Substance-related disorder

Researchers are testing Actívatexto, a mobile program that combines text messages, wearable activity trackers, and nicotine replacement therapy. The trial enrolls Latino adults who smoke at least three days a week, want to quit in the next month, and currently get less than the r…

This phase 2 trial tests an experimental drug called efimosfermin alfa in adults with alcohol-related liver disease. The study aims to see if the drug can improve liver health, measured by liver stiffness and a standard liver disease severity score. Participants receive either th…

This study is testing whether cannabidiol (CBD) can help people who drink alcohol regularly cut down on their drinking. Researchers are giving 150 adults either full-spectrum CBD, broad-spectrum CBD, or a placebo daily for 12 weeks. They will measure how much participants drink i…

This study tests whether adding accelerated transcranial magnetic stimulation (aTMS) to the standard smoking-cessation drug varenicline helps adults quit nicotine products like cigarettes and vapes. Thirty participants will take varenicline daily for 12 weeks and receive either r…

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer over 168 days. About 600 adults starting a new treatment episode will take part. The go…

This early-stage study tests whether the psychedelic drug DMT, combined with psychotherapy, can help people with alcohol use disorder. 63 participants will receive either a moderate or low dose of DMT, or a placebo, and their safety and desire to drink will be measured. The goal …

This study tests if semaglutide, a drug used for diabetes, can help veterans with alcohol use disorder drink less. About 622 veterans will get either the drug or a placebo shot for 28 weeks. The goal is to see if it safely reduces heavy drinking and improves health.

This study tests whether starting antiretroviral therapy within 7 days of an HIV diagnosis can reduce stigma and improve health outcomes for people who inject drugs. Researchers will develop a rapid-start strategy and pilot it with 135 participants at HIV clinics. The goal is to …

This study compares a once-monthly injectable buprenorphine to the standard daily sublingual tablet (with naloxone) for treating opioid use disorder in 952 veterans. The goal is to see which formulation better keeps people in treatment and helps them stay opioid-free over 48 week…

This study tests a device that uses magnetic pulses to stimulate the brain (Deep TMS) to help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will get either real or fake (sham) treatment over several weeks. The goal is to see if the re…

Researchers at Duke University are testing emPath, a digital platform that community outreach workers can use to connect adults with opioid use disorder to telemedicine visits and medication treatment. The pilot study enrolls 80 people in Durham, North Carolina, including 50 adul…

This Phase 2 trial tests whether adding brenipatide to standard buprenorphine treatment helps people with opioid use disorder stay off opioids longer. About 465 participants will receive either brenipatide or a placebo injection alongside their usual medication. The study measure…

This phase 3 study tests whether brenipatide can help adults with moderate-to-severe alcohol use disorder drink less and feel less urge to drink. About 1,100 motivated participants will receive either the drug or a placebo for 56 weeks. The main goal is to see changes in drinking…

This study is testing whether a private Facebook group, called Wiidookaage'Win, can help Native American women in Minnesota stay off opioids. The group includes social support, mindfulness, and cultural practices. Sixty women who are already on medication for opioid use and have …

This study is testing whether e-cigarettes (nicotine vapes) can help people who are in treatment for substance use disorder quit smoking. Participants will either switch to e-cigarettes or use FDA-approved nicotine patches and lozenges, with weekly counseling. The goal is to see …

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with therapy can change brain activity and reduce drinking in people with alcohol use disorder. Two hundred participants will receive either psilocybin or a placebo, plus supp…

This study tests whether the drug varenicline (Chantix) can help veterans who smoke at least 5 cigarettes a day but aren't ready to quit. Participants will either take varenicline or use nicotine lozenges to reduce smoking over 12 weeks. The goal is to see if this approach leads …

This study compares how adult smokers experience IQOS heated tobacco products versus their usual cigarettes. Participants use both products and rate them on appeal, taste, harshness, and satisfaction. Researchers also measure puffing behavior and nicotine withdrawal symptoms. The…

This pilot study tests whether deep brain stimulation (DBS) of the nucleus accumbens can help people with opioid use disorder who keep relapsing despite standard treatments. Only 3 participants will receive the implanted device. The main goal is to see if it is safe and whether i…

This study tests whether low-dose ketamine can reduce cravings and withdrawal symptoms in adults starting methadone treatment for opioid use disorder. Fifty participants will receive either a low or very low dose of ketamine four times over two weeks. Researchers will track cravi…

This trial tests whether giving prolonged exposure therapy for PTSD in a massed format, with multiple sessions each week, works as well as the standard once-a-week schedule for veterans who are also in intensive outpatient treatment for substance use disorder. Researchers will co…

This study tests whether a smartphone app called the Vira Platform, combined with peer recovery support, can help people with opioid use disorder stay on their medication (buprenorphine or methadone) and remain engaged in treatment. The app uses mobile sensing to detect patterns …

This trial tests whether a six-week body-focused mindfulness program can help people with alcohol use disorder feel more connected to their bodies, manage emotions better, and reduce alcohol cravings. Participants in inpatient treatment will either take part in mindfulness sessio…

This pilot trial tests a program called TRTME, designed to help hospitalized patients with opioid use disorder begin medication treatment after discharge. The program includes personalized education to correct misconceptions about MOUD, feedback on individual overdose risk factor…

This study tests an experimental medicine called brenipatide to see if it helps adults with alcohol use disorder drink less and reduce cravings. About 1,100 participants will receive either the drug or a placebo by injection for nearly a year. The goal is to find a safe, effectiv…

This study tests whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay on medication for opioid use disorder compared to referring them elsewhere. About 512 adults who use SSPs and have moderate to severe opioid use …

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch from smoking cigarettes. Fifty smokers will get either low (3 mg) or high (6 mg) nicotine pouches to use for 4 weeks. Researchers will check if they stop smoking and how much they use the …

This study tests whether an 8-week culturally responsive harm reduction program helps Black and Latinx people who use drugs engage more with services and reduce opioid or stimulant use. Researchers will compare the program to standard harm reduction services in 200 participants. …

This study tests whether a non-invasive brain stimulation technique called rTMS, given before cognitive-behavioral therapy, can help adults with cocaine use disorder quit. Thirty participants will receive either real or sham rTMS daily for 3 weeks, followed by 12 weeks of weekly …

This study investigates whether a mobile app called reSET can help men who have sex with men, are living with HIV, and have a stimulant use disorder reduce their drug use and keep their HIV under control. Participants use the app for 12 weeks, completing modules on topics like ma…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study tests a program called CONNECT Multilingual, designed to help Spanish and Cantonese speakers quit smoking while they undergo lung cancer screening. About 439 current smokers aged 50-80 will receive personalized video doctor messages, text support, and help getting nico…

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This study tests whether changing treatment can help smokers who relapse early after trying to quit. 544 participants who want to quit smoking will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. All visits are remote, and the study lasts 6 mon…

This study tests a mobile app and financial rewards to help veterans quit smoking before major elective surgery. Smoking increases the risk of complications after surgery, but quitting can be hard. The program uses a carbon monoxide monitor and app to verify abstinence, with ince…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with moderate to severe opioid use disorder stay in treatment and use fewer opioids when added to their regular buprenorphine medication. About 310 adults who recently started buprenor…

This study tests whether offering financial rewards to Alaska Native adults and their family members helps them quit smoking. About 1,312 participants will be randomly assigned to receive the family-based incentive program or standard support. Success is measured by a saliva test…

This trial tests whether an 8-week virtual mindfulness program can help substance use peer workers reduce their own relapse risk and burnout. Peer workers—people in recovery who support others with substance use issues—often face high stress. The study compares the mindfulness pr…

This study tests two types of non-invasive brain stimulation (rTMS) to help veterans stop smoking. About 56 veterans who smoke at least 10 cigarettes a day will receive either standard or precision-guided rTMS over three weeks. Researchers will measure how much smoking decreases …

This study tests a new drug, GSK4532990, in about 393 adults with liver inflammation from alcohol use. The goal is to see if it safely reduces liver stiffness and improves liver function over 52 weeks. Participants receive either the drug or a placebo, and researchers monitor sid…

This study tests a new approach where nurses, rather than doctors, adjust methadone doses for people starting treatment for opioid addiction. The goal is to see if this makes it easier for patients to stay in care for at least three months. The trial will enroll 182 adults in Fre…

This study tests whether a smartphone app called Connections can help people with alcohol-related liver disease stop drinking. About 298 participants from two medical centers will use the app along with their usual care, or just receive usual care alone. The goal is to see if the…

This early-stage trial tests a new naltrexone implant (iSTEP-N) that slowly releases medication over 12 months to block opioids. It will enroll 33 healthy adults and compare two implant doses to standard monthly injections. The goal is to see if the implant can maintain steady dr…

This trial tests whether a digital program called CanCEASE, combined with a health navigator who helps parents address unmet social needs like housing or food, can boost smoking-cessation rates. Around 1,000 parents who smoke and report at least one social risk will be randomly a…

This trial investigates whether digital recovery support services—like smartphone apps and online tools—can help Black and African American adults in recovery from alcohol use disorder maintain their progress. Participants receive a menu of vetted digital resources plus a phone a…

This study tests whether daily mindfulness text messages can help people taking medication for opioid use disorder who also have chronic pain. Participants receive medication reminders and either two or four mindfulness messages per day for six weeks, along with brief surveys thr…

This study tests whether a single high dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder stay off illicit opioids when added to standard buprenorphine treatment. About 90 adults who have already started buprenorphine will recei…

This study tests whether patient navigation—a series of coaching sessions—helps pregnant women with opioid use disorder stay in treatment and reduce drug use. About 429 pregnant women will be randomly assigned to either usual care or patient navigation, which includes up to 14 se…

