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Brain scans reveal how therapy may help schizophrenia patients kick the habit

NCT ID NCT07441928

Symptom relief Sponsor: The Hong Kong Polytechnic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to cravings. The trial involves 90 participants who will attend group therapy sessions over several weeks, with follow-up at 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acceptance and Commitment Therapy (ACT)
What this could lead to
If it works, this could offer a new way to help people with schizophrenia quit smoking and ease their psychotic symptoms.
What could go wrong
This is an early study with only 90 participants, so results may not apply to everyone. Previous research showed only modest quit rates, and the therapy may not work for all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals who have been diagnosed with schizophrenia or schizoaffective disorder and after at least one-year followup; * currently taking anti-psychotic medications for ≥ 3 months with good compliance; * aged 18 years or above; * able to communicate in Cantonese Exclusion Criteria: * Have any other current or past psychotic disorders; * with fleeting or actual suicidal/self-harm ideations, or acting-out behavior in the past; * with a known history of violence/aggression and a forensic history * Categorized with special care or intensive care (e.g., arson, battery, physical assault, rape, murder, etc.) * Have a lifetime history of substance abuse and/or are currently receiving treatment for substance abuse (e.g., opioids, cocaine, marijuana, or stimulants); * With alcohol consumption exceeding 25 standard drinks/week for men and 20 standard drinks/week for women over the last 6 months; * Have received a diagnosis of alcohol or drug dependence in the year preceding recruitment; * Are pregnant, breast-feeding, or planning a pregnancy for the duration of the study; * Have a history or current diagnosis of attention-deficit hyperactivity disorder (ADHD); * Have a history of epilepsy or a seizure disorder; * Experience disorientation, have developmental disabilities, and/or an organic mental disorder; * fMRI-related exclusion criteria promulgated by University Research Facility in Behavioural and Systems Neuroscience (UBSN), PolyU

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Conditions

The condition(s) this trial relates to.

nicotine dependence schizophrenia Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Schizophenia disorder Smoking cessation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Lok Hong Integrated Community Centre for Mental Wellness, Tung Wah Group of Hospitals

    RECRUITING

    Hong Kong, Hong Kong

  • Mental Health and Development, Christian Family Service Centre

    RECRUITING

    Hong Kong, Hong Kong

  • Out-patient Clinic (Psy), Pamela Youde Nethersole Eastern Hospital

    RECRUITING

    Hong Kong, Hong Kong

  • The Mental Health Association of Hong Kong

    RECRUITING

    Hong Kong, Hong Kong

  • The Society of Rehabilitation and Crime Prevention

    RECRUITING

    Hong Kong, Hong Kong

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