University Of Maryland, Baltimore

This study is testing a combination of two chemotherapy drugs (gemcitabine and nab-paclitaxel) with a precise type of radiation called proton therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to find the highest safe dose of…

This study tests whether using a smart insulin pen (InPen) along with a continuous glucose monitor and telemedicine visits can help veterans with type 2 diabetes control their blood sugar better than traditional insulin pens. About 50 adults on multiple daily insulin injections w…

This early study is testing whether HEPLISAV-B, a vaccine normally used to prevent hepatitis B, is safe for people who already have chronic hepatitis B. Ten adults on stable antiviral therapy will receive two vaccine shots and be monitored for side effects and immune responses ov…

This study compares two bone graft materials used to preserve jawbone after a tooth is pulled. One group gets a mix of human and animal bone graft, the other gets human bone graft alone. The goal is to see which better maintains bone shape for future dental implants. About 24 adu…

This study tests whether low-dose ketamine can reduce cravings and withdrawal symptoms in adults starting methadone treatment for opioid use disorder. Fifty participants will receive either a low or very low dose of ketamine four times over two weeks. Researchers will track cravi…

This study tests a two-step treatment for people whose brain tumors (gliomas) have come back after standard therapy. First, a laser is used to heat and destroy the tumor, followed by a short course of targeted radiation. The goal is to control the tumor safely and delay further g…

This study tests whether adding precise, high-dose radiation to cancer spots outside the prostate (called metastases) can help men whose prostate cancer has spread to just a few places. About 122 men with up to 5 metastatic spots will receive standard treatment plus either observ…

This study tests a drug called onvansertib in people with small cell lung cancer whose cancer did not respond to or came back after chemotherapy. Onvansertib blocks a protein that cancer cells need to repair themselves, aiming to shrink tumors. About 37 participants will receive …

This study is testing whether a home-based ankle robot, with or without functional electrical stimulation (FES), can improve leg movement and walking in people who have had a stroke. The trial will include 60 participants who are at least 6 months post-stroke and can walk a short…

This study tests whether giving patients electrical muscle stimulation and high-protein shakes soon after a type of stroke (aneurysmal subarachnoid hemorrhage) can prevent muscle loss and improve recovery. Thirty adults will receive the combo therapy or standard care. The main go…

This registry will follow 8,000 people with severe carotid artery disease who receive a stent to open the artery. The goal is to track how often strokes or deaths happen within 30 days after the procedure. The results will help select skilled doctors for a larger clinical trial t…

This study tests whether a prebiotic supplement (Prebiotin®) can reduce inflammation and improve thinking in people with schizophrenia or schizoaffective disorder. Sixty adults aged 18-60 who are stable on antipsychotics will take the prebiotic or a placebo for 12 weeks. Research…

This study is testing a single, focused dose of radiation delivered by the GammaPod machine before lumpectomy surgery for early-stage breast cancer. The goal is to find a safe and effective dose that minimizes side effects and improves cosmetic outcomes. About 50 women with invas…

This early-phase study tests whether adding heat therapy and a special type of radiation to standard chemoimmunotherapy is safe and feasible for people with advanced bile duct cancer that cannot be removed by surgery. About 15 participants will receive the combination treatment. …

This study tests two temporary wound treatments for severe open tibia fractures: an antibiotic bead pouch or a vacuum-sealed dressing. About 312 adults with these serious leg breaks will be randomly assigned to one method. The goal is to see which approach leads to better healing…

This study looks at how well the drug Imdusiran works in the liver of people with chronic hepatitis B. Ten adults will receive four injections of Imdusiran, one every 8 weeks, and will have two liver biopsies to measure drug levels and virus changes. The goal is to understand how…

This study tests whether taking a daily zinc supplement for one year can lower blood sugar and HbA1c levels in people with prediabetes. Researchers will compare zinc to a placebo in 200 Amish adults aged 18-80. The goal is to see if zinc can help control blood sugar and prevent t…

This early-phase study tests whether adding a short course of high-dose radiation before standard chemotherapy and immunotherapy can help shrink borderline resectable non-small cell lung cancer before surgery. About 18 adults with stage II to IIIC lung cancer will receive three d…

This study tests whether lowering body temperature to 34-35°C (therapeutic hypothermia) for 48 hours can help people with severe lung injury (ARDS) breathe better and need less time on a ventilator. About 340 adults on breathing machines will be randomly assigned to cooling or us…

This early-stage study tests whether MRI-guided focused ultrasound can safely treat task-specific focal hand dystonia, a condition that causes hand cramps during activities like writing or playing an instrument. Ten adults who have not improved with standard treatments will recei…

This study tests a two-step treatment for people newly diagnosed with high-grade gliomas, a fast-growing type of brain tumor. First, a laser is used to heat and destroy tumor tissue. Then, a short course of radiation is given to kill remaining cancer cells. The goal is to safely …

This study tests whether trained peer supporters can help Black adults with HIV or at high risk stay on track with long-acting injectable HIV medication (PrEP/ART) and reduce substance use. About 186 participants will receive either peer-delivered coaching or standard care. The g…