This study tests a stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD symptoms. The program adds group and individual therapy to standard medication treatment. Researchers will see if it helps wome…

This trial tests whether a training program for methadone clinic staff can help patients stay in treatment longer and reduce overdose risk. The program focuses on trauma-informed, patient-centered care and includes staff education, supervision, and clinic self-assessment. Researc…

This study tests whether mindfulness-based relapse prevention, combined with wearable heart rate sensors, can help people with alcohol use disorder improve self-regulation and reduce drinking. About 120 adults will attend weekly group sessions for 8 weeks, answer mood and drinkin…

This study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy to improve mental health and reduce HIV risk…

This study tests a smartphone app called ESCAPE, designed specifically for Black adults with HIV who smoke. The app teaches ways to handle stress, anxiety, and nicotine cravings, and is paired with nicotine patches or gum. 300 participants across the US will be randomly assigned …

This study tests a new method called ROLDI (rapid outpatient low-dose initiation) for starting buprenorphine in people with opioid use disorder who use fentanyl. The goal is to see if this approach can begin treatment without causing severe withdrawal symptoms. Participants will …

This study tests whether cognitive behavioral therapy (CBT) for parents of very premature infants in the NICU can reduce feelings of child vulnerability and improve the child's development. Parents in the intervention group receive five CBT sessions during and after the NICU stay…

This study will enroll 270 pregnant Native American and Alaska Native women with substance use disorders. Researchers will adapt standard pregnancy and addiction care to better fit Native cultural needs. The goal is to help mothers stay in treatment and attend follow-up visits af…

This study aims to create a way for mothers with opioid use disorder to receive treatment (buprenorphine) while visiting their babies in the neonatal intensive care unit (NICU). Researchers will interview mothers and healthcare providers to understand barriers and then develop a …

This study tests whether combining varenicline (a medication that helps people stop smoking) with financial rewards for clean urine samples can reduce alcohol and tobacco use in adults who both drink heavily and smoke daily. Participants are randomly assigned to receive either re…

This phase 2 trial tests whether mirtazapine, an antidepressant, can help adults who are already receiving medication for opioid use disorder to stop or reduce their methamphetamine use. Participants are randomly assigned to receive either mirtazapine or a placebo for 10 weeks, a…

This phase 3 trial investigates whether high-dose psilocybin, given alongside psychotherapy, can prevent relapse in people with severe alcohol use disorder who also have depressive symptoms. Participants receive either a high dose (25 mg) or a low dose (3 mg) of psilocybin in two…

This study investigates whether oxygen and the drug acetazolamide can help stabilize breathing during sleep in people who take prescription opioids and have sleep apnea. Researchers will measure breathing patterns and sleep quality in 150 veterans. The goal is to find new ways to…

This study looks at whether follow-up care for opioid use disorder via telehealth works as well as in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person clini…

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study…

This study investigates whether ketamine, given as four intravenous infusions over two weeks, can reduce depression and alcohol cravings in adults who have both conditions. Participants are already in inpatient addiction therapy and are randomly assigned to receive either ketamin…

This study tests whether a smartphone app can help people reduce their use of illegal opioids while they are in treatment for opioid addiction. The app uses a short test to predict the chance of relapse in the next week and adjusts medication doses accordingly. About 225 adults w…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders in Boston and Miami. The program uses text messages and coaching to help people manage shame and stigma, set health goals, and stay connected to HIV care. The goa…

This study looks at whether adding addiction counseling and monitoring after a liver transplant for alcohol-related liver disease can lower the chance of drinking again. About 720 adults who had a liver transplant for alcohol-related disease will be followed for two years. The go…

This study tests whether showing doctors a warning flag in electronic health records for patients at high risk of opioid overdose can lead to safer prescribing. About 1,350 adults who recently received an opioid prescription will be included. Doctors in some clinics will see a si…

This study looks at whether having regular motivational conversations after leaving the hospital for alcohol withdrawal can help people stay sober longer. About 104 adults who want to quit drinking completely will be split into two groups: one gets standard care, the other also g…

This study tests a digital tool called EMBED that helps emergency doctors identify patients with opioid use disorder and start them on buprenorphine, a medication that reduces cravings and withdrawal. The tool is built into the electronic health record and guides doctors through …

This study tests whether a common stop-smoking medication (varenicline) plus financial incentives can help adults aged 18-40 who use both e-cigarettes and cannabis quit vaping. All 105 participants will receive the drug and rewards for 12 weeks. Researchers will also track how ca…

This study tests new ways to help people with opioid use disorder continue their buprenorphine medication after starting it in the emergency department. About 3,500 adults will take part. The goal is to see if better coordination between the ER and outpatient clinics helps patien…

This study tests whether hemp-derived CBD (with or without a tiny amount of THC) can help people who use cannabis concentrates regularly to cut down or stop. 165 adults who want to reduce their cannabis use will take either CBD or a placebo for 8 weeks, plus attend therapy. Resea…

This study tests whether a drug called troiluzole can reduce the appeal of methamphetamine for people with methamphetamine use disorder. About 40 adults who use meth but are not seeking treatment will take the drug and then choose between meth and money in a lab setting. The goal…

This study tests whether a 12-week group therapy program called Mom Power can help new mothers with opioid use disorder improve their mood, reduce stress, and strengthen the bond with their child. About 160 mothers with a child aged 5 or younger will be assigned to either the Mom…

This study tests whether reducing methamphetamine use—without requiring complete abstinence—can improve health and quality of life. Researchers will give 300 adults with methamphetamine use disorder payments for providing drug-free urine samples over 12 weeks. They will measure b…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This study tests whether MDMA-assisted therapy can help veterans with both PTSD and alcohol use disorder. Eighty veterans will receive either a full dose of MDMA or a low-dose placebo during three therapy sessions. Researchers will measure changes in PTSD symptoms and drinking ha…

This study tests whether rosuvastatin, a cholesterol-lowering drug, can safely slow or stop liver scarring (cirrhosis) compared to a placebo. About 256 adults with compensated cirrhosis will take the drug or placebo for 2 years. The main goal is to measure changes in liver stiffn…

This phase 3 trial tests whether adding N-acetylcysteine or extending prednisolone treatment beyond the standard 30 days can improve outcomes for people with severe alcoholic hepatitis. About 477 participants will be enrolled. The goal is to see if these strategies increase the n…

This study tests whether semaglutide (Wegovy), a drug used for diabetes and weight loss, can help people with moderate to severe methamphetamine use disorder cut back or stop using. The trial has two parts: a small pilot study with 25 people, followed by a larger randomized trial…

This pilot study tests whether offering financial incentives (contingency management) can help people who started medication for opioid use disorder in the emergency department keep attending outpatient treatment. Thirty adults will be randomly assigned to receive either standard…

This study tests whether a higher starting dose of buprenorphine in the emergency room helps more people with opioid use disorder engage in treatment within 10 days. It also looks at whether the higher dose reduces cravings, withdrawal symptoms, and use of illicit opioids. The tr…

This study tests whether adding buprenorphine (a partial opioid) to the standard shot XR-naltrexone helps people with opioid use disorder stay in treatment and avoid relapse. 180 adults will receive either the combo or a placebo for 24 weeks. The goal is to see if the combo impro…

This study tests whether a mobile app with a virtual group support feature can help young Black women (ages 18-30) who misuse alcohol reduce their drinking and risky sexual behavior, and increase their use of PrEP (a daily pill that prevents HIV). About 500 HIV-negative women in …

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for HIV or already living with it, and who also have substance use issues. The program provides prevention, treatment, and support to help them start HIV prevention medication (PrEP) or lo…

This study tests a health system strategy called SAIA to improve care for people with opioid use disorder as they leave jail and connect to community clinics. Researchers will work with jail and clinic staff to identify bottlenecks and improve treatment continuity. The study invo…

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbo…

This study tests whether a mobile app can help people in addiction treatment avoid relapse. 150 participants will either receive standard care or standard care plus the app, which monitors warning signs and sends alerts. The goal is to see if the app improves long-term recovery.

This study tests whether deep transcranial magnetic stimulation (TMS) can help Veterans with alcohol use disorder reduce relapse. About 100 participants will receive TMS targeting brain circuits linked to craving and emotional processing. The goal is to increase alcohol-free days…

This study tests whether semaglutide (Wegovy), a drug used for weight loss, can help adults with cannabis use disorder use less cannabis. 100 participants will receive either semaglutide or a placebo injection weekly for 20 weeks. The main goal is to see if the drug reduces total…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and achieve undetectable viral loads. About 716 men will be randomly assigned to different co…

This study looks at whether different e-cigarette flavors can help people who smoke cigarettes and are being treated for opioid use disorder with buprenorphine to smoke fewer cigarettes. About 90 adults who smoke at least 5 cigarettes daily will try either a tobacco, sweet-coolin…

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This study tests whether a virtual reality experience can help people in early recovery from alcohol use disorder drink less and stay abstinent longer. About 500 participants who have been sober for at least two weeks but less than a year will use a VR program designed to strengt…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This study tests whether a telehealth pain management program can help veterans who have surgery outside VA hospitals avoid becoming long-term opioid users. About 400 veterans having orthopedic surgery will either receive the program or standard care. The goal is to see if the pr…

This study tests a simple program for smokers visiting emergency rooms. Participants get a $300 gift card for nicotine replacement products, self-help materials, and six months of phone support from a specialist. The goal is to see if this approach helps more people quit smoking …

