Wake Forest University Health Sciences

This study tests whether adding omeprazole (a common heartburn medicine) to standard chemotherapy can help shrink tumors or slow cancer growth in men with advanced prostate cancer that has stopped responding to other treatments. About 50 men will receive either cabazitaxel or doc…

This study tests a new approach to improve rotator cuff healing. A small piece of chest muscle is taken, broken into tiny fragments, and injected into the shoulder muscle during surgery. Researchers believe these fragments may help the muscle grow stronger and improve function. T…

This study is for people with head and neck cancer that has come back or spread. It tests whether the drug cetuximab, given alone, can shrink tumors or slow the disease in patients who no longer benefit from immunotherapy. About 38 adults will take part, and the main goal is to s…

This study looks at how well different treatments work for central centrifugal cicatricial alopecia (CCCA), a type of scarring hair loss that mainly affects African American women. Researchers will compare scalp photos taken before and after treatment in 250 women aged 18-60. The…

This early-stage trial tests a vaginal implant made from a woman's own cells for those born without a vagina (Mullerian duct anomaly). Ten participants will receive the implant and be monitored for safety and quality of life improvements. The goal is to see if this approach is sa…

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain. The goal is to see if it helps them live longer. The trial is for adults with certain types of breast cancer and is cur…

This pilot study is testing whether providing culturally appropriate food bundles and simple nutrition education can improve diabetes management for food-insecure adults. About 25 participants will receive food bundles, recipes, and cooking guides, then complete surveys at 3 and …

This study is for people with pancreatic cancer that is either borderline or locally advanced, meaning it has not spread far but is hard to remove surgically. Researchers want to see if giving two different chemotherapy combinations one after the other can shrink the tumor enough…

This study compares two diets—a low-carb (ketogenic) diet and a low-fat diet—in 120 adults with mild cognitive impairment (early memory loss). Participants follow their assigned diet for 16 weeks, then return to normal eating. Researchers measure changes in thinking skills, brain…

This study looks at two medications, levetiracetam and lacosamide, to see which one is better at preventing seizures in the first few days after a traumatic brain injury. Researchers will also check which drug causes fewer side effects like agitation or behavioral issues. The stu…

This study looks at whether giving radiation therapy six days a week (instead of the usual five) can better control head and neck cancer in people who start treatment more than six weeks after surgery. About 75 adults with certain types of head and neck cancer will be randomly as…

This study tests whether a personalized dialysis schedule (starting with fewer sessions based on remaining kidney function) is safer and improves quality of life compared to the standard fixed schedule. About 350 adults with new kidney failure will be randomly assigned to one of …

This study tests whether a monthly pill called risedronate can reduce bone and muscle loss that often happens after weight-loss surgery. About 200 people who have had sleeve gastrectomy will take either the drug or a placebo for 6 months and be followed for a year. The goal is to…

This study looks at whether a pharmacist-led review can safely reduce the number of medications taken by adults aged 75 and older who currently take six or more drugs. The goal is to see if cutting back leads to fewer falls, fewer hospital stays, and a better quality of life. Res…

This study looks at whether non-small cell lung cancer patients with a lower performance status (meaning they are less active or have more symptoms) can benefit from the same first-line chemo/immunotherapy as healthier patients. Researchers will compare how long the cancer stays …

This study tests whether combining exercise, a bone-strengthening drug (alendronate), and a calorie-restricted diet can prevent bone loss in older adults who are overweight or have low bone mass. About 900 participants will be followed for up to two years. The goal is to find saf…

This study tests whether adding the diabetes drug metformin to standard cancer therapy helps people with advanced soft tissue sarcoma live longer. About 50 adults whose cancer has spread or cannot be removed will receive metformin alongside their first-line treatment. The main go…

This study tests a new IVF-like procedure called ROSI for couples where the male partner has no sperm in his ejaculate due to a blockage or low production. Doctors will take immature sperm cells from the testicles and inject them into eggs to see if they can create a pregnancy. T…

