Teen sleep study seeks to unlock secrets of the adolescent brain
NCT ID NCT05336084
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how sleep and body clocks affect the brains of teenagers and their risk for using substances like alcohol or drugs. Researchers will monitor the sleep patterns and brain activity of 200 healthy teens aged 13-18. The goal is to understand how changes in sleep and daily rhythms might make some teens more impulsive or sensitive to rewards, which could lead to substance use.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2022
- Expected to finish
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May 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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13 to 18 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 13-18 years * Currently enrolled in a traditional high-school (not cyber- or home-schooled) \[school closures during the COVID-19 pandemic are an exception to this\] * Physically and psychiatrically healthy * Provision of written informed consent and assent Exclusion Criteria: * outside age range above * have a history of alcohol, cannabis, or illicit drug use greater than weekly use in the past year * have serious medical or neurological disorders, including history of seizures * have serious psychiatric disorders (e.g. bipolar disorder and schizophrenia) * taking antidepressants (SSRIs/SSNIs are OK) or medications known to impact sleep/wake function - some medications may be okay if willing and able to discontinue prior to and/or for laboratory procedures * have sleep disorders other than insomnia or Delayed Sleep Phase Disorder * have MRI contraindications (i.e., metal in the body; claustrophobia) * first degree relative with bipolar disorder * frequent headaches or migraines * inability to swallow pills/capsules. * pregnancy * participants with observed Obstructive Sleep Apnea via Apnealink, as indicated by an Apnea Hypopnea Index (AHI) of greater than 5 * Less than 80 lbs. or a BMI of greater than 35
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Western Psychiatric Hospital
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Other studies related to the condition(s) this trial covers.
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