New antibiotic depot aims to stop bone infections after severe leg breaks
NCT ID NCT05766670
First seen Oct 31, 2025 · Last updated Apr 30, 2026 · Updated 28 times
Summary
This study tests whether placing a calcium sulfate antibiotic depot inside the bone during surgery can prevent infections after severe open tibia fractures. About 497 adults with type II or III open fractures will be randomly assigned to receive either the depot plus standard care or standard care alone. The main goal is to see if the depot reduces deep surgical site infections within 12 months.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Atrium Health Cabarrus
RECRUITINGConcord, North Carolina, 28025, United States
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Atrium Health Carolinas Medical Center
RECRUITINGCharlotte, North Carolina, 28204, United States
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Atrium Health Navicent The Medical Center
RECRUITINGMacon, Georgia, 31201, United States
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Atrium Health Wake Forest Baptist Medical Center
RECRUITINGWinston-Salem, North Carolina, 27157, United States
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Cedars-Sinai
RECRUITINGLos Angeles, California, 90048, United States
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Louisiana State University Health Sciences Center
RECRUITINGNew Orleans, Louisiana, 70112, United States
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Pennsylvania State University
RECRUITINGHershey, Pennsylvania, 17033, United States
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University of Kentucky
NOT_YET_RECRUITINGLexington, Kentucky, 40508, United States
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Valley Health
RECRUITINGWinchester, Virginia, 22601, United States
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Vanderbilt University Medical Center
NOT_YET_RECRUITINGNashville, Tennessee, 37232, United States
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