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New hope for Brain-Spread breast cancer: High-Dose methotrexate trial opens

NCT ID NCT02422641

First seen Jan 04, 2026 · Last updated May 23, 2026 · Updated 31 times

Summary

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain. The goal is to see if it helps them live longer. The trial is for adults with certain types of breast cancer and is currently enrolling 16 participants.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Comprehensive Cancer Center at Wake Forest University (CCCWFU)

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

    Contact Email: •••••@•••••

  • Sidney Kimmel Comprehensive Cancer Center

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact Email: •••••@•••••

  • Siteman Cancer Center- Washington University School of Medicine in St. Louis

    ACTIVE_NOT_RECRUITING

    St Louis, Missouri, 63130, United States

Conditions

Explore the condition pages connected to this study.