SMOKING CESSATION

This study tests a telehealth program for cancer survivors to help them quit smoking, lose weight, and be more active. About 1500 adults who have had cancer (except skin cancer) and have at least one risk behavior will join. Some will get 12 coaching sessions by phone or video, w…

This study tests whether personalized stop-smoking plans help cancer patients quit better than standard care. Researchers use each patient's health history, genes, and lab results to recommend the best medication. The goal is to see if more patients take and stick with quitting a…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people who smoke cigarettes switch to a less harmful option. Fifty adult smokers will use the pouches for 4 weeks and report their smoking habits. The goal is to see if pouches reduce or replace cigaret…

This study tests a program called QuitAid, where pharmacists coach rural smokers on quitting. About 768 people from Virginia, Tennessee, Kentucky, and North Carolina will join. All get nicotine patches, and some also get extra support like text messages, phone counseling, or more…

This study tests whether giving smokers a personalized quit plan based on their genes, health history, and biomarkers helps them stop smoking more than standard care. About 850 adult smokers and their doctors will take part. The goal is to see if this approach increases the use o…

This study tests a smoking cessation program designed for LGBTQ+ adults in Oklahoma, Texas, and Arkansas who experience high stress and low social support. Participants will receive nicotine replacement therapy and empowerment-based support to help them quit smoking. The goal is …

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with overweight or obesity quit smoking. 300 smokers will receive either the drug or a placebo for 16 weeks, plus nicotine patches. The goal is to see if the drug improves quit rates a…

This study compares two smoking cessation programs for people who are getting lung cancer screening. About 1,188 participants will be randomly assigned to either a health system-based program or a quitline-based program. The goal is to see which approach helps more people quit sm…

This study tests a smartphone app that uses artificial intelligence to give personalized tips and connects pregnant smokers with a support person (like a partner or friend) to help them quit. About 790 pregnant women in Romania will use the app and receive video counseling. The g…

This study tests a smoking cessation program designed for people living with HIV who smoke at least 5 cigarettes a day. The goal is to find a cost-effective and sustainable way to help them quit, using methods like nicotine replacement therapy and counseling. About 500 participan…

This study tests how well nicotine pouches and nicotine mini lozenges help people replace cigarettes. About 300 adult smokers who aren't ready to quit yet will use one of these products or no product for a week, then try to stop smoking for 3 weeks. Researchers will track how man…

This study tests whether taking the medication bupropion for 6 months helps African American daily smokers quit better than the usual 7-week course. About 500 participants will be followed to see who stays smoke-free. The goal is to find a more effective way to support long-term …

This study tests a mindfulness-based program to help cancer survivors stop smoking and reduce heavy drinking. Researchers will compare the program to standard care in 600 survivors across Florida. The goal is to see if mindfulness can improve both habits and be cost-effective.

This study tests a simple online questionnaire (e-visit) to help people stop smoking. About 672 adults who smoke daily will be randomly assigned to receive the e-visit or not. The e-visit asks about smoking habits and preferences for quitting medications, and may offer a prescrip…

This study is testing a program that combines medication (Naltrexone + Bupropion) with counseling to help people lose weight and quit smoking before they have bariatric surgery. The goal is to see if this approach is practical and acceptable for patients. About 20 adults who smok…

This study tests a program to help smoking parents quit by combining brief advice, nicotine replacement therapy, and text message support. Researchers will enroll 1,200 daily smokers in Hong Kong who live with children aged 12 or under and a non-smoking family member. The goal is…

This study tests a personalized smoking cessation program for 424 hospitalized smokers with heart or lung disease. A nurse-led team provides tailored medication, counseling, and text-message support to help patients quit and stay smoke-free. The goal is to improve quit rates and …

This study tests whether offering financial rewards to both a smoker and a family member helps Alaska Native adults quit smoking. About 1,312 participants will be randomly assigned to receive the family-based incentive or standard support. Success is measured by a saliva test at …

This study tests whether an online questionnaire (e-visit) can help rural smokers quit. About 288 adult smokers will be randomly assigned to get the e-visit or not. The e-visit asks about smoking habits and medication preferences, and may lead to a prescription. Participants comp…

This study tests if automated text messages can help people living with HIV quit smoking. Researchers will enroll 800 smokers in Cambodia and provide tailored text support. The goal is to see if this approach helps them stop smoking for good.

This study tests a mobile program called Quitxt that sends tailored texts and videos to help young Latino smokers (ages 18-29) quit. About 1,200 participants will be randomly assigned to get Quitxt or standard quit-smoking information. The goal is to see if the personalized appro…

This study tests whether e-cigarettes or nicotine replacement therapy can help people quit smoking and manage weight gain. Researchers will track daily cigarette use, carbon monoxide levels, and weight changes in 60 adults with obesity who smoke at least 5 cigarettes per day. Par…

This study compares two smartphone apps designed to help people living with HIV quit smoking. About 314 participants will use one of the apps for 24 weeks, along with nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, with regul…

This study tests a program called Smokefree Family Living (SFL) to help Chinese American smokers quit and reduce harmful smoke residue that lingers on surfaces like carpets and furniture. About 760 Chinese American smokers and their non-smoking family members will take part. The …

This study tests a smoking cessation program in the construction industry, where safety managers are trained to help workers quit smoking. About 608 construction workers, safety managers, and company leaders will take part. The goal is to find the most effective and cost-effectiv…

