New combo aims to take the edge off opioid withdrawal
NCT ID NCT05995535
First seen Mar 05, 2026 · Last updated May 21, 2026 · Updated 11 times
Summary
This study tests whether adding pregabalin to lofexidine helps reduce withdrawal symptoms in people with opioid use disorder who want to start naltrexone treatment. About 150 adults will receive either the drug combo or a placebo for 8 days. The goal is to see if the combination makes withdrawal more tolerable and helps more people complete detox.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
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Contact
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Locations
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Mountain Manor Treatment Center
NOT_YET_RECRUITINGBaltimore, Maryland, 21229-3618, United States
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Contact
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University of Pennsylvania, Treatment Research Center
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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