University Of Pennsylvania

This trial tests whether B-OK bottles, which use beads to visually explain how HIV affects health and how treatment lowers viral load, can help people with HIV stick to their medication. Researchers will roll out the bottles across HIV case management agencies in Philadelphia and…

This trial tests whether transcranial magnetic stimulation (TMS) aimed at a brain circuit linked to the subgenual anterior cingulate cortex can reduce depression symptoms. Adults with major depressive disorder or persistent depressive disorder will receive either active or sham T…

This trial tests whether transcranial magnetic stimulation (TMS) can engage the amygdala—the brain's fear center—in adults with post-traumatic stress disorder (PTSD). Participants receive either active or sham TMS every weekday for six weeks, guided by MRI to target a personalize…

This trial tests whether simple reminders—sent to patients' phones and to their care teams—can increase the use of alcohol screening and brief counseling (SBIRT) during cancer care. About 315 adults with cancer across four clinics will take part, with some clinics using the remin…

This study looks at whether adding a special liquid diet (partial enteral nutrition) to standard medication helps people with active Crohn's disease achieve remission without steroids. About 80 participants will choose to either add the diet or not. The main goal is to see if mor…

This trial tests whether integrating tobacco cessation tools into electronic health records can increase the number of smokers who receive a prescription for nicotine replacement therapy (NRT) like patches or gum. Researchers will compare a new workflow at one primary care clinic…

This phase 1 trial tests a radioactive drug called 211At-MABG in 16 adults with advanced neuroendocrine cancers, including pheochromocytoma and paraganglioma. The drug delivers radiation directly to cancer cells that show up on a special scan. The main goal is to see if the treat…

This pilot study will develop and test a telehealth program designed to help marginalized patients access and stay in treatment for opioid use disorder. Researchers will enroll 60 people—half already in treatment and half not yet in treatment—and provide them with a user-friendly…

This study looks at the best time interval between two medications, mifepristone and misoprostol, for managing early pregnancy loss. Researchers will follow 1,000 participants to see which timing leads to the highest success rate with fewer side effects. The goal is to improve tr…

This study tests a new AI tool called INTERLACE that helps doctors diagnose older adults during primary care visits. The AI uses a patient's medical history, vital signs, and symptoms to suggest possible diagnoses and tests. Researchers want to see if the tool is easy to use and …

This study tests a program where nurses talk to parents of hospitalized children about safely storing firearms and offer free cable locks. The goal is to see if this brief conversation changes how parents store guns at home, potentially preventing accidental shootings and suicide…

This trial tests two drug-free programs to help adults with cirrhosis manage everyday pain. One group gets a self-guided digital platform with automated messages, while the other adds personalized coaching, group sessions, and a structured walking or meditation plan. Researchers …

This study tests a botulinum toxin called DaxibotulinumtoxinA (DAXI) for adults with blepharospasm, a condition causing uncontrollable blinking or eye muscle spasms. Twenty participants will receive up to three injection cycles over 12 months. The goal is to measure how long symp…

This study tests whether adding a second thyroid hormone (T3) to the standard T4 treatment can improve persistent symptoms like fatigue and brain fog in people with hypothyroidism. It involves 60 adults aged 18-70 who still have symptoms despite normal thyroid blood tests. Partic…

This study tests whether using brain images to program deep brain stimulation (DBS) devices works better than the usual method for reducing hand tremors in people with essential tremor. Twenty adults who already have DBS electrodes in their brain will try both programming approac…

This early-stage study tests whether the drug sodium phenylbutyrate (NaPB) can improve blood pressure and blood vessel function. It will include 30 healthy volunteers and people with diabetes. The goal is to see if NaPB might help ease vascular problems linked to diabetes.

This study looks at whether a nutritional ketone supplement can alter how the brain uses energy and reduce alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplement or a placebo, then u…

This study will test ways to improve how doctors choose electroconvulsive therapy (ECT) stimulation settings for people with severe depression or catatonia. Researchers will use real-time brain monitoring to measure brain activity and blood flow during ECT. The goal is to find th…

This pilot study tests whether a low-load resistance exercise program for the lower legs can improve blood flow and oxygen use in the calf muscles of people with pulmonary arterial hypertension (PAH). Participants will do the exercises for 12 weeks, and researchers will measure o…

This study will use combined PET and MRI scans to measure how the brain uses glucose and oxygen in healthy adults and people with Alzheimer's disease. Researchers want to see if a commercially available ketone drink can improve brain energy metabolism. The study involves 17 parti…

This trial tests whether giving clinicians a dashboard that breaks down their labor and delivery practices and outcomes by race and ethnicity can improve adherence to evidence-based care for labor induction. About 2,300 full-term pregnant people with a single baby and intact memb…

This study uses a non-invasive brain stimulation technique called TMS to temporarily change activity in a brain region linked to anxiety. Researchers will use fMRI scans to see how this affects brain connections and anxiety-related startle responses. 140 adults with anxiety will …

This study tests whether a type of magnetic brain stimulation called aiTBS can change brain wave patterns and improve performance on thinking tasks. About 80 healthy adults will receive stimulation over three days while their brain activity is recorded with EEG. The goal is to un…

This study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can change how people remember the order of emotional movie clips. Researchers will compare active TBS to a sham (fake) version in 120 healthy adults. The goal is to understan…

This study tests whether a personalized video platform called MyStroke can improve stroke knowledge and reduce hospital use after discharge. About 690 stroke patients and their caregivers will either get standard education or also access to tailored videos. Researchers will check…

This study tests a smart sharps disposal container that helps hemophilia patients safely throw away used needles at home. About 23 adults with moderate or severe hemophilia will use the device for several weeks. Researchers want to see if patients find it easy to use and if they …

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This early-phase study tests whether taking a low-dose aspirin in the evening can offset the blood pressure increases caused by the pain reliever celecoxib. Researchers will monitor blood pressure in 60 healthy adults over several weeks. The goal is to learn if timing matters for…

This study tests whether evolocumab, a drug that lowers 'bad' cholesterol, changes the cells in the wall of an abdominal aortic aneurysm. About 44 people scheduled for aneurysm repair will receive either the drug or a placebo before surgery. Researchers will then compare the tiss…

This study follows up with 220 people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect tears, saliva, blood, and other samples, along with eye and mouth exams, to trac…