ALCOHOL USE DISORDER

This study tests whether combining a gentle brain stimulation technique (tDCS) with cognitive training can improve thinking skills and help people with alcohol use disorder avoid relapse. About 40 adults who are already abstinent will receive the paired treatment and be followed …

This study tests whether apremilast, a drug already used for other conditions, can help reduce alcohol cravings in people with moderate to severe alcohol use disorder. About 100 adults seeking treatment will receive one of two doses of the drug or a placebo for several weeks. The…

This study tests whether offering specialized alcohol treatment right in the liver clinic helps people newly diagnosed with alcohol-related liver disease stop drinking. About 221 adults will be randomly assigned to either get the alcohol treatment offer or standard care. The main…

This early-stage study tests a new drug called NTX-2001 in 50 adults with Alcohol Use Disorder. Participants take the drug or a placebo daily for two weeks to see if it reduces alcohol consumption and is safe. The goal is to find a new treatment option for people who struggle wit…

This study is testing whether full-spectrum cannabidiol (CBD) can help people who drink alcohol regularly cut down on their drinking. Researchers will measure how much alcohol participants choose to drink in a lab setting and track their drinking habits over 12 weeks. The study i…

This study tests a short, computer-based relapse prevention program for 150 adults with HIV and alcohol use disorder. Participants will receive two sessions designed to help them avoid returning to risky drinking. The goal is to see if the program helps people stay alcohol-free l…

This study tests whether a smartphone app (CHESS Health Connections) helps people with alcohol-related liver disease stop drinking. About 298 participants will use the app alongside usual care for up to 6 months. The goal is to see if the app increases days without alcohol and re…

This study tests whether a modified ketogenic (low-carb, high-fat) diet can help people with alcohol use disorder reduce their drinking. Fifty adults with the condition will follow the diet and be monitored for up to 72 hours after their last drink. Researchers will track diet ad…

This study is testing whether a medication called donepezil, combined with cognitive training (brain exercises), can help people with alcohol use disorder drink less heavily. The study involves 160 adults who currently have heavy drinking days. Participants will receive either th…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can safely help people with alcohol use disorder drink less. About 67 adults will receive weekly shots of either semaglutide or a placebo for 20 weeks, along with behavioral therapy and brain scans. T…

This study tests whether a natural hormone called pregnenolone can help people with alcohol use disorder drink less. About 150 adults who drink heavily at least 3 times a week will take either pregnenolone or a placebo daily for 12 weeks. Researchers will track heavy drinking day…

This study tests whether tirzepatide, a drug approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. About 120 adults aged 21 and older will receive weekly injections of tirzepatide or a placebo for …

This study tests a brief family-involved treatment (B-FIT) delivered via telehealth for veterans with alcohol use disorder. About 400 veterans and a family member or friend will take part. The goal is to see if adding B-FIT to standard therapy helps reduce drinking and improve fa…

This study tests whether guanfacine, a drug used for high blood pressure, can help 200 adults with moderate to severe alcohol use disorder drink less. Participants take the drug or a placebo for 12 weeks and report their drinking, stress, and cravings through a smartphone app and…

This study tests a new medicine called brenipatide to see if it helps people with moderate-to-severe alcohol use disorder drink less and reduce cravings. About 1,100 adults who want to cut down or stop drinking will receive either the drug or a placebo for 56 weeks. The main goal…

This study tests a computer training program designed to change unconscious habits that may keep alcohol use disorder going. Researchers will compare a standard version of the training, an enhanced version that adds a planning strategy, and a fake version. 112 adults receiving ca…

This study tests whether suvorexant, a drug used for insomnia, can help people with alcohol use disorder drink less. 250 adults who want to cut back on alcohol will take either suvorexant or a placebo nightly for 8 weeks. Researchers will track heavy drinking days, cravings, and …

This study tests a new treatment called IR-TMS, which uses magnetic fields to target specific brain areas, to see if it can help people with alcohol use disorder drink less. About 150 participants will receive a few sessions of this brain stimulation, along with brain scans and b…

This study tests whether combining fMRI neurofeedback and TMS can help people being treated for alcohol use disorder drink less and feel fewer cravings. Over 4 weekly sessions, participants receive brain stimulation or MRI-based feedback, then are followed for up to 12 months. Th…

This study tests whether citicoline, an over-the-counter supplement, can reduce brain inflammation and improve thinking in teens and young adults (ages 16-22) who drink alcohol. Participants will take either citicoline or a placebo for a period, and researchers will measure immun…

This study tests a medicine called brenipatide to see if it helps adults with alcohol use disorder drink less and reduce cravings. About 1,100 people will take either the drug or a placebo for 56 weeks. The goal is to find a safe, effective treatment to help people cut down or st…

This study tests whether tirzepatide, a drug used for diabetes and obesity, can reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. About 108 participants will receive either tirzepatide or a placebo for 16 weeks. Researchers will also use brain …

This study tests spironolactone, a drug used for high blood pressure, in 20 adults with alcohol use disorder. Participants stay at a clinic for four week-long visits, taking the drug or a placebo, then drinking alcohol under observation. The goal is to see how the body processes …

This study is for people who have both an anxiety disorder and an alcohol use disorder. It tests whether a computer-based therapy can help reduce heavy drinking and improve anxiety symptoms. The program is designed to be easy to access and use, potentially helping many more peopl…