This study is testing a new service that assigns navigators to help people aged 13–35 with early psychosis stay connected to their care programs. The goal is to reduce the number of people who drop out of treatment and increase the time they stay in care. The service will be deve…

This study is testing whether measuring blood flow in the retina can help spot early glaucoma, a leading cause of blindness. Researchers will use special dyes and oxygen tests to see how eye blood vessels respond in 90 adults with early glaucoma. The goal is to create a reliable …

This early-phase study tests a new MRI technique that uses a special substance called hyperpolarized pyruvate to make brain tumors easier to see. The goal is to see if this method is safe and more accurate than standard MRI for diagnosing gliomas. Up to 5 adults with suspected or…

This study is testing a new type of MRI that uses a special form of sugar (pyruvate) to see how tumors use energy. Cancer cells consume more sugar than normal cells, and this scan aims to make that visible. About 25 adults with known or suspected tumors will be scanned to see if …

This study tests a personalized training program to reduce fall risk in older adults aged 60-85 who have fallen before or walk unsteadily. Participants receive home-based exercises guided by a cellphone app and hospital-based training targeting their specific balance or strength …

This study looks at whether taking methadone once a day or twice a day works better for people who have both chronic pain and opioid use disorder. About 150 adults currently on methadone treatment will be randomly assigned to one of the two dosing schedules. Researchers will trac…

This study tests a program called PAIN-CPG-EIT, designed to help nursing home staff better assess and manage pain in residents with dementia. The program includes monthly team meetings, staff education, mentoring, and ongoing checks. Researchers will compare this approach to educ…

This study is testing a special radiation device called the GammaPod to give a single, precise dose of radiation to the area where breast cancer was removed. The goal is to see if this approach can shorten the overall treatment time by a few days and improve patients' quality of …

This early-stage study tests whether diclofenac, an FDA-approved painkiller, can reduce alcohol cravings in people with alcohol use disorder. Researchers believe diclofenac may work by shifting brain chemistry away from harmful effects of alcohol. The study involves 24 adults who…

This study tests whether a wearable robot can help people who recently had a stroke recover movement in their legs and improve balance and walking. The robot provides intensive therapy to the ankle, which is often affected. The trial involves 140 participants who had a stroke wit…

This study tests whether buspirone, a medication for anxiety, can reduce withdrawal symptoms and cravings in people with opioid use disorder. About 100 adults will stay in a clinic for 10-12 days while they gradually stop taking opioids. Half will get buspirone and half a placebo…

This study tests a new glue for braces that skips the acid step, which can weaken teeth and cause white spots. Twenty people getting braces will have the new glue on one side of their mouth and the standard glue on the other. Researchers will check which side has fewer brackets p…

This study tests whether a virtual reality (VR) program used at home can help cancer survivors manage ongoing symptoms like pain, fatigue, anxiety, and depression. About 30 adults who finished cancer treatment at least 3 months ago will use either VR or an audio program daily for…

This study tests whether using virtual reality (VR) alongside standard care can reduce pain for adults with sickle cell disease who are in the emergency department with a painful crisis. About 30 participants will be split into three groups to compare pain scores and comfort. The…

This study tests whether following a healthy, anti-inflammatory diet for 16 weeks can reduce fatigue and improve muscle strength in adults aged 50 and older with long COVID. Participants are randomly assigned to either a personalized diet plan or general health sessions. The goal…

This study tests whether eating all food within a 10-hour window each day can reduce severe, long-lasting fatigue in blood cancer survivors. About 96 adults who finished cancer treatment at least 2 months ago will either follow this time-restricted eating plan or receive standard…

This study tests whether giving the drug daratumumab as a shot in the upper thigh works as well as the usual shot in the abdomen for people with plasma cell disorders like multiple myeloma. The goal is to find a less painful or more accessible injection spot. About 30 adults will…

This early-phase study at the University of Maryland is testing whether suvorexant, a sleep medication, can reduce the desire for drugs in people with opioid use disorder. Researchers will measure how much participants are willing to 'pay' for a study drug in a lab task, and whet…

This study gives healthy adults the licensed oral typhoid vaccine (Vivotif) and collects blood, saliva, and stool samples over up to eight years. Researchers want to learn how the vaccine triggers protective immune responses, which could help design better vaccines for typhoid an…

This early-phase study is testing whether the antidepressant fluoxetine (Prozac) and/or the hormone DHEA can improve the body's ability to defend against low blood sugar in people with type 1 diabetes. About 60 adults will take the drugs or a placebo for 8 weeks, then undergo two…

This study will test whether a special eye scan (OCT) can detect changes in the retina that show how well the MS drug ublituximab is working. Researchers will compare 15 people starting ublituximab with 15 people on other MS treatments. The goal is to find a new, non-invasive way…

This study is testing whether a blood test that looks for leftover tumor DNA after surgery can help decide who truly needs radiation. People with HPV-related throat cancer often do well, but standard treatments can cause harsh side effects. The goal is to give radiation only to t…

