University Of Pennsylvania

This study tests whether offering moderate financial rewards can encourage people with first-episode psychosis to keep attending their treatment programs. Researchers will work with about 80 patients and 15 clinicians at two clinics, plus 50 clinicians from other clinics, to see …

This study tests whether group preconception care, adapted from group prenatal care, can improve pregnancy and newborn outcomes for fertility patients. About 140 couples at Penn Fertility Care will be randomly assigned to either group virtual sessions or usual care. Researchers w…

This study compares three approaches for treating PTSD in military veterans: talk therapy (Prolonged Exposure), antidepressant medication (paroxetine or venlafaxine), or both together. About 300 veterans from six VA medical centers will be randomly assigned to one of these treatm…

This study looks at how your body's daily rhythms (chronobiome) change with age and sex. Researchers will analyze blood samples from 48 healthy adults—young (18-30) and older (55-75)—to find differences in proteins. No treatment is given; the goal is simply to learn more about ho…

This study uses a special PET scan to measure tau protein buildup in the brains of healthy older African Americans. The goal is to learn how these brain changes relate to normal aging versus early Alzheimer's disease. Participants are already part of a long-term study and will ha…

This study examines how the immune system controls hepatitis B virus during treatment. Researchers will analyze blood samples from 40 adults already enrolled in larger treatment trials. The goal is to understand why some people respond better to therapy, which could lead to impro…

This study looks at whether special monitors can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients. About 30 adults in the ICU with acute kidney injury or end-stage kidney failure will take part. The goal is to…

This study uses a special brain scan (PET imaging) to measure tau protein buildup in older adults with normal memory or mild cognitive impairment (MCI). The goal is to understand how tau relates to brain structure and function, helping distinguish normal aging from early Alzheime…

This study tests whether personalized educational videos can improve stroke survivors' understanding of their condition and risk factors. About 100 people who had a stroke 1-10 years ago will use a custom app and answer surveys after 7 and 90 days. The goal is to see if this appr…

This study looks at how a brain area called the subgenual cingulate responds to transcranial magnetic stimulation (TMS) in people with depression. Researchers will use MRI scans to see if TMS activates this region and how it changes over a 6-week treatment course. 50 adults with …

This study uses a special PET/CT scan to measure inflammation in the brain and body of people with alcohol use disorder (AUD) compared to healthy volunteers. Up to 90 participants (60 with AUD, 30 healthy) will receive one scan with an investigational tracer. The goal is to under…

This study collects lymph fluid from the chest of 24 people (some with MS, some healthy) to compare immune cells in the blood versus deep in the lymphatic system. In MS participants, researchers will also look at how these cells change after treatment with the approved drug ofatu…

This study looks at four different breast imaging techniques—MRI, digital mammography, ultrasound, and PET scans—to see how well they work together to determine the size and spread of breast cancer. About 400 women recently diagnosed with breast cancer will be scanned before surg…

This study creates a worldwide registry for up to 500 people with CDKL5 Deficiency Disorder (CDD), a rare genetic condition causing seizures and developmental delays. Caregivers and doctors will report symptoms, treatments, and milestones over several years. The goal is to better…

This study looks at how working night shifts changes the bacteria in your gut, which might increase the risk of certain diseases. Researchers will compare the gut bacteria of 12 healthy male night shift workers and day workers over time. The goal is to understand how sleep and wo…

This study tests whether an augmented reality virtual ruler can help doctors place PICC lines more safely and efficiently. Twenty adults scheduled for non-emergency PICC placement will have the ruler used during their procedure. Researchers will check if the catheter tip ends up …

This study watches 40 adults with heart failure to see how SGLT2 inhibitors affect their body's energy use and blood markers. Participants do a walking test, a leg MRI, and give blood samples before and after starting the drug. The goal is to understand the early metabolic change…