This study tests whether combining two types of therapy—cognitive processing therapy (CPT) for PTSD and relapse prevention (RP) for alcohol use—works better than relapse prevention alone. Researchers will enroll 200 adults with both PTSD and alcohol use disorder to see if the com…

This study tests a device that gently stimulates a nerve in the ear to help people going through alcohol withdrawal. Twenty adults with alcohol use disorder will wear the device for 5 days during detox. The goal is to see if it reduces withdrawal symptoms, cravings, and the need …

This study is testing whether a supervised physical activity program can help people with alcohol use disorder sleep better. Researchers will enroll 40 adults who have trouble sleeping and drink heavily. Participants will take part in exercise sessions and track their sleep using…

This study tests a non-invasive device that stimulates the vagus nerve to help veterans with alcohol use disorder. The goal is to reduce withdrawal-related distress, cravings, and improve quality of life. Eighty veterans will receive the stimulation and be monitored for changes i…

This study tests whether a single dose of a ketone ester drink can lower alcohol cravings and drinking in 20 adults with alcohol use disorder who are not seeking treatment. Participants will have two separate test days: one with the ketone drink and one with a placebo. Researcher…

This study tests whether a single dose of insulin given as a nasal spray can reduce cravings and the effects of alcohol in people with alcohol use disorder. Forty non-treatment-seeking adults will receive either insulin or a placebo and then be exposed to alcohol-related cues and…

This study tests whether immersive virtual reality (VR) nature experiences can reduce depression, anxiety, and stress in 50 adults with alcohol use disorder who are in an intensive outpatient program. Participants will either receive standard care or add VR nature sessions. The g…

This study looks at how the drug acamprosate affects brain function in people with moderate to severe alcohol use disorder. Researchers will use EEG to measure brain activity in 48 adults aged 21-65 who stay in the clinic for about 3 weeks. Half get acamprosate, half get a placeb…

This early-phase study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (including retinitis pigmentosa, Stargardt disease, and dry age-related macular degeneration). Researchers believe the drug may…

This study tests a cognitive behavioral therapy group designed specifically for women veterans who have alcohol use disorder or risky drinking habits. The goal is to see if this tailored approach helps reduce drinking and improve overall well-being. Researchers will enroll 162 wo…

This study tests whether a weekly injection of tirzepatide can reduce heavy drinking and improve health in 42 adults who have both alcohol use disorder and overweight or obesity. Participants will receive either the drug or a placebo for 8 weeks. The main goal is to see if the dr…

This study looks at how impulsivity and the way young adults feel when drinking alcohol are connected. Researchers will track 250 people aged 21-25 who drink regularly, using lab tests and daily surveys. The goal is to find new ways to prevent and treat alcohol use disorder by ta…

This study screens up to 10,000 adults aged 18-99, with or without substance or alcohol use disorders, to find eligible participants for future NIDA research. The goal is to understand why people use drugs, stop, or never start, and to develop better treatments. Participants unde…

This study tests a web-based program called Partners Connect for military couples where one partner drinks too much. The goal is to see if the program helps the drinking partner cut back and encourages the service member to seek help. About 744 couples will participate, and resea…

This study looks at whether having a trained peer recovery specialist in the emergency room helps people with substance use disorders connect to treatment and support. About 400 adults who visit the ER for substance-related issues will be followed for 6 months. Researchers will c…

This study looks at medical records of 20 adults who had bariatric surgery and later received treatment for alcohol use disorder. Researchers want to understand how the surgery was considered during addiction follow-up. The goal is to improve care for patients with both condition…

This study looks at why young adults with bipolar disorder are more likely to develop alcohol use disorders. Researchers will use brain scans and alcohol response tests to track changes over two years in 100 people aged 21-26, half with bipolar disorder and half without. The goal…

This study looks at how heavy drinking and posttraumatic stress disorder (PTSD) together may lead to violence between partners. Researchers will observe 70 couples in a lab and track their daily experiences for 28 days using phone surveys. The goal is to better understand these c…

This study looks at how thinking skills, reward processing, and negative emotions contribute to alcohol and cannabis use disorders. Researchers will assess 400 adults before and after a 12-week talk therapy program. The goal is to better understand these conditions and improve tr…

This study looks at why women are developing alcohol use disorder (AUD) faster than men. Researchers will measure brain activity and hormone levels in 100 adults who drink regularly. The goal is to find sex-specific risk factors to create better prevention and treatment strategie…

This study looks at how men and women react differently when they stop drinking alcohol for two weeks. Researchers will measure alcohol intake, brain responses, and personal feelings to see if these differences can help create better ways to prevent or treat alcohol use disorder.…

This study looks at how sleep patterns and stressful life events influence alcohol use in young adults aged 18-24 who are heavy drinkers. Researchers will track sleep, brain activity, and stress responses to understand these connections. The goal is to use this knowledge to creat…

This study looks at how alcohol use disorder (AUD) may change a person's sense of taste and smell. Researchers will compare 475 adults aged 18 to 65 with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to understand the link between al…

This study follows up to 7,500 adults with and without alcohol use disorder to collect health, genetic, and brain imaging data. It aims to better understand the condition and identify participants for future treatment studies. Participants may join as healthy volunteers, those no…