This study examines discarded tissue from 10 patients with benign tracheal stenosis, a rare condition where scarring narrows the windpipe. Researchers will analyze the tissue's RNA to identify what causes the scarring and inflammation. No new treatments are being tested—the goal …

This study aims to create a whole blood substitute by combining artificial oxygen carriers, plasma, and platelets. Researchers will test these mixtures in the lab using blood from 250 healthy volunteers to see if they can match the performance of real blood. The goal is to have a…

This pilot study is testing whether a non-contact imaging technique called Brillouin microscopy can measure corneal stiffness in people with glaucoma. Researchers will compare measurements between patients with high-tension glaucoma, normal-tension glaucoma, and healthy controls.…

This study tests a program that helps psychiatrists and clinics prescribe more medications for alcohol use disorder (AUD) to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and identify barriers. The study involves…

This study is testing two new risk scores that predict a patient's chance of developing sepsis or experiencing a sudden decline (like cardiac arrest or death) within the next 4 hours. The scores give a simple 1-to-4 color-coded risk level to alert hospital staff. The goal is to s…

This study looks at whether learning to play a pretend musical instrument can improve the brain's wiring in people with schizophrenia. The brain's white matter, which helps different areas communicate, is often damaged in schizophrenia and linked to slower thinking. Researchers w…

This study looks at how different levels of low blood sugar (hypoglycemia) affect blood vessels in healthy adults. Researchers want to understand if low blood sugar causes inflammation or blood clotting changes. The study involves 32 healthy volunteers and uses a controlled proce…

This study looks at two ways to treat pelvic fractures in people 60 and older: surgery or non-surgical care. Researchers want to see if patients and doctors are willing to join a larger trial to compare these options. The goal is to improve recovery and reduce healthcare costs.

This study tests if a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer common illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. The program focuses on strengthe…

This study looks at whether eating one cup of broccoli microgreens daily for two weeks is practical for obese breast cancer survivors. Researchers will check if participants stick with the diet and measure changes in body fat, blood sugar, and gut bacteria. The goal is to learn i…

This study looks at how immersive virtual reality changes the way the brain processes chronic pain, compared to a placebo effect. Researchers will measure brain activity and pain tolerance in 78 adults with temporomandibular disorder (jaw pain). The goal is to develop new, low-ri…

This study looks at how opioid withdrawal symptoms vary from person to person. Researchers will monitor 60 adults with opioid use disorder as they slowly stop taking opioids with the help of medication. The goal is to better understand withdrawal patterns, not to test a new treat…

This study looks at whether older adults (55+) receiving methadone for opioid use disorder can use fun, short brain games on a smartphone to track and possibly improve their thinking skills. Thirty participants will play these games for 15 days, and researchers will measure how o…

This study explores whether virtual reality exercise can help older adults (55+) stay physically active and maintain their strength and mental health while in the hospital. Researchers will test the approach with 140 participants to see if it is acceptable and practical. The goal…

This study explores whether a 12-week program combining computer-based brain training and aerobic exercise can improve brain function in older adults with mild cognitive impairment (MCI), a condition that sometimes leads to Alzheimer's. Researchers will measure changes in brain s…

This study is a small pilot trial to see if giving older adults a nerve block (a numbing injection) before leg fracture surgery is feasible for a larger study. Researchers want to know if this approach can reduce complications and improve recovery, beyond just pain relief. About …

This study tests whether a type of brain stimulation called repetitive TMS can increase natural brain inhibition in 34 people with schizophrenia. The goal is to see if this change relates to better thinking and memory. Participants will receive five days of treatment and undergo …

This study follows 250 adults aged 65 and older who have had a mild traumatic brain injury (TBI), often from a fall. Researchers will check their thinking, physical abilities, mood, and sleep at 2 weeks, 3 months, 6 months, and 1 year after the injury. The goal is to understand h…

This study looks at whether giving less fluid during heart surgery, a technique to reduce blood loss, increases the risk of kidney injury. Researchers will measure kidney injury markers in 100 adults having elective bypass surgery. The goal is to understand if this common practic…

This study collects information and biological samples from 150 adults who have had cancer therapy and now have eye complications, such as dry eye or graft-versus-host disease. Researchers will track their eye health over time using standard exams and lab tests. The goal is to le…

This study looks at whether it is safe to send people home the same day after hip or knee replacement without a final physical therapy check. Instead, patients learn to walk with a therapist before surgery and are helped by nurses after. The goal is to see if this approach leads …

This study is creating a registry and biobank for 350 adults with autosomal dominant polycystic kidney disease (ADPKD). Researchers will collect medical images, blood, urine, and DNA samples, and track quality of life. The goal is to provide a resource that helps other scientists…

This study looks at the best way to inform family members about their risk for two inherited conditions: Long QT Syndrome and Familial Hypercholesterolemia. Researchers will compare having the study team directly contact relatives versus asking the patient to contact them. About …

This study looks at eye changes in 150 adult cancer patients to understand why some develop severe dry eye after stem cell transplants (graft-versus-host disease). Researchers will collect eye samples and medical data to identify risk factors, markers, and possible treatment targ…