Could a low dose of ketamine curb opioid cravings?
NCT ID NCT06943859
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 29 times
Summary
This study tests whether low-dose ketamine can reduce cravings and withdrawal symptoms in adults starting methadone treatment for opioid use disorder. Fifty participants will receive either a low or very low dose of ketamine four times over two weeks. Researchers will track cravings, depression, pain, and sleep quality for 90 days.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Maryland Addiction Programs and Affiliated Clinics
RECRUITINGBaltimore, Maryland, 21201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ketamine (low dose)
What this could lead to
If it works, this could point toward a way to reduce opioid cravings and help people stay in treatment longer.
What could go wrong
This is a small, early-phase trial with only 50 participants. The very low dose group acts as a comparison, so the benefit may be small or not last. Ketamine can cause side effects like dizziness or dissociation.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.