This phase II trial tests whether adding a cannabis-based mouth spray (nabiximols) to standard chemotherapy helps people with recurrent glioblastoma live longer. About 120 adults whose brain tumor has returned after initial treatment will receive either the cannabis spray or a pl…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This study tests a smartphone app called Smart-T Alcohol that sends personalized messages to help homeless adults reduce their drinking. About 600 people from shelters in Dallas and Oklahoma City will either get the app plus usual care, or usual care alone. The goal is to see if …

This study tests a program called Peer Activate, where trained peer recovery specialists help people with opioid addiction stay on their medication and cut down on other drug use. The program teaches skills like finding rewarding activities without drugs. Researchers will compare…

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests whether bringing mobile health clinics to rural communities and pairing patients with a certified peer support specialist (someone who has personally recovered from opioid use disorder) can help more people start and stay on medication for opioid use disorder. Re…

This phase 2 trial tests whether moderate to high doses of LSD can reduce heavy drinking in people with alcohol use disorder. 128 participants who have recently detoxified will receive either LSD or a low-dose placebo, along with therapy. The study tracks drinking behavior and br…

This study tests a new way to help people stop smoking by combining standard quit-smoking programs with a computer task that retrains unconscious urges to approach cigarettes. About 300 adults who want to quit will be randomly assigned to one of three groups: standard treatment p…

This study tests whether varenicline (Chantix), a drug already used to help people quit smoking, can also help them reduce cannabis use. Two hundred adults in South Carolina who smoke cigarettes and use cannabis will receive either varenicline or a placebo, plus counseling. The g…

This study tests a smartphone app that lets people with severe opioid use disorder take their daily methadone at home while being recorded. The app helps clinics monitor safe use and cravings. Researchers will compare this approach to standard care in 100 adults to see if it keep…

This pilot study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with HIV reduce their alcohol use. Thirty participants will receive the drug along with support from a pharmacist and psychiatrist. The goal is to see if this approach is feasibl…

This study tests whether deep brain stimulation (DBS) can safely reduce drinking in people with severe alcohol use disorder who haven't improved with standard treatments. DBS uses implanted electrodes to send small electrical signals to brain areas linked to craving and self-cont…

This study tests whether starting nicotine replacement therapy (patches, gum, or lozenges) at a specific time in the menstrual cycle helps women quit smoking. About 1,200 women who smoke daily and have regular periods will be assigned to start their quit attempt during the follic…

This study tests two digital treatment programs for people recently released from prison who have a history of substance use problems. The goal is to see if these programs are practical and helpful in preventing relapse and return to prison. About 20 participants will use the dig…

This study compares three approved smoking cessation products—nicotine replacement therapy (patch plus gum or lozenge), cytisine, and varenicline—combined with coaching and home delivery from a virtual pharmacy. Researchers will track how well 150 Ontario adults who smoke use the…

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This study tests whether taking capsules of processed donor stool (fecal transplant) can help people with liver cirrhosis avoid serious infections and hospital stays. About 300 adults with alcohol-related or fatty liver cirrhosis will receive either the transplant or a placebo an…

This study tests a combination of telehealth, peer support, buprenorphine medication, and connections to addiction treatment programs for people who have had an opioid overdose and visited the emergency department. The goal is to help participants stay in treatment and prevent fu…

This study looks at whether adding addiction counseling and a community peer helper to regular primary care helps people with opioid use disorder stay on their medication (buprenorphine) and keep coming to their doctor visits. About 70 adults with opioid dependence and other medi…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from a Johns Hopkins HIV clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and drink le…

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests different treatment plans to help adults with opioid use disorder stay on buprenorphine longer. About 500 people from the emergency department will take part. Researchers will compare approaches to see which works best for keeping patients on medication and reduc…

This study tests whether tirzepatide, a drug used for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. Researchers will give weekly injections of tirzepatide or a placebo to 108 participants for 16 weeks, tracking heavy drinking d…

This study tests a new telehealth program called B-FIT, which adds a family member or friend to standard therapy for veterans with alcohol use disorder. The goal is to see if involving a loved one helps veterans drink less and improve family relationships. About 400 veterans and …

This study tests a program called Tabapsy to help people with mental health conditions who smoke. The program includes information meetings, assessments, and workshops on quitting. Researchers will compare it to usual care in 6,500 adults from psychiatric clinics, measuring if th…

This Phase 2 trial tests whether adding cannabidiol (CBD) to standard naltrexone treatment can reduce alcohol cravings in people with alcohol addiction. 150 participants will receive either a high or low dose of CBD plus naltrexone, or a placebo plus naltrexone, for 14 days. The …

This study is testing whether virtual reality (VR) training can help people with substance use and mental health disorders improve their social functioning and quality of life. Researchers will compare VR training plus standard care against standard care alone in 102 adults recei…

This study tests whether daily text reminders and mindfulness messages can help people taking medication for opioid use disorder stay on track with their treatment. About 60 adults who recently started or restarted methadone or buprenorphine will receive texts for up to 6 months …

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests a computer-based training program designed to change the automatic urge to approach alcohol in people being treated for alcohol use disorder. 112 participants will be randomly assigned to one of three versions of the training, including a sham version. The goal i…

This study tests the VapeAway system, a drug-free program that uses special filters to slowly lower nicotine intake, a sensory tool called the Fix Bar, and digital support to help people stop vaping. About 70 motivated adults who vape daily will use the system for 42 days. Resear…

This study tests a program called MINDSET for veterans with chronic conditions like heart disease or diabetes who smoke or drink too much. Participants receive a mailed packet with personalized health information and a brief motivational phone call. The goal is to see if this app…

This study tests a computer training called Approach Bias Modification (ABM) to see if it can reduce cocaine cravings and increase days of abstinence. Sixty adults with cocaine use disorder will either receive ABM training plus usual care or usual care alone. The training involve…

This study compares two smartphone apps designed to help people living with HIV quit smoking. Participants will use one of the apps for about six months and also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, using b…

This phase 3 trial tests whether adding cannabidiol (CBD) to standard opioid addiction treatment can reduce cravings and prevent relapse. About 450 adults with opioid use disorder who are already on methadone or buprenorphine will receive CBD or a placebo for 24 weeks. The goal i…

This study tests whether a single dose of ketamine, combined with real-time brain training (neurofeedback), can help people with alcohol use disorder drink less. 75 participants will receive either ketamine or placebo, plus real or fake neurofeedback. The goal is to see if the co…

This study tests whether a single dose of psilocybin or ketamine, combined with talk therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least four heavy drinking days per month will be randomly assigned to receive either ps…

This study tests a program called Youth Opioid Recovery Support (YORS) to help teenagers with opioid use disorder stay on their medication and avoid relapse. The program includes family involvement, easy access to medication, and regular check-ins. Researchers will enroll 80 teen…

This study tests whether trained peer recovery specialists can help Black individuals with substance use stick to their long-acting injectable HIV treatment or prevention. 186 participants will either get this peer support or standard care. The goal is to see if the peer program …

This study tests whether a combined infectious disease and substance use disorder clinic can reduce infection-related hospital readmissions. 304 hospitalized adults with opioid or stimulant use disorder and related infections will be randomly assigned to either the integrated cli…

This early study tests whether personalized deep brain stimulation (DBS) can safely reduce cravings and opioid use in 6 adults with severe, treatment-resistant opioid use disorder. Researchers will first map brain activity to find each person's craving signals, then deliver targe…

This study compares a higher daily dose of buprenorphine (24 mg) to the standard dose (16 mg) to see if it helps people with opioid use disorder stay in treatment longer. About 250 adults who have used fentanyl will be randomly assigned to one of the two doses. The goal is to imp…

This study tests a new way to help people with opioid use disorder in rural Georgia. Emergency rooms will use video calls to connect patients with poison center doctors who can start medication (buprenorphine) and link them to peer recovery coaches. The goal is to see if this app…

This study tests whether combining fMRI neurofeedback (brain activity training) and TMS (magnetic brain stimulation) can help people with alcohol use disorder drink less and feel fewer cravings. About 90 adults aged 19-65 who are already in treatment will attend weekly sessions f…

This study tests a community program called Young HEROES for youth aged 12-17 with opioid use disorder. It combines medication, counseling, and peer support to help them stay in treatment and stop using opioids. The goal is to see if this approach works better than usual care in …

This study tests a program called Youth Opioid Recovery Support (YORS) for young adults aged 18-28 with opioid use disorder. The program includes home delivery of medication, family involvement, and active outreach to help participants stay on their relapse prevention shots. The …

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with opioid use disorder reduce cravings and avoid relapse. About 46 adults who are already taking buprenorphine will receive either semaglutide or a placebo for 12 weeks. The goal is …

This trial tests a peer-led program called PEGISUS to reduce substance use and promote fair gender beliefs among 264 young people (ages 16-24) in vocational training in Zambia, Zimbabwe, and South Africa. Participants in peer groups will attend eight sessions, while a control gro…

This study tests a 'rooming-in' approach where mothers and babies stay together in a quiet hospital room instead of separating the baby to the NICU. About 240 full-term infants exposed to opioids during pregnancy will take part across Alberta hospitals. The goal is to reduce NICU…

This early-stage trial tests whether a single dose of insulin given as a nasal spray can reduce alcohol cravings and consumption in people with alcohol use disorder. Forty non-treatment-seeking volunteers will receive either insulin or a placebo and then be exposed to alcohol-rel…

Researchers are studying whether a blood test called HepQuant DuO can measure liver function over time in people with alcohol-related liver disease. Participants drink a natural compound called cholate, then give two blood samples at 20 and 60 minutes. The study follows about 40 …

This study will test a new, non-invasive device that measures blood flow and oxygen levels in the brains of newborn babies. Researchers will compare babies who were exposed to opioids before birth with those who were not. The goal is to see if the device can detect signs of opioi…

This study aims to see which of two blood tests, eLIFT or FibroMeter, is better at finding advanced liver scarring (fibrosis) in people with fatty liver disease or alcohol-related liver disease. About 1,788 adults from primary care clinics will take both tests. The goal is to imp…

This study is testing whether combining new blood tests and stool analysis can detect liver fibrosis earlier than current methods. Researchers will follow 1200 adults referred to a community liver clinic. The goal is to identify advanced liver disease sooner and reduce unnecessar…

Researchers are testing whether a three-session couples motivational interviewing program helps male couples reduce illicit drug use and behaviors that raise HIV transmission risk. The trial enrolls 360 male couples where at least one partner is HIV negative and at least one has …

This study works with 300 women in rural Kentucky jails who have opioid or stimulant use disorders. The goal is to lower their risk of overdose when they return to their communities. The program offers support and connects them to treatment options before and after release.