This study looks at whether taking vitamin D during chemotherapy can help women with triple negative breast cancer and low vitamin D levels achieve a complete response (no cancer left after treatment). About 50 participants will receive standard chemotherapy plus vitamin D supple…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce these health risks. About 200 adults with HIV who are patients at a North Carolina clin…

This study looks at whether giving the drug Durvalumab within two weeks of finishing chemotherapy and radiation is possible and helpful for people with stage III lung cancer that cannot be removed by surgery. About 28 participants will receive Durvalumab early, and researchers wi…

This study looks at whether a program where parents and children work together can help them lose weight and be healthier. About 90 families will join a weight management program that focuses on healthy eating, physical activity, and positive communication. The goal is to see if …

This study tests a weekly combination of chemotherapy (carboplatin and paclitaxel) plus immunotherapy (pembrolizumab) in 32 people with metastatic head and neck cancer who cannot take the standard drug 5-fluorouracil. The goal is to see if this regimen shrinks tumors better than …

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe …

This study compares two smartphone apps designed to help people living with HIV quit smoking. About 314 participants will use one of the apps for 24 weeks, along with nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, with regul…

This study is testing whether a custom leg brace (called IDEO) combined with a special rehab program helps people with lower leg injuries move better. About 370 adults who already have the brace will do walking, stair, and other tests before, during, and after the program. The go…

This study looks at 224 adults with uncontrolled high blood pressure who also struggle with food insecurity. Researchers will test different food support programs to see which ones best help people take their medications and lower their blood pressure. The goal is to find the mos…

This study is testing whether injections of a person's own muscle cells can help repair the anal sphincter muscle and improve bowel control. Researchers will enroll 10 adults with long-term fecal incontinence who haven't been helped by standard treatments. The goal is to see if t…

This study is testing whether an AI software called Belle.ai can help doctors correctly diagnose common skin diseases. About 400 patients visiting a dermatology clinic will have three photos taken of their skin condition. The AI will then suggest a list of possible diagnoses, whi…

This study is testing a computer tool that uses health records to predict if someone has COPD, a serious lung disease. Many people with COPD are not diagnosed until the disease is advanced, while others are wrongly told they have it. The goal is to see if the tool can correctly i…

This study offers free mobile low-dose CT scans to people aged 40-54 who have smoked heavily (30 pack-years or more) and live in North or South Carolina. The goal is to see if screening at a younger age can catch lung cancer earlier, when it's easier to treat. About 1,160 partici…

This study tests a new DNA-based method (Next Generation Sequencing) to detect bacteria in urine from women with UTI symptoms whose standard urine culture shows very few bacteria. The goal is to see if this advanced technique can find hidden infections and guide better treatment.…

This study aims to find multiple myeloma at its earliest, precancerous stage (MGUS) in people at higher risk—Black adults and those with a family history of plasma cell disorders. By screening with a simple blood test, researchers hope to catch the disease before it causes seriou…

This study tests whether taking a daily low-dose aspirin can prevent blood clots in people with advanced germ cell tumors (including testicular cancer) who are receiving standard chemotherapy. About 35 participants will take aspirin alongside their chemo for 26 weeks. The goal is…

This study combines peer navigation (trained community members) with a mobile health app to help gay, bisexual, and transgender people in rural Appalachia access HIV, STI, and hepatitis C testing and prevention services. About 141 participants will be split into two groups: one g…

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent future heart attacks and strokes. It involves 130 adults aged 40-75 who are at risk for heart disease but not yet on preventive medication. The approach follows national …

This study tests whether rinsing with virgin coconut oil can prevent severe mouth sores in children and young adults (ages 7-26) undergoing high-dose chemotherapy before a stem cell transplant. About 60 participants will either receive standard mouth rinses or standard rinses plu…

This study tests a new approach to prevent infection in people with severe open fractures of the shinbone. About 500 adults with a type II or III open tibia fracture will be randomly assigned to receive either standard care or standard care plus a calcium sulfate antibiotic depot…

