity and the way young adults feel when drinking alcohol are connected. Researchers will give alcohol or a placebo to 250 people aged 21–25 and track their reactions in the lab and daily life. The goal is to find new targets for preventing alcohol u…

This study looks at whether having a peer recovery specialist in the emergency department helps people with substance use disorders get into treatment and stay connected to support. Researchers will follow 400 adults who visit the ER for substance-related issues, comparing those …

This study looks at why young adults with bipolar disorder are much more likely to develop alcohol use disorders. Researchers will give participants alcohol or a placebo and use brain scans to track changes over two years. The goal is to find early warning signs that could lead t…

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will collect blood samples and mental health surveys from 500 adults at a psychiatric clinic. The goal …

This study looks at 350 hospitalized patients with alcohol use disorder to find out what makes someone more likely to relapse after detox. Researchers will group patients by shared traits and test a feedback system that shows test results to patients and doctors. The goal is to l…

This study looks at how drinking problems and posttraumatic stress disorder (PTSD) together may lead to violence between partners. Researchers will observe 70 couples in a lab and track their daily experiences for 28 days. The goal is to better understand these connections, not t…

This study looks at why people aged 21 to 65 with alcohol use disorder feel motivated to drink alcohol. Researchers will ask participants about their mood, habits, and thinking, and then give them alcohol through an IV while they press a button for more doses. The goal is to unde…

This study tests a new program to help liver doctors provide medications and counseling for alcohol use disorder. The program includes education for doctors and patients, plus tools to support decision-making. Researchers will enroll 30 clinicians to see if the program is feasibl…

This study looks at whether federal policy changes made during the COVID-19 pandemic helped more veterans get and stay on medication for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data …

This study looks at medical records of 20 adults who had bariatric surgery and later received treatment for alcohol use disorder. Researchers want to understand if and how the surgery was considered during addiction follow-up. The goal is to improve care for patients with both co…

This study is testing whether a smartphone app can help people in Michigan on Medicaid who are recovering from both opioid and alcohol use disorders. The app uses rewards to encourage healthy behaviors. Researchers want to see if people find the app useful and easy to use, and if…

This study looks at why alcohol use disorder is increasing faster in women than men. Researchers will measure brain activity, hormone levels, and drinking behavior in 100 adults to find sex-specific risk factors. The goal is to create better prevention and treatment strategies ta…

This study looks at how severe alcohol use disorder changes the brain's ability to understand emotions and social cues. Researchers will use brain scans and tests to compare 60 people with the disorder to healthy volunteers. The goal is to learn how these brain changes affect dai…

This study looks at how alcohol use disorder (AUD) changes a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to better understand these sensory changes, not to tes…

This study looks at how different activities and environments influence drinking habits and mental health in people with alcohol use disorder. About 44 adults will try virtual reality, games, or videos, then answer questions about cravings and alcohol use. The goal is to gather i…

This study looks at why people with alcohol use disorder feel anxious when they stop drinking. Researchers will use brain scans to compare people with AUD who take a medication to stay sober and healthy volunteers. The goal is to understand how anxiety changes over time during ab…

This study is testing whether a short, tailored alcohol intervention is practical and well-liked by people who are taking buprenorphine for opioid use and also drink alcohol. About 60 adults will take part. The goal is to see if this approach could work in a larger future study.

This study screens up to 10,000 adults aged 18-99 who have current, past, or no substance or alcohol use disorders. Participants undergo one visit with tests like physical exams, blood work, memory tests, and mental health evaluations. The goal is to find eligible volunteers for …

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with and without alcohol use disorders. Researchers will use MRI scans to see how the brain works during these tasks. The goal is to develop better tools for future st…

This study follows up to 7,500 adults with or without alcohol use disorder to learn more about the condition. Researchers will collect health information, blood samples, and brain scans to better understand the biology and genetics behind alcohol problems. The goal is to improve …

This study looks at how men and women react differently to two weeks of not drinking alcohol. Researchers will measure alcohol intake, brain responses, and personal feelings after the break. The goal is to use this information to create better ways to prevent and treat alcohol us…

This early study is testing whether low-intensity focused ultrasound (LIFU) can safely change brain activity in people with alcohol use disorder. Researchers will scan participants' brains to see how reward centers respond to alcohol-related cues before and after the ultrasound. …

This study looks at how sleep patterns and stressful events influence alcohol use in young adults aged 18-24 who are heavy drinkers. Researchers will track sleep, brain activity, and stress responses to understand why some people drink more. The goal is to use this knowledge to c…

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future…

This study looks at a brain protein called PDE4B in people with alcohol use disorder. Researchers want to see if levels of this protein change during alcohol withdrawal and after a few weeks of not drinking. The study involves 30 adults who will have two PET brain scans and possi…

This study looks at 400 people with alcohol or cannabis use disorders to understand how their thinking, motivation, and emotions affect their recovery. Participants will have detailed assessments and then take part in a 12-week talk therapy program. The goal is to learn which tra…

This small study is testing a new version of a counseling program called DeafMET, designed specifically for Deaf adults who use American Sign Language and have risky drinking habits. The goal is to see if the program is practical and helpful in motivating people to change their d…