SMOKING CESSATION

This study is creating and testing a new program to help pregnant women quit smoking, specifically designed for women who have experienced past trauma. Researchers are interviewing pregnant women and their healthcare providers to understand the challenges of quitting, then will a…

This study is testing whether tobacco-free nicotine pouches can help people who smoke cigarettes switch to a less harmful alternative. 50 adult smokers will try using either low or high nicotine pouches for 4 weeks instead of smoking. Researchers will measure if participants succ…

This study is testing whether an online questionnaire (an 'e-visit') can help people in rural areas quit smoking. About 288 adult smokers from rural South Carolina clinics will be randomly assigned to either complete the e-visit or receive usual care. The e-visit asks about smoki…

This study tests whether a special hospital support team can help patients with heart or lung disease quit smoking for good. The team provides personalized medication plans, counseling, and text message support after discharge. Researchers will compare this approach to usual hosp…

This study aims to find the most effective way to help people quit smoking when they come in for lung cancer screening. Researchers will compare two different phone-based support programs—one run by a state quitline and one run directly by the health system—for 1,188 current smok…

This study aims to understand how a smoking cessation medication called cytisinicline affects the brain's response to smoking triggers. Researchers will enroll 64 adults who smoke daily but are not currently trying to quit. Participants will take either the medication or a placeb…

This study is testing a new program where community pharmacists help people in rural Appalachia quit smoking. It will compare different combinations of support, like text messages, phone coaching, and nicotine replacement therapy (patches and lozenges), to see what works best. Th…

This small pilot study is testing whether giving cancer patients an indoor air quality monitor helps them keep their homes smoke-free. Researchers want to see if using the monitor for two weeks is practical and if patients attend related workshops. The goal is to improve air qual…

This study is testing whether nicotine pouches or mini lozenges can help people who smoke switch away from cigarettes. Researchers will compare how well these products work for 300 adults who smoke at least 5 cigarettes a day but aren't planning to quit right away. Participants w…

This study is testing whether a motivational AI chatbot on your phone can help people quit smoking. Researchers will enroll 440 adult smokers to use the digital coach, which provides encouragement, education, and helps create a personalized quit plan. The main goal is to see if p…

This study is testing a personalized approach to help Alaska Native and American Indian people quit smoking. Researchers will use a simple blood test to measure how quickly a person's body processes nicotine, then recommend the medication that might work best for them. The main g…

This study is testing two different smartphone apps designed to help people living with HIV quit smoking. All participants will receive nicotine patches and gum, plus one of the apps to use for six months. Researchers want to see which app approach works better to help this speci…

This study tests a new way to help people in rural areas who smoke but aren't ready to quit. It trains local paramedics to connect smokers with a free mobile phone game called 'Take a Break,' which guides them through short periods of not smoking. The goal is to build skills and …

This study is testing whether an automated text messaging program can help people living with HIV in Cambodia quit smoking. It will enroll 800 adult smokers with HIV who are willing to try to quit. Researchers will check if participants have quit by asking them and using a breath…

This study is testing a program to help low-income pregnant women quit smoking. It combines daily text message support with small financial rewards for staying smoke-free. Researchers want to see if this approach is practical and well-liked by participants, and if it helps them q…

This study aims to find the most effective combination of treatments to help people who both smoke cigarettes and vape to quit smoking. Researchers will test different medications (varenicline vs. nicotine patches) and counseling approaches (focusing on quitting both vs. just smo…

This study is testing whether an online questionnaire can help people quit smoking. About 672 adult smokers will be randomly assigned to either complete the online visit or not. The online visit asks about smoking habits and motivation to quit, and may lead to a prescription for …

This study is testing a personalized plan to help cancer patients quit smoking. It uses a patient's own genetic and health information to recommend the best quit-smoking medications. The goal is to see if this tailored approach helps more patients successfully quit and improves t…

This study is creating and testing a new program to help people who are planning weight-loss surgery. The goal is to help them quit smoking and lose weight at the same time before their operation. The program combines two medications with behavior change therapy. Researchers will…