This trial tests a police education program called SHIELD 2.0 in nine counties in Appalachian Kentucky. The program trains local behavioral health workers to teach police how to refer people who use drugs to treatment and social services instead of arresting them for low-level po…

This study tests two counseling programs—one focused on motivation and coping skills, the other on strengths and advocacy—to prevent opioid misuse in 300 homeless youth aged 14-24. Participants are randomly assigned to one of the programs or standard services, and tracked for two…

Researchers at Yale University are studying how to expand opioid agonist therapy (OAT) in prisons and probation systems in Tajikistan, Kyrgyzstan, Moldova, and Georgia. OAT uses medicines like methadone or buprenorphine to treat opioid dependence and can lower HIV transmission am…

This study is developing and testing a virtual reality tool to help young people aged 15-30 who have experienced trauma and are at risk for substance use and HIV. The goal is to see if the tool can reduce substance use and risky behaviors. Researchers are recruiting young men who…

This study tests a program called PAL that gives hospital patients personalized feedback on smoking, drinking, diet, and exercise. About 788 patients will be split into two groups: one gets the feedback and support, the other gets usual care. The goal is to see if this low-cost a…

This study is creating and testing short videos for teens (ages 12-17) and their parents after a traumatic injury that requires a hospital stay. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families an…

This study tests a mobile health program called WINGS+PrEP for women who have experienced heavy drinking, partner violence, and involvement with the criminal legal system. The program provides information about PrEP (a daily pill that prevents HIV) and offers support sessions. Re…

This study tests four different approaches to help people who inject drugs remember and stick with their daily HIV prevention pill (PrEP). Researchers will enroll 256 adults who are newly on medication for opioid use disorder and have started PrEP. The goal is to see which method…

This study tests a program called PREVENTURE for teenagers aged 14 to 17 who are at risk for alcohol and drug addiction. Participants are randomly assigned to either the program plus usual care or usual care alone. The goal is to see if the program reduces binge drinking and othe…

This pilot study tests whether a peer-driven program can help people who inject drugs in Baltimore reduce their risk of HIV, hepatitis C, and overdose. Researchers will identify high-risk injection settings and train peers to promote safer practices, like carrying naloxone and av…

This study tests a 9-month program called NE+ for American Indian youth aged 12-18. The program includes educational modules and cultural teachings to encourage abstinence, condom use, and avoid substance use. It also involves parents and school staff. The goal is to see if the p…

This study tests two approaches to help men who have sex with men and use methamphetamine start or restart HIV prevention (PrEP) or treatment (ART). 400 participants will receive either contingency management (rewards for filling prescriptions) alone or combined with motivational…

This study tests a program called Family Spirit Strengths (FSS) designed to help American Indian and Alaska Native mothers and caregivers cope with stress, build skills, and connect with their culture. About 188 participants will either receive FSS or a nutrition education progra…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience. The goal is to prevent substance …

This study tests a program called CHORUS+ that helps people who inject opioids get HIV prevention medication (PrEP) and treatment for opioid use disorder (MOUD). Participants receive HIV self-testing, rapid access to medications, and 6 months of support from a peer coach. The goa…

This study is testing whether a long-acting injectable HIV prevention drug, called cabotegravir, can work for people who inject drugs. The trial will enroll 100 adults who have injected non-prescription drugs in the past 6 months and are at risk for HIV through sexual contact. Pa…

This study tests a smartphone-based program called RISE Guide for women who have just been sexually assaulted. The goal is to see if it can reduce anxiety sensitivity and prevent posttraumatic stress disorder (PTSD) and cannabis use disorder (CUD). 68 women who seek emergency car…

This study tests a prevention program for binge drinking in 240 students aged 18-30. The program combines motivational interviewing with social psychology techniques to change drinking habits. Researchers will measure changes in binge drinking scores and readiness to change. The …

This study tests whether a brief, two-session alcohol counseling program can help Veterans reduce their drinking and prevent intimate partner violence. Researchers will compare this program to alcohol education or standard check-in calls. 300 Veterans who are already in a partner…

Researchers at Virginia Commonwealth University are testing whether adding high-definition transcranial direct current stimulation (HD-tDCS) to cognitive behavioral therapy can help people with cocaine use disorder. The trial enrolls 36 adults aged 18 to 65 who meet criteria for …

This pilot study tests whether engaging in enjoyable activities and virtual reality can reduce alcohol cravings and drinking in people with alcohol use disorder. About 44 adults will attend up to 10 visits, comparing active sessions (games, VR, crafts) with passive sessions (watc…

Researchers are testing an experimental drug called tezampanel to see if it is safe and can ease opioid withdrawal symptoms in adults with opioid use disorder. The trial enrolls 40 people who are seeking treatment and have recent opioid use. Participants stay in a research center…

Researchers are testing whether a 12-week home cycling program can help adults with alcohol use disorder and alcohol-related liver disease drink less and crave alcohol less. Thirty participants join either the exercise program plus standard care or standard care alone. The study …

This study tests whether cannabidiol (CBD) can reduce the need for strong painkillers (opioids) in people with end-stage prostate cancer that has spread and no longer responds to standard treatments. About 58 participants will receive either CBD or a placebo three times daily for…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This study looks at whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study involves …

Researchers in Vietnam are testing a peer-counseling program called Friendship Bench for women who use methamphetamine and have common mental health problems like depression, anxiety, or stress. The program trains peer workers to lead six weekly one-on-one sessions that help part…

This study looks at how two parts of cannabis, THC and CBD, affect thinking and bladder symptoms in people with Multiple Sclerosis (MS). Thirty adults with MS will take either THC or CBD oil for 15 weeks and complete tests and questionnaires. The goal is to see if one compound he…

Researchers at the University of Missouri-Columbia are studying whether improving insomnia can lead to better alcohol outcomes in heavy-drinking adults. The trial enrolls 256 adults who meet criteria for alcohol use disorder and insomnia disorder. Participants receive five weekly…

This study tests whether a brain-training technique called neurofeedback can help people with opioid use disorder who are on methadone feel more pleasure and recall positive memories. Participants learn to control their brain activity using real-time fMRI scans, a method that has…

This study tests whether low-intensity focused ultrasound (LIFU) can safely calm overactive brain areas linked to alcohol cravings. Twenty-five adults with alcohol use disorder will receive LIFU while researchers monitor side effects and measure brain activity changes with fMRI. …

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) to reduce nicotine cravings and vaping. 120 adults who vape heavily will receive either real TI stimulation to deep brain areas linked to addiction or a sham (fake) treatment during a …

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

Researchers are testing whether a personalized form of transcranial magnetic stimulation (TMS) changes reward-related brain activity more than standard TMS in adults who smoke cigarettes. Participants receive 15 TMS sessions over three weeks, with brain scans used to pick the sti…

This study tests whether a brief motivational interviewing session during a primary care visit can reduce alcohol and cannabis use among diverse teens aged 12 to 17. Researchers will enroll 500 participants who are at risk for substance use and track changes in how often they dri…

Many smokers are not ready to set a quit date, so traditional cessation programs miss them. This trial tests whether counseling focused on practice quitting, where smokers try not smoking for short periods without pressure to quit forever, helps them make a real quit attempt late…

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking. About 100 adults in Ontario who smoke at least 5 cigarettes daily will receive the drug alongside nicotine replacement therapy. The main goal is to see if a larger s…

This study tests a smartphone app called ACT on Vaping to help young adults (ages 18-30) quit using e-cigarettes. The app uses behavioral therapy to help users recognize triggers and build skills to stop vaping. About 1,178 participants will use the app or a control, and research…

This study tests whether a 5-session online program teaching positive thinking skills can help people with HIV who use stimulants. Researchers want to see if it reduces stimulant use and depression by changing brain and immune function. 189 participants will be followed for 3 mon…

This study looks at how the drug acamprosate affects brain function in people with moderate to severe alcohol use disorder. Researchers will use EEG to measure brain waves in 48 adults who stay in the clinic for about 3 weeks. Half get acamprosate, half get a placebo, and brain a…

This study compares two versions of a smartphone app called Living Free from Tobacco (LiFT) to help young adults ages 18-30 quit using nicotine and tobacco products. About 140 participants will use one of two app versions: one focuses on building mental flexibility to support qui…

This study tests a new medication called PP-01 to help adults with cannabis use disorder manage withdrawal symptoms when they stop using cannabis. About 420 participants will receive PP-01, an existing drug (nabilone), or a placebo daily for 34 days, with a one-week hospital stay…

This study looks at whether emergency medical services (EMS) can safely start buprenorphine treatment for people with opioid use disorder right at the scene of an emergency. Researchers will first test how practical and acceptable this approach is, then track whether patients sta…