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 with overweight or obesity who may become pregnant within two years. Participants will either join online group classes over 12 months or receive st…

This study tests whether a metal rod (nail) coated with antibiotics can prevent serious infections in people with severe open fractures of the shinbone. About 484 adults will be randomly assigned to get either the antibiotic-coated nail or the standard nail. Researchers will trac…

This study tests a safety program called COACH that teaches youth football coaches how to plan safer practices to reduce head impacts and concussions. About 880 young athletes will be monitored over a season to see if the program lowers the number of head hits and improves brain …

This study tests a program called Walk On! to see if it helps older adults prevent falls. Researchers want to know if joining group walking sessions twice a week for 12 weeks can reduce falls and improve confidence. The study involves 192 older adults who have trouble moving or f…

This study tests whether giving the medicine lidocaine through a vein during surgery can help control pain after paraesophageal hernia repair. About 50 adults having this surgery will be randomly assigned to receive either lidocaine or a placebo (inactive salt water). The goal is…

This study is testing whether a mobile app can help young women (ages 18-45) with breast cancer feel less distressed. About 120 participants will use the app for 26 weeks, and researchers will check if their distress scores improve. The goal is to see if the app is a useful tool …

This study tests a 24-week collaborative care program for 60 adults with epilepsy who also have anxiety or depression. The program adds extra support from a care manager to usual neurology care, aiming to improve emotional well-being and quality of life. Participants must be 18 o…

This study tests whether wearing a virtual reality (VR) headset during radiation therapy can help manage anxiety. About 54 adults with prostate, breast, lung, or head and neck cancer will try the VR device during their daily treatments. Researchers will measure how often patients…

This study tests two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will take part, and researchers will measure pain, mood, and sleep. The goal is to find the best way to improve recove…

This study tests whether using a single Perclose device to close the large blood-vessel entry point after TAVR works as well as the standard two-device method. About 300 adults having TAVR through the leg will be randomly assigned to one or two devices. The main goals are to see …

This study looks at two different ways to help women have their first bowel movement after vaginal surgery for pelvic organ prolapse. About 88 women will be randomly assigned to take either an oral senna or a rectal bisacodyl suppository. The goal is to see which option leads to …

This study tests whether an internet-based pain coping skills program can help cancer survivors manage ongoing pain. About 456 adults who have finished or are still receiving cancer treatment will take part. The program teaches skills to cope with pain and is compared to standard…

This study compares two non-drug virtual programs for adults with migraine. Both involve 8 weekly online sessions and extra learning materials. Participants keep their usual medications. The goal is to see which program better reduces migraine-related disability and improves well…

This study looks at two different ways to surgically fix certain types of breaks in the thigh bone just above the knee. The goal is to find out which method helps people get back to work and everyday activities sooner. About 144 adults with these fractures will be randomly assign…

This study tests whether taking a supplement called fisetin can reduce fatigue in older adults who have survived cancer. Researchers will enroll 60 people and measure changes in tiredness using a standard questionnaire. The goal is to find a safe, easy way to improve energy and q…

This study tests whether regular supportive phone calls from a care team can improve quality of life for adults with post-traumatic epilepsy who also have anxiety or depression. About 40 participants will either receive these calls over 24 weeks or continue with usual neurology c…

This early-phase study tests whether inhaled nitric oxide is safe for people having a stroke caused by a blood clot. About 36 adults will receive the gas during a procedure to remove the clot. The main goal is to find the highest safe dose without causing bleeding in the brain.

