Wake Forest University Health Sciences

This study is testing an experimental fertility procedure called Round Spermatid Injection (ROSI) for couples where the male partner produces no mature sperm. Researchers will collect very early sperm cells from the man's testicles and inject them into the female partner's eggs, …

This study compares two radiation methods for patients whose cancer has spread to the brain and who are receiving immunotherapy. Researchers want to see if spreading radiation over several days causes fewer side effects than giving it all at once. The trial will enroll 244 adults…

This study is testing whether injecting tiny pieces of a patient's own muscle tissue can help repair and strengthen the anal sphincter muscle in people with fecal incontinence. Researchers hope these muscle fragments will grow and connect with existing nerves and blood vessels to…

This study compares two surgical methods for treating high-grade vulvar dysplasia, a precancerous condition. Researchers want to see if a technique called 'Frozen-Section Directed Excision' removes abnormal tissue more completely than the current standard surgery. The study will …

This study tests whether high-dose methotrexate given through an IV can help patients with breast cancer that has spread to the membranes surrounding the brain and spinal cord. Researchers want to see if this treatment helps patients live longer than 12 weeks and measures how wel…

This study aims to understand how not having reliable access to food affects the health of people living with HIV, especially their risk for heart and metabolic problems like diabetes. Researchers will test a new bilingual program that uses peer support and mobile phone technolog…

This study is testing whether giving two different chemotherapy regimens in sequence—first Gemcitabine-Abraxane, then mFOLFIRINOX—can better shrink pancreatic tumors that are difficult or impossible to remove with surgery. The goal is to see if this approach makes successful surg…

This study aims to find the best way to restore vaccine protection in children who have finished cancer treatment. It compares giving a single booster shot versus restarting a full vaccine series. The goal is to help these young survivors rebuild their immune defenses against ser…

This study is for people with head and neck cancer who start radiation therapy more than six weeks after surgery. Researchers want to see if getting radiation six days a week is better at preventing the cancer from coming back than the standard five days a week. The trial will en…

This study is testing whether adding the immunotherapy drug nivolumab can improve treatment outcomes for patients with hard-to-treat multiple myeloma. The trial focuses on 50 patients whose cancer did not respond well enough to a specialized CAR-T cell therapy called idecabtagene…

This study is testing if adding a common heartburn medication (omeprazole) to a standard chemotherapy drug (cabazitaxel) can better control advanced prostate cancer that has stopped responding to other treatments. It will involve about 50 men whose cancer has progressed despite p…

This study compares two methods for closing the artery after a minimally invasive heart valve replacement procedure (TAVR). Researchers want to see if using one closure device works as well as the standard two devices at stopping bleeding and preventing complications. The trial w…

This study aims to improve stem cell transplants for adults with leukemia. Researchers want to see if they can personalize the dose of a key drug (cyclophosphamide) based on a patient's genetics and how their body processes the medication. The goal is to help the transplant fight…

This study is testing a new combination of four drugs for multiple myeloma, a cancer of the blood. The first part aims to find the safest dose for people whose cancer has come back. The second part will test how well the combination works for newly diagnosed patients with high-ri…

This early-stage trial is testing a new approach for women born with vaginal aplasia, a condition where the vagina is absent or underdeveloped. Doctors take a small sample of the patient's own cells, grow them in a lab to create a vaginal tissue implant, and then surgically place…

This study aims to find the best dose of intravenous magnesium to quickly lower a dangerously fast heart rate caused by atrial fibrillation or flutter. Researchers will compare a 2-gram dose, a 4-gram dose, and a placebo (saltwater) in 153 adult patients who are already receiving…

This study is testing whether injecting a person's own muscle tissue can help improve shoulder strength after rotator cuff surgery. Researchers take a small sample of chest muscle, process it into fragments, and inject it into the damaged shoulder muscle during the repair procedu…

This study is testing if a smartphone app that gives cash rewards can help people with opioid, cocaine, or methamphetamine addiction stay drug-free. The app tracks participants' progress with at-home drug tests and rewards them with money for clean results. Researchers want to se…

This study is testing whether a medication called risedronate can help prevent bone and muscle loss that sometimes happens after sleeve gastrectomy weight loss surgery. About 200 adults who have had this surgery will take either the real medication or a placebo pill for six month…