This study tests a new program called QUIT-AD that combines existing methods to help people with HIV or TB quit smoking. The program will be offered to 86 adults in Cape Town, South Africa who smoke daily. Researchers will check if the program is practical, well-liked, and helps …

This study looks at whether adding smoking cessation programs to low-dose CT scans for lung cancer helps more people quit smoking. About 1200 smokers aged 50-74 will be randomly assigned to different methods. The goal is to see which approach works best for quitting and early can…

This study looks at whether starting a quit attempt during the first half of the menstrual cycle (follicular phase) helps women stop smoking more successfully than starting during the second half (luteal phase) or without cycle timing. About 1,200 women who smoke daily and have r…

This study compares two approaches to help adults stop using tobacco and lower their cancer risk. About 5,000 people who smoke will get either extra reminders and support or standard quit advice. The goal is to see which method leads to more people using medication, counseling, o…

This study tests a counseling and education program designed to help Chinese and Korean American smokers quit smoking and get screened for lung cancer. About 50 participants will receive the program and be followed for 6 months. The goal is to see if a culturally tailored approac…

This study is testing a new chatbot that uses motivational interviewing to help people stop smoking. The chatbot will provide education, support, and a personalized quit plan. The study will enroll 440 adult smokers who are patients at a primary care clinic and follow them for 6 …

This study tests a program that combines text message support with financial rewards to help low-income pregnant women stop smoking. About 30 women will either get texts plus incentives or texts alone. The goal is to see if the program is easy to use and acceptable, and to check …

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia quit or reduce smoking. Fifty adults who smoke at least 5 cigarettes daily will receive active rTMS using one of two c…

This study tests a personalized approach to help Alaska Native and American Indian people quit smoking. Researchers use a simple test to measure how fast each person breaks down nicotine, then match them with the best medication. The goal is to see if this tailored method is prac…

This study is for Veterans who smoke and want to quit. Each Veteran picks a friend or family member to support them during the quitting process. Researchers will check if having this support person helps Veterans use proven quit-smoking treatments like medication or counseling. T…

This study looks at whether a type of talking therapy called acceptance and commitment therapy (ACT) can help people with schizophrenia stop smoking and reduce their psychotic symptoms. About 90 adults with schizophrenia who smoke will take part. Researchers will use brain scans …

This study tests whether the drug cytisinicline can change how the brain reacts to seeing smoking-related images. 64 daily smokers who are not trying to quit will receive either the drug or a placebo and undergo brain scans. The goal is to see if the drug reduces brain activity l…

This study tests whether adding music therapy to nicotine replacement therapy (NRT) helps reduce tobacco cravings in student smokers aged 18 to 25. 120 participants will be randomly assigned to receive either NRT alone or NRT plus a digital music therapy tool. The goal is to see …

This study aims to find the most effective combination of treatments to help people who both smoke cigarettes and use e-cigarettes (vape) quit smoking. Five hundred participants will try different approaches, including medication and nicotine patches, and be followed for a year. …

This study is developing a smartphone app that uses mindfulness techniques to help cancer survivors quit smoking. About 50 adults who have been diagnosed with cancer and smoke at least one cigarette a day will test the app. Researchers will measure how easy the app is to use and …

This study is creating a smartphone-based program to help cancer patients stop smoking. Researchers will test if the tool is easy to use and if patients like it. About 90 adults with cancer who smoke will take part. The goal is to build a resource that can be used across Florida.

This study aims to understand how to improve smoking cessation support for pregnant women who have experienced trauma. Researchers will interview both pregnant women and healthcare providers to gather ideas. The goal is to create a program that combines trauma-informed care with …

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. The goal is to establish normal ranges and learn how gene changes in airway cells may lead to disease. Participants must be 18 …

This study tests a new way to help smokers in rural areas who are not yet ready to quit. Paramedics will refer participants to a text-message program designed to motivate them to stop smoking. The goal is to see if this approach can reach more people and help them eventually quit…

This study looks at whether giving cancer patients an indoor air quality monitor can help them keep their homes smoke-free. Ten patients who smoke and are already in a tobacco treatment program will use the monitor for two weeks. The goal is to see if the device is easy to use an…

This study works with community organizations in Chicago to find out what makes it hard for people to quit smoking and what kind of help they need. Researchers will create a community advisory board and test a new smoking cessation program in a behavioral health center. The goal …

This study is testing whether a simple urine test every 6 months for 2 years can help find bladder cancer at an earlier stage in people at high risk. Participants must be 50 or older with a heavy smoking history or long-term exposure to certain workplace chemicals. The goal is to…

This study looks at how romantic partners who both smoke can work as a team to quit. Researchers will ask 250 couples to fill out daily surveys for two weeks while trying to stop smoking. The goal is to learn which types of support are most helpful, so better programs can be crea…

This study tests a program that combines help to quit smoking with lung cancer screening for African American smokers. About 250 people will take part. The goal is to see if this combined approach helps more people stop smoking and get screened, reducing lung cancer deaths in thi…

This study looks at what makes it easier or harder for African American smokers to use a smartphone app designed to help them quit. About 30 participants will use the app and give feedback. The goal is to learn how to make such apps more helpful for this community.

This study is testing a program called CONNECTing to LungCare that helps smokers and their doctors have better conversations about quitting smoking and getting screened for lung cancer. The program provides education and a personalized summary to guide these discussions. Research…