This study looks at whether different physical therapy wound care methods—like pulsed water cleaning and electrical stimulation—can help heal pressure sores (bedsores) in people with spinal cord injuries. About 40 adults in rehab will be assigned to one of three treatment groups.…

This study compares two types of catheters (SpeediCath and Luja) in 17 women who regularly use catheters to empty their bladder. The goal is to see which catheter allows urine to flow out faster and which one women prefer. Participants will have one visit and a follow-up phone ca…

This study is testing whether a low-frequency pulsed electromagnetic field (PEMF) device can safely reduce pelvic pain and urinary symptoms in women with Interstitial Cystitis/Bladder Pain Syndrome. About 75 female adults will use the device at home and report their pain levels o…

This study tests a telehealth program designed to help caregivers of patients undergoing a major cancer surgery (cytoreductive surgery with heated chemotherapy). The goal is to reduce caregivers' stress, depression, and financial worries by connecting them with helpful resources.…

This study aims to find the best way to give weekly feedback to people trying to lose weight. Researchers will test different types of messages to see which helps participants lose more weight. The study involves 300 adults with a BMI of 25 or higher who own a compatible smartpho…

This study looks at whether a yoga program is practical and helpful for people with functional dyspepsia or gastroparesis—conditions that cause nausea, vomiting, and stomach pain. Ten adults will try yoga sessions and report how they feel. The goal is to see if yoga can ease symp…

This small study tests a red LED cap in 5 women with central centrifugal cicatricial alopecia (CCCA), a scarring hair loss that mainly affects middle-aged Black women. The cap uses light therapy to reduce inflammation and may help ease scalp symptoms, slow hair loss, and possibly…

This study looks at whether injecting Xeomin® into the arm can improve walking and mobility in adults who have had a stroke. About 20 people with arm and leg stiffness will be tested before and 4-6 weeks after the injection using simple walking tests. The goal is to see if treati…

This study tests a program to help children and their caregivers manage post-traumatic stress and depression after a serious injury like a burn or car accident. About 24 child-caregiver pairs will take part. The goal is to see if the program reduces emotional distress and improve…

This study compares different ways of closing the skin after a cesarean section to see which method leads to better-looking scars and fewer wound problems. Researchers will take photos of scars and have doctors rate them. The study involves 52 women having scheduled cesareans.

This study looks at whether wearing a brace after ACL reconstruction helps people feel more confident and ready to return to sports. Researchers will compare people who wear a brace to those who don't. The goal is to see if bracing improves psychological readiness and reduces fea…

This study is testing whether oxytocin, given as a nasal spray or through an IV, can reduce pain caused by heat on the skin. Researchers will ask 24 healthy adults to rate their pain levels over 4 hours after receiving the drug. The goal is to see how well oxytocin works for pain…

This study tests whether telehealth can help primary care doctors better care for children with multiple chronic conditions and rare diseases. About 909 children under 18 who need care from at least 4 specialists or rely on medical devices like feeding tubes or ventilators will t…

This study tests whether adding magnesium to a common migraine drug (prochlorperazine) provides better pain relief for people in the emergency department. About 100 adults with migraines will receive either the standard drug alone or the standard drug plus magnesium. Researchers …

This study compares a new no-stitch drain holder (K-LOCK) to the usual stitch method in 140 adults having plastic surgery. The goal is to see if the new device improves patient satisfaction and reduces problems like pain or emergency visits. Participants will be randomly assigned…

This study looks at whether a structured exercise program (30 minutes, 5 days a week) can help children and young adults aged 2-25 who are newly diagnosed with cancer and undergoing chemotherapy. The goal is to see if exercise helps maintain physical function and improve quality …

This study tests a short group therapy program based on Dialectical Behavior Therapy (DBT) to help cancer patients reduce or stop smoking. Sixteen adults with cancer who smoke daily will attend eight video sessions and report their smoking habits. The main goal is to see if the p…

This study tests whether a 12-week high-velocity resistance training program is safe and doable for 30 older adults with advanced chronic kidney disease. Participants will either do the strength exercises or attend weekly healthy lifestyle group sessions. The goal is to see if th…

This study looks at whether giving older adults (65+) an antidepressant called duloxetine right after surgery for a broken leg can help prevent depression in the following year. About 100 people will take the medicine daily and be checked monthly with a depression screening. The …

This study looks at whether teaching cancer patients about taste changes from chemotherapy and how to manage them can reduce symptoms and help them eat better. About 400 adults starting chemotherapy will be split into two groups: one gets usual care, the other gets extra educatio…

