Could a gout drug help preterm adults handle salt?
NCT ID NCT04026776
First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 3 times
Summary
This study looks at how salt in the diet affects blood pressure in young adults who were born prematurely. Researchers will test whether the drug allopurinol can reduce salt sensitivity. 120 participants will follow high- and low-salt diets, and some will also take allopurinol to see if it helps control blood pressure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Allopurinol
- What this could lead to
- If successful, this could point toward a way to lower blood pressure in people born preterm by reducing salt sensitivity.
- What could go wrong
- This is a very early, small study (Phase 1, 120 participants). It only looks at short-term effects, and allopurinol may not work for everyone or have lasting benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2020
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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22 to 33 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Singleton birth * Born at less than 34 weeks gestational age (preterm cohort) * Born at greater than 36 weeks gestational age (term cohort) Exclusion Criteria: * Twin birth * Congenital anomalies or genetic syndromes * Currently pregnant or breast feeding * Subject-reported history of hypertension * Current use of antihypertensive medications * Active cancer * Chronic kidney disease * Heart failure * Liver failure
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
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- Ketone supplements may shield your body from too much salt