This early-stage study is testing whether inhaling nitric oxide gas is safe and feasible for patients undergoing emergency surgery to remove a blood clot from the brain after a stroke. The gas may help protect vulnerable brain tissue by improving blood flow to areas at risk of pe…

This study aims to find out if using one surgical implant or two is better for fixing severe fractures of the thighbone near the knee. It will enroll 144 adults with these injuries to see which method helps them return to work and normal activities more quickly and reliably. The …

This study aims to see if having a pharmacist review medications with older adults and their doctors can safely reduce the number of pills they take. The goal is to lower the risk of falls and hospital visits while improving quality of life. It will involve 100 participants aged …

This study aims to find the best way to help families who can't always afford enough healthy food, especially after their child has been in the hospital. Researchers are testing whether delivering free meals or providing grocery store gift cards for 4 weeks makes a meaningful dif…

This study is testing if a coordinated weight loss program for a parent and child together works better than separate programs. It involves 90 families where both the child and a parent are overweight. Researchers will compare three approaches: the child's program alone, both pro…

This study is testing whether a telehealth program can help paramedics in rural areas provide faster, life-saving treatment for severe heart attacks (STEMI). It will involve about 35 patients in Wilkes County and compare treatment times before and after the program starts. The go…

This small pilot study is testing whether a special light therapy cap can help control central centrifugal cicatricial alopecia (CCCA), a form of scarring hair loss that mostly affects Black women. Five participants will use the cap daily for six months to see if it can stop furt…

This study aims to find out which of two common treatment plans works better for Central Centrifugal Cicatricial Alopecia (CCCA), a type of scarring hair loss. It will enroll 250 African American women to compare a topical steroid with an oral antibiotic against a topical steroid…

This study is testing whether giving vitamin D supplements to patients with triple-negative breast cancer who are also vitamin D deficient can help their chemotherapy work better. Researchers want to see if the supplements help more patients achieve a 'pathologic complete respons…

This study is testing two different smartphone apps designed to help people living with HIV quit smoking. All participants will receive nicotine patches and gum, plus one of the apps to use for six months. Researchers want to see which app approach works better to help this speci…

This study tests a new way to help people in rural areas who smoke but aren't ready to quit. It trains local paramedics to connect smokers with a free mobile phone game called 'Take a Break,' which guides them through short periods of not smoking. The goal is to build skills and …

This study aims to find the most effective way to give weekly feedback to people in a weight loss program. Researchers will enroll 300 adults with overweight or obesity and provide them with education and tools to track their diet, activity, and weight. Each week, participants wi…

This study is testing whether a short, eight-session group therapy program can help cancer patients who smoke reduce or quit cigarettes. The program teaches skills to manage emotions and stress, which are common triggers for smoking. Researchers want to see if the program is prac…

This study is testing whether using telehealth (video calls) can help primary care doctors better manage the care of children with multiple, complex chronic conditions. It aims to see if this approach reduces the number of days children spend going to hospitals, emergency rooms, …

This study is testing if a standard first-line chemo/immunotherapy treatment for advanced lung cancer works as well and is as safe for patients in poorer health (Performance Status 2) as it is for patients in better health (Performance Status 0-1). It will enroll about 105 adults…

This study is testing different ways to help people who struggle to afford healthy food and also have uncontrolled high blood pressure. Researchers want to see if providing food assistance or support from a community health worker helps people better follow their diet and medicat…

This study aims to find the best way to prevent bone loss that can happen when older adults with low bone density lose weight. It will test a combination of special weight-bearing exercises and a common bone-strengthening medication (alendronate) alongside a supervised weight los…

This study is testing whether it's better and safer to send certain chest pain patients home from the emergency room for quick follow-up care, instead of admitting them to the hospital. It will involve 502 patients who come to the ER with chest pain but are at moderate risk for a…

This study is testing whether regular MRI brain scans after radiation treatment can detect cancer that has spread to the brain before it causes symptoms. It involves 60 adults with stage III non-squamous lung cancer who have finished radiation. Researchers will compare how often …

This study is testing a weekly combination of chemotherapy and immunotherapy for people with advanced head and neck cancer that has spread and who cannot take a standard chemotherapy drug called 5-FU. The goal is to see if this weekly schedule helps shrink tumors and control the …

This study aims to find out which of two common seizure-prevention medicines works better for adults with a serious traumatic brain injury. It will enroll 600 patients to see if one drug leads to fewer seizures and less agitation or behavioral problems than the other. The goal is…