This study tests a web-based platform called KulaMind-Recovery designed to help loved ones of people recovering from substance use disorders. The platform offers skill-building modules, one-on-one video sessions, text-based coaching, and a community forum. Researchers will see if…

This trial tests whether daily music training—either piano practice or listening to music—can improve behavior and thinking in children with fetal alcohol spectrum disorder (FASD). Each child will do both activities for 12 weeks each, in a random order, with tests before and afte…

This study looks at whether cannabis can help veterans who have PTSD and thoughts of suicide. About 500 veterans who have used cannabis in the past year will take part. Researchers will track changes in PTSD symptoms, mood, and suicide risk over time using interviews and question…

This trial compares two types of nerve blocks given before breast surgery to see which better prevents chronic pain that can last for months. Women aged 18-65 scheduled for mastectomy will receive either a serratus posterior superior intercostal plane block or an erector spinae p…

This study tests whether a non-invasive brain stimulation technique called TMS can reduce cravings and opioid use in people with opioid use disorder. One hundred participants will receive either real or sham TMS sessions over 8 weeks, with follow-up visits for about 5 months. The…

This study tests whether a short, four-session therapy program that helps people rethink their identity and memories related to drinking can reduce alcohol use and cravings. Sixty adults with alcohol use disorder will be randomly assigned to either receive this therapy plus usual…

This trial tests a peer-led program called Honest, Open, Proud (HOP) for veterans with mental health or substance use disorders who have been involved with the justice system. The program helps participants decide whether, when, and how to disclose their conditions, with the goal…

This study tests whether a digital avatar (virtual coach) program can help young adults aged 18-29 who come to the emergency department with alcohol misuse and suicidal thoughts. About 60 participants will either use the avatar program with supportive texts or a free suicide safe…

This trial tests a virtual program called iPAWS for adolescents and young adults having their wisdom teeth removed. The program teaches safe, effective ways to handle post-surgical pain and aims to reduce cannabis and other substance use. Researchers are enrolling 150 participant…

This study is adapting a friendly text-message chatbot called Penny to support pregnant and postpartum women who are recovering from opioid use disorder. The chatbot sends helpful messages and allows two-way conversations to reduce loneliness and keep women engaged in their care.…

This trial tests whether a culturally adapted, virtual group therapy called Emotional Awareness and Expression Therapy can help Israeli adults with chronic musculoskeletal pain who also use medical cannabis. Participants attend eight weekly sessions—one in person, the rest online…

This study tests whether giving testosterone to men with chronic back pain who take opioids can improve their pain, sexual function, fatigue, and quality of life. The men have low testosterone caused by opioids. Half will get testosterone injections and half a placebo. The trial …

This study tests whether a personalized approach to smoking cessation helps cancer patients quit. Researchers will use patients' clinical, genetic, and biomarker information to create tailored treatment plans. The study involves 112 participants and compares this precision treatm…

This early-phase trial at Yale tests whether dronabinol (Marinol), a synthetic form of THC, can reduce pain sensitivity and improve attention and mood in 36 adults with opioid use disorder who are stable on methadone or buprenorphine. Participants receive either 2.5 mg, 5 mg of d…

This study tests whether a device that gently stimulates the forehead during sleep can help children aged 8 to 12 who have ADHD linked to prenatal alcohol exposure. The device, already cleared for general pediatric ADHD, is used at home by parents each night for four weeks. Resea…

This study tests whether a non-invasive brain stimulation technique called TMS can reduce attention to cannabis cues and help heavy users cut down. Fifty near-daily cannabis users will receive either real or placebo TMS over five days, then be followed for four weeks. The goal is…

This study tests whether a four-week at-home memory training program called MemFlex can improve symptoms and brain function in people with opioid use disorder. Participants complete memory exercises and undergo brain and heart monitoring before and after training. The goal is to …

This pilot study tests whether tirzepatide, a drug used for diabetes, can help reduce cravings for alcohol in people with alcohol use disorder. Twenty adults will receive weekly injections of either the drug or a placebo for 4 weeks. The goal is to see if the drug lowers cue-trig…

This early-phase study tests whether a device that delivers specific smells can reduce cigarette cravings and help people stop smoking. About 132 smokers will use a smartphone app with or without the scent device for a week, then report cravings and quit attempts. The goal is to …

This study tests a behavioral program called QuitVaping, which combines counseling sessions with text message support, to help teenagers aged 14-18 quit vaping. About 400 participants who vape nicotine at least weekly will be randomly assigned to either the QuitVaping program or …

This study is for pregnant people who use tobacco and cannabis and want to quit. Researchers will test a program that helps with depressive symptoms to make quitting easier. The study involves 25 participants and will measure how well the program works and if people stick with it…

This study is testing a smartphone-based system called STAR that uses machine learning to predict when someone with alcohol use disorder might relapse. Participants will complete surveys and use the system to receive personalized recovery support messages. The goal is to see if t…

This study tests a hybrid dialectical behavior therapy (DBT) program for veterans with PTSD who have already completed inpatient treatment. The goal is to reduce lingering symptoms and prevent relapse. About 24 veterans will take part, combining in-person skill groups with online…

This Canadian study is testing whether cannabinoid oils (CBD and THC) can safely help manage symptoms like pain in children aged 4-17 with relapsed or refractory cancer. The trial will enroll 60 kids across three hospitals, giving them different ratios of CBD to THC oils to see w…

This study tests whether bright light therapy can help people going through cocaine withdrawal in a hospital. Cocaine withdrawal often disrupts sleep, mood, and daily rhythms, making it hard to stay drug-free. The therapy uses a special lamp to mimic daylight, which may improve s…

This study tests a new program where community health workers provide extra support to pregnant women who smoke. The goal is to help them quit smoking during pregnancy. About 105 women in San Bernardino County will take part and receive coaching to stop tobacco use.

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in people with opioid and alcohol use disorders. Sixty adults enrolled in an intensive outpatient program will receive daily TMS sessions for four weeks, alongside their usual ther…

This study tests whether IGC-AD1, a THC-based oral medication, can safely reduce agitation in people with mild to severe Alzheimer's dementia. About 164 participants will receive either the drug or a placebo twice daily for several weeks. Researchers will measure changes in agita…

This study tests a program that combines a smartphone breathalyzer, a blood alcohol estimator app, and a brief counseling session to help young adults who drink heavily. Researchers want to see if these tools are easy to use and helpful for drinking more moderately. The study inv…

This study tests whether a personalized exercise program can help smokers who are afraid of bodily sensations (like a racing heart) quit smoking. 360 adults will take part at YMCA locations. The goal is to see if exercise reduces smoking relapse and helps people stay smoke-free f…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults reduce or quit smoking and vaping. About 406 participants in Switzerland and Türkiye will be randomly assigned to the program or a control group. The program includes ei…

This study tests a program called the Transitional Pain Service Program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients manage pain and safely reduce opioid use. Researchers will com…

This pilot study tests a smartphone app called eMind that delivers an 8-week mindfulness programme to help smokers quit. Researchers want to see if smokers find the app acceptable and easy to use. The study involves 40 adult smokers motivated to quit, who will use the app and pro…

This study tests a 6-month holistic behavioral health program called EASE for 200 adults with HIV or seeking HIV prevention who also use alcohol or drugs. Participants receive counseling, case management, peer support, and education. Researchers will measure changes in depression…

This study compares two brief behavioral interventions for emerging adults aged 18-25 who use cannabis frequently (at least 20 days per month). Participants attend two 40-50 minute sessions a week apart and are followed for 6 months. The goal is to see if either program helps red…

This study tests whether a continuous pump delivering numbing medicine into the belly can reduce pain and the need for narcotics after minimally invasive hysterectomy. About 120 women having surgery for non-cancer reasons will be randomly assigned to receive either a numbing drug…

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the real patch or a placebo, along with standard pain…

This study tests whether a non-invasive device that stimulates the vagus nerve in the neck can reduce withdrawal symptoms in people with opioid use disorder. About 103 participants will stay in the hospital for a week, receive either active or sham stimulation, and have brain sca…

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to c…

This study tests whether an 8-week mindfulness program can help Hispanic young adults (ages 18-25) who binge drink reduce their alcohol use. Participants are randomly assigned to either the mindfulness group or a control group that only fills out surveys. The program teaches stre…

This study tests whether brief training in mindfulness or cognitive-behavioral techniques can reduce heavy drinking in young adults aged 18-26. Participants will complete 1-4 training sessions and report their drinking via smartphone. The goal is to see if these techniques help p…

This study tests whether a short writing therapy called Written Exposure Therapy (WET) can help veterans who have both posttraumatic stress disorder (PTSD) and a substance use disorder. About 170 veterans will complete five writing sessions about their trauma. The goal is to see …

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. Researchers want to see if this approach is practical and helps veterans stay smoke-free for at least 3 months. About 50 veter…

This study tests whether adding pregabalin to the standard withdrawal drug lofexidine helps people with opioid use disorder feel less sick while quitting. About 150 adults who want to start long-acting naltrexone will take either the combination or a placebo for 8 days. The goal …

This study tests an online, 9-week program designed to help parents and caregivers of LGBTQ+ youth of color become more supportive and accepting. Researchers will enroll 180 youth (ages 14-25) and their caregivers to see if the program reduces depression, anxiety, drug use, and o…

This study tests whether a supervised exercise program can improve sleep in people with alcohol use disorder. Forty adults with sleep problems will take part in activities like walking, cycling, and yoga. Researchers will track sleep quality, melatonin levels, and how well partic…

This study tests whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain. Researchers will give CBD or a placebo to 80 adults with chronic low back pain, with or without mild-to-moderate depression. They will use brain scans to m…

