University Of Pennsylvania

This study looks at a Philadelphia program that provides housing to people with HIV who are homeless or at risk. Researchers want to see if having a stable home helps people stay on their HIV medication and keep the virus under control. About 200 people will be randomly chosen to…

This study tests whether personalized marketing and discounts in an online grocery store can encourage people with prediabetes or type 2 diabetes to buy more whole grains instead of refined grains. About 216 adults aged 45-70 from Pennsylvania who already shop online for grocerie…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS, combined with standard cognitive therapy, can improve memory and thinking in people who recently had a stroke. Researchers will enroll 70 adults aged 18-90 who had a stroke within the past mont…

This study looks at whether a single dose of a nutritional ketone ester drink can change how the brain responds to alcohol cues and reduce the urge to drink in people with alcohol use disorder. Twenty adults who drink heavily but are not seeking treatment will receive either the …

This study tests whether using ultrasound to guide a steroid injection into the foot works better than relying on touch alone for treating plantar fasciitis (heel pain). About 62 adults with heel pain will receive one of the two injection methods. Researchers will measure pain le…

This study is adapting an existing texting chatbot, Penny, to better support pregnant and postpartum women who are dealing with opioid use disorder. The new chatbot, called Penny COPILOT, will send supportive texts and respond to messages to help reduce loneliness and keep women …

This study tests if a non-invasive magnetic stimulation device can reduce dangerous heart rhythm episodes in people with ventricular tachycardia storm. About 60 adults who have had multiple episodes despite medication will be randomly assigned to real or sham stimulation. The mai…

This study tests a new mouthpiece (bite block) for upper endoscopy, a procedure where a camera looks at your stomach. The goal is to see if the new design reduces mouth injuries and makes the procedure smoother. About 50 adults having routine endoscopy will try it out.

This study aims to improve how doctors plan epilepsy surgery by using advanced MRI scans to map brain connections. Researchers will compare these scans with electrical recordings from inside the brain in 290 people with drug-resistant epilepsy. The goal is to develop noninvasive …

This study uses a special PET scan to measure tau protein buildup in the brains of people with frontotemporal lobar degeneration (FTLD), atypical Alzheimer's disease, and healthy volunteers. Researchers want to see if this scan can help tell these conditions apart. About 72 adult…

This study follows 110 people with moderate to severe traumatic brain injury (TBI) for up to 3 years to see how their brains change compared to healthy individuals. Participants will give blood samples, have MRI scans, and take thinking and memory tests. The goal is to measure ho…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam versus vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury using more sensitive markers than standard…

This study looks at a telephone service called SUSTAIN that helps older adults (65+) manage depression, anxiety, or chronic pain. Researchers want to find out what factors make the program more effective and whether its benefits last over time. About 4,000 participants will be fo…

This study looks at how hormones during the menstrual cycle change the brain's ability to adapt, called plasticity, in healthy young women. Researchers will also compare these changes to those in men. Using a safe brain stimulation technique called TMS, they measure brain respons…

This study looks at how blocking a nerve cluster near the spine (stellate ganglion block) changes the heart's electrical activity in 20 adults with ventricular tachycardia who are already scheduled for a catheter ablation. Researchers will measure heart tissue recovery time and w…