ALCOHOL DEPENDENCE

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. About 108 participants will receive either the drug or a placebo for 16 weeks, and researchers will track thei…

This study tests whether psilocybin or ketamine, given alongside therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least 4 heavy drinking days per month will receive either psilocybin or ketamine in a double-blind setup. R…

This study tests a non-invasive brain stimulation device called Deep TMS to see if it can help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will either get real or fake (sham) stimulation over several weeks. The main goal is to see i…

This study tests a non-invasive brain stimulation technique called theta burst stimulation to help people with alcohol addiction reduce cravings and avoid relapse. Seventy-two adults who want to cut back or stop drinking will receive either real or placebo stimulation. The goal i…

This early-stage study tests two new long-acting injections, IVL3004 and IVL4002, in 40 healthy men aged 18-55. The goal is to see how the body processes these drugs compared to the approved medication Vivitrol, and to check for safety. If successful, these injections could offer…

This study tests whether a gentle nerve stimulation technique (tVNS) can make mindfulness training more effective at preventing relapse in people recovering from alcohol dependence. 140 detoxified patients will practice mindfulness with or without the stimulation. Researchers wil…

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in people who drink heavily and those who don't. Researchers will use a special brain scanner (MEG) to measure these effects in 10 adults. The goal is to gather early data to plan larger studie…

This study tests whether adding realistic smells to virtual reality (VR) scenes is a safe and acceptable way to study alcohol cravings in people with alcohol dependence. Researchers will have 20 participants experience VR environments with alcohol-related scents and measure their…

This study looks at how stress and mouth inflammation are linked in people with alcohol use disorder (AUD). Researchers will test a new oral health questionnaire and collect saliva, blood, and dental X-rays from 72 participants (AUD patients and healthy volunteers). The goal is t…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. About 1,000 adults aged 18 and older will participate in a single visit. No trea…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorder and healthy volunteers. Participants will complete tasks either inside or outside an MRI scanner to see how the brain works. The goal is to d…