This study compares two surgical approaches for severe heel fractures. One group gets standard treatment, the other gets an additional subtalar joint fusion. The goal is to see if fusion reduces long-term pain and helps people return to work and daily activities sooner. About 218…

This study looks at whether orthopaedic surgeons can safely screen for depression in patients recovering from a broken bone and offer medication (SSRIs or SNRIs) to treat it. About 100 adults who score at least 5 on a depression questionnaire will be offered treatment or choose n…

This study explores whether virtual reality (VR) can reduce phantom limb pain in people who have lost an arm or leg. About 20 adults with phantom limb pain will use VR experiences designed to help their brain 'see' and control the missing limb. The goal is to find a drug-free way…

This study tests whether giving magnesium through an IV can safely lower a dangerously fast heart rate in people with atrial fibrillation or flutter. About 153 adults will receive either a low dose (2g), a higher dose (4g), or a placebo. The main goal is to see if magnesium helps…

This study is testing a new, noninvasive hearing aid that uses a small, flexible patch to send sound vibrations directly to the inner ear. It is designed for children and adults with conductive hearing loss, where sound doesn't travel properly through the outer or middle ear. Res…

This study tests whether a custom 3D-printed mouth splint can help burn patients who have developed a small mouth opening (microstomia). Ten participants will use the splint and be measured for changes in mouth size and function using a special survey. The goal is to ease symptom…

This study compares two pain relief methods used during robotic kidney surgery: a cheaper mix of drugs called R.E.C.K and a more expensive option called Exparel. About 170 adults having robotic kidney removal will be randomly assigned to one of the two treatments. Researchers wil…

This study is testing whether using a virtual reality headset during a bone marrow biopsy can help lower pain and anxiety. About 160 adults with blood cancers will be randomly assigned to use the headset or receive standard care. The goal is to see if this simple, drug-free appro…

This study is testing a device called Cereset Research to see if it can help people who feel stressed, anxious, or have trouble sleeping. The device measures heart rate and blood pressure to guide relaxation. Researchers will track changes in heart rate variability and sleep qual…

This study compares two skin treatments—microneedling and dermabrasion—to see which works better for improving surgical scars on the face. About 30 adults with a vertical scar on the upper forehead will receive one of the treatments shortly after surgery. Researchers will measure…

This study tests if freezing certain nerves during surgery for broken ribs can reduce pain and the need for strong painkillers afterward. About 80 adults with multiple broken ribs will either get standard surgery or surgery plus nerve freezing. The goal is to see if the freezing …

This study is testing whether a low dose of clonidine, a drug usually used for high blood pressure, can help veterans with PTSD sleep better and feel less stressed. About 32 veterans will take the drug for 6 weeks while researchers track changes in sleep quality, PTSD symptoms, a…

This study is creating and testing a new speech therapy program for people who feel a constant lump in their throat (globus pharyngeus). Ten adults will try the therapy to see if it reduces that uncomfortable sensation. The goal is to develop a standard treatment that doctors can…

This study tests whether a tailored physical activity program can help preserve exercise capacity, heart function, memory, and quality of life in adults (ages 18-85) with Hodgkin or non-Hodgkin lymphoma or stage I-III breast cancer who are undergoing chemotherapy or other cardiot…

This study looks at whether people with chest pain who are at moderate risk for a heart attack can be safely evaluated as outpatients instead of being admitted to the hospital. About 502 adults will be randomly assigned to either rapid outpatient testing or standard hospital care…

This study aims to measure normal pressures in the brain's veins in people who do not have Idiopathic Intracranial Hypertension (IIH), a condition causing severe headaches and vision problems. Researchers will take these measurements during a routine angiogram in 10 participants.…

This study is for older adults with advanced colorectal cancer who are about to start chemotherapy. It aims to find out if having low muscle mass at the start of treatment leads to more severe side effects. Researchers will track side effects and survival over at least one year. …

This study looks at whether regular MRI scans of the brain after radiation therapy can find cancer that has spread to the brain before it causes symptoms. It involves 60 adults with stage III non-squamous lung cancer. The goal is to see if early detection can reduce the number of…