This study tests whether nabilone, a synthetic cannabinoid, can safely reduce agitation in people with Alzheimer's disease. Agitation is common and distressing, with few good treatment options. About 112 participants will receive either nabilone or a placebo for 8 weeks, and rese…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether a type of brain stimulation called cTBS can reduce cravings for alcohol in people with alcohol addiction. 34 adults will receive 15 stimulation sessions over 5 days, and researchers will measure changes in their cravings, heart rate, and brain activity. T…

This study tests whether mindfulness meditation in virtual reality can reduce cigarette cravings and help people quit smoking. Two hundred smokers will be split into two groups: one gets six VR meditation sessions over six weeks, and the other uses nicotine patches and gum. Resea…

This study is creating and testing a short, online therapy program for LGBTQ+ people who have experienced trauma and drink alcohol. In the first phase, participants share their thoughts to make the program more helpful and welcoming. In the second phase, some participants can try…

This study tests whether adding cannabidiol (CBD) to standard alcohol detox treatment helps people with severe alcohol use disorder stay sober longer. About 210 adults will receive either CBD or a placebo for 11 days during a hospital stay. Researchers will check if participants …

This study is testing three treatments one after another for people with chronic pain who are already taking long-term opioids. First, participants try a low-dose buprenorphine patch (a safer opioid) without going through withdrawal. Then, they receive a brief cognitive behaviora…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study tests whether a condensed form of PTSD therapy, called Massed Prolonged Exposure (M-PE), can help people who are also being treated for substance use disorders. About 168 adults will either receive M-PE alongside their usual substance use program or continue with stand…

This study tests a digital coaching program that uses a chatbot to help people quit smoking. The program aims to boost motivation, educate about quitting tools, and create a personalized quit plan. Researchers will enroll 440 adult smokers and check if they have quit after 6 mont…

This pilot study tests whether screening and treating sleep disorders during tobacco or cannabis cessation therapy helps people stay abstinent longer. 80 participants will either get usual care or extra sleep-focused care. The study follows them for 6 months to see if addressing …

This study tests a program called Contingency Management that gives Veterans rewards for quitting smoking, verified by breath tests. Researchers will first gather feedback from Veterans and staff, then run a small pilot with 20 Veterans over 5 weeks. If successful, a larger trial…

This study tests whether a ketone supplement drink can reduce alcohol withdrawal symptoms in 30 adults with moderate to severe alcohol use disorder. Participants will receive either the ketone drink or a placebo for 4 days during inpatient detox. The main goal is to see if the ke…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cravings in people addicted to nicotine. One hundred daily smokers who are highly dependent will receive tDCS sessions. The goal is to see if this painless, mild electrical stimulation can …

This study will test 70 healthy adults aged 21-55 to see how cannabis products labeled as indica, sativa, or generic affect thinking, driving, and feelings. Participants will complete memory tasks, driving simulations, and questionnaires after using cannabis. The goal is to under…

This study aims to create a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants will use an app that tracks phone activity and location, and answer short surveys about mood and substance use. The goal is …

This study looks at a brain protein called PDE4B in people with alcohol use disorder. Researchers want to see if levels of this protein change during alcohol withdrawal and after a few weeks of not drinking. The study involves 30 adults who will have two PET brain scans and possi…

This study looks at how the liver processes fat in people with alcohol use disorder who are quitting drinking. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity. The goal is to understand how the liver clears fat wh…

Researchers are using PET scans to measure mitochondrial Complex-I and glucose metabolism in the brains of people with alcohol use disorder and healthy volunteers. The study aims to see whether these markers differ between the two groups and whether they relate to alcohol craving…

This study is developing new MRI techniques to better understand how drug addiction changes the brain. Researchers will scan 1,000 healthy adults, smokers, and drug users to improve imaging methods. The goal is to create tools that can reveal the brain's structure and function in…

This observational study uses brain scans (MRI) and behavioral tasks to compare people with and without alcohol dependence. Researchers want to see if differences in brain structure and activity relate to personality, behavior, and genetics. Up to 1,000 adults will participate in…

Researchers are testing whether PT150, an experimental drug that blocks the body's stress hormone receptor, can reduce the physical and behavioral effects of stress and alcohol in people with alcohol use disorder. The study enrolls 34 adults who are not seeking treatment. Partici…

This study is testing whether simple saliva tests done at home can accurately show when someone has not used cannabis. Researchers will enroll 200 people aged 18-30 who use cannabis at least once a week. Participants will provide saliva and urine samples over 3-4 weeks, and resea…

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study is testing whether a smartwatch can detect when someone uses opioids or experiences withdrawal. Researchers will collect biometric data from 420 people with opioid use disorder who wear the watch for 14 days. The goal is to train a machine learning algorithm to recogni…

This study looks at how alcohol use disorder (AUD) changes a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to better understand these sensory changes, not to tes…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This study is testing how well a culturally adapted screening and brief counseling program works for American Indian and Alaska Native adults who have chronic pain or misuse opioids. Researchers will work with three clinics to see if the program is easy to use and helpful. The go…

This study uses a special PET imaging tracer to measure how much energy the brain uses in people with cocaine use disorder compared to healthy controls. The goal is to see if energy use in key brain regions, like the orbitofrontal cortex and midbrain, differs in addiction. This c…

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers. Researchers will also study how it affects thinking and reward processing in non-smokers. The goal is to understand if blocking a brain c…

This study looks at how people with opioid-use disorder learn and make choices compared to those without the disorder. Participants will complete a computer task where shapes are paired with different food odors. The goal is to understand if differences in learning and decision-m…

This study looks at heart electrical patterns (ECGs) in 240 people hospitalized for methamphetamine use, comparing those with and without psychosis. Researchers will check ECGs at admission and before discharge to see if psychosis is linked to more heart strain. The goal is to be…

This study uses brain scans to compare a specific receptor (CB1) in people with opioid use disorder who are on methadone treatment versus healthy volunteers. The goal is to understand how the endocannabinoid system works differently in addiction. No new treatment is tested; it is…

Researchers at the University of Rochester are testing a program called FMF Connect Pro that trains mental health providers to screen for prenatal alcohol exposure, diagnose fetal alcohol spectrum disorders, and support caregivers through a companion app. The study compares two t…

This study aims to improve pain relief after cesarean sections by looking at how a mother's genes affect her response to opioids. Researchers will enroll 700 women and track genetic markers linked to side effects like breathing problems and nausea. The goal is to create a persona…

This study will follow 90 people hospitalized with methamphetamine-induced psychotic disorder, comparing those who have also used cannabis in their lifetime to those who have not. Researchers will assess psychiatric symptoms, insight, addiction severity, and sleep quality weekly …

Researchers at Yale University are using PET brain scans to measure two types of opioid receptors, mu and kappa, in people with alcohol use disorder and in healthy volunteers. Participants with alcohol use disorder complete detoxification and then undergo scans within the first d…

This study adapts a parenting program called 'Proud of Baby and Me' for new mothers who are receiving medication for opioid use disorder. The goal is to see if the program helps mothers stay in treatment, reduce stress, and improve bonding with their baby. Ten women will particip…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study will give 22 occasional cannabis users oral THC, CBD, both, or a placebo to measure how these substances appear in blood and saliva, and how they affect thinking and behavior. The goal is to better understand drug detection and impairment from oral cannabinoids. It is …

This study tests a 10-week parenting program called Parenting in 2 Worlds (P2W), designed specifically for urban American Indian families. Researchers will compare it to a general health program in four U.S. cities with 1,440 parent-teen pairs. The goal is to see if P2W improves …

This study looks at how smoking high-potency cannabis affects pain relief, feelings of being high, and drug levels in the blood. Researchers will test 30 near-daily cannabis users who are not seeking treatment. Participants will smoke either placebo, low-dose, or high-dose THC ca…

This study looks at whether a blood marker called phosphatidylethanol (PEth), which reflects alcohol use over the past few weeks, can predict complications after surgery. Researchers will test PEth levels in 170 adults having elective surgery at University Hospitals Cleveland Med…

This early-stage study will test how a hemp-based CBD lotion with a small amount of THC is absorbed by the body. Twenty healthy adults will use the lotion in a clean, controlled environment. Researchers will measure cannabinoid levels in saliva, blood, and urine over time to unde…

This study explores whether a short substance use questionnaire and brief counseling session can be easily added to regular check-ups for adult survivors of childhood cancer. About 30 participants will fill out a screening tool and, if needed, receive supportive counseling during…

This study looks at how men and women differ in their attraction to and addiction risk from menthol-flavored e-cigarettes, both with and without nicotine. Researchers will measure choices and effort to get the product in 60 adult smokers who already use e-cigarettes. The goal is …

This study investigates how a person's genetic makeup influences their response to cannabis, including risk for addiction and psychosis. Healthy adults aged 21-60 receive either a very low or medium dose of THC (the active ingredient in cannabis) or a placebo intravenously. Resea…

This study will follow 40 adults aged 18-70 who currently take tirzepatide, a medication for blood sugar and appetite control. Researchers will temporarily stop the drug for 3-4 weeks and then restart it for 6-8 weeks, using brain scans, questionnaires, and stool samples to track…

Researchers at Yale University are using PET brain imaging with a radiotracer called Bavarostat to measure levels of an epigenetic marker, HDAC6, in people with PTSD, alcohol use disorder, or both. The study includes 150 adults aged 18 to 70 and compares them with control groups.…

This study follows up to 7,500 adults with or without alcohol use disorder to learn more about the condition. Researchers will collect health information, blood samples, and brain scans to better understand the biology and genetics behind alcohol problems. The goal is to improve …

