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Brain zaps and booze: new study probes TMS effects on alcohol addiction

NCT ID NCT06770556

Knowledge-focused Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 18, 2026 · Updated 2 times

Summary

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future research on TMS as a potential treatment for alcohol use disorder. Ten adults will participate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

5 people

The number who actually took part.

Started

Mar 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria non-AUD Participants: * Diagnostic and Statistical Manual of Mental Disorders (DSM-5) score for AUD = 0 * Alcohol Use Disorders Identification Test (AUDIT) score ≤ 7 * Is not a heavy alcohol consumer Inclusion Criteria AUD Participants: * DSM-5 score for AUD ≥ 3 * AUDIT score ≥ 8 * Is a heavy alcohol consumer Exclusion Criteria: * Current substance use disorder other than alcohol use disorder and/or frequent use of non-prescribed psychoactive substances. * Current serious psychiatric disorder, and/or any history of a psychotic disorder * Any health problem that would interfere with the study or could be aggravated by study procedures (e.g., history of migraines, claustrophobia). * Is currently taking or initiates a medication known to affect alcohol intake and/or craving. * History of traumatic brain injury resulting in hospitalization, loss of consciousness, and/or having ever been informed he/she has an epidural, subdural, or subarachnoid hemorrhage. * Does not meet safety criteria for TMS or MRI. * Females of childbearing potential who are pregnant (by urine HCG), planning to become pregnant, nursing, or who are not using a reliable form of birth control. * Is at an elevated risk of seizure (i.e. has a history of seizures, is currently prescribed medications known to lower seizure threshold and has had a change in their medication). * Clinical Intake Withdrawal Assessment (CIWA\>5) (to prevent delivering TMS to individuals in withdrawal). * Not able to read and understand questionnaires, assessments, and/or the informed consent.

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Conditions

The condition(s) this trial relates to.

alcohol abuse alcohol dependence Alcohol Drinking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alcohol consumption Alcohol dependence Alcohol use disorder

Contacts and locations

Locations

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.