This study explores how genetic differences influence side effects and treatment response in adults with newly diagnosed acute myeloid leukemia (AML) who are starting therapy with azacitidine and venetoclax. Researchers will analyze blood samples from 50 participants to look for …

This study is looking at how a breast cancer medicine called an aromatase inhibitor changes the bacteria in your gut. Researchers will collect stool and blood samples from 25 women before and after starting the drug to see how these changes affect estrogen levels. The goal is to …

This study looks at how myotonic dystrophy type 2 (DM2) affects the brain. Many people with DM2 have trouble thinking clearly, but we don't know much about why. Researchers will use MRI scans, thinking and movement tests, and blood samples to compare people with DM2, DM1, and hea…

This study follows 2000 adults with newly diagnosed cancers (breast, colorectal, lung, melanoma, or lymphoma) who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps reduce symptoms like pain, nausea, or fatigue, and al…

This study looks at genetic differences in people with pancreatic cancer to understand why many develop severe muscle wasting (cachexia). Researchers will collect blood samples from 100 patients and track weight loss over three months. The goal is to find genetic markers that cou…

This study looks at how to better support adults aged 65 and older who are receiving chemotherapy. Researchers will measure each person's resilience and create a personalized care plan to meet their needs. The goal is to see if this approach helps reduce hospital stays and emerge…

This study is testing a blood test called a liquid biopsy to see if it can detect tumor DNA in people with bone or soft tissue sarcoma. Researchers will collect blood samples before, during, and after treatment to track how well the test works. The goal is to find a less invasive…

This study looks at whether a nurse-led support program helps new mothers and babies in rural North Carolina get better care and avoid unnecessary hospital visits. About 1,300 women who deliver at a specific birth center and live in one of five rural counties will be randomly ass…

This study collects blood and tissue samples from up to 20,000 people with suspected solid tumors. The samples are stored in a research bank so scientists can study them later to better understand cancer. Participants must be scheduled for a biopsy or surgery. No direct treatment…

This study looks at whether offering personalized financial navigation alongside standard care can lower the financial stress (called financial toxicity) felt by adults aged 18-64 who are being treated for acute myeloid leukemia. About 120 participants will be randomly assigned t…

This study looks at whether PET scans and blood tests can predict how radiation treatment for high-grade glioma affects memory and thinking. About 16 adults with this type of brain tumor will have scans and cognitive tests before and after treatment. The goal is to find ways to i…

This study aims to create better tools to measure quality of life in adolescents and young adults (ages 15-39) with cancer. Researchers will ask 3,000 participants—including patients, survivors, and their caregivers—about body image, fertility concerns, and financial stress. The …

This study tests two types of reward programs to help people with opioid, cocaine, or methamphetamine use disorders stay abstinent. Participants use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to find the b…

This study follows 200 people who have broken their pelvis or hip socket to understand how they recover over time. Researchers will measure pain, physical function, and how quickly patients return to work and daily activities. The goal is to learn what recovery looks like for the…

This study looks at how 3-4 cycles of chemotherapy before surgery affects frailty in adults over 55 with advanced ovarian or endometrial cancer. Researchers will use an electronic frailty index to measure changes in fitness and cognitive function. The goal is to understand whethe…

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in people who drink heavily and those who don't. Researchers will use a special brain scanner (MEG) to measure these effects in 10 adults. The goal is to gather early data to plan larger studie…

This study aims to understand cancer-related fatigue in 20 people with non-small cell lung cancer who are receiving immunotherapy. Researchers will interview participants twice and use questionnaires to learn about fatigue patterns, daily life impacts, and preferences for physica…

This study looks at why some children with high blood pressure develop heart or kidney damage. Researchers will measure certain chemicals in the blood and urine of 125 children aged 7-18 with a new diagnosis of high blood pressure, as well as healthy children. The goal is to bett…