This study is testing if a personalized dialysis schedule, tailored to a patient's remaining kidney function, works better than the standard one-size-fits-all schedule. It will enroll 350 adults with kidney failure who are new to dialysis, along with 140 of their caregivers, and …

This study is testing a special nurse support program for new mothers and their babies in five rural North Carolina counties. The program provides home visits, remote health monitoring, and help connecting to resources. Researchers want to see if this extra support helps moms and…

This study is testing whether starting an immunotherapy drug called durvalumab sooner after finishing chemotherapy and radiation can better control stage III lung cancer. Researchers want to see if starting treatment within 14 days (instead of the usual longer wait) is safe, effe…

This study is testing if adding the common diabetes medication metformin to standard first-line chemotherapy can help people with advanced soft tissue sarcoma that has spread or cannot be surgically removed. About 50 adults who are starting their first treatment for this advanced…

This study aims to find out if wearing a functional knee brace after ACL reconstruction surgery helps people recover better. It will compare young, active patients who wear a brace after surgery to those who do not. The main goal is to see if bracing improves confidence to return…

This study is testing if a drug called cetuximab can help control head and neck cancer that has returned or spread after standard immunotherapy has stopped working. It will involve about 38 adults who have already tried a PD-1 inhibitor drug. The main goal is to see if the cancer…

This study is comparing two surgical methods for fixing severe, displaced heel bone fractures. Researchers want to see if adding a joint fusion step to the standard repair helps patients return to work sooner and reduces long-term pain and arthritis. About 218 adults with these s…

This study is testing a new computer program designed to predict how difficult it will be for doctors to place a breathing tube during surgery. It works by analyzing three photos of a patient's face and neck to look for features linked to this difficulty. The goal is to create a …

This study is testing a new, more sensitive lab test to detect bacteria in urine when traditional tests show very low levels. It aims to see if this new test can help guide better antibiotic treatment for people with these hard-to-diagnose urinary tract infections. The study will…

This study is testing a computer tool designed to predict who might have COPD by analyzing their existing health records. It aims to help doctors identify the disease earlier and more accurately, before serious complications occur. The tool will be evaluated in 500 adults who hav…

This study is testing whether mobile low-dose CT scans can effectively detect lung cancer in younger, high-risk smokers. It focuses on people aged 40-54 with a heavy smoking history (30+ pack-years) in North and South Carolina. The goal is to see if starting screening earlier tha…

This study is testing a new smartphone app that uses artificial intelligence to help doctors diagnose skin problems. The app analyzes photos of a skin condition and suggests what it might be from a database of over 2,000 possibilities. Researchers are enrolling 400 patients at de…

This study aims to see if starting a common antidepressant medication when older adults leave the hospital after a leg fracture can help prevent them from developing depression during their recovery. Researchers will enroll 100 patients aged 65+ and give them a low dose of duloxe…

This study is testing an enhanced online lifestyle program for young women with overweight or obesity who are planning to become pregnant. The goal is to see if improving health before conception can reduce the risks of obesity and diabetes for both the mother during pregnancy an…

This study is testing a new program that combines peer support with a mobile health app to help people in rural Appalachia get tested and access care for HIV, sexually transmitted infections (STIs), and Hepatitis C. It is designed for gay, bisexual, and other men who have sex wit…

This study is testing if a daily low-dose aspirin pill can prevent dangerous blood clots in men with advanced testicular or germ cell cancer who are receiving chemotherapy. The trial will enroll 35 participants at high risk for clots to take aspirin daily for 6 months while under…

This large study is testing a digital program called mPATH-Lung to see if it can get more eligible smokers to complete recommended lung cancer screening CT scans. It will enroll 27,000 people and compare different outreach methods, with a special focus on including rural resident…

This study is testing a new program that starts heart disease prevention for patients visiting the emergency room for chest pain. The program checks cholesterol, calculates heart risk, and prescribes medication right away, with the goal of preventing future heart attacks and stro…

This study is testing a new way to help pregnant women who struggle to afford enough healthy food. It will see if a flexible support system, offering different types of food assistance based on individual needs, is practical to run. The goal is to improve food security and health…

This study is testing whether adding a virgin coconut oil mouth rinse to standard care can help prevent severe mouth sores (oral mucositis) in children and young adults (ages 7-26) who are receiving strong chemotherapy before a stem cell transplant. Researchers will compare two g…

