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Cash for clean tests: App-Based rewards aim to curb opioid and cocaine use

NCT ID NCT04927143

Disease control Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating rewards for clean tests, while a control group gets no rewards. The goal is to find the best way to design these incentives to encourage long-term abstinence.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
financial incentives via smartphone app
What this could lead to
If successful, this could provide a low-cost, scalable way to help people with substance use disorders achieve and maintain abstinence.
What could go wrong
This is a behavioral study, not a drug trial. The effect may be modest, and long-term abstinence after incentives stop is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2021

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age at least 18 years old; * Meet DSM-5 OUD, CoUD, or MUD criteria as evidenced by an OUD CPT code F11\* (opioid related disorders), a CoUD CPT code F14\* (cocaine related disorders), a MUD CPT code F15.1/F15.2 or other clinical notes indicating illicit opioid/cocaine/methamphetamine use for treatment * Have access to a smartphone (iOS or Android) with data plan and willing to download DynamiCare app; * Have an email and can access it from their smartphone; * Are in residential, day (PHP), partial day (IOP), or outpatient (OP) AODA treatment; * Are likely to be helped by contingency management because at least ONE of the following conditions is true: 1. Were first enrolled in residential, PHP, or IOP substance use treatment no longer than 2 treatment weeks (14 days/encounters of treatment) prior to providing informed consent. 2. Used non-medical opioids, cocaine, and/or methamphetamine within the last 21 days. * Understands English. Exclusion Criteria: * Have evidence of active (non-substance related) psychosis that might impair participation as determined by the PI. * Has significant cognitive impairment that might confound participation as determined by the PI or are so significantly cognitively impaired that they have a legal guardian.

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Conditions

The condition(s) this trial relates to.

amphetamine abuse cocaine abuse cocaine dependence methamphetamine dependence opiate dependence opioid abuse substance abuse substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cocaine use Cocaine use disorder Methamphetamine abuse Methamphetamine-dependence Opioid use Opioid-use disorder Substance use

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Advocate Aurora Behavioral Health Services

    RECRUITING

    Wauwatosa, Wisconsin, 53212, United States

  • Rogers Behavioral Health

    RECRUITING

    Oconomowoc, Wisconsin, 53066, United States

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