This study looks at whether a flexible, step-by-step food support program can help pregnant women who struggle to afford enough food. About 60 pregnant women in their first trimester will receive different levels of help based on their needs. The goal is to see if this approach i…

This study tests a new way to help smokers in rural areas who are not yet ready to quit. Paramedics will refer participants to a text-message program designed to motivate them to stop smoking. The goal is to see if this approach can reach more people and help them eventually quit…

This study looks at how a gene called APOL1 affects kidney transplant success. African Americans and others with recent African ancestry are more likely to have a risky version of this gene. Researchers will test DNA from 5000 donors and recipients to see if the gene leads to kid…

This study looks at whether firefighters' exposure to dangerous chemicals on the job raises their risk of developing blood cancers. Researchers will test blood samples from 300 firefighters in Charlotte, NC, for early signs of cancer, such as abnormal blood cells or proteins. The…

This study looks at whether a special genetic test can help doctors pick the right dose or type of medicine for people with cancer. About 120 adults with gastrointestinal or other cancers who are already getting a standard genetic test will also receive a broader test. The goal i…

This study looks at how many opioid pain pills patients actually take after leaving the hospital following surgery for bladder, kidney, or prostate cancer. About 684 adults will fill out a survey 30 days after discharge to report their opioid use and disposal. The study also test…

This study looks at why people with a CALR gene mutation and a type of blood cancer called MPN have a lower risk of dangerous blood clots than those with a JAK2 mutation. Researchers will measure certain immune markers and inflammatory proteins in blood samples from 35 adults wit…

This study asks 300 adolescents and young adults (ages 15-39) who have or had cancer to fill out surveys. The goal is to find out what topics—like exercise, sexual health, fertility, money issues, and clinical trials—they feel they didn't get enough education about. No treatment …

This study aims to identify frailty in people aged 50 and older living with HIV. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging. The study involves 100 participants from a specialty clinic and does not test a…

This study is testing whether a wearable activity tracker can be used by people with pancreatic or breast cancer to track fatigue during treatment. About 46 participants will wear the device for 14 days and share heart rate data. The goal is to see if patients find the tracker ea…

This study is not testing a treatment. Instead, it aims to develop a better way to measure muscle changes in people with myotonic dystrophy using MRI scans. Researchers will enroll 75 adults (ages 18-65) with or without the condition to see if muscle imaging can serve as a reliab…

This study aims to find better ways to help people with atopic dermatitis (eczema) use their topical medication as prescribed. About 30 participants will be split into groups: one gets standard care, another gets a hands-on demonstration, and a third uses a mobile app. Researcher…

This study looks at how well the immune system works in children who have finished cancer treatment. It also tests giving vaccines earlier than usual, starting at 3 months after therapy ends. Researchers will compare a single booster shot to a full series of vaccines to see which…

This study is gathering basic health and survival information from 2000 people who are getting a stem cell transplant for blood cancers or immune diseases. The goal is to build a database that doctors can use to improve care and answer future questions. No experimental treatments…

This study looks at whether wearable technology (like a smartwatch) plus personalized wellness coaching can help first-year medical students stay healthy and avoid burnout. Researchers will track heart rate, sleep, and stress levels in 49 students. The goal is to see if these too…

This study is testing a program created by the community to encourage behaviors that reduce the spread of viruses like COVID-19. Researchers will enroll 546 adults from specific areas in North Carolina who have not had COVID-19. The goal is to see if the program is acceptable and…

This study looks at how very low nicotine cigarettes change heart rate and heart rhythm in people who smoke daily or occasionally. About 49 adult smokers will have their heart activity measured before and after smoking different types of research cigarettes. The goal is to unders…

This study compares different outreach methods to see which works best for getting people at high risk for lung cancer to complete a screening CT scan. It includes 27,000 participants, focusing on racial/ethnic minorities and rural residents. The goal is to find the most effectiv…

This study watches 600 children under 10 years old to see what helps them breathe well when their breathing tube is removed after surgery. The children receive a special type of anesthesia that doesn't use gas. The goal is to find better rules for removing the tube safely and avo…