This study is testing a safety program called COACH, designed with community input, to help youth football coaches run safer practices. The goal is to reduce the number of head impacts and concussions in young athletes by changing how practices are planned and run. Researchers wi…

This study is testing if a new type of surgical nail coated with antibiotics can prevent deep bone infections in patients with severe open leg fractures. It will compare this new nail to the standard, uncoated nail currently used. Researchers will follow about 484 adult patients …

This study is testing if placing a slow-release antibiotic pellet inside the bone during surgery is better at preventing serious infections after a severe open leg fracture. It will compare this new approach to the current standard treatment in about 500 adults with these injurie…

This study is testing whether a combination of wearable technology and personalized wellness coaching can help medical students build resilience and reduce burnout. First-year medical students will use a smartwatch app that tracks sleep and heart rate, paired with virtual coachin…

This small pilot study is testing whether a specific type of exercise is safe and practical for older adults with advanced kidney disease. Researchers want to see if doing fast-paced, low-weight strength training for 12 weeks can help improve muscle power and make daily activitie…

This study is testing whether a seated yoga program is practical and helpful for people with functional dyspepsia or gastroparesis, conditions that cause chronic nausea and vomiting. Researchers are adapting a yoga program originally designed for cancer patients to see if it's su…

This study is testing whether using virtual reality (VR) can help reduce phantom limb pain in people who have had an arm or leg amputated. Researchers will enroll 20 adult participants who experience this type of pain to try a standardized VR therapy program. The main goal is to …

This study is testing whether a structured exercise program helps children and young adults (ages 2-25) who are newly diagnosed with cancer and undergoing treatment. Researchers want to see if exercising 30 minutes, five days a week helps maintain physical function and improves q…

This study is comparing two different ways to close the skin after a C-section to see which one gives a better-looking scar. Researchers will randomly assign participants to have their incision closed with either traditional dissolvable stitches or newer absorbable staples. The m…

This study is testing whether providing financial guidance to people with acute myeloid leukemia (AML) can reduce the money-related stress of cancer treatment and improve their overall health and quality of life. It will enroll 120 adults who are starting intensive chemotherapy. …

This study is testing if a new clip device (K-LOCK™) makes surgical drains more comfortable and causes fewer problems than the usual method of stitching them in place. About 140 adults having plastic surgery will be randomly assigned to have their drains secured with either the c…

This study is testing a counseling program designed to help children and their parents manage stress and depression after a serious injury. Researchers will work with 24 families where a child is hospitalized for an injury like a burn or car accident. The program screens for emot…

This study is testing a combined treatment for adults with serious leg injuries. The treatment pairs a custom-made, energy-storing ankle brace with a high-intensity physical therapy program. Researchers want to see if this approach helps people walk better, climb stairs more easi…

This study is testing whether a personalized exercise program can help lymphoma and breast cancer patients maintain their physical fitness, heart function, and quality of life during cancer treatment. Researchers will compare two approaches: one group will follow a structured phy…

This study tests whether a telehealth program can help reduce stress, depression, and financial strain for people caring for loved ones undergoing a major cancer surgery and heated chemotherapy. Researchers will enroll 50 caregivers and provide half with a one-hour virtual sessio…

This study is testing whether a gentle, at-home brain stimulation technique can help cancer survivors who smoke reduce their cigarette use and feel less distress. Researchers will recruit 46 participants who are interested in quitting smoking and have mild to moderate distress. T…

This study tests whether a team-based care program can improve emotional well-being for adults with epilepsy who also experience anxiety or depression. Researchers will compare the new program against standard neurology care in 60 participants over 24 weeks. The program involves …

This study compares two different pain control methods for patients having robotic kidney removal surgery. Researchers want to see if a new combination of four common pain medications (called R.E.C.K.) works as well as the more expensive standard medication (Exparel) at reducing …

This study is testing two different phone-delivered support programs to see which one better helps women recover after abdominal surgery for suspected gynecologic cancer. It will compare a mindful movement and breathing program against a life reflection program. The goal is to se…

This study is testing whether microneedling or dermabrasion works better to improve the look of new surgical scars on the face. Researchers will enroll 30 adults who have a fresh vertical scar on their forehead. Each participant will receive one of the two treatments, and doctors…