This study looks at whether giving opioid treatment programs (OTPs) regular reports on how well they retain patients, plus a quality-improvement toolkit, can help more people stay in treatment for at least 90 days. Some clinics will also get extra help from an outside facilitator…

This trial investigates whether simply seeing, smelling, and holding a beverage—without drinking—changes craving in adults with alcohol use disorder. Participants will complete two sessions where they are exposed to water and a visually matched test beverage while rating their cr…

This study aims to understand why some people with opioid use disorder have more severe addiction than others. Researchers will collect blood, saliva, and hair samples from 350 participants and combine that with detailed interviews about their social and mental health. The goal i…

This study tests whether community health workers can help more eligible people get screened for lung cancer and quit smoking. The workers will reach out to patients, help them make informed decisions, offer smoking cessation counseling, and navigate barriers to care. The study w…

This study looks at how social behaviors and feelings of connection impact treatment for opioid use disorder. Researchers will collect daily reports from 230 patients and a close friend or family member over several weeks. The goal is to find patterns that could lead to more pers…

This study looks at whether a drug called fampridine, which blocks potassium channels in the brain, can improve working memory in people with cocaine use disorder. Forty chronic cocaine users will receive either the drug or a placebo and then take memory tests. The goal is to und…

This study tests a new program for adults in prison who have both ADHD and substance use disorder. The program includes workshops to improve care and support. Researchers will check if the program is acceptable and if it improves quality of life.

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers think special light-sensitive cells in the eye might be involved. They will measure pupil responses, brain waves during sleep, and daily sleep patterns in 200 adults…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study tests a training program called INSPIRE designed for healthcare teams caring for people with substance use disorder during childbirth. The program includes online learning and in-person simulations. Researchers want to see if the training changes healthcare providers' …

This study is testing whether a smartphone app can help people in Michigan on Medicaid who are recovering from both opioid and alcohol use disorders. The app uses rewards to encourage healthy behaviors. Researchers want to see if people find the app useful and easy to use, and if…

This trial compares an online training program (COPEWeb) to in-person training for behavioral health providers. The goal is to see if the online version is as effective at teaching providers to deliver a combined treatment for PTSD and substance use disorders. Providers will be r…

This study is looking at whether detailed heart imaging can help predict heart problems in people with liver cirrhosis who undergo a procedure called TIPSS, which creates a shunt to relieve pressure in the liver. Participants will have heart MRIs and echocardiograms before, short…

This study follows 700 people with substance use disorders over two years to see how addiction symptoms, especially craving, are connected and whether those connections change as addiction severity shifts. Participants complete annual diagnostic assessments and two-week periods o…

This study recruits 600 adults who want to quit smoking. Participants use a smartphone app to take photos of their environment when they smoke and at random times. Researchers use artificial intelligence to analyze these images and identify environmental triggers that lead to rel…

This study follows 400 parents in rural Ohio who are part of the Ohio START program, which connects them to substance use treatment and peer mentors. Researchers want to see if having treatment services close to home and strong social support helps parents recover and improves th…

This study works with Black teens on probation and their families to adapt alcohol and drug treatment to better address experiences of racial discrimination. Researchers will interview teens and hold focus groups with parents and community advocates to learn what works. The goal …

This study looks at how sex hormones like testosterone, estrogen, and progesterone relate to pain levels and opioid use after surgery in girls aged 11 to 16. Researchers will also examine whether immune factors help explain these effects. The goal is to better understand why pain…

This study looks at whether a blood test for a marker of heavy drinking (carbohydrate-deficient transferrin, or CDT) can help predict how well critically ill patients will do in the intensive care unit. Researchers will follow 800 adults admitted to the ICU through the emergency …

This study looks at young adults aged 18 to 25 who use both tobacco/nicotine products and cannabis. Researchers want to understand what happens to cannabis use when participants try to quit nicotine. All participants receive remote counseling and incentives to stop using nicotine…

This study looks at whether federal policy changes made during the COVID-19 pandemic helped more veterans get and stay on medication for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data …

This study investigates how THC and CBD in cannabis affect recognition memory in healthy adults who use cannabis regularly. Participants perform a memory task after smoking cannabis and on a separate sober day, while their brain activity is recorded via EEG. Blood samples measure…

This phase 1 trial at Ohio State University is studying how nicotine analogs compare to regular nicotine in e-cigarettes. Researchers want to understand if these newer chemicals are just as addictive and what they do to the heart and blood vessels. The study involves 70 adult e-c…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This study looks at how THC and CBD, two compounds found in cannabis, affect the body's stress response in people who are sleep-deprived and have higher-than-average anxiety. Sixty healthy volunteers will take either THC, CBD, both, or a placebo after a night of restricted sleep.…

This study follows 32 people with cocaine use disorder as they go through detox. Researchers use wearable sleep monitors, questionnaires, and urine tests to track sleep quality and body rhythms during active use, early withdrawal, and late withdrawal. The goal is to understand ho…

This study looks at how preterm and full-term babies adapt to noises and lights—a skill called habituation. Researchers will compare 70 infants near their due date to see if differences in this ability can help spot those at risk for developmental delays. The goal is to find earl…

This study looks at whether regular cannabis users can adjust how much they vape when using high-potency concentrates (30%, 60%, and 90% THC). Researchers will measure blood THC levels, puffing behavior, and subjective feelings of intoxication. The goal is to understand if people…

This study is testing whether a short, tailored alcohol intervention is practical and well-liked by people who are taking buprenorphine for opioid use and also drink alcohol. About 60 adults will take part. The goal is to see if this approach could work in a larger future study.

This study looks at why some smokers develop COPD while others don't. Researchers will collect lung cells from 40 former smokers using a bronchoscopy and analyze them to find differences in immune cells called macrophages. The goal is to understand the biological reasons behind C…

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain and/or opioid use to healthy women. The goal is to find new ways to treat chronic pain without relyi…

This study looks at how severe alcohol use disorder changes the brain's ability to understand emotions and social cues. Researchers will use brain scans and tests to compare 60 people with the disorder to healthy volunteers. The goal is to learn how these brain changes affect dai…

This study looks at how inflammation and liver repair differ in people with alcoholic hepatitis versus those with alcoholic cirrhosis or healthy livers. Researchers will collect blood, liver tissue, and fluid samples from 450 participants. The goal is to better understand what dr…

This study follows 7,500 heavy drinkers over time to learn how alcoholic liver disease develops and worsens. Researchers will use non-invasive tests like ultrasound and blood markers to identify who is at risk for cirrhosis and liver cancer. The goal is to improve screening and e…

This study is observing heavy drinkers with jaundice to learn more about alcoholic hepatitis, a serious liver condition. Researchers will track survival and liver function over 12 months, and collect genetic samples to better understand the disease. The goal is to improve diagnos…

This study follows 35 men in residential rehab for severe substance use. They write weekly stories about their feelings and challenges, and fill out questionnaires every two weeks. Researchers use natural language processing to analyze the stories and look for patterns that might…

This study uses brain scans (MRI, MRS, EEG) to see how ibogaine affects the brain in 20 people with moderate to severe opioid use disorder. Participants will already be receiving legal ibogaine treatment outside the U.S. The research team only observes and measures brain activity…

This study looks at how a single session of exercise changes blood markers related to brain health in people who use cannabis regularly compared to those who don't. Researchers will measure endocannabinoids and other substances in the blood, along with cognitive tests. The goal i…

This study aims to see how Jägerbombs (a mix of energy drink and alcohol) affect young adults differently than drinking alcohol alone during a binge-drinking session. Researchers will measure reaction time, coordination, vision, stress hormones, and hangover symptoms in 24 health…

This study tests whether a non-invasive brain stimulation technique called TMS can change how people with severe cannabis use disorder recognize their cannabis-related problems. Twenty-four participants will receive real and sham TMS while researchers measure brain activity and e…

This study is investigating how common cannabis use is among lung cancer patients under 60 and whether it is linked to more aggressive tumors. Researchers will collect blood and hair samples from 150 participants across three French hospitals. The goal is to better understand if …

This study aims to understand what makes it easier or harder for African American smokers to use a smartphone app designed to help them quit. Researchers will first get feedback from a small group to improve the app, then test it with 30 people who want to quit. The app sends rem…

This study looks at whether a special training and support program can help addiction clinics start using contingency management, a proven method that gives rewards to patients who stay off stimulants. Researchers will work with 76 clinics and track how many patients and counselo…

This study looks at how CBD and THC, two compounds found in cannabis, affect inflammation and brain health in people with HIV. About 90 participants will take both substances in a random order over six weeks. Researchers will measure blood markers and brain function to better und…

This study is collecting information on lifestyle, quality of life, and health markers from 2,000 adults in Greece, including people with chronic diseases, opioid use disorders, and those in prison. The goal is to understand why some groups have worse health and to suggest polici…

This study looks at 350 hospitalized patients with alcohol use disorder to find out what makes someone more likely to relapse after detox. Researchers will group patients by shared traits and test a feedback system that shows test results to patients and doctors. The goal is to l…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study looks at how the active ingredient in cannabis, THC, affects men and women differently. Researchers will give THC to 100 healthy adults who have used cannabis before and measure their feelings of being 'high' and memory performance. The goal is to understand why men an…

This study compares two support programs for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation only; the other also gets employment help and up to $340 in incentives. Researchers want to see which approach better co…

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study is collecting information from 80 adults who have both ADHD and an addiction. Researchers will track their symptoms and daily functioning over 12 months to better understand how these conditions affect each other. The goal is to gather data that could improve future tr…