This study looks at how long-term marijuana use affects brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure changes in brain health. The goal is to understand the effects, not to test a new treatment. About 220…

This study looks at how oxytocin, a natural hormone, affects the part of the nervous system that controls rest and digestion. Researchers will measure changes in pupil size after an injection of oxytocin or a placebo. The goal is to understand how the body responds to pain, not t…

This study surveys 500 surgeons and advanced practice providers to see how often they prescribe blood clot prevention medication after abdominal or pelvic cancer surgery. The goal is to understand current practices and improve adherence to guidelines. No patients receive treatmen…

This study looks at how salt in the diet affects blood pressure in young adults who were born prematurely. Researchers will compare the salt sensitivity of people born preterm with those born full-term. They will also test if a drug called allopurinol can reduce salt sensitivity.…

This study aims to find out if younger women (45 and under) experience more pain from pegfilgrastim, a drug that helps boost white blood cells during chemotherapy, compared to older women. About 115 women with non-metastatic breast cancer will report their pain levels and have th…

This study looks at whether oxytocin, a natural hormone, can change how nerves send pain signals after mild heat. Sixty healthy adults will receive either oxytocin or a placebo through an IV. Researchers will measure nerve activity and pain scores before and after heating a small…

This study aims to identify early risk factors for Alzheimer's disease by following 850 adults with normal memory or mild cognitive issues. Researchers will track changes in thinking skills, brain scans, and spinal fluid markers over time, with a special focus on how blood sugar …

This study aims to create a computer program that can predict how easy or hard it will be to place a breathing tube by analyzing photos of a patient's face. Researchers will take pictures from three angles and compare the computer's predictions to standard manual checks. If succe…

This study looks at whether removing stomach contents before heart surgery helps doctors get clearer ultrasound pictures of the heart. About 200 adults having heart surgery will have their stomach emptied and then compare image quality before and after. The goal is to find the be…

This study is creating 3D mini-tumors (organoids) from bone marrow samples of 70 people with blood cancers. The goal is to test different chemotherapy combinations on these organoids to see which works best for each person. This approach aims to provide personalized treatment gui…

This study looks at whether a special education and mentorship program called COACH-APP can help advanced practice providers (like nurse practitioners and physician assistants) feel more confident about taking part in cancer research. About 97 providers from community cancer cent…

This study looks at two ways to help families who don't have steady access to enough food while their child is in the hospital. Researchers will compare giving families free meal deliveries versus grocery gift cards. The goal is to find out which method works best to support thes…

This study is for people with blood cancers who are getting a stem cell transplant from a donor. It looks at how a person's genes and the amount of a drug called cyclophosphamide in their blood affect the risk of graft-versus-host disease (GVHD), a serious complication. The goal …

This study looks at how belly pressure changes during a heart procedure called pulsed field ablation, which treats atrial fibrillation. Researchers will compare pressure levels when patients receive general anesthesia versus sedation. About 50 adults having this standard heart tr…

This study looks at how chronic stress changes brain and immune function in people with HIV who use stimulants. Researchers will use brain scans and interviews to understand these changes, with the goal of finding better ways to treat depression and reduce stimulant use. The stud…

This study looks at whether patients who talk to an EMS doctor over the phone are more likely to agree to go to the hospital by ambulance. About 250 adults who want to refuse transport will be included. The goal is to see if a doctor's advice can reduce the number of people who r…

This study looks at whether simulation training for doctors, nurses, and midwives can reduce the number of cervical exams women receive during labor and make exam results more consistent. Over 1,100 healthcare providers and patients will take part. The goal is to improve care by …

This study works with families of children with cancer to design a program called CERCA. The goal is to identify and address non-medical needs like housing, food, or transportation. Researchers will interview caregivers and clinic staff to understand current challenges and build …

This study listens to cancer survivors to understand how they experience and talk about fatigue. Researchers will interview 80 survivors and their doctors to create a visual poster that helps patients describe their fatigue better. The goal is to improve communication and help pe…