This study is testing whether a safe, non-invasive device that uses pulsed electromagnetic fields (PEMF) can reduce pelvic pain and urinary symptoms in women with interstitial cystitis/bladder pain syndrome (IC/BPS). Researchers will give the device to 75 participants to use at h…

This study is testing which of two common laxative methods works better to prevent painful constipation after pelvic organ prolapse surgery. Researchers will compare an oral medication (senna) with a rectal suppository (bisacodyl) in 88 women having this type of vaginal surgery. …

This study is testing whether custom 3D-printed mouth splints can help burn patients who have developed a tight, small mouth opening (microstomia). The splints are designed to be worn at home to gently stretch the mouth, aiming to improve eating, speaking, and overall quality of …

This study aims to find out which of two specific catheters helps urine flow faster and is more comfortable for women who need to use catheters regularly to empty their bladders. Participants will try both catheters during a single visit, and researchers will measure how quickly …

This study aims to understand if using cannabis or related products helps people manage symptoms like pain and nausea during cancer treatment. It will follow 2,000 adults newly diagnosed with certain cancers who are starting chemotherapy or immunotherapy. Researchers will track p…

This study is testing whether a mobile app can help reduce cancer-related distress in young women with breast cancer. It will enroll 120 women aged 18-45 who are experiencing significant distress. The research will see if using the app for connection and education makes a measura…

This study is testing whether adding magnesium to the standard migraine medication prochlorperazine helps reduce pain faster for people visiting the emergency room. Researchers will enroll 100 adults with migraines to compare pain relief at 30, 45, and 60 minutes after treatment.…

This study is testing whether using a virtual reality headset during a bone marrow biopsy can help reduce the pain and anxiety patients feel. It will involve 160 adults with or suspected of having blood cancers who are scheduled for this outpatient procedure. Researchers will com…

This study is testing whether education and self-monitoring tools can help cancer patients better manage taste changes caused by chemotherapy. It will involve 400 patients starting chemo, comparing usual care to an approach where nurses teach patients to track symptoms and use st…

This study is testing whether freezing specific nerves during rib fracture surgery helps patients experience less pain and need fewer opioid painkillers afterward. Researchers will compare patients who receive this nerve-freezing procedure (called cryoablation) during surgery to …

This study is testing whether the hormone oxytocin can reduce pain. Researchers are comparing how well it works when given as a nasal spray versus through an IV drip in 24 healthy adults. Participants will have a small, controlled heat applied to their skin and rate their pain af…

This study is testing whether adding intravenous lidocaine (a common local anesthetic) to standard pain management can better control pain after hernia repair surgery. Researchers will compare lidocaine to a placebo in 50 patients to see if it reduces the need for opioid painkill…

This study is testing a new, flexible hearing aid that sticks to the skin like a Band-Aid for people with conductive hearing loss. It aims to provide a comfortable, non-surgical alternative to current devices or implants. The trial will enroll 200 participants, from infants to ad…

This study aims to create and test a standardized speech therapy program for people with globus pharyngeus, the persistent feeling of a lump or tightness in the throat. Researchers will work with 10 adult volunteers who have this condition to develop the treatment protocol. The g…

This study is testing whether a dietary supplement called fisetin can help reduce persistent fatigue in older adults who have survived cancer. It will involve 60 participants aged 65 and over who report significant tiredness. In this carefully designed trial, participants will ta…

This study is testing whether an online pain coping skills program helps cancer survivors manage persistent pain better than standard care alone. Researchers will enroll 456 adult cancer survivors who have pain that started or worsened after cancer diagnosis or treatment. Partici…

This study is testing whether regular phone check-ins from a mental health team can improve quality of life for adults with epilepsy caused by a past brain injury. It will compare a 6-month program of collaborative care calls to standard neurology visits. The goal is to see if th…

This small pilot study is testing if an injection of Xeomin (a botulinum toxin) into the arm of a stroke survivor can also improve their walking and balance. Researchers will measure how 20 adults walk and move before and after the injection to see if it helps. The goal is to see…

This study aims to understand if pressure inside the belly changes during a heart procedure called pulsed field ablation, which treats irregular heartbeats. Researchers will measure this pressure in 50 adult patients using a special monitor attached to a standard urinary catheter…

This study aims to gather preliminary data to understand how a non-invasive brain stimulation technique affects brain activity in people with and without heavy alcohol use. Researchers will use a special brain scanner (MEG) to measure activity before and after magnetic stimulatio…