This study is recruiting 710 adults with fatty liver disease or alcohol-related liver disease, with or without cirrhosis, to understand why some develop liver cancer. Researchers will analyze genetic markers, immune factors, and imaging data from routine liver biopsies and blood …

This study looks at how sleep and body clocks affect the brains of teenagers and their risk for using substances like alcohol or drugs. Researchers will monitor the sleep patterns and brain activity of 200 healthy teens aged 13-18. The goal is to understand how changes in sleep a…

This study tests whether adding a tool called the Pleasuremeter to standard harm reduction services helps men who have sex with men and transgender people who use drugs or engage in chemsex talk about and improve their sexual pleasure. The goal is to see if people are willing to …

This study interviews 50 transgender adults in Thailand about their chemsex behaviors—reasons, patterns, and impacts—along with stigma and HIV prevention needs. Researchers also gather input from stakeholders to identify barriers and facilitators for creating transgender-friendly…

This study looks at how cannabis use and stopping it affect sleep, daily body rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users with non-users using sleep monitors, light tests, and pupil measurements. The goal i…

This study is gathering information from men who have sex with men who take part in chemsex (using drugs before or during sex) in Bangkok, Thailand. Researchers will survey party hosts and guests about their drug use, sexual health, mental health, and experiences of stigma. The g…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study looks at how age and how often someone uses cannabis affect driving skills. Researchers will compare young (19-25) and middle-aged (35-45) drivers who use cannabis occasionally or frequently. Participants will smoke a cannabis cigarette or a placebo and then drive in a…

This study compares two approaches to screening and counseling teens about alcohol and drug use during primary care visits. One approach involves only the teen, while the other includes the whole family. Researchers will follow 2,300 teens and their caregivers for one year to see…

This study follows 20,000 adolescents aged 12-17 who receive opioids after major surgery. Researchers track pain, opioid use, and other factors for one year to identify early warning signs of opioid use disorder. Participants complete surveys and allow access to their medical rec…

This study aims to help Oregon decision-makers—like health officials, community leaders, and policymakers—use up-to-date, easy-to-understand data to improve substance use services and prevent overdoses. About 341 adults who have authority over substance use policies or programs w…

This study looks at whether virtual reality (VR) can measure how smokers pay attention to smoking-related cues, which may help understand nicotine addiction. Two hundred daily smokers will take either a medication (varenicline) or a placebo, and their eye movements and cravings w…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study is building a Canada-wide registry of people who come to emergency departments with opioid poisoning. Researchers will track treatments and outcomes for up to 7,200 patients. The goal is to learn what works best and create a tool to predict who is at highest risk of dy…

This study looks at how daily vapers and cigarette smokers experience withdrawal when they stop using nicotine for 24 hours. Researchers will measure mood, cravings, attention, and other symptoms in 370 participants. The goal is to better understand nicotine dependence and help d…

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will take blood samples and do mental health check-ins with 500 adults over several visits. The goal is…

This study looks at whether Native American adults who smoke can lower their risk of chronic pain by quitting smoking for 4 weeks. Researchers will measure pain sensitivity and other health markers before and after a stop-smoking program. The goal is to see if this approach is fe…

This study looks at how sleep patterns and stressful events influence alcohol use in young adults aged 18-24 who are heavy drinkers. Researchers will track sleep, brain activity, and stress responses to understand why some people drink more. The goal is to use this knowledge to c…

This study looks at medical records of about 800 full-term newborns with Neonatal Opioid Withdrawal Syndrome (NOWS) to compare two standard treatments: buprenorphine and morphine. Researchers want to find out which medicine helps babies recover and become ready for discharge soon…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This pilot study tests whether telemedicine can help people living with HIV in Alabama who also struggle with opioid or stimulant misuse get follow-up care. Thirty participants will receive either telemedicine or standard care. The goal is to see if telemedicine is feasible and a…

This study looks at bacteria found in the liver, blood, and stool of 50 people with severe alcoholic hepatitis. Researchers want to see if these bacteria are linked to how well patients respond to treatment and their overall survival. The goal is to find new ways to treat this se…

This study looks at whether a substance called PlGF in the umbilical cord and placenta can act as an early warning sign for brain damage in babies whose mothers drank alcohol during pregnancy. Researchers will compare PlGF levels between 60 pairs of mothers and babies—some with a…

This study aims to see if giving patients with alcohol-related liver disease customized alcohol treatment choices increases their participation in therapy or support groups. Researchers will enroll 268 adults from University of Michigan clinics and hospitals. The main goal is to …

This study tests whether a brief online video about cannabis withdrawal can increase awareness and insight in people who use cannabis daily. Researchers will recruit 100 heavy users (at least 25 days per month and 3.5 grams per week) through an online platform. Participants will …

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with psychotic disorders (like schizophrenia) or cannabis use disorder, compared to healthy volunteers. The goal is to understand how brain connection changes relate to …

This study aims to observe a specific behavior called behavioral sensitization in people addicted to crack-cocaine. Researchers will track the movement and sleep patterns of 20 participants over 3 weeks using a wearable device called an actimeter. The goal is to see how crack use…

This study aims to understand what causes substance use and cravings in veterans, especially when combined with issues like anxiety, depression, or PTSD. Researchers will create a personal model for each participant showing their unique triggers, then give them feedback on how to…

This study looks at why young adults with bipolar disorder are much more likely to develop alcohol use disorders. Researchers will give participants alcohol or a placebo and use brain scans to track changes over two years. The goal is to find early warning signs that could lead t…

This study watches 363 people with stab or gunshot wounds to the belly to see if alcohol, drugs, or pain medicine changes how fast doctors decide on surgery. It does not test any new treatment—just observes what happens in two hospitals in Colombia. The goal is to learn if these …

This study looks at how age and sex influence the effects of THC, the main psychoactive ingredient in cannabis. Researchers will give smoked and oral THC to 103 adults aged 18-65 who use cannabis regularly. They will measure pain relief, intoxication, impairment, and how the body…

This study looks at what happens when people who regularly use both marijuana and tobacco use them together. Researchers will measure how much THC and nicotine get into the blood and how the body responds. The goal is to better understand the health effects of using both substanc…

This study follows up to 10,000 medical students in Orléans, France, for up to 22 years to understand what puts them at risk for depression and other mental health issues. Participants fill out an annual online questionnaire. The goal is to identify early warning signs so that fu…

This study is testing how opioids (morphine) and benzodiazepines (alprazolam) affect mood, anxiety, and thinking when taken alone or together. Researchers will give 24 people with a history of using these drugs single doses in a lab and measure their responses. The goal is to und…

This pilot study compares regular cannabis users to non-users to find biomarkers that can estimate when someone last inhaled cannabis. Researchers will measure chemicals in blood and look at genetic factors. The goal is to improve road safety by developing a more accurate test fo…

This study is testing a 10-week group parenting program called EQUIPE for parents with alcohol use disorder who have children aged 4 to 12. The goal is to see if the program reduces parental stress and improves parent-child relationships. Researchers will enroll 90 parents and me…

This study is testing whether different doses of cannabidiol (CBD) can reduce the psychoactive effects of THC in healthy adults who use cannabis occasionally. One hundred participants will inhale various combinations of CBD and THC and report their experiences. The goal is to fin…

This study follows 600 pregnant women who are taking buprenorphine for opioid use disorder. Researchers will collect genetic samples, perform MRIs, and track health outcomes to better understand why some mothers and babies have complications. The goal is to improve treatment and …

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the compound that makes you high). Researchers will give both substances to 30 regular cannabis users who are not seeking treatment. They want to see if CBD can reduce the abuse potenti…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This study looks at medical records of 20 adults who had bariatric surgery and later received treatment for alcohol use disorder. Researchers want to understand if and how the surgery was considered during addiction follow-up. The goal is to improve care for patients with both co…

Acute alcoholic hepatitis is a serious liver condition with a high risk of death, but current prediction tools are limited. This study will analyze data from 1,400 patients to find more accurate markers of prognosis. By integrating clinical, lab, and tissue information, researche…

This study tests whether the drug cytisinicline changes how the brain reacts to seeing smoking-related images in daily smokers who are not trying to quit. Sixty-four participants will receive either the drug or a placebo and undergo brain scans while watching videos of smoking an…

This study looks at whether a patient navigation program called NavSTAR can help people with opioid use disorder start treatment after a hospital stay and avoid going back to the hospital. Researchers will first test the program with 32 people at four hospitals in Philadelphia, t…

This study is following 10,000 people who are seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological health over several years using interviews, questionnaires, and cognitive tests. The goal is to better underst…

This study looks at how quitting smoking temporarily increases pain in people with chronic pain, and how the brain processes this. Researchers will use brain scans and daily reports from 132 smokers—some with chronic back pain, some without—to understand these changes. The goal i…

This registry study is collecting real-world data from 1,000 adults with cancer who use cannabis. Participants use an app to track symptoms, cannabis use, and changes in other medications. The goal is to help patients and doctors make informed decisions about using cannabis for s…

This study follows 600 black and white adults with solid tumor cancer who use cannabis at least weekly or not at all. Participants report pain, symptoms, and cannabis use through a smartphone app and surveys for one year. The goal is to understand how cannabis affects pain and op…

This study is testing a program called Get Better Together, designed to help military couples work as a team through life's challenges. About 1,000 couples will be randomly assigned to attend a weekend retreat or continue as usual. Researchers will track changes in mental health,…

This study tests whether very low nicotine little cigars change how people smoke and affect their lungs compared to regular cigars. About 50 adult little cigar smokers will attend three 4-hour visits at Ohio State University. They will fill surveys, give blood, do breathing tests…

This study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…