This study is testing if taking the quit-smoking medication bupropion for 6 months works better than the usual 7-week course for African American daily smokers. It will enroll 500 adults who want to quit and provide them all with personalized counseling. The main goal is to see i…

This study is testing a new support program designed to help people in South Africa who have HIV and/or tuberculosis (TB) quit smoking. The program, called QUIT-AD, combines counseling and support to help people stop smoking and also stick to their important HIV or TB medications…

This study is testing two types of magnetic brain stimulation to help people with schizophrenia quit smoking. Researchers believe the high smoking rates in this group may be due to overlapping brain circuits for addiction and schizophrenia. They will measure changes in brain acti…

This study tests whether personalized treatment recommendations based on a person's genetic and health information can help smokers quit more effectively than standard care. The research involves 850 adult smokers and their doctors across primary care clinics. It compares the new…

This study aims to find the best way to help Native Hawaiian adults quit smoking. It will test three approaches: nicotine gum alone, group counseling alone, or a combination of both. The goal is to see which method is most effective and well-liked by the community.

This study is testing whether paying Alaska Native families helps smokers quit for good. It compares a program offering cash rewards for quitting to standard support materials. Researchers will track if smokers in the payment group are more likely to stay smoke-free for 6 and 12 …

This study is testing a new smartphone app designed to help cancer survivors quit smoking. The app delivers mindfulness-based support in real-time, combined with brief counseling and nicotine replacement therapy. Researchers are recruiting 50 adult cancer survivors who currently …

This study is testing whether having a support person helps Veterans quit smoking. Veterans who smoke will choose a friend or family member to support them, and some support persons will receive special coaching. Researchers will track if this approach helps Veterans use proven q…

This study is testing whether helping a patient and the people they live with quit smoking at the same time works better than just helping the patient alone. It involves 231 adult smokers who are patients at a UK hospital and live with other smokers. Both the patient and their ho…

This study is testing a new education and support program called 'CONNECTing to LungCare.' The goal is to help people who smoke have better conversations with their doctors about quitting smoking and getting screened for lung cancer. Participants will receive personalized informa…

This study aims to prevent cancer by helping people quit smoking. Researchers are comparing two different digital support strategies to see which one better helps 5,000 adult smokers receive treatment (like medication or counseling) and successfully quit. The trial is testing whe…

This study is testing a smartphone app designed to help pregnant women quit smoking and stay smoke-free after giving birth. The app uses artificial intelligence to personalize support and connects users with a chosen friend or family member for encouragement. Researchers in Roman…

This study is testing if starting a quit attempt during a specific phase of a woman's menstrual cycle makes it easier to stop smoking. It will enroll 1200 women who smoke daily and want to quit. Participants will be randomly assigned to start their quit attempt in one of two cycl…

This study tests whether training workplace safety managers to help construction workers quit smoking makes programs more effective and affordable. It compares three different approaches to find the best balance of success, cost, and practicality for construction companies. The g…

This study is testing a counseling and education program designed specifically for Chinese and Korean American smokers who are at high risk for lung cancer. About 50 participants will be randomly assigned to receive either this new culturally tailored program or standard care. Th…

This study is testing different ways to help long-term smokers quit and find lung cancer early. It will compare using a smartphone app, written guides, and a special low-dose lung scan. The goal is to see which combination is most effective at helping people stop smoking and dete…

This study is testing whether adding a digital music therapy program to standard nicotine replacement patches (like gum or patches) helps student smokers manage their cravings better than using the patches alone. It will involve 120 student smokers aged 18 to 25 who want to quit.…

This study is testing whether a gentle, at-home brain stimulation technique can help cancer survivors who smoke reduce their cigarette use and feel less distress. Researchers will recruit 46 participants who are interested in quitting smoking and have mild to moderate distress. T…

This study aims to understand how a specific type of therapy affects the brain in people with schizophrenia who smoke. Researchers will use brain scans (fMRI) to see if group therapy can change brain activity related to tobacco cravings and psychiatric symptoms. The study involve…

This study aims to collect blood, urine, and airway samples from both healthy people and people with lung diseases like COPD and pulmonary fibrosis. Researchers will compare the samples to understand what causes these diseases and how they develop. The goal is to gather basic inf…