This study is building a large collection of blood and tissue samples from patients with suspected solid tumors. The purpose is to create a resource for future cancer research, not to provide treatment to participants. Samples are stored for scientists to study the genetic and bi…

This study aims to find out if emptying the stomach during heart surgery improves the quality of ultrasound images of the heart. Researchers will compare images taken before and after stomach suctioning in 200 patients undergoing heart surgery. The goal is to determine the best m…

This study aims to understand the best signs that show when children can safely have their breathing tubes removed after surgery. Researchers will observe 600 children under age 10 who receive intravenous anesthesia during surgery. They'll track which indicators most accurately p…

This study is testing whether a more comprehensive genetic test can help doctors prescribe safer and more effective drug doses for cancer patients. Researchers will enroll 120 adults with cancer who are already eligible for a standard genetic test related to a specific chemothera…

This study aims to identify early risk factors that predict cognitive decline and Alzheimer's disease in adults aged 55 and older. Researchers will follow 850 participants with normal cognition, mild impairment, or early Alzheimer's to track how metabolic health and brain changes…

This study aims to understand how many opioid pain pills patients actually take after cancer surgery and what they do with leftover pills. Researchers will survey about 700 patients for 30 days after they leave the hospital to track their medication use and disposal habits. In th…

This study aims to understand if giving chemotherapy before surgery changes how fit or frail older adults with advanced ovarian or endometrial cancer feel. Researchers will measure frailty and thinking skills in about 35 participants before and after 3-4 rounds of pre-surgery che…

This study aims to document what normal pressure levels are inside the veins of the brain. Researchers will measure these pressures in 10 adults who are already scheduled for a standard brain angiogram for an unrelated medical reason. The goal is to gather baseline information to…

This study aims to understand if having low muscle mass at diagnosis is linked to experiencing more severe side effects from chemotherapy. It will follow 300 older adults newly diagnosed with advanced colorectal cancer who are starting standard chemotherapy. The goal is to gather…

This study is testing whether a mobile phone app can reliably collect information from patients about their skin rash caused by radiation therapy. Sixteen adults with head and neck cancer will use the app to report on their rash and submit photos while also using a prescribed ski…

This study aims to understand how variations in a specific gene called APOL1 affect the long-term success of kidney transplants and the health of living kidney donors. It will enroll 5,000 participants, focusing on people of recent African ancestry who are more likely to have the…

This study aims to understand how chronic stress affects brain activity and immune system function in people living with HIV who also use stimulants like methamphetamine or cocaine. Researchers will test whether a 5-session online program focused on positive emotions can reduce s…

This study aims to find early signs of multiple myeloma, a type of blood cancer, in people before they develop symptoms. Researchers will screen over 1,600 adults in the Charlotte area who are at higher risk, primarily focusing on Black/African American individuals and relatives …

This study is testing whether a short, hands-on demonstration helps people with eczema use the right amount of prescription cream. Researchers will compare patients who get the special demo to those who receive standard written and verbal instructions. The goal is to see if bette…

This study aims to design a program called CERCA to help families of children with cancer access community resources for needs like food, housing, and transportation. Researchers will interview caregivers, healthcare workers, and community organizations to understand current gaps…

This study aims to understand how a common breast cancer medication (an aromatase inhibitor) changes the bacteria in a patient's gut. Researchers will check stool and blood samples from 25 participants before starting the drug and again after 4 and 12 weeks of treatment. The goal…

This study aims to understand if a hormone called oxytocin affects a specific type of pupil movement (hippus) as a way to measure brain activity. Researchers will compare healthy volunteers to people with chronic knee pain from arthritis. Participants receive either oxytocin or a…

This study aims to map out the recovery journey for 200 people who have suffered serious fractures of the pelvis or hip socket (acetabulum). Researchers will follow patients over time, whether they had surgery or not, to understand how long it takes to return to work and normal a…

This study is testing a new blood test to find tiny pieces of cancer DNA from sarcoma, a type of bone or soft tissue cancer. It will enroll 300 patients of all ages, including children, who have or are suspected of having sarcoma. The goal is to see if this 'liquid biopsy' can he…

This study aims to understand how very low nicotine cigarettes affect the heart compared to regular cigarettes. Researchers will measure heart rate and electrical activity in 49 smokers while they smoke different types of research cigarettes. The goal is to gather information to …

This study aims to create 3D models from patients' bone marrow samples to test how different chemotherapy combinations affect blood cancer cells. Researchers will grow these 'mini-tumors' in the lab and expose them to various drug combinations to see which ones kill cancer cells …

This study aims to see if PET scans and blood tests can help predict which brain cancer patients might experience thinking and memory problems after radiation treatment. Researchers will follow 16 adults with high-grade glioma who are scheduled for standard radiation and chemothe…

This study aims to understand if the hormone oxytocin changes how nerves in the skin respond to touch and pressure after the skin is briefly heated. Researchers will compare oxytocin to a placebo in 60 healthy volunteers. They will measure nerve signals directly using a fine need…

This study aims to understand the challenges of aging for people 50 and older who are living with HIV. Researchers will screen 100 participants for signs of frailty and offer a personalized activity and nutrition plan to some. The main goal is to learn more about aging with HIV t…

This study aims to see if detailed MRI scans can accurately measure muscle health in people with myotonic dystrophy, a progressive muscle-wasting disease. Researchers will compare scan results with physical strength tests and other health measures in 75 participants. The goal is …

This study tests a mentorship and education program called COACH-APP. It aims to help advanced practice providers (like nurse practitioners) in community cancer clinics feel more confident and capable of joining clinical research teams. The goal is to see if better supporting the…

This study aims to better understand the experience of cancer-related fatigue in people with non-small cell lung cancer who are receiving immunotherapy. Researchers will conduct two interviews with 20 patients to learn about how often fatigue occurs, how severe it is, and how it …

This study aims to understand if exposure to hazardous chemicals during firefighting increases early signs that can lead to blood cancers. Researchers will enroll 300 Charlotte firefighters aged 40-49 with at least 5 years of experience to test their blood for these early markers…

This study aims to understand if younger women (45 and under) experience more or worse pain from a common white blood cell booster drug (pegfilgrastim) used during breast cancer chemotherapy compared to older women. Researchers will track pain levels and blood cell counts over a …

This study is testing whether a new training program for doctors, nurses, and midwives leads to better care for women in labor. All staff in a specific hospital's labor and delivery unit will practice cervical exams on a simulator until they reach a set skill level. Researchers w…

This study aims to understand how older adults with advanced ovarian or endometrial cancer maintain their physical strength and thinking skills during intensive treatment. Researchers will measure walking speed, memory, and grip strength before and after surgery and chemotherapy.…

This study collects health information from patients receiving stem cell transplants for various blood cancers and immune disorders. Researchers will track 2,000 patients over time to gather data on survival rates and treatment complications. The goal is to build a comprehensive …

This study aims to understand how myotonic dystrophy (types 1 and 2) affects the brain and thinking skills. Researchers will compare brain scans, thinking tests, and blood samples from 100 adults with the disease to healthy people. The goal is to gather information that can help …

This small pilot study is testing whether patients undergoing cancer treatment will consistently use a commercial fitness tracker to collect heart rate data. Researchers want to see if the devices are easy to use and if the collected data can help them learn more about cancer-rel…

This study aims to understand why patients with a specific genetic mutation (CALR) in a rare blood cancer called MPN have a different risk of blood clots compared to patients with another common mutation (JAK2). Researchers will collect a single blood sample from about 35 adult p…

This study aims to understand why most pancreatic cancer patients experience severe, life-threatening weight loss called cachexia. Researchers will collect genetic samples from 100 patients with advanced pancreatic cancer to look for DNA patterns linked to this condition. The goa…

This study aims to understand how a person's genetic makeup influences the side effects they experience and how well they respond to a standard two-drug treatment for acute myeloid leukemia (AML). Researchers will enroll 50 adults newly diagnosed with AML who are receiving azacit…

This study aims to understand the underlying causes of high blood pressure in children and how it damages the heart and kidneys. Researchers will follow 125 children and teens, some with newly diagnosed high blood pressure and some healthy, for two years. They will collect blood …

This study aims to understand how surgeons currently prevent dangerous blood clots in patients after major cancer surgery. It will survey and interview 500 surgeons and their teams across the U.S. to learn about their practices, identify barriers to following best-practice guidel…

This study aims to understand how cancer survivors experience and talk about the fatigue that often lingers after treatment. Researchers will interview 80 survivors and their doctors to learn the words and descriptions they use. The goal is to create a visual poster to help patie…